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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu,... See more...
Aliases for GSTA4 Gene
Aliases for GSTA4 Gene
External Ids for GSTA4 Gene
- HGNC: 4629
- Entrez Gene: 2941
- Ensembl: ENSG00000170899
- OMIM: 605450
- UniProtKB: O15217
Previous GeneCards Identifiers for GSTA4 Gene
- GC06M052844
- GC06M052889
- GC06M052950
- GC06M052674
- GC06M052842
Summaries for GSTA4 Gene
-
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GSTA4 Gene
GSTA4 (Glutathione S-Transferase Alpha 4) is a Protein Coding gene. Diseases associated with GSTA4 include Hepatocellular Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTA2.
UniProtKB/Swiss-Prot Summary for GSTA4 Gene
-
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
Additional gene information for GSTA4 Gene
- HGNC(4629)
- Entrez Gene(2941)
- Ensembl(ENSG00000170899)
- OMIM(605450)
- UniProtKB(O15217)
- Open Targets Platform(ENSG00000170899)
- Monarch Initiative
- Search for GSTA4 at DataMed
- Search for GSTA4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTA4 Gene
Genomics for GSTA4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSTA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTA4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTA4
- Top Transcription factor binding sites by QIAGEN in the GSTA4 gene promoter:
-
- Nkx2-5
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
- POU2F2C
Genomic Locations for GSTA4 Gene
Genomic Locations for GSTA4 Gene
- chr6:52,977,948-52,995,332
- (GRCh38/hg38)
- Size:
- 17,385 bases
- Orientation:
- Minus strand
- chr6:52,842,746-52,860,178
- (GRCh37/hg19)
- Size:
- 17,433 bases
- Orientation:
- Minus strand
Genomic View for GSTA4 Gene
Genes around GSTA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by HGNC
- 6p12.2 by Entrez Gene
- 6p12.2 by Ensembl
GSTA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTA4 Gene
Proteins for GSTA4 Gene
-
Protein details for GSTA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15217-GSTA4_HUMAN
- Recommended name:
- Glutathione S-transferase A4
- Protein Accession:
- O15217
- B2RD15
- Q5T7Q8
- Q6P4G1
- Q9BX18
- Q9H414
Protein attributes for GSTA4 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25704 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for GSTA4 Gene
Selected DME Specific Peptides for GSTA4 Gene
- O15217:
-
- SNIPTIK
- RYFPVFEK
- LAAAGVEF
- QVPMVEIDGMKL
- FLVGNQLS
Post-translational modifications for GSTA4 Gene
Other Protein References for GSTA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GSTA4 Antibody
- Novus Biologicals Antibodies for GSTA4
-
Abcam antibodies for GSTA4
- Invitrogen Antibodies for GSTA4 (AFLGC-GSTA4)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA4
- Origene Custom Protein Services for GSTA4
-
Abcam proteins for GSTA4
Assay Products
- antibodies-online: Show 32 available GSTA4 Elisa Kits ranked by validation data
- Compare Top GSTA4 Elisa Kits
-
Quality Products:
Domains & Families for GSTA4 Gene
Gene Families for GSTA4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GSTA4 Gene
- InterPro:
- Blocks:
-
- Glutathione S-transferase, N-terminal
- Alpha-class glutathione S-transferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTA4 Gene
- GenScript: Design optimal peptide antigens:
-
- Glutathione S-transferase A4-4 (GSTA4_HUMAN)
- Glutathione S-transferase (Q6P4G1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15217- Family:
-
- Belongs to the GST superfamily. Alpha family.
Function for GSTA4 Gene
Molecular function for GSTA4 Gene
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10329152, ECO:0000269|PubMed:20085333};.
- GENATLAS Biochemistry:
- glutathione S-transferase,alpha 4,ubiquitously expressed
Enzyme Numbers (IUBMB) for GSTA4 Gene
Phenotypes From GWAS Catalog for GSTA4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS,IDA | 10329152 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 16189514 |
| GO:0042803 | protein homodimerization activity | IPI | 10329152 |
Phenotypes for GSTA4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GSTA4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA4 - Select products 50% OFF >
- * GSTA4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA4
miRNA for GSTA4 Gene
- miRTarBase miRNAs that target GSTA4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
Clone Products
- Applied Biological Materials (abm): Clones for GSTA4 - Select products 50% OFF >
- * GSTA4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
Cell Line Products
-
Horizon Cell Lines for GSTA4
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTA4 Gene
Localization for GSTA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTA4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTA4 Gene
Pathways & Interactions for GSTA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Metabolism |
.40
|
|
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTA4 Gene
4 BioSystems pathways for GSTA4 Gene
4 Reactome pathways for GSTA4 Gene
10 KEGG pathways for GSTA4 Gene
2 GeneGo (Thomson Reuters) pathways for GSTA4 Gene
- 2-Naphthylamine and 2-Nitronaphtalene metabolism
- Glutathione metabolism
Interacting Proteins for GSTA4 Gene
Selected Interacting proteins:
O15217-GSTA4_HUMAN
ENSP00000360002
for GSTA4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GSTA4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IDA | 10329152 |
| GO:0006805 | xenobiotic metabolic process | IDA | 10329152 |
| GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for GSTA4 Gene
Drugs & Compounds for GSTA4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-Hydroxynonenal |
|
75899-68-2 | ||||
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
(2) ApexBio Compounds for GSTA4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| LB42708 | Selective FTase inhibitor | 226929-39-1 |
| Lonafarnib | Ftase inhibitor,potent and selective | 193275-84-2 |
Transcripts for GSTA4 Gene
mRNA/cDNA for GSTA4 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370959 793 nts (view in UCSC)
- ENST00000370960 859 nts (view in UCSC)
- ENST00000370963 1240 nts (view in UCSC)
- ENST00000457564 379 nts (view in UCSC)
- ENST00000477599 1127 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA4 - Select products 50% OFF >
- * GSTA4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
Clone Products
- Applied Biological Materials (abm): Clones for GSTA4 - Select products 50% OFF >
- * GSTA4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - |
| ExUns: | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: | |||||||||||
| SP17: | |||||||||||
| SP18: |
Relevant External Links for GSTA4 Gene
- GeneLoc Exon Structure for
- GSTA4
Expression for GSTA4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for GSTA4 Gene
This gene is overexpressed in Adrenal Gland (x8.9).
This gene is overexpressed in Adrenal (19.9), Fetal testis (18.5), and Fetal Brain (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTA4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTA4
SOURCE GeneReport for Unigene cluster for GSTA4 Gene:
Hs.485557mRNA Expression by UniProt/SwissProt for GSTA4 Gene:
O15217-GSTA4_HUMAN
Tissue specificity:
Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.
Evidence on tissue expression from TISSUES for GSTA4 Gene
- Nervous system(4.9)
- Muscle(4.5)
- Heart(4.4)
- Pancreas(4.4)
- Liver(2.8)
- Skin(2.8)
- Adrenal gland(2.8)
- Kidney(2.6)
- Eye(2.2)
- Intestine(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for GSTA4
-
OriGene qPCR primer pairs and template standards for GSTA4
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA4 Gene
Orthologs for GSTA4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GSTA4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GSTA4 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | GSTA4 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GSTA4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GSTA4 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gsta3 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | GSTA 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:173961 31 |
|
ManyToMany | |
| gstal 31 |
|
ManyToMany | |||
| zgc:173962 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | gst-41 31 |
|
ManyToMany | |
| gst-10 31 |
|
ManyToMany | |||
| Y45G12C.3 31 |
|
ManyToMany | |||
| F56A4.4 31 |
|
ManyToMany | |||
| F56A4.3 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GSTA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GSTA4 Gene
- ENSEMBL:
- Gene Tree for GSTA4 (if available)
- TreeFam:
- Gene Tree for GSTA4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTA4: view image
Paralogs for GSTA4 Gene
Paralogs for GSTA4 Gene
(5) SIMAP similar genes for GSTA4 Gene using alignment to 3 proteins:
- GSTA4_HUMAN
- Q5JW88_HUMAN
- Q6P4G1_HUMAN
Variants for GSTA4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTA4 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 779335 | Benign: not provided | 52,984,544(-) | A/G | SYNONYMOUS_VARIANT | |
| rs4147617 | - | p.Thr163Ala | |||
| rs45551133 | - | p.Leu100Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759430 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.80;
16.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTA4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GSTA4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA4 Gene
Disorders for GSTA4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
Search GSTA4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTA4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA4 Gene
Publications for GSTA4 Gene
- Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board PG (The Biochemical journal 1998) 2 3 4 23
- Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. (PMID: 20085333) Balogh LM … Atkins WM (Biochemistry 2010) 3 4 23
- Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (PMID: 20097730) Tang H … Li D (Carcinogenesis 2010) 3 23 41
- Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (PMID: 16054170) Coppedè F … Migliore L (Mutation research 2005) 3 23 41
- Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products. (PMID: 10329152) Bruns CM … Tainer JA (Journal of molecular biology 1999) 3 4 23
ExternalLinks
Products for GSTA4 Gene
- Custom Antibody ServicesOriGene Antibodies for GSTA4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA4
- Origene Custom Protein Services for GSTA4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA4
- Browse OriGene Inhibitory RNA Products For GSTA4
- OriGene qPCR primer pairs for GSTA4
- OriGene qPCR primer pairs and template standards for GSTA4
- OriGene CRISPR knockouts for GSTA4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GSTA4
- Sino Biological Human cDNA Clone for GSTA4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GSTA4
- Novus Biologicals proteins and lysates for GSTA4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GSTA4
- Abcam proteins for GSTA4
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Taconic Biosciences Mouse Models for GSTA4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GSTA4 (AFLGC-GSTA4)
- ApexBio compounds for GSTA4
- VectorBuilder Custom and pre-made DNA vectors for GSTA4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GSTA4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GSTA4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GSTA4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GSTA4
- antibodies-online: Show 51 available GSTA4 Antibodies ranked by validation data
- Compare Top GSTA4 Antibodies
- antibodies-online: Show 32 available GSTA4 Elisa Kits ranked by validation data
- Compare Top GSTA4 Elisa Kits
- Quality Products:
- antibodies-online: Show 19 available GSTA4 Proteins ranked by validation data
- Compare Top GSTA4 Proteins
- Horizon Cell Lines for GSTA4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GSTA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA4
Sources for GSTA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB