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Aliases for GSPT1 Gene
Aliases for GSPT1 Gene
External Ids for GSPT1 Gene
- HGNC: 4621
- Entrez Gene: 2935
- Ensembl: ENSG00000103342
- OMIM: 139259
- UniProtKB: P15170
Previous GeneCards Identifiers for GSPT1 Gene
- GC16M011749
- GC16M012118
- GC16M011932
- GC16M011874
- GC16M011961
- GC16M011878
Summaries for GSPT1 Gene
GeneCards Summary for GSPT1 Gene
GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Gene Expression. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GSPT2.
UniProtKB/Swiss-Prot Summary for GSPT1 Gene
-
Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
Additional gene information for GSPT1 Gene
- HGNC(4621)
- Entrez Gene(2935)
- Ensembl(ENSG00000103342)
- OMIM(139259)
- UniProtKB(P15170)
- Open Targets Platform(ENSG00000103342)
- Search for GSPT1 at DataMed
- Search for GSPT1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSPT1 Gene
Genomics for GSPT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSPT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSPT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSPT1
- Top Transcription factor binding sites by QIAGEN in the GSPT1 gene promoter:
-
- Arnt
- IRF-1
- p53
- XBP-1
Genomic Locations for GSPT1 Gene
Genomic Locations for GSPT1 Gene
- chr16:11,868,128-11,916,654
- (GRCh38/hg38)
- Size:
- 48,527 bases
- Orientation:
- Minus strand
- chr16:11,961,985-12,010,519
- (GRCh37/hg19)
- Size:
- 48,535 bases
- Orientation:
- Minus strand
Genomic View for GSPT1 Gene
Genes around GSPT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by HGNC
- 16p13.13 by Entrez Gene
- 16p13.13 by Ensembl
GSPT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSPT1 Gene
Proteins for GSPT1 Gene
-
Protein details for GSPT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15170-ERF3A_HUMAN
- Recommended name:
- Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
- Protein Accession:
- P15170
- J3KQG6
- Q96GF2
Protein attributes for GSPT1 Gene
- Size:
- 499 amino acids
- Molecular mass:
- 55756 Da
- Quaternary structure:
-
- Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). The ETF1-GSPT1 complex interacts with JMJD4 (PubMed:24486019). Interacts with PABPC1 (By similarity). Interacts with SHFL (PubMed:30682371).
Three dimensional structures from OCA and Proteopedia for GSPT1 Gene
Protein Expression for GSPT1 Gene
Post-translational modifications for GSPT1 Gene
Other Protein References for GSPT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ eRF3a Antibody
- GeneTex Anti-GSPT1 antibody
-
Custom Antibody ServicesOriGene Antibodies for GSPT1
- Novus Biologicals Antibodies for GSPT1
-
Abcam antibodies for GSPT1
- Invitrogen Antibodies for GSPT1 (AFLGC-GSPT1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSPT1
Protein Products
-
OriGene Purified Proteins for GSPT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSPT1
- Origene Custom Protein Services for GSPT1
- Novus Biologicals proteins for GSPT1
- antibodies-online: Show 4 available GSPT1 Proteins ranked by validation data
- Compare Top GSPT1 Proteins
-
Quality Products:
-
Abcam proteins for GSPT1
No data available for DME Specific Peptides for GSPT1 Gene
Domains & Families for GSPT1 Gene
Gene Families for GSPT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GSPT1 Gene
- InterPro:
- Blocks:
-
- Elongation factor Tu, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for GSPT1 Gene
- GenScript: Design optimal peptide antigens:
-
- G1 to S phase transition protein 1 homolog (ERF3A_HUMAN)
- GSPT1 protein (Q96GF2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15170UniProtKB/Swiss-Prot:
ERF3A_HUMAN :- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
- Family:
-
- Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
Function for GSPT1 Gene
Molecular function for GSPT1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
- GENATLAS Biochemistry:
- peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed release,mapping at the FRA16A locus
Phenotypes From GWAS Catalog for GSPT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003747 | translation release factor activity | IBA,IMP | 15326224 |
| GO:0003924 | GTPase activity | IEA,TAS | 15326224 |
| GO:0005515 | protein binding | IPI | 9620853 |
Phenotypes for GSPT1 Gene
- GenomeRNAi human phenotypes for GSPT1:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Synthetic lethal with Ras
- Increased G1 DNA content
- Decreased NF-kappaB reporter expression
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased POU5F1-GFP protein expression
- Decreased interferon-beta reporter expression
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- G0/1 arrest
- Increased G1 length
- Increased G1 length, increased S length
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSPT1 - Select products 50% OFF >
- * GSPT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSPT1
miRNA for GSPT1 Gene
- miRTarBase miRNAs that target GSPT1
-
- hsa-let-7b-5p (MIRT032238)
- hsa-miR-361-5p (MIRT044090)
- hsa-miR-183-5p (MIRT047129)
- hsa-miR-383-3p (MIRT282792)
- hsa-miR-873-5p (MIRT343125)
- hsa-miR-218-5p (MIRT440531)
- hsa-miR-1273e (MIRT444624)
- hsa-miR-7160-5p (MIRT444625)
- hsa-miR-1827 (MIRT444626)
- hsa-miR-4649-3p (MIRT444627)
- hsa-miR-940 (MIRT444628)
- hsa-miR-6893-5p (MIRT444629)
- hsa-miR-6808-5p (MIRT444630)
- hsa-miR-302f (MIRT444631)
- hsa-miR-6864-3p (MIRT476020)
- hsa-miR-3672 (MIRT476022)
- hsa-miR-6801-5p (MIRT476023)
- hsa-miR-769-5p (MIRT476024)
- hsa-miR-4786-5p (MIRT476025)
- hsa-miR-6500-3p (MIRT476026)
- hsa-miR-3614-5p (MIRT476027)
- hsa-miR-4275 (MIRT537013)
- hsa-miR-205-3p (MIRT537015)
- hsa-miR-576-3p (MIRT537016)
- hsa-miR-5197-5p (MIRT537017)
- hsa-miR-374c-3p (MIRT537018)
- hsa-miR-8055 (MIRT632864)
- hsa-miR-7977 (MIRT632865)
- hsa-miR-6884-5p (MIRT632866)
- hsa-miR-485-5p (MIRT632867)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSPT1
- Browse OriGene Inhibitory RNA Products For GSPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSPT1
Clone Products
- Applied Biological Materials (abm): Clones for GSPT1 - Select products 50% OFF >
- * GSPT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208005
- MG209166
- MG218849
- MR208005
- MR208005L3
- MR208005L4
- MR209166
- MR209166L3
- MR209166L4
- MR218849
- MR218849L3
- MR218849L4
- RC225858
- RC225858L3
- RC225858L4
- RC226048
- RC226048L3
- RC226048L4
- RC229318
- RC229318L1
- RC229318L2
- RC229318L3
- RC229318L4
- RG225858
- RG226048
- RG229318
- RR215669
- RR215669L3
- RR215669L4
- MR208005L3V
- MR208005L4V
- MR209166L3V
- MR209166L4V
- MR218849L3V
- MR218849L4V
- RC225858L3V
- RC225858L4V
- RC226048L3V
- RC226048L4V
- RC229318L1V
- RC229318L2V
- RC229318L3V
- RC229318L4V
- RR215669L3V
- RR215669L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSPT1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSPT1 Gene
Localization for GSPT1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0018444 | translation release factor complex | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSPT1 Gene
Pathways & Interactions for GSPT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.77
|
|
| 2 | Translational Control | ||
| 3 | mRNA surveillance pathway | ||
| 4 | Gene Expression |
.48
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for GSPT1 Gene
7 Reactome pathways for GSPT1 Gene
1 KEGG pathway for GSPT1 Gene
1 Cell Signaling Technology pathway for GSPT1 Gene
Interacting Proteins for GSPT1 Gene
Selected Interacting proteins:
P15170-ERF3A_HUMAN
ENSP00000398131
for GSPT1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GSPT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | 2511002 |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | 15326224 |
| GO:0002184 | cytoplasmic translational termination | IBA | 21873635 |
| GO:0006412 | translation | IBA | 21873635 |
| GO:0006449 | regulation of translational termination | IMP | 30682371 |
No data available for SIGNOR curated interactions for GSPT1 Gene
Transcripts for GSPT1 Gene
mRNA/cDNA for GSPT1 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000420576 1603 nts (view in UCSC)
- ENST00000434724 7141 nts (view in UCSC)
- ENST00000439887 2509 nts (view in UCSC)
- ENST00000562169 466 nts (view in UCSC)
- ENST00000562794 501 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSPT1 - Select products 50% OFF >
- * GSPT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSPT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSPT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSPT1
- Browse OriGene Inhibitory RNA Products For GSPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSPT1
Clone Products
- Applied Biological Materials (abm): Clones for GSPT1 - Select products 50% OFF >
- * GSPT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208005
- MG209166
- MG218849
- MR208005
- MR208005L3
- MR208005L4
- MR209166
- MR209166L3
- MR209166L4
- MR218849
- MR218849L3
- MR218849L4
- RC225858
- RC225858L3
- RC225858L4
- RC226048
- RC226048L3
- RC226048L4
- RC229318
- RC229318L1
- RC229318L2
- RC229318L3
- RC229318L4
- RG225858
- RG226048
- RG229318
- RR215669
- RR215669L3
- RR215669L4
- MR208005L3V
- MR208005L4V
- MR209166L3V
- MR209166L4V
- MR218849L3V
- MR218849L4V
- RC225858L3V
- RC225858L4V
- RC226048L3V
- RC226048L4V
- RC229318L1V
- RC229318L2V
- RC229318L3V
- RC229318L4V
- RR215669L3V
- RR215669L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSPT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSPT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for GSPT1 Gene
- GeneLoc Exon Structure for
- GSPT1
Expression for GSPT1 Gene
This gene is overexpressed in Lymph node (11.0), Peripheral blood mononuclear cells (7.4), and Amniocyte (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSPT1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSPT1
SOURCE GeneReport for Unigene cluster for GSPT1 Gene:
Hs.528780Evidence on tissue expression from TISSUES for GSPT1 Gene
- Lung(4.6)
- Nervous system(4.1)
- Intestine(3.3)
- Skin(2.6)
- Kidney(2.3)
- Liver(2.3)
- Muscle(2.2)
- Heart(2.1)
- Bone marrow(2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for GSPT1
-
OriGene qPCR primer pairs and template standards for GSPT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSPT1 Gene
Orthologs for GSPT1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Chimpanzee (Pan troglodytes) |
Mammalia | GSPT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GSPT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GSPT1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Mouse (Mus musculus) |
Mammalia | Gspt1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gspt1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | GSPT1 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gspt1 30 |
|
||
| Str.3230 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7810 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gspt1l 31 |
|
ManyToMany | |
| gspt1 30 30 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009310 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Elf 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | H19N07.1 32 |
|
|
|
| erfa-3 31 |
|
OneToMany | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D17424g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SUP35 30 31 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL145W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G18070 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1162 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0270100 30 |
|
||
| Os.16925 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9703 31 |
|
OneToMany | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sup35 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04790 30 |
|
- Species where no ortholog for GSPT1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GSPT1 Gene
- ENSEMBL:
- Gene Tree for GSPT1 (if available)
- TreeFam:
- Gene Tree for GSPT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSPT1: view image
Paralogs for GSPT1 Gene
Paralogs for GSPT1 Gene
(7) SIMAP similar genes for GSPT1 Gene using alignment to 4 proteins:
- ERF3A_HUMAN
- H3BMT9_HUMAN
- H3BR35_HUMAN
- H3BSV8_HUMAN
Pseudogenes.org Pseudogenes for GSPT1 Gene
Variants for GSPT1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1298n106 | CNV | deletion | 24896259 |
| esv2343500 | CNV | deletion | 18987734 |
| esv2651942 | CNV | deletion | 19546169 |
| esv2713982 | CNV | deletion | 23290073 |
| esv3553124 | CNV | deletion | 23714750 |
| esv7500 | CNV | loss | 19470904 |
| nsv1043909 | CNV | gain | 25217958 |
| nsv1151765 | CNV | deletion | 26484159 |
| nsv1735 | CNV | deletion | 18451855 |
| nsv519892 | CNV | loss | 19592680 |
| nsv524025 | CNV | loss | 19592680 |
| nsv571458 | CNV | gain | 21841781 |
| nsv958188 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.44;
90.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSPT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSPT1 Gene
Disorders for GSPT1 Gene
Additional Disease Information for GSPT1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for GSPT1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSPT1 Gene
Publications for GSPT1 Gene
- A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PMID: 2511002) Hoshino S … Ui M (The EMBO journal 1989) 2 3 4
- Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. (PMID: 30682371) Wang X … Gao G (Cell 2019) 3 4
- Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. (PMID: 20418951) Kozlov G … Gehring K (PloS one 2010) 3 4
- SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A … Ohno S (Genes & development 2009) 3 4
- eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. (PMID: 19424636) Malta-Vacas J … Brito M (Oncology reports 2009) 3 23
ExternalLinks
Products for GSPT1 Gene
- Custom Antibody ServicesOriGene Antibodies for GSPT1
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- antibodies-online: Show 8 available GSPT1 Antibodies ranked by validation data
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- antibodies-online: Search results for available GSPT1 related products ranked by validation data
- antibodies-online: Show 4 available GSPT1 Proteins ranked by validation data
- Compare Top GSPT1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for GSPT1
- Search Santa Cruz Biotechnology (SCBT) for GSPT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSPT1
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for GSPT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSPT1
Sources for GSPT1 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (30) HomoloGene
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- (33) SGD
- (34) FlyBase
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- (36) Pseudogene
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- (39) GenAtlas
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- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
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- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (86) PaxDb
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- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (163) LncBase
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB