Aliases for GSTA4 Gene
Aliases for GSTA4 Gene
External Ids for GSTA4 Gene
- HGNC: 4629
- Entrez Gene: 2941
- Ensembl: ENSG00000170899
- OMIM: 605450
- UniProtKB: O15217
Previous GeneCards Identifiers for GSTA4 Gene
- GC06M052844
- GC06M052889
- GC06M052674
- GC06M052842
Summaries for GSTA4 Gene
-
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GSTA4 Gene
GSTA4 (Glutathione S-Transferase Alpha 4) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTA2.
UniProtKB/Swiss-Prot for GSTA4 Gene
-
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Additional gene information for GSTA4 Gene
- Monarch Initiative
- Search for GSTA4 at DataMed
- Search for GSTA4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTA4 Gene
Genomics for GSTA4 Gene
GeneHancer (GH) Regulatory Elements for GSTA4 Gene
Promoters and enhancers for GSTA4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J052992 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.3 | 339 | 4.1 | ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC | ENSG00000202198 GC06P052997 GSTA4 RN7SK MCM3 EFHC1 ICK TRAM2 GSTA3 GC06P052982 | |
| GH06J052908 | Promoter/Enhancer | 1 | EPDnew ENCODE | 8.2 | +85.7 | 85734 | 3.1 | SKI RFX1 HLF FOS ZBTB17 | GSTA3 GSTA4 GSTA10P | |
| GH06J053685 | Enhancer | 0.8 | dbSUPER | 9.9 | -691.5 | -691510 | 2.3 | FOXA2 ZNF493 ZFP64 ZNF213 ZNF138 ZNF366 ZNF202 ZNF680 ZNF654 ZBTB11 | LOC105375095 GSTA4 KLHL31 ENSG00000227885 | |
| GH06J052928 | Enhancer | 1.1 | Ensembl ENCODE | 7 | +65.7 | 65743 | 1.5 | FOXA2 ZFP64 TCF12 ZNF766 GATA2 ATF7 FOS RXRA SP5 NCOA1 | GSTA4 LINC01564 GC06P052940 GSTA3 | |
| GH06J052918 | Enhancer | 0.9 | ENCODE | 8.5 | +75.7 | 75661 | 3.4 | FOXA2 FEZF1 YY1 FOS RXRA NFYC REST SREBF1 NFIL3 MIER3 | GSTA4 GSTA3 LRRC1 GC06P052940 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTA4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GSTA4 gene promoter:
-
- Nkx2-5
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
- POU2F2C
Regulatory Element Products
Genomic Locations for GSTA4 Gene
Genomic Locations for GSTA4 Gene
- chr6:52,977,948-52,995,380
- (GRCh38/hg38)
- Size:
- 17,433 bases
- Orientation:
- Minus strand
- chr6:52,842,746-52,860,178
- (GRCh37/hg19)
- Size:
- 17,433 bases
- Orientation:
- Minus strand
Genomic View for GSTA4 Gene
Genes around GSTA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by Entrez Gene
- 6p12.2 by HGNC
- 6p12.2 by Ensembl
GSTA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTA4 Gene
Proteins for GSTA4 Gene
-
Protein details for GSTA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15217-GSTA4_HUMAN
- Recommended name:
- Glutathione S-transferase A4
- Protein Accession:
- O15217
- B2RD15
- Q5T7Q8
- Q6P4G1
- Q9BX18
- Q9H414
Protein attributes for GSTA4 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25704 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for GSTA4 Gene
Post-translational modifications for GSTA4 Gene
Other Protein References for GSTA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GSTA4
-
Abcam antibodies for GSTA4
- Invitrogen Antibodies for GSTA4
- GeneTex GSTA4 Antibody for GSTA4
-
Boster Bio Antibodies for GSTA4
Protein Products
-
OriGene Purified Proteins for GSTA4
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA4
- Origene Custom Protein Services for GSTA4
- Search GeneTex for Proteins for GSTA4
-
Abcam proteins for GSTA4
Assay Products
No data available for DME Specific Peptides for GSTA4 Gene
Domains & Families for GSTA4 Gene
Gene Families for GSTA4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GSTA4 Gene
Suggested Antigen Peptide Sequences for GSTA4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15217- Family:
-
- Belongs to the GST superfamily. Alpha family.
Function for GSTA4 Gene
Molecular function for GSTA4 Gene
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
- UniProtKB/Swiss-Prot CatalyticActivity:
- RX + glutathione = HX + R-S-glutathione.
- GENATLAS Biochemistry:
- glutathione S-transferase,alpha 4,ubiquitously expressed
Enzyme Numbers (IUBMB) for GSTA4 Gene
Phenotypes From GWAS Catalog for GSTA4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 16189514 |
| GO:0042803 | protein homodimerization activity | IPI | 10329152 |
Phenotypes for GSTA4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GSTA4
- Cyagen custom Knockout/knockin (KOKI) mouse models for GSTA4
-
CRISPR Products
-
OriGene CRISPR knockouts for GSTA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
- genomics-online: gRNA clones - Search results for available GSTA4 gene related products
- Applied Biological Materials CRISPR for GSTA4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA4
- GenScript: Design CRISPR guide RNA sequences for GSTA4
miRNA for GSTA4 Gene
- miRTarBase miRNAs that target GSTA4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
- genomics-online: shRNA clones - Search results for available GSTA4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GSTA4
- VectorBuilder custom plasmid, inducible vectors for GSTA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTA4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
- genomics-online: cdna clones - Search results for available GSTA4 gene related products
- orf clones - Search results for available GSTA4 gene related products
- Applied Biological Materials Clones for GSTA4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GSTA4
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTA4 Gene
Localization for GSTA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTA4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTA4 Gene
Pathways & Interactions for GSTA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glutathione metabolism | ||
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Fluid shear stress and atherosclerosis | ||
| 5 | Gastric cancer | ||
Pathways by source for GSTA4 Gene
4 BioSystems pathways for GSTA4 Gene
4 Reactome pathways for GSTA4 Gene
9 KEGG pathways for GSTA4 Gene
2 GeneGo (Thomson Reuters) pathways for GSTA4 Gene
Interacting Proteins for GSTA4 Gene
Selected Interacting proteins:
ENSP00000359998
O15217-GSTA4_HUMAN
for GSTA4 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for GSTA4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IDA | 10329152 |
| GO:0006805 | xenobiotic metabolic process | IDA | 10329152 |
| GO:0008152 | metabolic process | IEA | -- |
| GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for GSTA4 Gene
Drugs & Compounds for GSTA4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
| Trichloroethylene | Approved | Pharma | 5 | |||
| Water | Approved | Pharma | 0 | |||
| Lonafarnib | Investigational | Pharma | Ftase inhibitor,potent and selective | 0 | ||
| LB42708 | Pharma | Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-Hydroxynonenal |
|
75899-68-2 | ||||
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
Drug Products
Transcripts for GSTA4 Gene
mRNA/cDNA for GSTA4 Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (271) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000486559 1698 bps (uc063pav.1)
- ENST00000477599 1127 bps (uc063paw.1)
- ENST00000370963 1334 bps (uc003pbf.4)
- ENST00000370960 859 bps (uc063pax.1)
- ENST00000370959 793 bps (uc063pay.1)
Unigene Clusters for GSTA4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GSTA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
- genomics-online: gRNA clones - Search results for available GSTA4 gene related products
- Applied Biological Materials CRISPR for GSTA4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA4
- GenScript: Design CRISPR guide RNA sequences for GSTA4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
- genomics-online: shRNA clones - Search results for available GSTA4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GSTA4
- VectorBuilder custom plasmid, inducible vectors for GSTA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTA4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
- genomics-online: cdna clones - Search results for available GSTA4 gene related products
- orf clones - Search results for available GSTA4 gene related products
- Applied Biological Materials Clones for GSTA4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - |
| ExUns: | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: |
Expression for GSTA4 Gene
mRNA differential expression in normal tissues according to GTEx for GSTA4 Gene
This gene is overexpressed in Adrenal Gland (x8.9).
This gene is overexpressed in Adrenal (19.9), Fetal testis (18.5), and Fetal Brain (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTA4 Gene
NURSA nuclear receptor signaling pathways regulating expression of GSTA4 Gene:
GSTA4SOURCE GeneReport for Unigene cluster for GSTA4 Gene:
Hs.485557mRNA Expression by UniProt/SwissProt for GSTA4 Gene:
O15217-GSTA4_HUMAN
Tissue specificity:
Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Evidence on tissue expression from TISSUES for GSTA4 Gene
- Nervous system(4.9)
- Heart(4.3)
- Muscle(4.3)
- Pancreas(4.3)
- Liver(2.4)
- Skin(2.4)
- Adrenal gland(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for GSTA4
-
OriGene qPCR primer pairs for GSTA4
- genomics-online: primer clones - Search results for available GSTA4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA4 Gene
Orthologs for GSTA4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GSTA4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GSTA4 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | GSTA4 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GSTA4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GSTA4 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gsta3 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | GSTA 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | zgc:173961 34 |
|
ManyToMany | |
| gstal 34 |
|
ManyToMany | |||
| zgc:173962 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | gst-41 34 |
|
ManyToMany | |
| gst-10 34 |
|
ManyToMany | |||
| Y45G12C.3 34 |
|
ManyToMany | |||
| F56A4.4 34 |
|
ManyToMany | |||
| F56A4.3 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GSTA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for GSTA4 Gene
- ENSEMBL:
- Gene Tree for GSTA4 (if available)
- TreeFam:
- Gene Tree for GSTA4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTA4: view image
Paralogs for GSTA4 Gene
Variants for GSTA4 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000210850 | -- | 52,994,666(-) | A/C | intron_variant | |
| rs1000360756 | -- | 52,995,937(-) | G/A | upstream_transcript_variant | |
| rs1000576131 | -- | 52,979,320(-) | A/T | intron_variant | |
| rs1000600490 | -- | 52,984,005(-) | C/G/T | intron_variant | |
| rs1000728494 | -- | 52,977,506(-) | C/T | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759430 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.80;
16.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTA4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GSTA4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA4 Gene
Disorders for GSTA4 Gene
Additional Disease Information for GSTA4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GSTA4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTA4 Gene
Publications for GSTA4 Gene
- Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board PG (The Biochemical journal 1998) 2 3 4 22 58
- Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PMID: 20085333) Balogh LM … Atkins WM (Biochemistry 2010) 3 4 22 58
- Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PMID: 20097730) Tang H … Li D (Carcinogenesis 2010) 3 22 44 58
- Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PMID: 16054170) Coppedè F … Migliore L (Mutation research 2005) 3 22 44 58
- Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PMID: 10329152) Bruns CM … Tainer JA (Journal of molecular biology 1999) 3 4 22 58
Products for GSTA4 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for GSTA4
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA4
- Origene Custom Protein Services for GSTA4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- OriGene qPCR primer pairs and template standards for GSTA4
- OriGene qPCR primer pairs for GSTA4
- OriGene CRISPR knockouts for GSTA4
- OriGene ORF clones in human for GSTA4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GSTA4
- GenScript: Next-day shipping of latest version cDNA ORF clones for GSTA4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GSTA4
- GenScript Custom Assay Services for GSTA4
- GenScript Custom overexpressing Cell Line Services for GSTA4
- GenScript: Design CRISPR guide RNA sequences for GSTA4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GSTA4
- Sino Biological Human cDNA Clone for GSTA4
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for GSTA4
- Novus Biologicals proteins and lysates for GSTA4
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- Novus Biologicals Tissue Microarrays
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- Taconic Biosciences Mouse Models for GSTA4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GSTA4
- Cyagen custom Knockout/knockin (KOKI) mouse models for GSTA4
- VectorBuilder custom plasmid, inducible vectors for GSTA4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTA4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 81 available GSTA4 Antibodies ranked by validation data
- Compare Top GSTA4 Antibodies
- antibodies-online: Search results for 25 available GSTA4 Elisa Kits ranked by validation data
- Compare Top GSTA4 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 20 available GSTA4 Proteins ranked by validation data
- Compare Top GSTA4 Proteins
- GeneTex GSTA4 Antibody for GSTA4
- Search GeneTex for Proteins for GSTA4
- Horizon Cell Lines for GSTA4
- genomics-online: cdna clones - Search results for available GSTA4 gene related products
- orf clones - Search results for available GSTA4 gene related products
- genomics-online: gRNA clones - Search results for available GSTA4 gene related products
- genomics-online: primer clones - Search results for available GSTA4 gene related products
- genomics-online: shRNA clones - Search results for available GSTA4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
- GeneCopoeia miRNA 3'UTR Target clone products for GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
- Boster Bio Antibodies for GSTA4
- Browse Boster Bio ELISA Kits
Sources for GSTA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
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- (135) Horizon
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- (139) VectorBuilder
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- (144) ProteoGenix
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- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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- (158) Applied Biosystems
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- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt