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GSDMA (Gasdermin A) is a Protein Coding gene. Diseases associated with GSDMA include Inflammatory Bowel Disease 22 and Gastric Cancer. An important paralog of this gene is GSDMD.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001786 | phosphatidylserine binding | IBA | 21873635 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IBA | 21873635 |
GO:0070273 | phosphatidylinositol-4-phosphate binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0048471 | perinuclear region of cytoplasm | IEA,IDA | 17471240 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | IDA | 17471240 |
GO:0012501 | programmed cell death | IEA | -- |
GO:0042742 | defense response to bacterium | IBA | 21873635 |
GO:0070269 | pyroptosis | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GSDMA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GSDMA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GSDMA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gsdma 30 17 31 |
|
OneToMany | |
Gsdma2 31 |
|
OneToMany | |||
Gsdma3 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Gsdma 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GSDMA 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | GSDMA 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs58338887 | Benign: not specified | 39,970,658(+) | AACAC/A | INTRON_VARIANT | |
rs3894194 | - | p.Arg18Gln | |||
rs56030650 | - | p.Thr314Asn | |||
rs7212938 | - | p.Val128Leu | |||
rs7212944 | - | p.Glu130Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1007042 | CNV | gain | 20482838 |
esv3386093 | CNV | insertion | 20981092 |
esv3573064 | CNV | gain | 25503493 |
nsv1123130 | CNV | deletion | 24896259 |
nsv1146669 | OTHER | inversion | 26484159 |
Disorder | Aliases | PubMed IDs |
---|---|---|
inflammatory bowel disease 22 |
|
|
gastric cancer |
|