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Aliases for GRXCR2 Gene

Aliases for GRXCR2 Gene

  • Glutaredoxin And Cysteine Rich Domain Containing 2 2 3 5
  • Glutaredoxin Domain-Containing Cysteine-Rich Protein 1-Like Protein 3 4
  • Glutaredoxin, Cysteine Rich 2 2 3
  • GRXCR1-Like Protein 3 4
  • Glutaredoxin Domain-Containing Cysteine-Rich Protein 2 3
  • DFNB101 3

External Ids for GRXCR2 Gene

Previous GeneCards Identifiers for GRXCR2 Gene

  • GC05M145220
  • GC05M140386

Summaries for GRXCR2 Gene

Entrez Gene Summary for GRXCR2 Gene

  • This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. [provided by RefSeq, Jun 2014]

GeneCards Summary for GRXCR2 Gene

GRXCR2 (Glutaredoxin And Cysteine Rich Domain Containing 2) is a Protein Coding gene. Diseases associated with GRXCR2 include Deafness, Autosomal Recessive 101 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and heat shock protein binding. An important paralog of this gene is GRXCR1.

UniProtKB/Swiss-Prot for GRXCR2 Gene

  • Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.

Additional gene information for GRXCR2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRXCR2 Gene

Genomics for GRXCR2 Gene

GeneHancer (GH) Regulatory Elements for GRXCR2 Gene

Promoters and enhancers for GRXCR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I145833 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 +101.9 101870 3.8 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B PRELID2 GRXCR2 LARS TCERG1 GC05M145704
GH05I145851 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +82.8 82780 5.2 HDGF PKNOX1 FOXA2 ARNT POLR2B ZNF766 E2F8 ZNF143 FOS ZNF592 GRXCR2 SH3RF2 PRELID2 GC05P145887
GH05I145974 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -42.1 -42069 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 ZNF2 YY1 ZNF213 TCERG1 RBM27 SH3RF2 LARS GRXCR2 GC05P145976 LOC100431175
GH05I145682 Enhancer 1.2 Ensembl ENCODE 10.4 +255.4 255422 0.3 ATF1 FOXA2 MLX ARNT ARID4B FEZF1 ZNF2 ZNF213 ZNF143 ATF7 GRXCR2 GC05P145691 PIR44965 GC05P145639 PRELID2
GH05I145847 Enhancer 0.6 ENCODE 11.3 +88.9 88874 1.8 AFF1 PHF21A DPF2 FOSL1 NFIC JUND HMBOX1 KDM1A FOS SPI1 GRXCR2 SH3RF2 ASS1P10 PRELID2 GC05P145887
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRXCR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRXCR2 gene promoter:

Genomic Locations for GRXCR2 Gene

Genomic Locations for GRXCR2 Gene
78,790 bases
Minus strand

Genomic View for GRXCR2 Gene

Genes around GRXCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRXCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRXCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRXCR2 Gene

Proteins for GRXCR2 Gene

  • Protein details for GRXCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutaredoxin domain-containing cysteine-rich protein 2
    Protein Accession:

    Protein attributes for GRXCR2 Gene

    248 amino acids
    Molecular mass:
    28284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRXCR2 Gene

Post-translational modifications for GRXCR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRXCR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRXCR2 Gene

Domains & Families for GRXCR2 Gene

Gene Families for GRXCR2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for GRXCR2 Gene

Suggested Antigen Peptide Sequences for GRXCR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GRXCR1 family.
  • Belongs to the GRXCR1 family.
genes like me logo Genes that share domains with GRXCR2: view

Function for GRXCR2 Gene

Molecular function for GRXCR2 Gene

UniProtKB/Swiss-Prot Function:
Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.

Phenotypes for GRXCR2 Gene

genes like me logo Genes that share phenotypes with GRXCR2: view

Human Phenotype Ontology for GRXCR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GRXCR2 Gene

MGI Knock Outs for GRXCR2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for GRXCR2 Gene

Localization for GRXCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRXCR2 Gene

Cell projection, stereocilium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRXCR2 gene
Compartment Confidence
nucleus 3
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GRXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005902 microvillus IMP 24619944
GO:0032420 stereocilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GRXCR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRXCR2 Gene

Pathways & Interactions for GRXCR2 Gene

SuperPathways for GRXCR2 Gene

No Data Available

Interacting Proteins for GRXCR2 Gene

Gene Ontology (GO) - Biological Process for GRXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA,IMP 24619944
genes like me logo Genes that share ontologies with GRXCR2: view

No data available for Pathways by source and SIGNOR curated interactions for GRXCR2 Gene

Drugs & Compounds for GRXCR2 Gene

No Compound Related Data Available

Transcripts for GRXCR2 Gene

mRNA/cDNA for GRXCR2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRXCR2 Gene

Glutaredoxin, cysteine rich 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRXCR2 Gene

No ASD Table

Relevant External Links for GRXCR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRXCR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRXCR2 Gene

mRNA differential expression in normal tissues according to GTEx for GRXCR2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x21.7), Testis (x14.9), and Heart - Left Ventricle (x7.7).

Protein differential expression in normal tissues from HIPED for GRXCR2 Gene

This gene is overexpressed in Plasma (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRXCR2 Gene

Protein tissue co-expression partners for GRXCR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRXCR2 Gene:


SOURCE GeneReport for Unigene cluster for GRXCR2 Gene:


Phenotype-based relationships between genes and organs from Gene ORGANizer for GRXCR2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with GRXCR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for GRXCR2 Gene

Orthologs for GRXCR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRXCR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRXCR2 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia GRXCR2 33 34
  • 90.05 (n)
(Bos Taurus)
Mammalia GRXCR2 33 34
  • 89.7 (n)
(Rattus norvegicus)
Mammalia Grxcr2 33
  • 82.59 (n)
(Mus musculus)
Mammalia Grxcr2 33 16 34
  • 81.98 (n)
(Monodelphis domestica)
Mammalia GRXCR2 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia GRXCR2 34
  • 53 (a)
(Gallus gallus)
Aves GRXCR2 33 34
  • 59.36 (n)
(Anolis carolinensis)
Reptilia GRXCR2 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grxcr2 33
  • 60.77 (n)
(Danio rerio)
Actinopterygii LOC100535155 33
  • 59.1 (n)
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31559 34
  • 10 (a)
CG12206 34
  • 9 (a)
(Caenorhabditis elegans)
Secernentea Y46E12A.3 34
  • 16 (a)
Species where no ortholog for GRXCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRXCR2 Gene

Gene Tree for GRXCR2 (if available)
Gene Tree for GRXCR2 (if available)

Paralogs for GRXCR2 Gene

Paralogs for GRXCR2 Gene

genes like me logo Genes that share paralogs with GRXCR2: view

Variants for GRXCR2 Gene

Sequence variations from dbSNP and Humsavar for GRXCR2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs587777424 pathogenic, Deafness, autosomal recessive 101 145,859,766(-) A/AA coding_sequence_variant, frameshift
rs151087704 uncertain-significance, not provided 145,872,749(-) G/C coding_sequence_variant, intron_variant, missense_variant
rs559768717 uncertain-significance, not specified 145,866,496(-) C/A/T intron_variant
rs1000021931 -- 145,929,341(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000023388 -- 145,883,036(-) G/C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRXCR2 Gene

Variant ID Type Subtype PubMed ID
esv3570480 CNV loss 25503493

Variation tolerance for GRXCR2 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.52; 77.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRXCR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRXCR2 Gene

Disorders for GRXCR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRXCR2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 101
  • dfnb101
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
- elite association - COSMIC cancer census association via MalaCards


  • Deafness, autosomal recessive, 101 (DFNB101) [MIM:615837]: A form of non-syndromic deafness characterized by bilateral, moderate to severe hearing loss. Vestibular function is unaffected. {ECO:0000269 PubMed:24619944}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GRXCR2

genes like me logo Genes that share disorders with GRXCR2: view

No data available for Genatlas for GRXCR2 Gene

Publications for GRXCR2 Gene

  1. A frameshift mutation in GRXCR2 causes recessively inherited hearing loss. (PMID: 24619944) Imtiaz A … Naz S (Human mutation 2014) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for GRXCR2 Gene

Sources for GRXCR2 Gene

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