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This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene. An important paralog of this gene is WDR59.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IDA | 25990725 |
GO:0003688 | DNA replication origin binding | IDA | 25990725 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IEA,IPI | 17041588 |
GO:0042393 | histone binding | IDA | 25990725 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 25990725 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005694 | chromosome | IEA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006260 | DNA replication | IMP | 25990725 |
GO:0006334 | nucleosome assembly | IMP | 27552915 |
GO:0006337 | nucleosome disassembly | IMP | 27552915 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRWD1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GRWD1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRWD1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grwd1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Grwd1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | GRWD1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRWD1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grwd1 30 |
|
||
MGC76117 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | grwd-pending-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | grwd1 30 31 |
|
OneToOne | |
Dr.16542 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5026 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007125 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)09851 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y54H5A.1 30 |
|
||
Y54H5A.1 31 |
|
OneToOne | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR242C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F17237g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RRB1 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G19540 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os11g0134500 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09521 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC1711.07 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2566 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs147327994 | Uncertain Significance: Malignant tumor of prostate | 48,450,437(+) | G/A | MISSENSE_VARIANT | |
rs2302951 | - | p.Arg319Gln |
No disorders were found for GRWD1 Gene.