This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple tran... See more...

Aliases for GSTK1 Gene

Aliases for GSTK1 Gene

  • Glutathione S-Transferase Kappa 1 2 3 4 5
  • GST Class-Kappa 3 4
  • GST 13-13 3 4
  • GSTK1-1 3 4
  • HGSTK1 3 4
  • Glutathione S-Transferase Subunit 13 Homolog 3
  • Glutathione S-Transferase Subunit 13 4
  • Glutathione S-Transferase K1 3
  • EC 2.5.1.18 4
  • GST13-13 3
  • GST13 3
  • GST 3

External Ids for GSTK1 Gene

Previous GeneCards Identifiers for GSTK1 Gene

  • GC00U913601
  • GC07U901487
  • GC07P142477
  • GC07P142670
  • GC07P142942
  • GC07P137297
  • GC07P143245
  • GC07P144236
  • GC07P144371
  • GC07P144499
  • GC07P143248
  • GC07P143399
  • GC07P143546
  • GC07P143680
  • GC07P143819
  • GC07P143961
  • GC07P144092

Summaries for GSTK1 Gene

Entrez Gene Summary for GSTK1 Gene

  • This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GeneCards Summary for GSTK1 Gene

GSTK1 (Glutathione S-Transferase Kappa 1) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and glutathione transferase activity.

UniProtKB/Swiss-Prot Summary for GSTK1 Gene

  • Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

Gene Wiki entry for GSTK1 Gene

Additional gene information for GSTK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTK1 Gene

Genomics for GSTK1 Gene

GeneHancer (GH) Regulatory Elements for GSTK1 Gene

Promoters and enhancers for GSTK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143262 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 510.4 +19.9 19851 3.1 ZBTB40 ZNF217 SIN3A NRF1 POLR2G NCOR1 GTF2E2 PHF8 ZIC2 POLR2A GSTK1 NONHSAG049032.2 piR-44878-046 ENSG00000231840 LOC105375545 LOC105375546
GH07J143244 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 500.7 +1.2 1203 1.3 ZNF266 FOS FOSL2 MCM7 PRDM6 MITF TOE1 FOXA1 STAT3 GSTK1 CASP2 RN7SL535P FAM131B TMEM139 ENSG00000231840 ENSG00000253882 ENSG00000232533 ZYX TCAF2
GH07J143245 Enhancer 0.4 ENCODE 500.7 -0.3 -296 1 MYC MEIS2 KDM1A MAX PKNOX1 GSTK1 RF00017-6710 LOC105375546
GH07J143243 Enhancer 0.2 ENCODE 500.7 -0.9 -870 0.2 GSTK1 RF00017-6710 LOC105375546
GH07J143299 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.8 +56.5 56508 4 ZNF217 CTCF FOS REST CUX1 SMC3 CTBP1 RAD21 SPI1 GATA3 GSTK1 ENSG00000232533 ZYX FAM131B EPHB6 CASP2 RN7SL481P RF00017-6712 lnc-TMEM139-3 HINT1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTK1

Top Transcription factor binding sites by QIAGEN in the GSTK1 gene promoter:
  • AP-4
  • Cart-1
  • E47
  • Hand1
  • ISGF-3
  • p300
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • STAT3

Genomic Locations for GSTK1 Gene

Genomic Locations for GSTK1 Gene
chr7:143,244,093-143,270,854
(GRCh38/hg38)
Size:
26,762 bases
Orientation:
Plus strand
chr7:142,941,186-142,967,947
(GRCh37/hg19)
Size:
26,762 bases
Orientation:
Plus strand

Genomic View for GSTK1 Gene

Genes around GSTK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTK1 Gene

Proteins for GSTK1 Gene

  • Protein details for GSTK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Q3-GSTK1_HUMAN
    Recommended name:
    Glutathione S-transferase kappa 1
    Protein Accession:
    Q9Y2Q3
    Secondary Accessions:
    • B4DIH1
    • B4DSY2
    • Q6P4H0
    • Q7Z520
    • Q9P1S4

    Protein attributes for GSTK1 Gene

    Size:
    226 amino acids
    Molecular mass:
    25497 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTK1 Gene

    Alternative splice isoforms for GSTK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTK1 Gene

Post-translational modifications for GSTK1 Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GSTK1 Gene

Domains & Families for GSTK1 Gene

Gene Families for GSTK1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GSTK1 Gene

Blocks:
  • DSBA oxidoreductase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GSTK1 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione S-transferase subunit 13 (GSTK1_HUMAN)
  • GSTK1 protein (Q2NLC8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2Q3

UniProtKB/Swiss-Prot:

GSTK1_HUMAN :
  • Belongs to the GST superfamily. Kappa family.
Family:
  • Belongs to the GST superfamily. Kappa family.
genes like me logo Genes that share domains with GSTK1: view

Function for GSTK1 Gene

Molecular function for GSTK1 Gene

UniProtKB/Swiss-Prot Function:
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18;.

Enzyme Numbers (IUBMB) for GSTK1 Gene

Phenotypes From GWAS Catalog for GSTK1 Gene

Gene Ontology (GO) - Molecular Function for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 14742434
GO:0004602 glutathione peroxidase activity IDA,IEA 14742434
GO:0005515 protein binding IPI 19011089
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTK1: view
genes like me logo Genes that share phenotypes with GSTK1: view

Animal Models for GSTK1 Gene

MGI Knock Outs for GSTK1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTK1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTK1 Gene

Localization for GSTK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTK1 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTK1 gene
Compartment Confidence
peroxisome 5
mitochondrion 4
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005739 mitochondrion IBA,IEA 21873635
GO:0005759 mitochondrial matrix TAS,IEA --
GO:0005777 peroxisome IBA,IDA 14742434
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with GSTK1: view

Pathways & Interactions for GSTK1 Gene

genes like me logo Genes that share pathways with GSTK1: view

Pathways by source for GSTK1 Gene

1 GeneGo (Thomson Reuters) pathway for GSTK1 Gene
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GSTK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006625 protein targeting to peroxisome TAS --
GO:0006749 glutathione metabolic process IEA,IBA 21873635
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GSTK1: view

No data available for SIGNOR curated interactions for GSTK1 Gene

Drugs & Compounds for GSTK1 Gene

(7) Drugs for GSTK1 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Trichloroethylene Approved Pharma 5
Water Approved Pharma 0
GLUTATHIONE SULFINATE Experimental Pharma Target 0
Hydrochloric acid Experimental Pharma 0

(35) Additional Compounds for GSTK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane

(2) ApexBio Compounds for GSTK1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTK1: view

Transcripts for GSTK1 Gene

mRNA/cDNA for GSTK1 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTK1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for GSTK1 Gene

GeneLoc Exon Structure for
GSTK1

Expression for GSTK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTK1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTK1 Gene



Protein tissue co-expression partners for GSTK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTK1

SOURCE GeneReport for Unigene cluster for GSTK1 Gene:

Hs.390667

mRNA Expression by UniProt/SwissProt for GSTK1 Gene:

Q9Y2Q3-GSTK1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GSTK1 Gene

  • Liver(4.6)
  • Nervous system(4.6)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Blood(4.3)
  • Pancreas(4.3)
  • Intestine(3.4)
  • Heart(2.6)
  • Lung(2.5)
  • Muscle(2.5)
  • Skin(2.4)
  • Kidney(2.1)
  • Gall bladder(2)
  • Stomach(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with GSTK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTK1 Gene

Orthologs for GSTK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTK1 31 30
  • 96.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GSTK1 30
  • 86.43 (n)
-- 31
  • 85 (a)
OneToMany
-- 31
  • 73 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia GSTK1 31 30
  • 81.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gstk1 30
  • 76.99 (n)
mouse
(Mus musculus)
Mammalia Gstk1 17 31 30
  • 73.3 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 73 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GSTK1 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTK1 31 30
  • 62.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTK1 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstk1 30
  • 61.99 (n)
zebrafish
(Danio rerio)
Actinopterygii gstk1 31 30
  • 56.54 (n)
OneToMany
GSTK1 (4 of 4) 31
  • 45 (a)
OneToMany
GSTK1 (3 of 4) 31
  • 43 (a)
OneToMany
GSTK1 (1 of 4) 31
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gstk-1 31 30
  • 46.57 (n)
OneToMany
gstk-2 31
  • 30 (a)
OneToMany
Species where no ortholog for GSTK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTK1 Gene

ENSEMBL:
Gene Tree for GSTK1 (if available)
TreeFam:
Gene Tree for GSTK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTK1: view image

Paralogs for GSTK1 Gene

(1) SIMAP similar genes for GSTK1 Gene using alignment to 4 proteins:

  • GSTK1_HUMAN
  • C9JNT3_HUMAN
  • E9PFN5_HUMAN
  • Q2NLC8_HUMAN
genes like me logo Genes that share paralogs with GSTK1: view

No data available for Paralogs for GSTK1 Gene

Variants for GSTK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTK1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
708871 Likely Benign: not provided 143,265,090(+) A/G MISSENSE_VARIANT
726354 Benign: not provided 143,268,111(+) C/T SYNONYMOUS_VARIANT
776267 Benign: not provided 143,268,784(+) C/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GSTK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GSTK1 Gene

Variant ID Type Subtype PubMed ID
esv2735280 CNV deletion 23290073
nsv831169 CNV loss 17160897

Variation tolerance for GSTK1 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTK1 Gene

Human Gene Mutation Database (HGMD)
GSTK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTK1 Gene

Disorders for GSTK1 Gene

Additional Disease Information for GSTK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GSTK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTK1 Gene

Publications for GSTK1 Gene

  1. Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases. (PMID: 14709161) Robinson A … Board PG (The Biochemical journal 2004) 3 4 23 26 54
  2. Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization. (PMID: 14742434) Morel F … Guillouzo A (The Journal of biological chemistry 2004) 2 3 4 23 54
  3. Polymorphism of DsbA-L gene associates with insulin secretion and body fat distribution in Chinese population. (PMID: 19225211) Gao F … Xiang K (Endocrine journal 2009) 3 41 54
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 41 54
  5. Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme. (PMID: 16081649) Li J … Ding J (Protein science : a publication of the Protein Society 2005) 3 4 54

Products for GSTK1 Gene

Sources for GSTK1 Gene