Aliases for GSPT1 Gene
External Ids for GSPT1 Gene
Previous GeneCards Identifiers for GSPT1 Gene
GeneCards Summary for GSPT1 Gene
GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Gene Expression. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GSPT2.
UniProtKB/Swiss-Prot Summary for GSPT1 Gene
Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).