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Aliases for GSTCD Gene

Aliases for GSTCD Gene

  • Glutathione S-Transferase C-Terminal Domain Containing 2 3 5

External Ids for GSTCD Gene

Previous GeneCards Identifiers for GSTCD Gene

  • GC04P106849
  • GC04P106629
  • GC04P102364

Summaries for GSTCD Gene

GeneCards Summary for GSTCD Gene

GSTCD (Glutathione S-Transferase C-Terminal Domain Containing) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and rRNA methyltransferase activity.

Additional gene information for GSTCD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTCD Gene

Genomics for GSTCD Gene

GeneHancer (GH) Regulatory Elements for GSTCD Gene

Promoters and enhancers for GSTCD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I105707 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 604.1 +0.5 464 4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 GSTCD INTS12 LOC101929577 TBCK EEF1A1P9 AIMP1 LOC101929529 TET2 ARHGEF38
GH04I105637 Enhancer 0.8 Ensembl dbSUPER 42.3 -71.1 -71077 0.2 ZNF132 SMAD1 NFIB HLF ZNF331 ZNF195 FEZF1 YY1 NFIC LCORL LOC101929577 GSTCD TBCK LOC105377352 ARHGEF38 AIMP1 ENSG00000248778 ARHGEF38-IT1
GH04I105683 Enhancer 0.6 ENCODE 11.2 -25.6 -25559 0.2 SMARCE1 NFIB DPF2 FOXA1 ZNF217 CTBP1 GATA3 RCOR1 CUX1 INTS12 GSTCD ENSG00000248778 ARHGEF38
GH04I105612 Enhancer 0.5 dbSUPER 10.1 -95.1 -95069 1.6 SMARCE1 ZNF217 CTBP1 GATA3 DPF2 MNT INTS12 LOC105377352 ARHGEF38 GSTCD ARHGEF38-IT1 ENSG00000248778
GH04I104965 Enhancer 1 Ensembl ENCODE 5 -741.8 -741780 2.5 PKNOX1 CLOCK RB1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 ENSG00000248242 TET2 GSTCD RNU6-351P ENSG00000248373
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTCD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTCD gene promoter:

Genomic Locations for GSTCD Gene

Genomic Locations for GSTCD Gene
chr4:105,708,778-105,847,728
(GRCh38/hg38)
Size:
138,951 bases
Orientation:
Plus strand
chr4:106,629,935-106,768,885
(GRCh37/hg19)

Genomic View for GSTCD Gene

Genes around GSTCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTCD Gene

Proteins for GSTCD Gene

  • Protein details for GSTCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEC7-GSTCD_HUMAN
    Recommended name:
    Glutathione S-transferase C-terminal domain-containing protein
    Protein Accession:
    Q8NEC7
    Secondary Accessions:
    • A8K8J0
    • A8MVD3
    • H9KV97
    • Q9H8S3

    Protein attributes for GSTCD Gene

    Size:
    633 amino acids
    Molecular mass:
    71079 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14532.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BX648355; Type=Frameshift; Positions=474; Evidence={ECO:0000305};

    Alternative splice isoforms for GSTCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTCD Gene

Post-translational modifications for GSTCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSTCD Gene

Domains & Families for GSTCD Gene

Gene Families for GSTCD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GSTCD Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEC7

UniProtKB/Swiss-Prot:

GSTCD_HUMAN :
  • Belongs to the GSTCD family.
Family:
  • Belongs to the GSTCD family.
genes like me logo Genes that share domains with GSTCD: view

Function for GSTCD Gene

Phenotypes From GWAS Catalog for GSTCD Gene

Gene Ontology (GO) - Molecular Function for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with GSTCD: view
genes like me logo Genes that share phenotypes with GSTCD: view

Animal Models for GSTCD Gene

MGI Knock Outs for GSTCD:

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTCD

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTCD Gene

Localization for GSTCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTCD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTCD gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 24058608
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with GSTCD: view

Pathways & Interactions for GSTCD Gene

genes like me logo Genes that share pathways with GSTCD: view

Pathways by source for GSTCD Gene

1 BioSystems pathway for GSTCD Gene

Gene Ontology (GO) - Biological Process for GSTCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GSTCD: view

No data available for SIGNOR curated interactions for GSTCD Gene

Drugs & Compounds for GSTCD Gene

No Compound Related Data Available

Transcripts for GSTCD Gene

Unigene Clusters for GSTCD Gene

Glutathione S-transferase, C-terminal domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTCD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7: -
SP8: - -

Relevant External Links for GSTCD Gene

GeneLoc Exon Structure for
GSTCD
ECgene alternative splicing isoforms for
GSTCD

Expression for GSTCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTCD Gene

Protein differential expression in normal tissues from HIPED for GSTCD Gene

This gene is overexpressed in Liver (50.1) and Monocytes (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTCD Gene



Protein tissue co-expression partners for GSTCD Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTCD Gene:

GSTCD

SOURCE GeneReport for Unigene cluster for GSTCD Gene:

Hs.161429

mRNA Expression by UniProt/SwissProt for GSTCD Gene:

Q8NEC7-GSTCD_HUMAN
Tissue specificity: Widely expressed in cell types relevant to airway function, including airway smooth muscle cells and epithelial cells.
genes like me logo Genes that share expression patterns with GSTCD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTCD Gene

Orthologs for GSTCD Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTCD 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia GSTCD 34 33
  • 91.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GSTCD 34 33
  • 88.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gstcd 33 16 34
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Gstcd 33
  • 79.83 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTCD 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSTCD 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSTCD 33 34
  • 70.97 (n)
lizard
(Anolis carolinensis)
Reptilia GSTCD 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstcd 33
  • 65.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14885 33
zebrafish
(Danio rerio)
Actinopterygii gstcd 33 34
  • 58.8 (n)
Dr.20454 33
fruit fly
(Drosophila melanogaster)
Insecta CG10428 33 34
  • 48.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008668 33
  • 46.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for GSTCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTCD Gene

ENSEMBL:
Gene Tree for GSTCD (if available)
TreeFam:
Gene Tree for GSTCD (if available)

Paralogs for GSTCD Gene

No data available for Paralogs for GSTCD Gene

Variants for GSTCD Gene

Sequence variations from dbSNP and Humsavar for GSTCD Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000000969 -- 105,846,457(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000012156 -- 105,798,340(+) T/A intron_variant
rs10000340 -- 105,842,521(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000049044 -- 105,847,270(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000059387 -- 105,746,079(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTCD Gene

Variant ID Type Subtype PubMed ID
esv26261 CNV loss 19812545
esv2658421 CNV deletion 23128226
esv3306864 CNV mobile element insertion 20981092
esv3372040 CNV insertion 20981092
esv3372129 CNV insertion 20981092
esv3601669 CNV loss 21293372
nsv1000196 CNV loss 25217958
nsv1000947 CNV loss 25217958
nsv436449 CNV deletion 17901297
nsv441904 CNV loss 18776908
nsv514237 CNV loss 21397061
nsv526871 CNV gain 19592680

Variation tolerance for GSTCD Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTCD Gene

Human Gene Mutation Database (HGMD)
GSTCD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTCD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTCD Gene

Disorders for GSTCD Gene

Additional Disease Information for GSTCD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GSTCD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTCD Gene

Publications for GSTCD Gene

  1. GSTCD and INTS12 regulation and expression in the human lung. (PMID: 24058608) Obeidat M … Hall IP (PloS one 2013) 3 4 58
  2. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 44 58
  3. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PMID: 20010835) Hancock DB … London SJ (Nature genetics 2010) 3 44 58
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for GSTCD Gene

Sources for GSTCD Gene

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