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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu,... See more...
Aliases for GSTA3 Gene
Aliases for GSTA3 Gene
External Ids for GSTA3 Gene
- HGNC: 4628
- Entrez Gene: 2940
- Ensembl: ENSG00000174156
- OMIM: 605449
- UniProtKB: Q16772
Previous GeneCards Identifiers for GSTA3 Gene
- GC06M052763
- GC06M052704
- GC06M052808
- GC06M052869
- GC06M052761
- GC06M052592
- GC06M052847
Summaries for GSTA3 Gene
-
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for GSTA3 Gene
GSTA3 (Glutathione S-Transferase Alpha 3) is a Protein Coding gene. Diseases associated with GSTA3 include Autosomal Dominant Non-Syndromic Intellectual Disability 3 and Loeys-Dietz Syndrome 2. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.
UniProtKB/Swiss-Prot Summary for GSTA3 Gene
-
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
Additional gene information for GSTA3 Gene
- HGNC(4628)
- Entrez Gene(2940)
- Ensembl(ENSG00000174156)
- OMIM(605449)
- UniProtKB(Q16772)
- Open Targets Platform(ENSG00000174156)
- Search for GSTA3 at DataMed
- Search for GSTA3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTA3 Gene
Genomics for GSTA3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSTA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTA3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTA3
- Top Transcription factor binding sites by QIAGEN in the GSTA3 gene promoter:
-
- En-1
- Ik-2
- STAT3
- YY1
Genomic Locations for GSTA3 Gene
Genomic Locations for GSTA3 Gene
- chr6:52,896,639-52,909,799
- (GRCh38/hg38)
- Size:
- 13,161 bases
- Orientation:
- Minus strand
- chr6:52,761,437-52,774,496
- (GRCh37/hg19)
- Size:
- 13,060 bases
- Orientation:
- Minus strand
Genomic View for GSTA3 Gene
Genes around GSTA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by HGNC
- 6p12.2 by Entrez Gene
- 6p12.2 by Ensembl
GSTA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTA3 Gene
Proteins for GSTA3 Gene
-
Protein details for GSTA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16772-GSTA3_HUMAN
- Recommended name:
- Glutathione S-transferase A3
- Protein Accession:
- Q16772
- O43468
- Q068V6
- Q8WWA8
- Q9H415
Protein attributes for GSTA3 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25302 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=AAA74634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAD04712.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for GSTA3 Gene
Selected DME Specific Peptides for GSTA3 Gene
- Q16772:
-
- KERALIDMY
- IDMYTEG
- QTRAILNYIA
- RYFPAFE
- KYNLYGKD
- AAGVEFE
- AGVEFEE
- SNLPTVKKFLQPGS
- LAAAGVEF
- QVPMVEIDGMKL
- LVGNKLS
- SHGQDYLVGN
Post-translational modifications for GSTA3 Gene
Other Protein References for GSTA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GSTA3
- Novus Biologicals Antibodies for GSTA3
-
Abcam antibodies for GSTA3
- Invitrogen Antibodies for GSTA3 (AFLGC-Gsta3)
-
Biorbyt antibodies for GSTA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTA3
- Sino Biological Antibodies for GSTA3
Protein Products
-
OriGene Purified Proteins for GSTA3
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA3
- Origene Custom Protein Services for GSTA3
-
Abcam proteins for GSTA3
Assay Products
- antibodies-online: Show 23 available GSTA3 Elisa Kits ranked by validation data
- Compare Top GSTA3 Elisa Kits
-
Quality Products:
Domains & Families for GSTA3 Gene
Gene Families for GSTA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GSTA3 Gene
- InterPro:
- Blocks:
-
- Glutathione S-transferase, N-terminal
- Alpha-class glutathione S-transferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTA3 Gene
- GenScript: Design optimal peptide antigens:
-
- Glutathione S-transferase A3-3 (GSTA3_HUMAN)
- Glutathione S-transferase (Q5JW85_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16772- Family:
-
- Belongs to the GST superfamily. Alpha family.
Function for GSTA3 Gene
Molecular function for GSTA3 Gene
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000305|PubMed:11418619};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence={ECO:0000269|PubMed:11418619};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=pregn-5-ene-3,20-dione = progesterone; Xref=Rhea:RHEA:43928, ChEBI:CHEBI:17026, ChEBI:CHEBI:63837; Evidence={ECO:0000269|PubMed:11418619};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=23 uM for androst-5-ene-3,17-dione {ECO:0000269|PubMed:15595823}; KM=24 uM for androst-5-ene-3,17-dione (at pH 8.0 and 30 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=24 uM for androst-5-ene-3,17-dione (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=17 uM for pregn-5-ene-3,20-dione (at pH 8.0 and 30 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=17 uM for pregn-5-ene-3,20-dione (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:11418619}; Vmax=99 umol/min/mg enzyme for delta(5)-androstene-3,17-dione isomerization {ECO:0000269|PubMed:15595823}; Note=kcats are 102 sec(-1) and 27 sec(-1) for androst-5-ene-3,17-dione and pregn-5-ene-3,20-dione as substrates, respectively (at pH 8.0 and 30 degrees Celsius). {ECO:0000269|PubMed:11418619};
- GENATLAS Biochemistry:
- glutathione S-transferase,alpha 3
Enzyme Numbers (IUBMB) for GSTA3 Gene
Phenotypes From GWAS Catalog for GSTA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS,ISS | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GSTA3 Gene
- MGI mutant phenotypes for GSTA3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GSTA3:
Animal Models for GSTA3 Gene
- MGI Knock Outs for GSTA3:
-
- Gsta3 Gsta3<tm1Sell>
Animal Model Products
-
Taconic Biosciences Mouse Models for GSTA3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA3 - Select products 50% OFF >
- * GSTA3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA3
miRNA for GSTA3 Gene
- miRTarBase miRNAs that target GSTA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA3
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Clone Products
- Applied Biological Materials (abm): Clones for GSTA3 - Select products 50% OFF >
- * GSTA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA3
Cell Line Products
-
Horizon Cell Lines for GSTA3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTA3 Gene
Localization for GSTA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTA3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for GSTA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Metabolism |
.40
|
|
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTA3 Gene
2 BioSystems pathways for GSTA3 Gene
4 Reactome pathways for GSTA3 Gene
10 KEGG pathways for GSTA3 Gene
2 GeneGo (Thomson Reuters) pathways for GSTA3 Gene
- 2-Naphthylamine and 2-Nitronaphtalene metabolism
- Glutathione metabolism
Interacting Proteins for GSTA3 Gene
GPS-Prot Interaction Network for GSTA3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | ISS | -- |
| GO:0006805 | xenobiotic metabolic process | IBA | 21873635 |
| GO:1901687 | glutathione derivative biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for GSTA3 Gene
Drugs & Compounds for GSTA3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
| Testosterone | Approved, Experimental, Investigational | Pharma | Endogenous androgen receptor agonist | 660 | ||
| Trichloroethylene | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| 4-S-Glutathionyl-5-pentyl-tetrahydro-furan-2-ol | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
(2) ApexBio Compounds for GSTA3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| LB42708 | Selective FTase inhibitor | 226929-39-1 |
| Lonafarnib | Ftase inhibitor,potent and selective | 193275-84-2 |
Transcripts for GSTA3 Gene
mRNA/cDNA for GSTA3 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000211122 908 nts (view in UCSC)
- ENST00000370968 775 nts (view in UCSC)
- ENST00000431899 411 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA3 - Select products 50% OFF >
- * GSTA3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA3
- Browse OriGene Inhibitory RNA Products For GSTA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA3
Clone Products
- Applied Biological Materials (abm): Clones for GSTA3 - Select products 50% OFF >
- * GSTA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA3
Relevant External Links for GSTA3 Gene
- GeneLoc Exon Structure for
- GSTA3
Expression for GSTA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for GSTA3 Gene
This gene is overexpressed in Adrenal Gland (x32.1), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Skin - Sun Exposed (Lower leg) (x4.8).
This gene is overexpressed in Fetal testis (23.0), Fetal ovary (17.3), and Adrenal (15.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTA3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTA3
SOURCE GeneReport for Unigene cluster for GSTA3 Gene:
Hs.102484Evidence on tissue expression from TISSUES for GSTA3 Gene
- Liver(3.4)
- Kidney(3.1)
- Skin(2.4)
- Adrenal gland(2.3)
- Lung(2.2)
- Nervous system(2.1)
- Intestine(2.1)
- Heart(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for GSTA3
-
OriGene qPCR primer pairs and template standards for GSTA3
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA3 Gene
Orthologs for GSTA3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GSTA3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GSTA3 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | GSTA5 30 |
|
||
| GSTA1 31 |
|
ManyToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Gsta3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gsta3 30 17 |
|
||
| Gm8074 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| GSTA3 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:173961 31 |
|
ManyToMany | |
| zgc:173962 31 |
|
ManyToMany | |||
| gstal 31 |
|
ManyToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6393 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | F56A4.3 31 |
|
ManyToMany | |
| gst-41 31 |
|
ManyToMany | |||
| F56A4.4 31 |
|
ManyToMany | |||
| gst-10 31 |
|
ManyToMany | |||
| Y45G12C.3 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GSTA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GSTA3 Gene
- ENSEMBL:
- Gene Tree for GSTA3 (if available)
- TreeFam:
- Gene Tree for GSTA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTA3: view image
Paralogs for GSTA3 Gene
Paralogs for GSTA3 Gene
(6) SIMAP similar genes for GSTA3 Gene using alignment to 3 proteins:
- GSTA3_HUMAN
- Q5JW84_HUMAN
- Q5JW85_HUMAN
Pseudogenes.org Pseudogenes for GSTA3 Gene
Variants for GSTA3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTA3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 725541 | Benign: not provided | 52,896,853(-) | C/T | MISSENSE_VARIANT | |
| 728744 | Benign: not provided | 52,896,870(-) | C/G | MISSENSE_VARIANT | |
| 774447 | Benign: not provided | 52,902,401(-) | T/C | MISSENSE_VARIANT | |
| rs1052661 | - | p.Ile71Leu | |||
| rs41273858 | - | p.Asn73Asp |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3609013 | CNV | loss | 21293372 |
| nsv970123 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.55;
64.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTA3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA3 Gene
Disorders for GSTA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autosomal dominant non-syndromic intellectual disability 3 |
|
|
| loeys-dietz syndrome 2 |
|
|
| cataract 4, multiple types |
|
|
| enchondromatosis, multiple, ollier type |
|
|
| loeys-dietz syndrome |
|
|
Search GSTA3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA3 Gene
Publications for GSTA3 Gene
- Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board PG (The Biochemical journal 1998) 2 3 4 26
- Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity. (PMID: 15595823) Gu Y … Ji X (Biochemistry 2004) 3 4 23
- Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes. (PMID: 8307579) Suzuki T … Board PG (Genomics 1993) 2 3 4
- Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases. (PMID: 20083122) Tars K … Mannervik B (Journal of molecular biology 2010) 3 4
- Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
ExternalLinks
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- Browse cDNA Clones
- Browse ELISA Kits
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GSTA3
- Novus Biologicals proteins and lysates for GSTA3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GSTA3
- Abcam proteins for GSTA3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for GSTA3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GSTA3 (AFLGC-Gsta3)
- ApexBio compounds for GSTA3
- VectorBuilder Custom and pre-made DNA vectors for GSTA3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GSTA3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GSTA3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GSTA3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GSTA3
- antibodies-online: Show 133 available GSTA3 Antibodies ranked by validation data
- Compare Top GSTA3 Antibodies
- antibodies-online: Show 23 available GSTA3 Elisa Kits ranked by validation data
- Compare Top GSTA3 Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available GSTA3 Proteins ranked by validation data
- Compare Top GSTA3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GSTA3
- Search Santa Cruz Biotechnology (SCBT) for GSTA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSTA3
- Horizon Cell Lines for GSTA3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GSTA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA3
- Biorbyt antibodies for GSTA3
Sources for GSTA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB