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This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen spec... See more...
Aliases for GSTA1 Gene
Aliases for GSTA1 Gene
External Ids for GSTA1 Gene
- HGNC: 4626
- Entrez Gene: 2938
- Ensembl: ENSG00000243955
- OMIM: 138359
- UniProtKB: P08263
Previous GeneCards Identifiers for GSTA1 Gene
- GC06M052658
- GC06M052657
- GC06M052703
- GC06M052764
- GC06M052656
- GC06M052486
Summaries for GSTA1 Gene
-
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for GSTA1 Gene
GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. Diseases associated with GSTA1 include Dental Fluorosis and Hepatocellular Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Naphthalene metabolism. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA2.
UniProtKB/Swiss-Prot Summary for GSTA1 Gene
-
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
Additional gene information for GSTA1 Gene
- HGNC(4626)
- Entrez Gene(2938)
- Ensembl(ENSG00000243955)
- OMIM(138359)
- UniProtKB(P08263)
- Open Targets Platform(ENSG00000243955)
- Search for GSTA1 at DataMed
- Search for GSTA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTA1 Gene
Genomics for GSTA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSTA1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J052803 | Promoter | 0.4 | EPDnew | 600.7 | +0.0 | 24 | 0.1 | RAD21 | GSTA1 GSTA2 piR-42671-002 | |
| GH06J052802 | Promoter | 0.3 | Ensembl | 600.7 | +0.6 | 559 | 1 | GSTA1 piR-42671-002 GSTA2 | ||
| GH06J052761 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 12.7 | +40.9 | 40915 | 2 | GATAD2A CTCF TFE3 RCOR2 RXRB IRF2 CEBPA KMT2B SOX13 FOXA1 | GSTA2 GSTA1 piR-42671-001 TMEM14A | |
| GH06J052814 | Enhancer | 1 | Ensembl ENCODE | 15.8 | -11.6 | -11588 | 1 | GATAD2A CTCF SOX13 RCOR2 RBFOX2 RXRB SP1 TRIM22 DPF2 ZNF600 | GSTA6P lnc-GSTA1-1 piR-45150 GSTA1 GSTA3 CILK1 GSTA5 | |
| GH06J052787 | Enhancer | 0.9 | Ensembl ENCODE | 16.1 | +15.1 | 15128 | 2.7 | GATAD2A REST RXRB SP1 CEBPA SOX13 HMBOX1 EGR1 NFE2 FOXA2 | piR-53063-219 GSTA1 GSTA7P piR-42671-002 GSTA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTA1
- Top Transcription factor binding sites by QIAGEN in the GSTA1 gene promoter:
-
- AP-1
- AP-4
- ATF-2
- c-Jun
- FOXD1
- HNF-1
- HNF-1A
- Lmo2
- Nkx2-5
- Sp1
Genomic Locations for GSTA1 Gene
Genomic Locations for GSTA1 Gene
- chr6:52,791,371-52,803,860
- (GRCh38/hg38)
- Size:
- 12,490 bases
- Orientation:
- Minus strand
- chr6:52,656,178-52,668,708
- (GRCh37/hg19)
- Size:
- 12,531 bases
- Orientation:
- Minus strand
Genomic View for GSTA1 Gene
Genes around GSTA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by HGNC
- 6p12.2 by Entrez Gene
- 6p12.2 by Ensembl
GSTA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTA1 Gene
Proteins for GSTA1 Gene
-
Protein details for GSTA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08263-GSTA1_HUMAN
- Recommended name:
- Glutathione S-transferase A1
- Protein Accession:
- P08263
- Q14750
- Q5GHF8
- Q5SZC1
Protein attributes for GSTA1 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25631 Da
- Quaternary structure:
-
- Homodimer or heterodimer of GSTA1 and GSTA2.
Protein Expression for GSTA1 Gene
Selected DME Specific Peptides for GSTA1 Gene
- P08263:
-
- KERALIDMY
- QTRAILNYIA
- RYFPAFE
- KYNLYGKD
- AAGVEFE
- AGVEFEE
- PAFEKVLKSH
- SNLPTVKKFLQPGS
- LAAAGVEF
- QVPMVEIDGMKL
- LVGNKLS
- SHGQDYLVGN
Post-translational modifications for GSTA1 Gene
Other Protein References for GSTA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GSTA1 Antibody
- NSJ Bioreagents GSTA Antibody (alpha 1-5)
-
Custom Antibody ServicesOriGene Antibodies for GSTA1
- Novus Biologicals Antibodies for GSTA1
- Invitrogen Antibodies for GSTA1 (AFLGC-GSTA1)
-
Boster Bio Antibodies for GSTA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTA1
- Sino Biological Antibodies for GSTA1
Protein Products
-
OriGene Purified Proteins for GSTA1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTA1
- Origene Custom Protein Services for GSTA1
- Sino Biological Recombinant Proteins for GSTA1
- Sino Biological Cell Lysates for GSTA1
-
Signalway Proteins for GSTA1
-
Abcam proteins for GSTA1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for GSTA1
- Novus Biologicals ELISA Kits for GSTA1
Domains & Families for GSTA1 Gene
Gene Families for GSTA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GSTA1 Gene
- InterPro:
- Blocks:
-
- Glutathione S-transferase, N-terminal
- Alpha-class glutathione S-transferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTA1 Gene
- GenScript: Design optimal peptide antigens:
-
- GTH1 (GSTA1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08263UniProtKB/Swiss-Prot:
GSTA1_HUMAN :- The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
- Belongs to the GST superfamily. Alpha family.
- Domain:
-
- The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
- Family:
-
- Belongs to the GST superfamily. Alpha family.
Function for GSTA1 Gene
Molecular function for GSTA1 Gene
- UniProtKB/Swiss-Prot Function:
- Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:20606271};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione; Xref=Rhea:RHEA:50796, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133768; Evidence={ECO:0000269|PubMed:9084911};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione; Xref=Rhea:RHEA:50804, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133771; Evidence={ECO:0000269|PubMed:9084911};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48888, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90850; Evidence={ECO:0000269|PubMed:16624487};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=androst-5-ene-3,17-dione = androst-4-ene-3,17-dione; Xref=Rhea:RHEA:43936, ChEBI:CHEBI:16422, ChEBI:CHEBI:83865; Evidence={ECO:0000269|PubMed:11152686};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=160 uM for prostaglandin A2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911}; KM=160 uM for glutathione (at pH 8.0) {ECO:0000269|PubMed:11152686}; KM=58 uM for androst-5-ene-3,17-dione (at pH 8.0) {ECO:0000269|PubMed:11152686}; Vmax=121 nmol/min/mg enzyme for the formation of the glutathione-S-conjugate of prostaglandin A2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911}; Vmax=40 umol/min/mg enzyme for the isomerization of androst-5-ene-3,17-dione (at pH 8.0) {ECO:0000269|PubMed:11152686}; Note=kcat is 29.3 sec(-1) for the isomerization of androst-5-ene-3,17-dione. {ECO:0000269|PubMed:11152686}; pH dependence: Optimum pH is 8.0 for the isomerization of androst-5-ene-3,17-dione. {ECO:0000269|PubMed:11152686};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The isomerase activity is inhibited by S-methylglutathione (GSMe).
- GENATLAS Biochemistry:
- glutathione S-transferase 1,alpha,expressed in liver,with a proximal promoter essential for the binding of activating transcription factor complexes
Enzyme Numbers (IUBMB) for GSTA1 Gene
Phenotypes From GWAS Catalog for GSTA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | IBA,NAS | 1731620 |
| GO:0004601 | peroxidase activity | IEA | -- |
| GO:0004602 | glutathione peroxidase activity | IDA | 16624487 |
| GO:0004769 | steroid delta-isomerase activity | IDA | 11152686 |
| GO:0005504 | fatty acid binding | IPI | 16624487 |
Phenotypes for GSTA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA1 - Select products 50% OFF >
- * GSTA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA1
miRNA for GSTA1 Gene
- miRTarBase miRNAs that target GSTA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA1
- Browse OriGene Inhibitory RNA Products For GSTA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA1
Clone Products
- Applied Biological Materials (abm): Clones for GSTA1 - Select products 50% OFF >
- * GSTA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA1
Cell Line Products
-
Horizon Cell Lines for GSTA1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTA1 Gene
Localization for GSTA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTA1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for GSTA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Metabolism |
.40
|
|
| 4 | Cytochrome P450 - arranged by substrate type | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTA1 Gene
5 BioSystems pathways for GSTA1 Gene
4 Reactome pathways for GSTA1 Gene
3 PharmGKB pathways for GSTA1 Gene
10 KEGG pathways for GSTA1 Gene
3 GeneGo (Thomson Reuters) pathways for GSTA1 Gene
- 2-Naphthylamine and 2-Nitronaphtalene metabolism
- Glutathione metabolism
- Naphthalene metabolism
Interacting Proteins for GSTA1 Gene
GPS-Prot Interaction Network for GSTA1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006693 | prostaglandin metabolic process | IDA | 9084911 |
| GO:0006749 | glutathione metabolic process | IDA | 11851347 |
| GO:0006805 | xenobiotic metabolic process | IBA | 21873635 |
| GO:0030855 | epithelial cell differentiation | IEP | 21492153 |
| GO:0043651 | linoleic acid metabolic process | IDA | 16624487 |
Drugs & Compounds for GSTA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Busulfan | Approved, Investigational | Pharma | Enzyme, substrate | 622 | ||
| Glutathione | Approved, Investigational | Nutra | Target, Enzyme, substrate | 0 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 | ||
| Azathioprine | Approved | Pharma | Enzyme, substrate | 227 | ||
| Curcumin | Approved, Experimental, Investigational | Pharma | Enzyme, inhibitor | Tyrosinase inhibitor | 221 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
(1) ApexBio Compounds for GSTA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ezatiostat hydrochloride | GST inhibitor | 286942-97-0 |
Transcripts for GSTA1 Gene
mRNA/cDNA for GSTA1 Gene
- 2 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000334575 1218 nts (view in UCSC)
- ENST00000476213 460 nts (view in UCSC)
- ENST00000493331 760 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTA1 - Select products 50% OFF >
- * GSTA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTA1
- Browse OriGene Inhibitory RNA Products For GSTA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTA1
Clone Products
- Applied Biological Materials (abm): Clones for GSTA1 - Select products 50% OFF >
- * GSTA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GSTA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTA1
Relevant External Links for GSTA1 Gene
- GeneLoc Exon Structure for
- GSTA1
Expression for GSTA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- XY Germ Cells Testis Cord
- NULL (Uncategorized)
-
Gonad
- XY Germ Cells Testis Cord
- Liver (Hepatobiliary System)
- Placenta (Extraembryonic Tissues)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for GSTA1 Gene
This gene is overexpressed in Adrenal Gland (x19.8), Liver (x13.9), Kidney - Cortex (x5.4), and Small Intestine - Terminal Ileum (x4.5).
This gene is overexpressed in Liver, secretome (24.3) and Liver (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTA1
SOURCE GeneReport for Unigene cluster for GSTA1 Gene:
Hs.446309mRNA Expression by UniProt/SwissProt for GSTA1 Gene:
P08263-GSTA1_HUMAN
Tissue specificity:
Liver.
Evidence on tissue expression from TISSUES for GSTA1 Gene
- Liver(4.9)
- Nervous system(4.4)
- Kidney(3.6)
- Adrenal gland(3.2)
- Intestine(3.2)
- Stomach(2.7)
- Pancreas(2.5)
- Lung(2.2)
- Heart(2.1)
- Blood(2.1)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for GSTA1
-
OriGene qPCR primer pairs and template standards for GSTA1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTA1 Gene
Orthologs for GSTA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GSTA1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gsta2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | GSTA2 30 31 |
|
ManyToMany | |
| Mouse (Mus musculus) |
Mammalia | Gsta2 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| GSTA3 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:173962 31 |
|
ManyToMany | |
| gstal 31 |
|
ManyToMany | |||
| zgc:173961 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | gst-41 31 |
|
ManyToMany | |
| gst-10 31 |
|
ManyToMany | |||
| F56A4.3 31 |
|
ManyToMany | |||
| Y45G12C.3 31 |
|
ManyToMany | |||
| F56A4.4 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GSTA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GSTA1 Gene
- ENSEMBL:
- Gene Tree for GSTA1 (if available)
- TreeFam:
- Gene Tree for GSTA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTA1: view image
Paralogs for GSTA1 Gene
Variants for GSTA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTA1 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718439 | Benign: not provided | 52,796,178(-) | G/A | INTRON_VARIANT | |
| 726193 | Benign: not provided | 52,799,253(-) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 747861 | Likely Benign: not provided | 52,796,280(-) | A/C | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| rs1051578 | - | p.Thr19Ile | |||
| rs1051745 | - | p.Pro113Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10661n54 | CNV | loss | 21841781 |
| dgv1182e214 | CNV | gain | 21293372 |
| dgv5961n100 | CNV | loss | 25217958 |
| dgv5962n100 | CNV | loss | 25217958 |
| dgv5963n100 | CNV | loss | 25217958 |
| esv2436160 | CNV | deletion | 19546169 |
| esv2656678 | CNV | deletion | 23128226 |
| esv2666921 | CNV | deletion | 23128226 |
| esv2732085 | CNV | deletion | 23290073 |
| esv2732086 | CNV | deletion | 23290073 |
| esv2752126 | CNV | gain | 17911159 |
| esv2759429 | CNV | loss | 17122850 |
| esv2760993 | CNV | gain | 21179565 |
| esv2763990 | CNV | loss | 21179565 |
| esv3609005 | CNV | loss | 21293372 |
| esv3609008 | CNV | gain | 21293372 |
| esv3890845 | CNV | gain | 25118596 |
| esv4858 | OTHER | sequence alteration | 18987735 |
| esv9378 | CNV | loss | 19470904 |
| nsv1019011 | CNV | loss | 25217958 |
| nsv1032774 | CNV | gain | 25217958 |
| nsv436888 | CNV | insertion | 17901297 |
| nsv462945 | CNV | loss | 19166990 |
| nsv470818 | CNV | loss | 18288195 |
| nsv482096 | CNV | gain | 20164927 |
| nsv603106 | CNV | loss | 21841781 |
| nsv970122 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.80;
33.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTA1 Gene
Disorders for GSTA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dental fluorosis |
|
|
| hepatocellular carcinoma |
|
|
Search GSTA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTA1 Gene
Publications for GSTA1 Gene
- Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation. (PMID: 17425746) Kim I … Kim BK (Clinical transplantation 2007) 3 23 26 41
- Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. (PMID: 19584821) Ansari M … Krajinovic M (Bone marrow transplantation 2010) 3 23 41
- Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer. (PMID: 20056632) Steinbrecher A … Linseisen J (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
- Glutathione S-Transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. (PMID: 20331903) Chen YL … Tsai HT (BMC medical genetics 2010) 3 23 41
- Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 23 41
ExternalLinks
Products for GSTA1 Gene
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- Signalway Proteins for GSTA1
Sources for GSTA1 Gene
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