Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRWD1 Gene

Aliases for GRWD1 Gene

  • Glutamate Rich WD Repeat Containing 1 2 3 5
  • Glutamate-Rich WD Repeat-Containing Protein 1 3 4
  • WDR28 3 4
  • GRWD 3 4
  • Regulator Of Ribosome Biogenesis 1 Homolog 3
  • CUL4- And DDB1-Associated WDR Protein 4 3
  • Glutamate Rich WD Repeat Protein GRWD 3
  • WD Repeat Domain 28 3
  • KIAA1942 4
  • CDW4 3
  • RRB1 3

External Ids for GRWD1 Gene

Previous GeneCards Identifiers for GRWD1 Gene

  • GC19P053640
  • GC19P048949
  • GC19P045329

Summaries for GRWD1 Gene

Entrez Gene Summary for GRWD1 Gene

  • This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

GeneCards Summary for GRWD1 Gene

GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene. An important paralog of this gene is WDR59.

UniProtKB/Swiss-Prot for GRWD1 Gene

  • Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).

Gene Wiki entry for GRWD1 Gene

Additional gene information for GRWD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRWD1 Gene

Genomics for GRWD1 Gene

GeneHancer (GH) Regulatory Elements for GRWD1 Gene

Promoters and enhancers for GRWD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048444 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 632 -0.8 -772 4 ZFX CTCF ELF3 MNT SIX5 NKRF POLR2A GTF2F1 CSDE1 NFRKB GRWD1 BICRA SNRNP70 CYTH2 NOP53 KDELR1 RPL18 NOP53-AS1 ENSG00000268093 BAX
GH19J048958 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 47.2 +518.3 518256 10.2 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 SIX5 ZNF148 NKRF POLR2A FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PRR12 PTOV1-AS2 GRWD1 PIH1D1 IRF3
GH19J048871 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 54.2 +430.0 429979 8.2 MTA3 SP1 CC2D1A ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF POLR2A MLLT1 GC19M048876 PPP1R15A SNRNP70 PRR12 GRWD1 PTOV1-AS2 IRF3 SNORD35A SNORD35B PIH1D1
GH19J048644 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 53.8 +200.0 200028 3.2 SP1 CC2D1A CTCF SIX5 ZNF148 MLLT1 ZSCAN21 CDC5L BACH1 MCM2 CA11 GRWD1 SNORD35A NOP53-AS1 ALDH16A1 SNORD35B PRR12 NOP53 RPS11 SNRNP70
GH19J047712 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 52.3 -731.6 -731580 2.8 CTCF CC2D1A NCOA6 ZNF404 ZNF680 EGR1 ZNF560 GMEB1 POLR2A ARID2 EHD2 ZC3H4 BICRA NOP53-AS1 GRWD1 CYTH2 CCDC9 KDELR1 NOP53 ENSG00000268093
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRWD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRWD1 gene promoter:
  • AML1a
  • C/EBPalpha
  • Egr-2
  • Ik-3
  • RP58
  • SRY
  • STAT1
  • STAT1alpha
  • STAT5A
  • YY1

Genomic Locations for GRWD1 Gene

Genomic Locations for GRWD1 Gene
chr19:48,445,773-48,457,022
(GRCh38/hg38)
Size:
11,250 bases
Orientation:
Plus strand
chr19:48,949,030-48,960,279
(GRCh37/hg19)
Size:
11,250 bases
Orientation:
Plus strand

Genomic View for GRWD1 Gene

Genes around GRWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRWD1 Gene

Proteins for GRWD1 Gene

  • Protein details for GRWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ67-GRWD1_HUMAN
    Recommended name:
    Glutamate-rich WD repeat-containing protein 1
    Protein Accession:
    Q9BQ67
    Secondary Accessions:
    • A0MNN5
    • Q8TF59

    Protein attributes for GRWD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49419 Da
    Quaternary structure:
    • Interacts with METTL18 (PubMed:23349634). Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Binds to histone H2A-H2B and H3-H4 complexes (PubMed:25990725).

neXtProt entry for GRWD1 Gene

Post-translational modifications for GRWD1 Gene

  • Ubiquitination at posLast=297297, isoforms=333, posLast=172172, and posLast=237237
  • Modification sites at PhosphoSitePlus

Other Protein References for GRWD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRWD1 Gene

Domains & Families for GRWD1 Gene

Gene Families for GRWD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GRWD1 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate-rich WD repeat containing 1 (A0MNN5_HUMAN)
  • Glutamate-rich WD repeat-containing protein 1 (GRWD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRWD1: view

No data available for UniProtKB/Swiss-Prot for GRWD1 Gene

Function for GRWD1 Gene

Molecular function for GRWD1 Gene

UniProtKB/Swiss-Prot Function:
Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
UniProtKB/Swiss-Prot Induction:
Induced by E2F transcription factors (PubMed:14990995).

Phenotypes From GWAS Catalog for GRWD1 Gene

Gene Ontology (GO) - Molecular Function for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 25990725
GO:0003688 DNA replication origin binding IDA 25990725
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IEA,IPI 17041588
GO:0042393 histone binding IDA 25990725
genes like me logo Genes that share ontologies with GRWD1: view
genes like me logo Genes that share phenotypes with GRWD1: view

Animal Model Products

CRISPR Products

miRNA for GRWD1 Gene

miRTarBase miRNAs that target GRWD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRWD1

Clone Products

  • Applied Biological Materials (abm): Clones for GRWD1 - Now 50% OFF >
  • * GRWD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GRWD1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRWD1 Gene

Localization for GRWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRWD1 Gene

Nucleus, nucleolus. Nucleus. Chromosome. Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725). {ECO:0000269 PubMed:25990725}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRWD1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 0
mitochondrion 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25990725
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0032991 protein-containing complex IDA 23349634
genes like me logo Genes that share ontologies with GRWD1: view

Pathways & Interactions for GRWD1 Gene

PathCards logo

SuperPathways for GRWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 25990725
GO:0006334 nucleosome assembly IMP 27552915
GO:0006337 nucleosome disassembly IMP 27552915
genes like me logo Genes that share ontologies with GRWD1: view

No data available for Pathways by source and SIGNOR curated interactions for GRWD1 Gene

Drugs & Compounds for GRWD1 Gene

No Compound Related Data Available

Transcripts for GRWD1 Gene

mRNA/cDNA for GRWD1 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(265) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GRWD1 Gene

Glutamate-rich WD repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRWD1

Clone Products

  • Applied Biological Materials (abm): Clones for GRWD1 - Now 50% OFF >
  • * GRWD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GRWD1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GRWD1 Gene

No ASD Table

Relevant External Links for GRWD1 Gene

GeneLoc Exon Structure for
GRWD1
ECgene alternative splicing isoforms for
GRWD1

Expression for GRWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRWD1 Gene

Protein differential expression in normal tissues from HIPED for GRWD1 Gene

This gene is overexpressed in Pancreas (11.5), Peripheral blood mononuclear cells (10.4), and Lung (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRWD1 Gene



Protein tissue co-expression partners for GRWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRWD1 Gene:

GRWD1

SOURCE GeneReport for Unigene cluster for GRWD1 Gene:

Hs.400625

Evidence on tissue expression from TISSUES for GRWD1 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with GRWD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRWD1 Gene

Orthologs for GRWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRWD1 35 34
  • 99.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRWD1 35 34
  • 90.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRWD1 35 34
  • 88.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Grwd1 17 35 34
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Grwd1 34
  • 86.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRWD1 35
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRWD1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grwd1 34
  • 66.67 (n)
MGC76117 34
African clawed frog
(Xenopus laevis)
Amphibia grwd-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii grwd1 35 34
  • 64.93 (n)
OneToOne
Dr.16542 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5026 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007125 34
  • 59.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)09851 35 34
  • 56.75 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54H5A.1 34
  • 50.49 (n)
Y54H5A.1 35
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR242C 34
  • 49.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17237g 34
  • 46.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRB1 37 35 34
  • 44.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19540 34
  • 50.43 (n)
rice
(Oryza sativa)
Liliopsida Os11g0134500 34
  • 51.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
Cin.2566 34
bread mold
(Neurospora crassa)
Ascomycetes NCU09521 34
  • 52.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.07 34
  • 48.45 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2566 34
Species where no ortholog for GRWD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRWD1 Gene

ENSEMBL:
Gene Tree for GRWD1 (if available)
TreeFam:
Gene Tree for GRWD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRWD1: view image

Paralogs for GRWD1 Gene

Paralogs for GRWD1 Gene

(1) SIMAP similar genes for GRWD1 Gene using alignment to 4 proteins:

  • GRWD1_HUMAN
  • A0MNN5_HUMAN
  • L8EB83_HUMAN
  • M0QX71_HUMAN
genes like me logo Genes that share paralogs with GRWD1: view

Variants for GRWD1 Gene

Sequence variations from dbSNP and Humsavar for GRWD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs147327994 uncertain-significance, Malignant tumor of prostate 48,450,437(+) G/A/C coding_sequence_variant, missense_variant
rs1000278968 -- 48,449,874(+) G/A intron_variant
rs1000511465 -- 48,454,071(+) C/T downstream_transcript_variant
rs1000851469 -- 48,452,298(+) A/G intron_variant
rs1000915004 -- 48,451,744(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRWD1 Gene

Variant ID Type Subtype PubMed ID
nsv828572 CNV loss 20364138
nsv9739 CNV gain+loss 18304495

Variation tolerance for GRWD1 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRWD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRWD1 Gene

Disorders for GRWD1 Gene

Additional Disease Information for GRWD1

No disorders were found for GRWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRWD1 Gene

Publications for GRWD1 Gene

  1. Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. (PMID: 25990725) Sugimoto N … Fujita M (Nucleic acids research 2015) 3 4 58
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  3. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa LA … Zhang H (Nature cell biology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. (PMID: 15885502) Gratenstein K … Fletcher BS (Genomics 2005) 2 3 58

Products for GRWD1 Gene

Sources for GRWD1 Gene

Content
Loading form....