Free for academic non-profit institutions. Other users need a Commercial license
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
GSTA5 (Glutathione S-Transferase Alpha 5) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004364 | glutathione transferase activity | IBA,ISS | -- |
GO:0005515 | protein binding | IPI | 28514442 |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IBA,IDA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
2 | Drug metabolism - cytochrome P450 | ||
3 | Cytochrome P450 - arranged by substrate type | ||
4 | Metabolism |
.40
|
|
5 | Fluid shear stress and atherosclerosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006749 | glutathione metabolic process | ISS | -- |
GO:0006805 | xenobiotic metabolic process | IBA | 21873635 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
(1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
1,1-Dichloroethylene epoxide |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GSTA5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Gsta2 30 17 |
|
||
Gsta1 17 31 |
|
ManyToMany | |||
Gm10639 17 |
|
||||
Gm3776 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Gsta5 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | GSTA3 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.11028 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:173961 31 |
|
ManyToMany | |
gstal 31 |
|
ManyToMany | |||
zgc:173962 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | gst-41 31 |
|
ManyToMany | |
F56A4.4 31 |
|
ManyToMany | |||
Y45G12C.3 31 |
|
ManyToMany | |||
gst-10 31 |
|
ManyToMany | |||
F56A4.3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2397118 | - | p.Val55Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2436160 | CNV | deletion | 19546169 |
esv2673977 | CNV | deletion | 23128226 |
esv2732085 | CNV | deletion | 23290073 |
esv2732088 | CNV | deletion | 23290073 |
esv2732089 | CNV | deletion | 23290073 |
esv3609011 | CNV | loss | 21293372 |
nsv1032774 | CNV | gain | 25217958 |
nsv462945 | CNV | loss | 19166990 |
nsv470818 | CNV | loss | 18288195 |
nsv482097 | CNV | gain | 20164927 |
nsv603106 | CNV | loss | 21841781 |
nsv981144 | CNV | duplication | 23825009 |
No disorders were found for GSTA5 Gene.