Aliases for GSTA1 Gene
External Ids for GSTA1 Gene
Previous GeneCards Identifiers for GSTA1 Gene
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for GSTA1 Gene
GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. Diseases associated with GSTA1 include Ovarian Endodermal Sinus Tumor and Ovarian Primitive Germ Cell Tumor. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTA2.
UniProtKB/Swiss-Prot for GSTA1 Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.