Aliases for GSG1L Gene
Aliases for GSG1L Gene
External Ids for GSG1L Gene
- HGNC: 28283
- Entrez Gene: 146395
- Ensembl: ENSG00000169181
- OMIM: 617161
- UniProtKB: Q6UXU4
Previous GeneCards Identifiers for GSG1L Gene
- GC16M027706
- GC16M025889
Summaries for GSG1L Gene
GeneCards Summary for GSG1L Gene
GSG1L (GSG1 Like) is a Protein Coding gene. An important paralog of this gene is GSG1.
UniProtKB/Swiss-Prot for GSG1L Gene
-
As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSG1L Gene
Genomics for GSG1L Gene
GeneHancer (GH) Regulatory Elements for GSG1L Gene
Promoters and enhancers for GSG1L Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I027888 | Promoter | 0.9 | EPDnew | 550.1 | +175.3 | 175322 | 0.1 | MAZ USF1 USF2 ZIC2 ZFHX2 GLIS2 ZNF512 GLIS1 EGR2 | GSG1L RNU6-159P RNU6-1241P GC16M027998 | |
| GH16I028063 | Promoter | 0.7 | EPDnew | 550.8 | 0.0 | -9 | 0.1 | MAZ ZBTB26 EZH2 | GSG1L GC16P028082 | |
| GH16I027312 | Promoter/Enhancer | 2.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 5 | +740.7 | 740736 | 19.6 | HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 | IL4R FLJ21408 NSMCE1 GTF3C1 IL21R KIAA0556 GSG1L ENSG00000259940 KDM8 ENSG00000274092 | |
| GH16I027577 | Enhancer | 1.1 | Ensembl ENCODE | 10.3 | +484.5 | 484476 | 2.1 | FOXA2 ZFP64 ARID4B ZNF48 FOS SP3 SP5 JUNB ZHX2 MXD4 | IL21R-AS1 GSG1L KIAA0556 ENSG00000261736 | |
| GH16I027625 | Enhancer | 1 | Ensembl ENCODE | 10.7 | +437.8 | 437830 | 2.4 | ELF3 FOXA2 FEZF1 ZSCAN9 RARA ETS1 ZNF335 RCOR1 MIXL1 CEBPB | IL21R-AS1 GSG1L ENSG00000261736 KIAA0556 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GSG1L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GSG1L Gene
Genomic Locations for GSG1L Gene
- chr16:27,787,529-28,063,509
- (GRCh38/hg38)
- Size:
- 275,981 bases
- Orientation:
- Minus strand
- chr16:27,798,850-28,074,830
- (GRCh37/hg19)
Genomic View for GSG1L Gene
Genes around GSG1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.1 by Ensembl
- 16p12.1 by Entrez Gene
- 16p12.1 by HGNC
GSG1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSG1L Gene
Proteins for GSG1L Gene
-
Protein details for GSG1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UXU4-GSG1L_HUMAN
- Recommended name:
- Germ cell-specific gene 1-like protein
- Protein Accession:
- Q6UXU4
- Q7Z6F8
- Q8TB81
Protein attributes for GSG1L Gene
- Size:
- 331 amino acids
- Molecular mass:
- 36774 Da
- Quaternary structure:
-
- Component of the inner core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).
Post-translational modifications for GSG1L Gene
Other Protein References for GSG1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Novus Biologicals Antibodies for GSG1L
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Protein Products
-
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- Search GeneTex for Proteins for GSG1L
Assay Products
No data available for DME Specific Peptides for GSG1L Gene
Domains & Families for GSG1L Gene
Gene Families for GSG1L Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for GSG1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UXU4- Family:
-
- Belongs to the GSG1 family.
Function for GSG1L Gene
Molecular function for GSG1L Gene
- UniProtKB/Swiss-Prot Function:
- As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.
Phenotypes From GWAS Catalog for GSG1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GSG1L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GSG1L gene
- Search ViGene Biosciences for GSG1L
CRISPR Products
-
OriGene CRISPR knockouts for GSG1L
- genomics-online: gRNA clones - Search results for available GSG1L gene related products
- Applied Biological Materials CRISPR for GSG1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSG1L
- GenScript: Design CRISPR guide RNA sequences for GSG1L
miRNA for GSG1L Gene
- miRTarBase miRNAs that target GSG1L
miRNA Products
- Search ViGene Biosciences for GSG1L
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GSG1L
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- genomics-online: shRNA clones - Search results for available GSG1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GSG1L gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GSG1L
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GSG1L gene related products
- orf clones - Search results for available GSG1L gene related products
- Applied Biological Materials Clones for GSG1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GSG1L
-
ViGene Biosciences adenoviral particle packaged cDNA for GSG1L gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSG1L Gene
Localization for GSG1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSG1L Gene
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSG1L Gene
Pathways & Interactions for GSG1L Gene
No Data Available
Interacting Proteins for GSG1L Gene
Selected Interacting proteins:
Q6UXU4-GSG1L_HUMAN
ENSP00000394954
for GSG1L Gene via
IID
STRING
UniProtKB
| Symbol | External ID(s) | Details |
|---|---|---|
| LXN |
No data available for Pathways by source and SIGNOR curated interactions for GSG1L Gene
Transcripts for GSG1L Gene
mRNA/cDNA for GSG1L Gene
- (6) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GSG1L Gene
- GSG1-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GSG1L
- genomics-online: gRNA clones - Search results for available GSG1L gene related products
- Applied Biological Materials CRISPR for GSG1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSG1L
- GenScript: Design CRISPR guide RNA sequences for GSG1L
miRNA Products
- Search ViGene Biosciences for GSG1L
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GSG1L
- Browse OriGene Inhibitory RNA Products For GSG1L
- genomics-online: shRNA clones - Search results for available GSG1L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GSG1L gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GSG1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSG1L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GSG1L gene related products
- orf clones - Search results for available GSG1L gene related products
- Applied Biological Materials Clones for GSG1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: |
Expression for GSG1L Gene
mRNA differential expression in normal tissues according to GTEx for GSG1L Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.0), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x6.1), and Heart - Atrial Appendage (x4.7).
NURSA nuclear receptor signaling pathways regulating expression of GSG1L Gene:
GSG1LSOURCE GeneReport for Unigene cluster for GSG1L Gene:
Hs.91910Evidence on tissue expression from TISSUES for GSG1L Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for GSG1L
-
OriGene qPCR primer pairs and template standards for GSG1L
- genomics-online: primer clones - Search results for available GSG1L gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSG1L Gene
Orthologs for GSG1L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GSG1L 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GSG1L 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GSG1L 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gsg1l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gsg1l 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GSG1L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GSG1L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GSG1L 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GSG1L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485075 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.26237 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gsg1l 33 34 |
|
||
| Dr.29187 33 |
|
- Species where no ortholog for GSG1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GSG1L Gene
(1) SIMAP similar genes for GSG1L Gene using alignment to 2 proteins:
Variants for GSG1L Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021486 | -- | 28,009,599(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000024395 | -- | 28,012,197(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000080708 | -- | 28,004,656(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000081209 | -- | 27,836,907(-) | A/G | intron_variant | |
| rs1000090547 | -- | 27,807,106(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.53;
29.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSG1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GSG1L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSG1L Gene
Disorders for GSG1L Gene
Additional Disease Information for GSG1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GSG1L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSG1L Gene
Publications for GSG1L Gene
- GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. (PMID: 26932439) Gu X … Lu W (Nature communications 2016) 2 3 58
- Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L. (PMID: 22813734) Shanks NF … Nakagawa T (Cell reports 2012) 2 3 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients. (PMID: 27010727) Yang HC … Liu YL (PLoS genetics 2016) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for GSG1L Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GSG1L
- VectorBuilder custom plasmid, inducible vectors for GSG1L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSG1L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available GSG1L related products ranked by validation data
- antibodies-online: Search results for available GSG1L related products ranked by validation data
- antibodies-online: Search results for available GSG1L related products ranked by validation data
- Search GeneTex for Antibodies for GSG1L
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- ViGene Biosciences adenoviral particle packaged cDNA for GSG1L gene
- ViGene Biosciences lentiviral particle packaged cDNA for GSG1L gene
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- genomics-online: cdna clones - Search results for available GSG1L gene related products
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- genomics-online: primer clones - Search results for available GSG1L gene related products
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Sources for GSG1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
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