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Aliases for GRWD1 Gene

Aliases for GRWD1 Gene

  • Glutamate Rich WD Repeat Containing 1 2 3 5
  • WDR28 3 4
  • GRWD 3 4
  • Regulator Of Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2
  • Glutamate-Rich WD Repeat-Containing Protein 1 3
  • Regulator Of Ribosome Biogenesis 1 Homolog 3
  • CUL4- And DDB1-Associated WDR Protein 4 3
  • Glutamate Rich WD Repeat Protein GRWD 3
  • WD Repeat Domain 28 3
  • KIAA1942 4
  • CDW4 3
  • RRB1 3

External Ids for GRWD1 Gene

Previous GeneCards Identifiers for GRWD1 Gene

  • GC19P053640
  • GC19P048949
  • GC19P045329

Summaries for GRWD1 Gene

Entrez Gene Summary for GRWD1 Gene

  • This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

GeneCards Summary for GRWD1 Gene

GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GRWD1 Gene

  • Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).

Gene Wiki entry for GRWD1 Gene

Additional gene information for GRWD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRWD1 Gene

Genomics for GRWD1 Gene

GeneHancer (GH) Regulatory Elements for GRWD1 Gene

Promoters and enhancers for GRWD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I048444 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 582.2 +0.0 2 2.3 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 GRWD1 RPL18 KDELR1 NOP53 SNORD23 BAX BICRA SNRNP70 NOP53-AS1 ENSG00000268746
GH19I048871 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 54.2 +430.2 430242 8.8 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 GC19M048876 PPP1R15A PRR12 SNRNP70 IRF3 GRWD1 SNORD35A PTOV1-AS2 SNORD35B PIH1D1
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.9 +518.3 518256 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
GH19I048632 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 45.3 +190.7 190704 7.8 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 SEC1P DBP PRR12 SNRNP70 GRWD1 PIH1D1 ENSG00000268093 SNORD35A RPS11 NOP53-AS1
GH19I048644 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 53.8 +200.2 200157 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B POLR2B CA11 GRWD1 SNORD35A NOP53-AS1 ALDH16A1 SNORD35B PRR12 NOP53 RPS11 SNRNP70
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRWD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRWD1 gene promoter:

Genomic Locations for GRWD1 Gene

Genomic Locations for GRWD1 Gene
chr19:48,445,773-48,457,022
(GRCh38/hg38)
Size:
11,250 bases
Orientation:
Plus strand
chr19:48,949,030-48,960,279
(GRCh37/hg19)

Genomic View for GRWD1 Gene

Genes around GRWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRWD1 Gene

Proteins for GRWD1 Gene

  • Protein details for GRWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ67-GRWD1_HUMAN
    Recommended name:
    Glutamate-rich WD repeat-containing protein 1
    Protein Accession:
    Q9BQ67
    Secondary Accessions:
    • A0MNN5
    • Q8TF59

    Protein attributes for GRWD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49419 Da
    Quaternary structure:
    • Interacts with METTL18 (PubMed:23349634). Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Binds to histone H2A-H2B and H3-H4 complexes (PubMed:25990725).

neXtProt entry for GRWD1 Gene

Post-translational modifications for GRWD1 Gene

  • Ubiquitination at isoforms=172, isoforms=237, isoforms=297, and posLast=333333

Other Protein References for GRWD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRWD1 Gene

Domains & Families for GRWD1 Gene

Gene Families for GRWD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GRWD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRWD1: view

No data available for UniProtKB/Swiss-Prot for GRWD1 Gene

Function for GRWD1 Gene

Molecular function for GRWD1 Gene

UniProtKB/Swiss-Prot Function:
Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
UniProtKB/Swiss-Prot Induction:
Induced by E2F transcription factors (PubMed:14990995).

Phenotypes From GWAS Catalog for GRWD1 Gene

Gene Ontology (GO) - Molecular Function for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 25990725
GO:0003688 DNA replication origin binding IDA 25990725
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 17041588
GO:0042393 histone binding IDA 25990725
genes like me logo Genes that share ontologies with GRWD1: view
genes like me logo Genes that share phenotypes with GRWD1: view

Animal Model Products

CRISPR Products

miRNA for GRWD1 Gene

miRTarBase miRNAs that target GRWD1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRWD1 Gene

Localization for GRWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRWD1 Gene

Nucleus, nucleolus. Nucleus. Chromosome. Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725). {ECO:0000269 PubMed:25990725}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRWD1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25990725
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0043234 protein complex IDA 23349634
genes like me logo Genes that share ontologies with GRWD1: view

Pathways & Interactions for GRWD1 Gene

SuperPathways for GRWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 25990725
GO:0006334 nucleosome assembly IMP 27552915
GO:0006337 nucleosome disassembly IMP 27552915
genes like me logo Genes that share ontologies with GRWD1: view

No data available for Pathways by source and SIGNOR curated interactions for GRWD1 Gene

Drugs & Compounds for GRWD1 Gene

No Compound Related Data Available

Transcripts for GRWD1 Gene

mRNA/cDNA for GRWD1 Gene

Unigene Clusters for GRWD1 Gene

Glutamate-rich WD repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRWD1 Gene

No ASD Table

Relevant External Links for GRWD1 Gene

GeneLoc Exon Structure for
GRWD1
ECgene alternative splicing isoforms for
GRWD1

Expression for GRWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRWD1 Gene

Protein differential expression in normal tissues from HIPED for GRWD1 Gene

This gene is overexpressed in Pancreas (11.5), Peripheral blood mononuclear cells (10.4), and Lung (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRWD1 Gene



Protein tissue co-expression partners for GRWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRWD1 Gene:

GRWD1

SOURCE GeneReport for Unigene cluster for GRWD1 Gene:

Hs.400625

Evidence on tissue expression from TISSUES for GRWD1 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with GRWD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRWD1 Gene

Orthologs for GRWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRWD1 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia GRWD1 33 34
  • 90.88 (n)
dog
(Canis familiaris)
Mammalia GRWD1 33 34
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Grwd1 33 16 34
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Grwd1 33
  • 86.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRWD1 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRWD1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grwd1 33
  • 66.67 (n)
MGC76117 33
African clawed frog
(Xenopus laevis)
Amphibia grwd-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii grwd1 33 34
  • 64.93 (n)
Dr.16542 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5026 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007125 33
  • 59.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)09851 33 34
  • 56.75 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54H5A.1 33
  • 50.49 (n)
Y54H5A.1 34
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR242C 33
  • 49.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17237g 33
  • 46.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRB1 33 34 36
  • 44.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19540 33
  • 50.43 (n)
rice
(Oryza sativa)
Liliopsida Os11g0134500 33
  • 51.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09521 33
  • 52.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.07 33
  • 48.45 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2566 33
Species where no ortholog for GRWD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRWD1 Gene

ENSEMBL:
Gene Tree for GRWD1 (if available)
TreeFam:
Gene Tree for GRWD1 (if available)

Paralogs for GRWD1 Gene

(1) SIMAP similar genes for GRWD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GRWD1: view

No data available for Paralogs for GRWD1 Gene

Variants for GRWD1 Gene

Sequence variations from dbSNP and Humsavar for GRWD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs147327994 uncertain-significance, Malignant tumor of prostate 48,450,437(+) G/A coding_sequence_variant, missense_variant
rs1000278968 -- 48,449,874(+) G/A intron_variant
rs1000511465 -- 48,454,071(+) C/T downstream_transcript_variant
rs1000851469 -- 48,452,298(+) A/G intron_variant
rs1000915004 -- 48,451,744(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRWD1 Gene

Variant ID Type Subtype PubMed ID
nsv828572 CNV loss 20364138
nsv9739 CNV gain+loss 18304495

Variation tolerance for GRWD1 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRWD1 Gene

Disorders for GRWD1 Gene

Additional Disease Information for GRWD1

No disorders were found for GRWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRWD1 Gene

Publications for GRWD1 Gene

  1. Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. (PMID: 25990725) Sugimoto N … Fujita M (Nucleic acids research 2015) 3 4 58
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa LA … Zhang H (Nature cell biology 2006) 3 4 58
  5. The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. (PMID: 15885502) Gratenstein K … Fletcher BS (Genomics 2005) 2 3 58

Products for GRWD1 Gene

Sources for GRWD1 Gene

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