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The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Alzheimer Disease and Bipolar Disorder. Among its related pathways are Neuroscience and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3A.
Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0001085 | RNA polymerase II transcription factor binding | IPI | 20864106 |
GO:0002020 | protease binding | IPI | 25118933 |
GO:0002039 | p53 binding | IDA | 14744935 |
GO:0004672 | protein kinase activity | IEA,TAS | 22988876 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 14744935 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,IDA | 14744935 |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005813 | centrosome | IDA | 17139249 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | S45 mutants of beta-catenin arent phosphorylated | ||
2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Development Thrombopoietin-regulated cell processes
.38
|
|
3 | RET signaling |
.92
|
|
4 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Translation Regulation of EIF2 activity
.47
|
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
|
5 | GAB1 signalosome |
.89
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001837 | epithelial to mesenchymal transition | IMP | 15448698 |
GO:0001954 | positive regulation of cell-matrix adhesion | IMP | 18156211 |
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0005977 | glycogen metabolic process | IDA | 8638126 |
GO:0006468 | protein phosphorylation | IEA,TAS | 26049140 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Lithium carbonate | Approved | Pharma | Target | Mood stabilizer; inhibits Na+/K+ ATPase pump activity | 301 | |
Lithium citrate | Approved | Pharma | Target | 0 | ||
Citalopram | Approved | Pharma | 597 | |||
Fluoxetine | Approved, Vet_approved | Pharma | Channel blocker, Antagonist, Inhibitor, Inhibition | 278 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
Indirubin-3'-oxime | GSK-3beta inhibitor. Also inhibits other protein kinases | 160807-49-8 |
MeBIO | Inactive analog of BIO (Cat. No. 3194) | 667463-95-8 |
SB 216763 | Potent, selective GSK-3 inhibitor | 280744-09-4 |
Compound | Action | Cas Number |
---|---|---|
1-Azakenpaullone | GSK-3β inhibitor,potent and selective,cell-permeable | 676596-65-9 |
A 1070722 | 1384424-80-9 | |
AR-A014418 | GSK3β inhibitor, ATP-competitive and selective | 487021-52-3 |
AZD1080 | GSK3βinhibitor | 612487-72-6 |
AZD2858 | GSK-3 inhibitor,potent and selective | 486424-20-8 |
Bikinin | GSK3 inhibitor and Brassinosteroid activator | 188011-69-0 |
BIO-acetoxime | 667463-85-6 | |
CHIR 99021 trihydrochloride | ||
CHIR-98014 | GSK-3β inhibitor,selective and ATP-competitive | 252935-94-7 |
CHIR-99021 (CT99021) | GSK-3 inhibitor, Cell-permeable, ATP-competitive | 252917-06-9 |
CHIR-99021 (CT99021) HCl | GSK-3α/β inhibitor | 252917-06-9 |
GSK-3 Inhibitor IX (BIO) | 667463-62-9 | |
IM-12 | 1129669-05-1 | |
Indirubin | 479-41-4 | |
Indirubin-3'-oxime | 160807-49-8 | |
LY2090314 | Potent GSK-3 inhibitor | 603288-22-8 |
SB 216763 | GSK-3 inhibitor,ATP-competitive,potent and selective | 280744-09-4 |
SB 415286 | GSK-3 inhibitor,potent and selective | 264218-23-7 |
TC-G 24 | 1257256-44-2 | |
TCS 183 | ||
TCS 184 | 1315378-71-2 | |
TCS 2002 | GSK -3β inhibitor, potent | 1005201-24-0 |
TDZD-8 | GSK-3β inhibitor | 327036-89-5 |
Tideglusib | 865854-05-3 | |
TWS119 | GSK-3β inhibitor | 601514-19-6 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | GSK3B 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | GSK3B 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GSK3B 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GSK3B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GSK3B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gsk3b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gsk3b 30 |
|
||
Chicken (Gallus gallus) |
Aves | GSK3B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GSK3B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gsk3b 30 |
|
||
Str.19775 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xgsk-3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | GSK3B (2 of 2) 31 |
|
OneToMany | |
gsk3b 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | gskt 31 32 |
|
ManyToMany | |
Pk34A 32 |
|
|
|||
sgg 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | Y18D10A.5 32 |
|
|
|
gsk-3 30 31 |
|
OneToMany | |||
C44H4.6 32 |
|
|
|||
R03D7.5 32 |
|
|
|||
F21F3.2 32 |
|
|
|||
C36B1.10 32 |
|
|
|||
Y106G6D.4 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RIM11 31 33 |
|
ManyToMany | |
MRK1 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SK13 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7461 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0134000 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.6802 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718992 | Likely Benign: not provided | 120,002,229(-) | G/A | SYNONYMOUS_VARIANT | |
721176 | Benign: not provided | 119,923,394(-) | C/T | SYNONYMOUS_VARIANT | |
784016 | Benign: not provided | 119,863,444(-) | A/G | SYNONYMOUS_VARIANT | |
791946 | Benign: not provided | 119,843,259(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv883e199 | CNV | deletion | 23128226 |
esv22981 | CNV | loss | 19812545 |
esv2516850 | CNV | deletion | 19546169 |
esv2631534 | CNV | deletion | 19546169 |
esv2666502 | CNV | deletion | 23128226 |
esv3562450 | CNV | deletion | 23714750 |
esv3568979 | CNV | loss | 25503493 |
esv3597569 | CNV | loss | 21293372 |
nsv1073239 | CNV | deletion | 25765185 |
nsv3964 | CNV | deletion | 18451855 |
nsv478074 | CNV | novel sequence insertion | 20440878 |
nsv478327 | CNV | novel sequence insertion | 20440878 |
nsv507120 | OTHER | sequence alteration | 20534489 |
nsv829696 | CNV | gain | 17160897 |
nsv829697 | CNV | loss | 17160897 |
nsv955330 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alzheimer disease |
|
|
bipolar disorder |
|
|
familial adenomatous polyposis |
|
|
alzheimer disease 14 |
|
|
usher syndrome, type iia |
|
|