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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
GSTA4 (Glutathione S-Transferase Alpha 4) is a Protein Coding gene. Diseases associated with GSTA4 include Hepatocellular Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTA2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004364 | glutathione transferase activity | TAS,IDA | 10329152 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016740 | transferase activity | IEA | -- |
GO:0042802 | identical protein binding | IPI | 16189514 |
GO:0042803 | protein homodimerization activity | IPI | 10329152 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glutathione metabolism |
Glutathione metabolism
.60
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2 | Drug metabolism - cytochrome P450 | ||
3 | Cytochrome P450 - arranged by substrate type | ||
4 | Metabolism |
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5 | Fluid shear stress and atherosclerosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006749 | glutathione metabolic process | IDA | 10329152 |
GO:0006805 | xenobiotic metabolic process | IDA | 10329152 |
GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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4-Hydroxynonenal |
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75899-68-2 | ||||
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
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(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
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(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
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(1S,2R)-Naphthalene 1,2-oxide |
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Compound | Action | Cas Number |
---|---|---|
LB42708 | Selective FTase inhibitor | 226929-39-1 |
Lonafarnib | Ftase inhibitor,potent and selective | 193275-84-2 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP18: | - | - | - |
ExUns: | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | |||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: | |||||||||||
SP10: | |||||||||||
SP11: | |||||||||||
SP12: | |||||||||||
SP13: | |||||||||||
SP14: | |||||||||||
SP15: | |||||||||||
SP16: | |||||||||||
SP17: | |||||||||||
SP18: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GSTA4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GSTA4 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | GSTA4 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GSTA4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GSTA4 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gsta3 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | GSTA 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | zgc:173961 31 |
|
ManyToMany | |
gstal 31 |
|
ManyToMany | |||
zgc:173962 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | gst-41 31 |
|
ManyToMany | |
gst-10 31 |
|
ManyToMany | |||
Y45G12C.3 31 |
|
ManyToMany | |||
F56A4.4 31 |
|
ManyToMany | |||
F56A4.3 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
779335 | Benign: not provided | 52,984,544(-) | A/G | SYNONYMOUS_VARIANT | |
rs4147617 | - | p.Thr163Ala | |||
rs45551133 | - | p.Leu100Pro |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759430 | CNV | loss | 17122850 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
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