Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu,... See more...

Aliases for GSTA3 Gene

Aliases for GSTA3 Gene

  • Glutathione S-Transferase Alpha 3 2 3 5
  • Glutathione S-Transferase A3 2 3 4
  • Glutathione S-Transferase A3-3 3 4
  • GST Class-Alpha Member 3 3 4
  • EC 2.5.1.18 4 50
  • S-(Hydroxyalkyl)Glutathione Lyase A3 3
  • Glutathione S-Aralkyltransferase A3 3
  • Glutathione S-Alkyltransferase A3 3
  • Glutathione S-Aryltransferase A3 3
  • GSTA3-3 3
  • GSTA3 5
  • GTA3 3

External Ids for GSTA3 Gene

Previous GeneCards Identifiers for GSTA3 Gene

  • GC06M052763
  • GC06M052704
  • GC06M052808
  • GC06M052869
  • GC06M052761
  • GC06M052592
  • GC06M052847

Summaries for GSTA3 Gene

Entrez Gene Summary for GSTA3 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTA3 Gene

GSTA3 (Glutathione S-Transferase Alpha 3) is a Protein Coding gene. Diseases associated with GSTA3 include Autosomal Dominant Non-Syndromic Intellectual Disability 3 and Enchondromatosis, Multiple, Ollier Type. Among its related pathways are Drug metabolism - cytochrome P450 and Gastric cancer. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA1.

UniProtKB/Swiss-Prot Summary for GSTA3 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).

Gene Wiki entry for GSTA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTA3 Gene

Genomics for GSTA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GSTA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J052908 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 250.7 +0.2 153 3.1 HLF FOS RFX1 ZBTB17 GSTA3 GSTA4 GSTA10P GSTA5
GH06J053054 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -152.0 -151968 15.5 BCLAF1 SP1 ZNF207 ZNF654 MYC NCOR1 ZNF600 IKZF1 SIX5 SSRP1 CILK1 FBXO9 MCM3 EFHC1 TRAM2 GSTA3 ENSG00000288646 piR-38352-469 HSALNG0050645
GH06J052992 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -85.1 -85102 4.6 BCLAF1 NCOR1 ZNF207 MYC IKZF1 ZNF600 SSRP1 ZNF580 ZNF592 ATF2 4WKR_C ENSG00000202198 GSTA4 MN298307 RN7SK MCM3 CILK1 EFHC1 GSTA3 RF00019-088
GH06J053040 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 10 -133.0 -132973 4.4 JUND ZIC2 MAFF ZNF316 NFE2 MAFK SMARCA4 MAFG DPF2 ARID1B ENSG00000288614 GSTA3 CILK1 LRRC1 FBXO9 piR-38352-469 HSALNG0050645
GH06J052814 Enhancer 1 Ensembl ENCODE 11 +94.3 94304 1.1 ZNF654 ZNF600 ZMYM3 CEBPA ATF3 CTCF FOXA1 TRIM22 HOMEZ ZNF217 piR-45150 GSTA1 GSTA3 CILK1 GSTA6P HSALNG0050637 HSALNG0050635 GSTA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTA3

Top Transcription factor binding sites by QIAGEN in the GSTA3 gene promoter:
  • En-1
  • Ik-2
  • STAT3
  • YY1

Genomic Locations for GSTA3 Gene

Latest Assembly
chr6:52,896,639-52,909,799
(GRCh38/hg38)
Size:
13,161 bases
Orientation:
Minus strand

Previous Assembly
chr6:52,761,444-52,774,496
(GRCh37/hg19 by Entrez Gene)
Size:
13,053 bases
Orientation:
Minus strand

chr6:52,761,437-52,774,483
(GRCh37/hg19 by Ensembl)
Size:
13,047 bases
Orientation:
Minus strand

Genomic View for GSTA3 Gene

Genes around GSTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTA3 Gene

Proteins for GSTA3 Gene

  • Protein details for GSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16772-GSTA3_HUMAN
    Recommended name:
    Glutathione S-transferase A3
    Protein Accession:
    Q16772
    Secondary Accessions:
    • O43468
    • Q068V6
    • Q8WWA8
    • Q9H415

    Protein attributes for GSTA3 Gene

    Size:
    222 amino acids
    Molecular mass:
    25302 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAA74634.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAD04712.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTA3 Gene

neXtProt entry for GSTA3 Gene

Selected DME Specific Peptides for GSTA3 Gene

Q16772:
  • KERALIDMY
  • IDMYTEG
  • QTRAILNYIA
  • RYFPAFE
  • KYNLYGKD
  • AAGVEFE
  • AGVEFEE
  • SNLPTVKKFLQPGS
  • LAAAGVEF
  • QVPMVEIDGMKL
  • LVGNKLS
  • SHGQDYLVGN

Post-translational modifications for GSTA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTA3 Gene

Domains & Families for GSTA3 Gene

Gene Families for GSTA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GSTA3 Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Alpha-class glutathione S-transferase signature

Suggested Antigen Peptide Sequences for GSTA3 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione S-transferase A3-3 (GSTA3_HUMAN)
  • Glutathione S-transferase (Q5JW85_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16772

UniProtKB/Swiss-Prot:

GSTA3_HUMAN :
  • Belongs to the GST superfamily. Alpha family.
Family:
  • Belongs to the GST superfamily. Alpha family.
genes like me logo Genes that share domains with GSTA3: view

Function for GSTA3 Gene

Molecular function for GSTA3 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000305|PubMed:11418619};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence={ECO:0000269|PubMed:11418619};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=pregn-5-ene-3,20-dione = progesterone; Xref=Rhea:RHEA:43928, ChEBI:CHEBI:17026, ChEBI:CHEBI:63837; Evidence={ECO:0000269|PubMed:11418619};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=23 uM for androst-5-ene-3,17-dione {ECO:0000269|PubMed:15595823}; KM=24 uM for androst-5-ene-3,17-dione (at pH 8.0 and 30 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=24 uM for androst-5-ene-3,17-dione (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=17 uM for pregn-5-ene-3,20-dione (at pH 8.0 and 30 degrees Celsius) {ECO:0000269|PubMed:11418619}; KM=17 uM for pregn-5-ene-3,20-dione (at pH 7.4 and 37 degrees Celsius) {ECO:0000269|PubMed:11418619}; Vmax=99 umol/min/mg enzyme for delta(5)-androstene-3,17-dione isomerization {ECO:0000269|PubMed:15595823}; Note=kcats are 102 sec(-1) and 27 sec(-1) for androst-5-ene-3,17-dione and pregn-5-ene-3,20-dione as substrates, respectively (at pH 8.0 and 30 degrees Celsius). {ECO:0000269|PubMed:11418619};
GENATLAS Biochemistry:
glutathione S-transferase,alpha 3

Enzyme Numbers (IUBMB) for GSTA3 Gene

Phenotypes From GWAS Catalog for GSTA3 Gene

Gene Ontology (GO) - Molecular Function for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS,ISS --
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTA3: view
genes like me logo Genes that share phenotypes with GSTA3: view

Animal Models for GSTA3 Gene

MGI Knock Outs for GSTA3:

Animal Models for research

  • Taconic Biosciences Mouse Models for GSTA3

miRNA for GSTA3 Gene

miRTarBase miRNAs that target GSTA3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTA3 Gene

Localization for GSTA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTA3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTA3 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GSTA3: view

Pathways & Interactions for GSTA3 Gene

genes like me logo Genes that share pathways with GSTA3: view

Pathways by source for GSTA3 Gene

2 BioSystems pathways for GSTA3 Gene
2 GeneGo (Thomson Reuters) pathways for GSTA3 Gene
  • 2-Naphthylamine and 2-Nitronaphtalene metabolism
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IEA,ISS --
GO:0006805 xenobiotic metabolic process IBA 21873635
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTA3: view

No data available for SIGNOR curated interactions for GSTA3 Gene

Drugs & Compounds for GSTA3 Gene

(9) Drugs for GSTA3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Lonafarnib Approved, Investigational Pharma Ftase inhibitor,potent and selective 36
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 711
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0

(38) Additional Compounds for GSTA3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane

(2) ApexBio Compounds for GSTA3 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTA3: view

Drug products for research

Transcripts for GSTA3 Gene

mRNA/cDNA for GSTA3 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA3

Alternative Splicing Database (ASD) splice patterns (SP) for GSTA3 Gene

No ASD Table

Relevant External Links for GSTA3 Gene

GeneLoc Exon Structure for
GSTA3

Expression for GSTA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTA3 Gene

This gene is overexpressed in Adrenal Gland (x32.1), Skin - Not Sun Exposed (Suprapubic) (x6.4), and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for GSTA3 Gene

This gene is overexpressed in Fetal testis (23.0), Fetal ovary (17.3), and Adrenal (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTA3 Gene



Protein tissue co-expression partners for GSTA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTA3

SOURCE GeneReport for Unigene cluster for GSTA3 Gene:

Hs.102484

Evidence on tissue expression from TISSUES for GSTA3 Gene

  • Liver(3.3)
  • Kidney(2.8)
  • Adrenal gland(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with GSTA3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA3 Gene

Orthologs for GSTA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSTA3 29 30
  • 99.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GSTA3 29
  • 87.09 (n)
-- 30
  • 51 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia GSTA5 29
  • 83.03 (n)
GSTA1 30
  • 82 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Gsta3 29
  • 78.79 (n)
Mouse
(Mus musculus)
Mammalia Gsta3 29 16
  • 78.64 (n)
Gm8074 30
  • 68 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 61 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 64 (a)
ManyToMany
GSTA3 30
  • 62 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 69 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:173961 30
  • 54 (a)
ManyToMany
zgc:173962 30
  • 54 (a)
ManyToMany
gstal 30
  • 54 (a)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6393 29
Worm
(Caenorhabditis elegans)
Secernentea F56A4.3 30
  • 28 (a)
ManyToMany
gst-41 30
  • 28 (a)
ManyToMany
F56A4.4 30
  • 27 (a)
ManyToMany
gst-10 30
  • 27 (a)
ManyToMany
Y45G12C.3 30
  • 27 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToMany
Species where no ortholog for GSTA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GSTA3 Gene

ENSEMBL:
Gene Tree for GSTA3 (if available)
TreeFam:
Gene Tree for GSTA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTA3: view image
Alliance of Genome Resources:
Additional Orthologs for GSTA3

Paralogs for GSTA3 Gene

Paralogs for GSTA3 Gene

(6) SIMAP similar genes for GSTA3 Gene using alignment to 3 proteins:

  • GSTA3_HUMAN
  • Q5JW84_HUMAN
  • Q5JW85_HUMAN
genes like me logo Genes that share paralogs with GSTA3: view

Variants for GSTA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTA3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs149910347 Benign: not provided 52,896,870(-) C/G
NM_000847.5(GSTA3):c.605G>C (p.Ser202Thr)
MISSENSE
rs41273858 Benign: not provided 52,902,401(-) T/Cp.Asn73Asp
NM_000847.5(GSTA3):c.217A>G (p.Asn73Asp)
MISSENSE
rs45620832 Benign: not provided 52,896,853(-) C/Tp.Ala208Thr
NM_000847.5(GSTA3):c.622G>A (p.Ala208Thr)
MISSENSE
rs1052661 -- p.Ile71Leu
rs45504096 -- p.Gly36Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GSTA3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GSTA3 Gene

Variant ID Type Subtype PubMed ID
esv3609013 CNV loss 21293372
nsv970123 CNV duplication 23825009

Variation tolerance for GSTA3 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTA3 Gene

Human Gene Mutation Database (HGMD)
GSTA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTA3
Leiden Open Variation Database (LOVD)
GSTA3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA3 Gene

Disorders for GSTA3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GSTA3 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search GSTA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTA3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GSTA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA3 Gene

Publications for GSTA3 Gene

  1. Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4. (PMID: 9480897) Board PG (The Biochemical journal 1998) 2 3 4 25
  2. Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity. (PMID: 15595823) Gu Y … Ji X (Biochemistry 2004) 3 4 22
  3. Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes. (PMID: 8307579) Suzuki T … Board PG (Genomics 1993) 2 3 4
  4. Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases. (PMID: 20083122) Tars K … Mannervik B (Journal of molecular biology 2010) 3 4
  5. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40

Products for GSTA3 Gene

  • Biorbyt antibodies for GSTA3

Sources for GSTA3 Gene