The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008] See more...

Aliases for GSTA5 Gene

Aliases for GSTA5 Gene

  • Glutathione S-Transferase Alpha 5 2 3 5
  • Glutathione S-Transferase A5 2 3 4
  • Glutathione S-Transferase A5-5 3 4
  • GST Class-Alpha Member 5 3 4
  • EC 2.5.1.18 4 51
  • GSTA5 5

External Ids for GSTA5 Gene

Previous GeneCards Identifiers for GSTA5 Gene

  • GC06M052652
  • GC06M052697
  • GC06M052743
  • GC06M052804
  • GC06M052696
  • GC06M052527

Summaries for GSTA5 Gene

Entrez Gene Summary for GSTA5 Gene

  • The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]

GeneCards Summary for GSTA5 Gene

GSTA5 (Glutathione S-Transferase Alpha 5) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTA5 Gene

Genomics for GSTA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GSTA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTA5

Top Transcription factor binding sites by QIAGEN in the GSTA5 gene promoter:
  • AP-4
  • CUTL1
  • Evi-1
  • GATA-3
  • HNF-1
  • HNF-1A
  • HNF-4alpha1
  • YY1

Genomic Locations for GSTA5 Gene

Genomic Locations for GSTA5 Gene
chr6:52,831,655-52,846,095
(GRCh38/hg38)
Size:
14,441 bases
Orientation:
Minus strand
chr6:52,696,453-52,710,893
(GRCh37/hg19)
Size:
14,441 bases
Orientation:
Minus strand

Genomic View for GSTA5 Gene

Genes around GSTA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA5 Gene

Proteins for GSTA5 Gene

  • Protein details for GSTA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTV2-GSTA5_HUMAN
    Recommended name:
    Glutathione S-transferase A5
    Protein Accession:
    Q7RTV2
    Secondary Accessions:
    • Q5SZC2

    Protein attributes for GSTA5 Gene

    Size:
    222 amino acids
    Molecular mass:
    25722 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTA5 Gene

Selected DME Specific Peptides for GSTA5 Gene

Q7RTV2:
  • KERALIDMY
  • IDMYTEG
  • QTRAILNYIA
  • RYFPAFE
  • KYNLYGKD
  • PAFEKVLKSH
  • SNLPTVKKFLQPGS
  • QVPMVEIDGMKL
  • LVGNKLS
  • KKFLQPGSQR

Post-translational modifications for GSTA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSTA5 Gene

Gene Families for GSTA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GSTA5 Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Alpha-class glutathione S-transferase signature
ProtoNet:

Suggested Antigen Peptide Sequences for GSTA5 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione S-transferase A5-5 (GSTA5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7RTV2

UniProtKB/Swiss-Prot:

GSTA5_HUMAN :
  • Belongs to the GST superfamily. Alpha family.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA5: view

Function for GSTA5 Gene

Molecular function for GSTA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:19664689};.

Enzyme Numbers (IUBMB) for GSTA5 Gene

Phenotypes From GWAS Catalog for GSTA5 Gene

Gene Ontology (GO) - Molecular Function for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA,ISS --
GO:0005515 protein binding IPI 28514442
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTA5: view
genes like me logo Genes that share phenotypes with GSTA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTA5 Gene

Localization for GSTA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTA5 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,IDA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GSTA5: view

Pathways & Interactions for GSTA5 Gene

genes like me logo Genes that share pathways with GSTA5: view

Pathways by source for GSTA5 Gene

2 GeneGo (Thomson Reuters) pathways for GSTA5 Gene
  • 2-Naphthylamine and 2-Nitronaphtalene metabolism
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
GO:0006805 xenobiotic metabolic process IBA 21873635
genes like me logo Genes that share ontologies with GSTA5: view

No data available for SIGNOR curated interactions for GSTA5 Gene

Drugs & Compounds for GSTA5 Gene

(5) Drugs for GSTA5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0
Hydrochloric acid Experimental Pharma 0
Sulfate Experimental, Investigational Pharma 0

(37) Additional Compounds for GSTA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTA5: view

Transcripts for GSTA5 Gene

mRNA/cDNA for GSTA5 Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA5

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA5 Gene

No ASD Table

Relevant External Links for GSTA5 Gene

GeneLoc Exon Structure for
GSTA5

Expression for GSTA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA5 Gene

This gene is overexpressed in Testis (x17.0), Adrenal Gland (x7.5), Minor Salivary Gland (x7.1), Liver (x6.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GSTA5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GSTA5 Gene



Protein tissue co-expression partners for GSTA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTA5

SOURCE GeneReport for Unigene cluster for GSTA5 Gene:

Hs.646984

mRNA Expression by UniProt/SwissProt for GSTA5 Gene:

Q7RTV2-GSTA5_HUMAN
Tissue specificity: Expression not detected.

Evidence on tissue expression from TISSUES for GSTA5 Gene

  • Liver(2.8)
  • Nervous system(2.6)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with GSTA5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA5 Gene

Orthologs for GSTA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSTA5 30 31
  • 98.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 82 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gsta2 30 17
  • 81.38 (n)
Gsta1 17 31
  • 74 (a)
ManyToMany
Gm10639 17
Gm3776 17
Rat
(Rattus norvegicus)
Mammalia Gsta5 30
  • 80.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 59 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 57 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GSTA3 31
  • 63 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 65 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11028 30
Zebrafish
(Danio rerio)
Actinopterygii zgc:173961 31
  • 52 (a)
ManyToMany
gstal 31
  • 52 (a)
ManyToMany
zgc:173962 31
  • 52 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea gst-41 31
  • 28 (a)
ManyToMany
F56A4.4 31
  • 27 (a)
ManyToMany
Y45G12C.3 31
  • 27 (a)
ManyToMany
gst-10 31
  • 27 (a)
ManyToMany
F56A4.3 31
  • 27 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToMany
Species where no ortholog for GSTA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GSTA5 Gene

ENSEMBL:
Gene Tree for GSTA5 (if available)
TreeFam:
Gene Tree for GSTA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTA5: view image

Paralogs for GSTA5 Gene

Paralogs for GSTA5 Gene

(5) SIMAP similar genes for GSTA5 Gene using alignment to 1 proteins:

  • GSTA5_HUMAN

Pseudogenes.org Pseudogenes for GSTA5 Gene

genes like me logo Genes that share paralogs with GSTA5: view

Variants for GSTA5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTA5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2397118 - p.Val55Ile

Additional dbSNP identifiers (rs#s) for GSTA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GSTA5 Gene

Variant ID Type Subtype PubMed ID
esv2436160 CNV deletion 19546169
esv2673977 CNV deletion 23128226
esv2732085 CNV deletion 23290073
esv2732088 CNV deletion 23290073
esv2732089 CNV deletion 23290073
esv3609011 CNV loss 21293372
nsv1032774 CNV gain 25217958
nsv462945 CNV loss 19166990
nsv470818 CNV loss 18288195
nsv482097 CNV gain 20164927
nsv603106 CNV loss 21841781
nsv981144 CNV duplication 23825009

Variation tolerance for GSTA5 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA5 Gene

Disorders for GSTA5 Gene

Additional Disease Information for GSTA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for GSTA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA5 Gene

Publications for GSTA5 Gene

  1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PMID: 12042665) Morel F … Guillouzo A (Pharmacogenetics 2002) 2 3 4
  2. The human hGSTA5 gene encodes an enzymatically active protein. (PMID: 19664689) Singh SP … Zimniak P (Biochimica et biophysica acta 2010) 3 4
  3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 41
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 41

Products for GSTA5 Gene

  • Signalway ELISA kits for GSTA5

Sources for GSTA5 Gene