GSPT1 Gene (Protein Coding)

G1 To S Phase Transition 1

GC16M011868
GIFtS:
40
See more...

Aliases for GSPT1 Gene

Aliases for GSPT1 Gene

  • G1 To S Phase Transition 1 2 3 5
  • ERF3a 2 3 4
  • Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A 3 4
  • Eukaryotic Peptide Chain Release Factor Subunit 3a 3 4
  • G1 To S Phase Transition Protein 1 Homolog 3 4
  • Eukaryotic Release Factor 3a 2 3
  • ETF3A 2 3
  • GST1 2 3
  • 551G9.2 3
  • GSPT1 5
  • ERF3A 4

External Ids for GSPT1 Gene

Previous GeneCards Identifiers for GSPT1 Gene

  • GC16M011749
  • GC16M012118
  • GC16M011932
  • GC16M011874
  • GC16M011961
  • GC16M011878

Summaries for GSPT1 Gene

GeneCards Summary for GSPT1 Gene

GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GSPT2.

UniProtKB/Swiss-Prot Summary for GSPT1 Gene

  • Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).

Gene Wiki entry for GSPT1 Gene

Additional gene information for GSPT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSPT1 Gene

Genomics for GSPT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GSPT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSPT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSPT1

Top Transcription factor binding sites by QIAGEN in the GSPT1 gene promoter:
  • Arnt
  • IRF-1
  • p53
  • XBP-1

Genomic Locations for GSPT1 Gene

Latest Assembly
chr16:11,868,128-11,916,654
(GRCh38/hg38)
Size:
48,527 bases
Orientation:
Minus strand

Previous Assembly
chr16:11,961,985-12,010,511
(GRCh37/hg19 by Entrez Gene)
Size:
48,527 bases
Orientation:
Minus strand

chr16:11,961,985-12,009,939
(GRCh37/hg19 by Ensembl)
Size:
47,955 bases
Orientation:
Minus strand

Genomic View for GSPT1 Gene

Genes around GSPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSPT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GSPT1 Gene

Proteins for GSPT1 Gene

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  • Protein details for GSPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15170-ERF3A_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Protein Accession:
    P15170
    Secondary Accessions:
    • J3KQG6
    • Q96GF2

    Protein attributes for GSPT1 Gene

    Size:
    499 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    • Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). The ETF1-GSPT1 complex interacts with JMJD4 (PubMed:24486019). Interacts with PABPC1 (By similarity). Interacts with SHFL (PubMed:30682371).

    Three dimensional structures from OCA and Proteopedia for GSPT1 Gene

    Alternative splice isoforms for GSPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSPT1 Gene

Protein Expression for GSPT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GSPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSPT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for GSPT1 Gene

Domains & Families for GSPT1 Gene

Gene Families for GSPT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GSPT1 Gene

InterPro:
Blocks:
  • Elongation factor Tu, C-terminal

Suggested Antigen Peptide Sequences for GSPT1 Gene

GenScript: Design optimal peptide antigens:
  • G1 to S phase transition protein 1 homolog (ERF3A_HUMAN)
  • GSPT1 protein (Q96GF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15170

UniProtKB/Swiss-Prot:

ERF3A_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
genes like me logo Genes that share domains with GSPT1: view

Function for GSPT1 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for GSPT1 Gene

UniProtKB/Swiss-Prot Function:
Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth (PubMed:2511002). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).
GENATLAS Biochemistry:
peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed release,mapping at the FRA16A locus

Phenotypes From GWAS Catalog for GSPT1 Gene

Gene Ontology (GO) - Molecular Function for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003747 translation release factor activity IBA,IMP 15326224
GO:0003924 GTPase activity IEA,TAS 15326224
GO:0005515 protein binding IPI 9620853
genes like me logo Genes that share ontologies with GSPT1: view
genes like me logo Genes that share phenotypes with GSPT1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSPT1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSPT1 Gene

Localization for GSPT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSPT1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0018444 translation release factor complex IBA 21873635
genes like me logo Genes that share ontologies with GSPT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSPT1 Gene

Pathways & Interactions for GSPT1 Gene

genes like me logo Genes that share pathways with GSPT1: view

Gene Ontology (GO) - Biological Process for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 2511002
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 15326224
GO:0002184 cytoplasmic translational termination IBA 21873635
GO:0006412 translation IBA 21873635
GO:0006449 regulation of translational termination IMP 30682371
genes like me logo Genes that share ontologies with GSPT1: view

No data available for SIGNOR curated interactions for GSPT1 Gene

Drugs & Compounds for GSPT1 Gene

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(2) Drugs for GSPT1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GSPT1: view

Transcripts for GSPT1 Gene

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mRNA/cDNA for GSPT1 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSPT1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for GSPT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for GSPT1 Gene

GeneLoc Exon Structure for
GSPT1

Expression for GSPT1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSPT1 Gene

mRNA expression in normal human tissues for GSPT1 Gene
mRNA expression by BioGPS for GSPT1 GenemRNA expression by GTEx for GSPT1 Gene

Protein differential expression in normal tissues from HIPED for GSPT1 Gene

This gene is overexpressed in Lymph node (11.0), Peripheral blood mononuclear cells (7.4), and Amniocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSPT1 Gene



Protein tissue co-expression partners for GSPT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSPT1

SOURCE GeneReport for Unigene cluster for GSPT1 Gene:

Hs.528780

Evidence on tissue expression from TISSUES for GSPT1 Gene

  • Lung(4.6)
  • Nervous system(4.1)
  • Intestine(3.3)
  • Skin(2.5)
  • Kidney(2.2)
  • Liver(2.2)
  • Muscle(2.2)
  • Heart(2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with GSPT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSPT1 Gene

Orthologs for GSPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSPT1 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 98 (a)
 ManyToMany
-- 30
  • 75 (a)
 ManyToMany
Chimpanzee
(Pan troglodytes)
 Mammalia GSPT1 29 30
  • 97.49 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GSPT1 29 30
  • 94.24 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GSPT1 29 30
  • 94.01 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 94 (a)
 ManyToMany
-- 30
  • 86 (a)
 ManyToMany
Mouse
(Mus musculus)
 Mammalia Gspt1 29 16 30
  • 91.75 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gspt1 29
  • 91.42 (n)
Chicken
(Gallus gallus)
 Aves GSPT1 29 30
  • 83.88 (n)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 94 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gspt1 29
  • 82.45 (n)
Str.3230 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7810 29
Zebrafish
(Danio rerio)
 Actinopterygii gspt1l 30
  • 79 (a)
 ManyToMany
gspt1 29 29 30
  • 73.87 (n)
 ManyToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009310 29
  • 64 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Elf 29 30 31
  • 63.78 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea H19N07.1 31
  • 59 (a)
erfa-3 30
  • 56 (a)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D17424g 29
  • 61.32 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SUP35 29 30
  • 60.69 (n)
 OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AGL145W 29
  • 60.46 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT1G18070 29
  • 60.27 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.1162 29
Rice
(Oryza sativa)
 Liliopsida Os04g0270100 29
  • 61.58 (n)
Os.16925 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.9703 30
  • 68 (a)
 OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes sup35 29
  • 58.45 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU04790 29
  • 58.33 (n)
Species where no ortholog for GSPT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GSPT1 Gene

ENSEMBL:
Gene Tree for GSPT1 (if available)
TreeFam:
Gene Tree for GSPT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSPT1: view image
Alliance of Genome Resources:
Additional Orthologs for GSPT1

Paralogs for GSPT1 Gene

Paralogs for GSPT1 Gene

(7) SIMAP similar genes for GSPT1 Gene using alignment to 4 proteins:

  • ERF3A_HUMAN
  • H3BMT9_HUMAN
  • H3BR35_HUMAN
  • H3BSV8_HUMAN

Pseudogenes.org Pseudogenes for GSPT1 Gene

genes like me logo Genes that share paralogs with GSPT1: view

Variants for GSPT1 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GSPT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GSPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1298n106 CNV deletion 24896259
esv2343500 CNV deletion 18987734
esv2651942 CNV deletion 19546169
esv2713982 CNV deletion 23290073
esv3553124 CNV deletion 23714750
esv7500 CNV loss 19470904
nsv1043909 CNV gain 25217958
nsv1151765 CNV deletion 26484159
nsv1735 CNV deletion 18451855
nsv519892 CNV loss 19592680
nsv524025 CNV loss 19592680
nsv571458 CNV gain 21841781
nsv958188 CNV deletion 24416366

Variation tolerance for GSPT1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.44; 90.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSPT1 Gene

Human Gene Mutation Database (HGMD)
GSPT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSPT1
Leiden Open Variation Database (LOVD)
GSPT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSPT1 Gene

Disorders for GSPT1 Gene

Additional Disease Information for GSPT1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GSPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSPT1 Gene

Publications for GSPT1 Gene

  1. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PMID: 2511002) Hoshino S … Ui M (The EMBO journal 1989) 2 3 4
  2. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. (PMID: 30682371) Wang X … Gao G (Cell 2019) 3 4
  3. Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. (PMID: 20418951) Kozlov G … Gehring K (PloS one 2010) 3 4
  4. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A … Ohno S (Genes & development 2009) 3 4
  5. eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. (PMID: 19424636) Malta-Vacas J … Brito M (Oncology reports 2009) 3 22

ExternalLinks

View latest publications for GSPT1 gene in Mastermind

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