This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 201... See more...

Aliases for GSK3A Gene

Aliases for GSK3A Gene

  • Glycogen Synthase Kinase 3 Alpha 2 3 5
  • Serine/Threonine-Protein Kinase GSK3A 3 4
  • Glycogen Synthase Kinase-3 Alpha 3 4
  • EC 2.7.11.26 4 51
  • GSK-3 Alpha 3 4
  • EC 2.7.11.1 4
  • EC 2.7.11 51
  • GSK3A 5

External Ids for GSK3A Gene

Previous GeneCards Identifiers for GSK3A Gene

  • GC19M043380
  • GC19M043126
  • GC19M047410
  • GC19M047426
  • GC19M042734
  • GC19M039164

Summaries for GSK3A Gene

Entrez Gene Summary for GSK3A Gene

  • This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

GeneCards Summary for GSK3A Gene

GSK3A (Glycogen Synthase Kinase 3 Alpha) is a Protein Coding gene. Diseases associated with GSK3A include Alzheimer Disease and Schizophrenia. Among its related pathways are Neuroscience and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GSK3B.

UniProtKB/Swiss-Prot Summary for GSK3A Gene

  • Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).

Tocris Summary for GSK3A Gene

  • Glycogen synthase kinase 3 (GSK-3) is a serine-threonine kinase with two isoforms (alpha and beta), that was originally discovered as an important enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cellular division, proliferation, motility and survival.

Gene Wiki entry for GSK3A Gene

Additional gene information for GSK3A Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSK3A Gene

Genomics for GSK3A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GSK3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042241 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.0 -1010 7.5 ZNF221 SP1 HNRNPL CREB1 CTCF TEAD4 PRDM10 ZNF629 REST RFX1 ENSG00000279539 GSK3A lnc-ERF-1 ZNF526 HNRNPUL1 CCDC97 RPS19 ZNF574 CIC GRIK5
GH19J042240 Promoter 0.4 EPDnew 600.7 +3.2 3177 0.1 PRDM1 GSK3A lnc-ERF-1 lnc-DEDD2-2 ENSG00000268643 ZNF526
GH19J042236 Promoter 0.3 EPDnew 600.4 +6.4 6420 0.1 GSK3A lnc-DEDD2-2 lnc-ERF-1 ENSG00000268643 ZNF526
GH19J042267 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.9 -27.5 -27540 6.9 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 CIC piR-36065 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19
GH19J042216 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +24.7 24729 6.8 ZNF221 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 IKZF1 POU2F2 ZNF526 DEDD2 hsa-miR-5095-280 lnc-DEDD2-1 ZNF574 GRIK5 GSK3A CIC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSK3A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSK3A

Top Transcription factor binding sites by QIAGEN in the GSK3A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • p53

Genomic Locations for GSK3A Gene

Genomic Locations for GSK3A Gene
chr19:42,230,186-42,243,330
(GRCh38/hg38)
Size:
13,145 bases
Orientation:
Minus strand
chr19:42,734,338-42,746,777
(GRCh37/hg19)
Size:
12,440 bases
Orientation:
Minus strand

Genomic View for GSK3A Gene

Genes around GSK3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSK3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSK3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSK3A Gene

Proteins for GSK3A Gene

  • Protein details for GSK3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49840-GSK3A_HUMAN
    Recommended name:
    Glycogen synthase kinase-3 alpha
    Protein Accession:
    P49840
    Secondary Accessions:
    • O14959

    Protein attributes for GSK3A Gene

    Size:
    483 amino acids
    Molecular mass:
    50981 Da
    Quaternary structure:
    • Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin (PubMed:17229088). Interacts with CTNND2 (PubMed:19706605). Interacts with LMBR1L (PubMed:31073040). Interacts with DDX3X (PubMed:18846110). Interacts with TNFRSF10B (PubMed:18846110).
    Miscellaneous:
    • Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350).

    Three dimensional structures from OCA and Proteopedia for GSK3A Gene

neXtProt entry for GSK3A Gene

Selected DME Specific Peptides for GSK3A Gene

P49840:
  • TPPEAIALCS
  • VAIKKVLQD
  • HRDIKPQNLL
  • IKVLGTPTRE
  • IFPGDSGVDQ
  • SYICSRYYRAPEL
  • PLEACAHSFFDELR
  • LPPLFNF
  • YVPETVYRVARH
  • ELLLGQP
  • CDFGSAK
  • YFFYSSG
  • MNPNYTEFKFPQIK
  • FPQIKAHPW
  • DFGSAKQL
  • KDELYLNL
  • VPETVYR
  • DQLVEIIK
  • YRAPELIFG

Post-translational modifications for GSK3A Gene

  • Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSK3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GSK3A Gene

Gene Families for GSK3A Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GSK3A Gene

Suggested Antigen Peptide Sequences for GSK3A Gene

GenScript: Design optimal peptide antigens:
  • Glycogen synthase kinase-3 alpha (GSK3A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49840

UniProtKB/Swiss-Prot:

GSK3A_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
genes like me logo Genes that share domains with GSK3A: view

Function for GSK3A Gene

Molecular function for GSK3A Gene

UniProtKB/Swiss-Prot Function:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350). Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350). Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350). Regulates glycogen metabolism in liver, but not in muscle (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001). In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088). Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548). May be involved in the regulation of replication in pancreatic beta-cells (By similarity). Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, leading to activate KAT5/TIP60 acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA-COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:22539723};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
GENATLAS Biochemistry:
glycogen synthase kinase 3 alpha,regulator of glycogen synthesis in skeletal muscle,unstabilized in response to insulin with both protein level and activity increased by heat stress

Enzyme Numbers (IUBMB) for GSK3A Gene

Phenotypes From GWAS Catalog for GSK3A Gene

Gene Ontology (GO) - Molecular Function for GSK3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS 8725894
GO:0005102 signaling receptor binding IPI 20371704
GO:0005515 protein binding IPI 10481074
genes like me logo Genes that share ontologies with GSK3A: view
genes like me logo Genes that share phenotypes with GSK3A: view

Animal Models for GSK3A Gene

MGI Knock Outs for GSK3A:
  • Gsk3a Gsk3a<tm1b(EUCOMM)Hmgu>
  • Gsk3a Gsk3a<tm1a(EUCOMM)Hmgu>
  • Gsk3a Gsk3a<tm1.1Jrw>
  • Gsk3a Gsk3a<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for GSK3A

CRISPR Products

miRNA for GSK3A Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSK3A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSK3A Gene

Localization for GSK3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSK3A gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 4
cytoskeleton 3
plasma membrane 2
extracellular 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GSK3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS 11035810
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with GSK3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSK3A Gene

Pathways & Interactions for GSK3A Gene

genes like me logo Genes that share pathways with GSK3A: view

Pathways by source for GSK3A Gene

2 Sino Biological pathways for GSK3A Gene
9 GeneGo (Thomson Reuters) pathways for GSK3A Gene
  • Development IGF-1 receptor signaling
  • Development Thrombopoietin-regulated cell processes
  • Development_Leptin signaling via PI3K-dependent pathway
  • G-protein signaling G-Protein alpha-s signaling cascades
  • Immune response NFAT in immune response
4 Tocris pathways for GSK3A Gene
16 Qiagen pathways for GSK3A Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Akt Signaling
  • cAMP Pathway
  • DHA Signaling
4 Cell Signaling Technology pathways for GSK3A Gene
2 GeneTex pathways for GSK3A Gene

SIGNOR curated interactions for GSK3A Gene

Gene Ontology (GO) - Biological Process for GSK3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure ISS --
GO:0003214 cardiac left ventricle morphogenesis ISS --
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
genes like me logo Genes that share ontologies with GSK3A: view

Drugs & Compounds for GSK3A Gene

(34) Drugs for GSK3A Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
CHIR-124 Experimental Pharma Chk1 inhibitor,novel and potent 0
Tideglusib Investigational, Withdrawn Pharma 0
Indirubin Investigational Pharma 5
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for GSK3A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(3) Tocris Compounds for GSK3A Gene

Compound Action Cas Number
Indirubin-3'-oxime GSK-3beta inhibitor. Also inhibits other protein kinases 160807-49-8
MeBIO Inactive analog of BIO (Cat. No. 3194) 667463-95-8
SB 216763 Potent, selective GSK-3 inhibitor 280744-09-4

(24) ApexBio Compounds for GSK3A Gene

Compound Action Cas Number
1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 676596-65-9
A 1070722 1384424-80-9
AR-A014418 GSK3β inhibitor, ATP-competitive and selective 487021-52-3
AZD1080 GSK3βinhibitor 612487-72-6
AZD2858 GSK-3 inhibitor,potent and selective 486424-20-8
Bikinin GSK3 inhibitor and Brassinosteroid activator 188011-69-0
BIO-acetoxime 667463-85-6
CHIR 99021 trihydrochloride
CHIR-124 Chk1 inhibitor,novel and potent 405168-58-3
CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive 252935-94-7
CHIR-99021 (CT99021) GSK-3 inhibitor, Cell-permeable, ATP-competitive 252917-06-9
CHIR-99021 (CT99021) HCl GSK-3α/β inhibitor 252917-06-9
GSK-3 Inhibitor IX (BIO) 667463-62-9
IM-12 1129669-05-1
Indirubin 479-41-4
Indirubin-3'-oxime 160807-49-8
LY2090314 Potent GSK-3 inhibitor 603288-22-8
SB 216763 GSK-3 inhibitor,ATP-competitive,potent and selective 280744-09-4
SB 415286 GSK-3 inhibitor,potent and selective 264218-23-7
TC-G 24 1257256-44-2
TCS 183
TCS 184 1315378-71-2
Tideglusib 865854-05-3
TWS119 GSK-3β inhibitor 601514-19-6
genes like me logo Genes that share compounds with GSK3A: view

Drug Products

Transcripts for GSK3A Gene

mRNA/cDNA for GSK3A Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSK3A

Alternative Splicing Database (ASD) splice patterns (SP) for GSK3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2:
SP3:

Relevant External Links for GSK3A Gene

GeneLoc Exon Structure for
GSK3A

Expression for GSK3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSK3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSK3A Gene

This gene is overexpressed in Lung (12.1), Fetal Brain (7.1), and Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSK3A Gene



Protein tissue co-expression partners for GSK3A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSK3A

SOURCE GeneReport for Unigene cluster for GSK3A Gene:

Hs.466828

Evidence on tissue expression from TISSUES for GSK3A Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Pancreas(4.4)
  • Eye(4.3)
  • Muscle(3.4)
  • Intestine(3.1)
  • Kidney(2.8)
  • Heart(2.6)
  • Skin(2.5)
  • Lung(2.4)
  • Blood(2.4)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GSK3A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSK3A Gene

Orthologs for GSK3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSK3A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSK3A 30 31
  • 99.59 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia GSK3A 30 31
  • 93.52 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia GSK3A 30
  • 93.22 (n)
-- 31
  • 93 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Gsk3a 30
  • 91.52 (n)
Mouse
(Mus musculus)
Mammalia Gsk3a 30 17 31
  • 89.53 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 83 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gsk3a 30
  • 75.37 (n)
Zebrafish
(Danio rerio)
Actinopterygii gsk3ab 31
  • 79 (a)
ManyToMany
gsk3aa 30 31
  • 76.75 (n)
ManyToMany
gsk3a 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1135 30
Fruit Fly
(Drosophila melanogaster)
Insecta gskt 31 32
  • 47 (a)
ManyToMany
Pk34A 31 32
  • 36 (a)
ManyToMany
CG6800 32
  • 35 (a)
sgg 31 32
  • 25 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea Y18D10A.5 32
  • 76 (a)
gsk-3 31
  • 69 (a)
OneToMany
C44H4.6 32
  • 44 (a)
R03D7.5 32
  • 37 (a)
F21F3.2 32
  • 32 (a)
Y106G6D.4 32
  • 31 (a)
C36B1.10 32
  • 30 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR253W 30
  • 61.92 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM11 30 31
  • 58.76 (n)
ManyToMany
MRK1 31
  • 37 (a)
ManyToMany
MCK1 33
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17006g 30
  • 54.53 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ATSK12 30
  • 62.75 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3400 30
Rice
(Oryza sativa)
Liliopsida Os01g0252100 30
  • 63.82 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.3019 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 75 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU04185 30
  • 67.57 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gsk3 30
  • 55.28 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5080 30
Species where no ortholog for GSK3A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GSK3A Gene

ENSEMBL:
Gene Tree for GSK3A (if available)
TreeFam:
Gene Tree for GSK3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSK3A: view image

Paralogs for GSK3A Gene

Paralogs for GSK3A Gene

(32) SIMAP similar genes for GSK3A Gene using alignment to 2 proteins:

  • GSK3A_HUMAN
  • A8MT37_HUMAN
genes like me logo Genes that share paralogs with GSK3A: view

Variants for GSK3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSK3A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
720784 Benign: not provided 42,232,623(-) G/A SYNONYMOUS_VARIANT
rs1131690798 Uncertain Significance: Primary dilated cardiomyopathy 42,242,320(-) C/G MISSENSE_VARIANT
rs35454502 - p.Leu461Phe
rs35978177 - p.Gln109Glu

Additional dbSNP identifiers (rs#s) for GSK3A Gene

Structural Variations from Database of Genomic Variants (DGV) for GSK3A Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV deletion 17116639
nsv1160627 CNV deletion 26073780
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv526186 CNV gain 19592680
nsv833833 CNV loss 17160897
nsv833834 CNV loss 17160897
nsv953583 CNV deletion 24416366

Variation tolerance for GSK3A Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSK3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSK3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSK3A Gene

Disorders for GSK3A Gene

MalaCards: The human disease database

(2) MalaCards diseases for GSK3A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GSK3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSK3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GSK3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSK3A Gene

Publications for GSK3A Gene

  1. Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes. (PMID: 9809441) Shaw PC … Anderton BH (Genome 1998) 2 3 23
  2. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3 4
  3. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. (PMID: 22539723) Lin SY … Lin SC (Science (New York, N.Y.) 2012) 3 4
  4. Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity. (PMID: 20113358) Benedetti F … Smeraldi E (Genes, brain, and behavior 2010) 3 41
  5. GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. (PMID: 19706605) Oh M … Kim K (The Journal of biological chemistry 2009) 3 4

Products for GSK3A Gene

  • Addgene plasmids for GSK3A