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Aliases for GSTA5 Gene

Aliases for GSTA5 Gene

  • Glutathione S-Transferase Alpha 5 2 3 5
  • EC 4 56
  • Glutathione S-Transferase A5-5 4
  • Glutathione S-Transferase A5 2
  • GST Class-Alpha Member 5 4

External Ids for GSTA5 Gene

Previous GeneCards Identifiers for GSTA5 Gene

  • GC06M052652
  • GC06M052697
  • GC06M052743
  • GC06M052804
  • GC06M052696
  • GC06M052527

Summaries for GSTA5 Gene

Entrez Gene Summary for GSTA5 Gene

  • The glutathione S-transferases (GST; EC catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]

GeneCards Summary for GSTA5 Gene

GSTA5 (Glutathione S-Transferase Alpha 5) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.

Additional gene information for GSTA5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA5 Gene

Genomics for GSTA5 Gene

GeneHancer (GH) Regulatory Elements for GSTA5 Gene

Promoters and enhancers for GSTA5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I052846 Promoter 0.6 EPDnew 550.8 -0.1 -57 0.1 EGR2 GSTA5 GC06P052867
GH06I052508 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +331.7 331705 12.4 PKNOX1 SMAD1 FOXA2 MLX ARID4B FEZF1 DMAP1 IRF4 YY1 POLR2B EFHC1 MCM3 PAQR8 TRAM2 TRAM2-AS1 GSTA5 PIR40531 PIR31355
GH06I052549 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +294.2 294155 5 FOXA2 NFIB INSM2 ARID4B KLF17 SIN3A BATF RAD21 YY1 ZSCAN5C TRAM2-AS1 TRAM2 EFHC1 PAQR8 GSTA5 GC06P052544
GH06I052839 Enhancer 0.9 ENCODE 0.4 +6.3 6327 0.2 ZFP64 ARID4B ZNF48 ZNF143 FOS REST MIER2 SMARCB1 PPARG ZNF592 GSTA5 GC06P052825
GH06I052856 Enhancer 0.7 ENCODE 0.4 -10.4 -10359 0.9 ELF3 FOXA2 SAP130 ARID4B ZIC2 ZNF644 ZBTB40 TEAD3 ZFHX2 FOXK2 GSTA1 GSTA3 ICK GSTA7P GC06P052867 GSTA11P GSTA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTA5 gene promoter:

Genomic Locations for GSTA5 Gene

Genomic Locations for GSTA5 Gene
14,441 bases
Minus strand

Genomic View for GSTA5 Gene

Genes around GSTA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA5 Gene

Proteins for GSTA5 Gene

  • Protein details for GSTA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase A5
    Protein Accession:
    Secondary Accessions:
    • Q5SZC2

    Protein attributes for GSTA5 Gene

    222 amino acids
    Molecular mass:
    25722 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTA5 Gene

Selected DME Specific Peptides for GSTA5 Gene


Post-translational modifications for GSTA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GSTA5 Gene

Gene Families for GSTA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GST superfamily. Alpha family.
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA5: view

Function for GSTA5 Gene

Molecular function for GSTA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.

Enzyme Numbers (IUBMB) for GSTA5 Gene

Gene Ontology (GO) - Molecular Function for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity ISS --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTA5: view
genes like me logo Genes that share phenotypes with GSTA5: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTA5 Gene

Localization for GSTA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTA5 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with GSTA5: view

Pathways & Interactions for GSTA5 Gene

genes like me logo Genes that share pathways with GSTA5: view

Gene Ontology (GO) - Biological Process for GSTA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process ISS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with GSTA5: view

No data available for SIGNOR curated interactions for GSTA5 Gene

Drugs & Compounds for GSTA5 Gene

(3) Drugs for GSTA5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(39) Additional Compounds for GSTA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTA5: view

Transcripts for GSTA5 Gene

mRNA/cDNA for GSTA5 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA5 Gene

No ASD Table

Relevant External Links for GSTA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA5 Gene

This gene is overexpressed in Testis (x17.0), Adrenal Gland (x7.5), Minor Salivary Gland (x7.1), Liver (x6.9), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GSTA5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTA5 Gene

Protein tissue co-expression partners for GSTA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTA5 Gene:


SOURCE GeneReport for Unigene cluster for GSTA5 Gene:


mRNA Expression by UniProt/SwissProt for GSTA5 Gene:

Tissue specificity: Expression not detected.

Evidence on tissue expression from TISSUES for GSTA5 Gene

  • Liver(2.6)
genes like me logo Genes that share expression patterns with GSTA5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA5 Gene

Orthologs for GSTA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GSTA5 33 34
  • 98.5 (n)
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
(Mus musculus)
Mammalia Gsta2 33 16
  • 81.38 (n)
Gsta1 34
  • 74 (a)
(Rattus norvegicus)
Mammalia Gsta5 33
  • 80.63 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Canis familiaris)
Mammalia -- 34
  • 57 (a)
(Gallus gallus)
Aves GSTA3 34
  • 63 (a)
-- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11028 33
(Danio rerio)
Actinopterygii gstal 34
  • 52 (a)
zgc:173961 34
  • 52 (a)
zgc:173962 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea gst-41 34
  • 28 (a)
F56A4.3 34
  • 27 (a)
F56A4.4 34
  • 27 (a)
gst-10 34
  • 27 (a)
Y45G12C.3 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for GSTA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTA5 Gene

Gene Tree for GSTA5 (if available)
Gene Tree for GSTA5 (if available)

Paralogs for GSTA5 Gene

Paralogs for GSTA5 Gene

(5) SIMAP similar genes for GSTA5 Gene using alignment to 1 proteins: Pseudogenes for GSTA5 Gene

genes like me logo Genes that share paralogs with GSTA5: view

Variants for GSTA5 Gene

Sequence variations from dbSNP and Humsavar for GSTA5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000346022 -- 52,842,207(-) A/G intron_variant
rs1000450229 -- 52,836,859(-) C/T intron_variant
rs1000551504 -- 52,837,125(-) A/C/G intron_variant
rs1001114666 -- 52,839,021(-) C/T intron_variant
rs1001168805 -- 52,839,279(-) TGGATGGA/TGGA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTA5 Gene

Variant ID Type Subtype PubMed ID
esv2436160 CNV deletion 19546169
esv2673977 CNV deletion 23128226
esv2732085 CNV deletion 23290073
esv2732088 CNV deletion 23290073
esv2732089 CNV deletion 23290073
esv3609011 CNV loss 21293372
nsv1032774 CNV gain 25217958
nsv462945 CNV loss 19166990
nsv470818 CNV loss 18288195
nsv482097 CNV gain 20164927
nsv603106 CNV loss 21841781
nsv981144 CNV duplication 23825009

Variation tolerance for GSTA5 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA5 Gene

Disorders for GSTA5 Gene

Additional Disease Information for GSTA5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GSTA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA5 Gene

Publications for GSTA5 Gene

  1. The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter. (PMID: 12042665) Morel F … Guillouzo A (Pharmacogenetics 2002) 2 3 4 58
  2. The human hGSTA5 gene encodes an enzymatically active protein. (PMID: 19664689) Singh SP … Zimniak P (Biochimica et biophysica acta 2010) 3 4 58
  3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58

Products for GSTA5 Gene

Sources for GSTA5 Gene

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