Aliases for GRTP1 Gene

Aliases for GRTP1 Gene

  • Growth Hormone Regulated TBC Protein 1 2 3 5
  • Growth Hormone-Regulated TBC Protein 1 3 4
  • TBC1 Domain Family Member 6 3 4
  • TBC1D6 3 4

External Ids for GRTP1 Gene

Previous GeneCards Identifiers for GRTP1 Gene

  • GC13M108615
  • GC13M113065
  • GC13M111926
  • GC13M111927
  • GC13M113027
  • GC13M113978
  • GC13M094417

Summaries for GRTP1 Gene

GeneCards Summary for GRTP1 Gene

GRTP1 (Growth Hormone Regulated TBC Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D2.

UniProtKB/Swiss-Prot Summary for GRTP1 Gene

Additional gene information for GRTP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRTP1 Gene

Genomics for GRTP1 Gene

GeneHancer (GH) Regulatory Elements for GRTP1 Gene

Promoters and enhancers for GRTP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J113362 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 546.7 +0.3 333 2.8 HNRNPK ZNF217 POLR2G ZFX ZBTB5 ZBTB26 CHD1 CTBP1 HINFP ZEB1 GRTP1 RF00017-1494 lnc-ADPRHL1-6 UPF3A GRTP1-AS1
GH13J113489 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 13.4 -128.2 -128230 8.4 HNRNPK EP300 ZSCAN5C NRF1 TCF12 POLR2G SP1 PHF8 JUND SIX5 TMCO3 ADPRHL1 DCUN1D2 GRTP1 DCUN1D2-AS GRTP1-AS1 F7 F10 PROZ ENSG00000276916
GH13J113393 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 16.4 -29.8 -29784 1.5 CTCF MYC POLR2G ZNF639 ZBTB11 ZBTB26 REST RAD21 ZBTB7A POLR2A HSALNG0099589 PCID2 CDC16 GRTP1 TUBGCP3 GRTP1-AS1 CUL4A DCUN1D2-AS DCUN1D2 RASA3
GH13J113182 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 +177.9 177907 6.5 EP300 ZNF217 ZSCAN5C TCF12 SP1 NCOR1 JUND FOS ZNF639 ZIC2 PROZ CUL4A PCID2 ENSG00000230371 F10-AS1 F10 GRTP1 F7 LAMP1 ENSG00000269356
GH13J113272 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.3 +90.0 90010 3.5 CTCF FOS CUX1 RAD21 SKI NR2F2 BCL11A ZNF316 SMC3 FOSL1 lnc-GRTP1-5 LAMP1 PROZ CUL4A GRTP1 PCID2 DCUN1D2-AS DCUN1D2 lnc-CUL4A-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRTP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRTP1

Top Transcription factor binding sites by QIAGEN in the GRTP1 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • CUTL1
  • GATA-1
  • RSRFC4
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for GRTP1 Gene

Genomic Locations for GRTP1 Gene
39,986 bases
Minus strand
39,959 bases
Minus strand

Genomic View for GRTP1 Gene

Genes around GRTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRTP1 Gene

Proteins for GRTP1 Gene

  • Protein details for GRTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth hormone-regulated TBC protein 1
    Protein Accession:
    Secondary Accessions:
    • B9A6K2
    • Q2M232
    • Q5TC64
    • Q66K26
    • Q6P659
    • Q8N528
    • Q9H695

    Protein attributes for GRTP1 Gene

    336 amino acids
    Molecular mass:
    38554 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH80640.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12124.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12126.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GRTP1 Gene


neXtProt entry for GRTP1 Gene

Post-translational modifications for GRTP1 Gene

  • Ubiquitination at Lys124 and Lys323
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRTP1 Gene

Domains & Families for GRTP1 Gene

Gene Families for GRTP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRTP1 Gene

  • Somatotropin hormone
  • RabGAP/TBC domain

Suggested Antigen Peptide Sequences for GRTP1 Gene

GenScript: Design optimal peptide antigens:
  • TBC1 domain family member 6 (GRTP1_HUMAN)
genes like me logo Genes that share domains with GRTP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GRTP1 Gene

Function for GRTP1 Gene

Molecular function for GRTP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Phenotypes From GWAS Catalog for GRTP1 Gene

Gene Ontology (GO) - Molecular Function for GRTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA 21873635
GO:0017137 Rab GTPase binding IBA 21873635
genes like me logo Genes that share ontologies with GRTP1: view
genes like me logo Genes that share phenotypes with GRTP1: view

Animal Models for GRTP1 Gene

MGI Knock Outs for GRTP1:
  • Grtp1 Grtp1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for GRTP1 Gene

miRTarBase miRNAs that target GRTP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRTP1 Gene

Localization for GRTP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRTP1 gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for GRTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with GRTP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GRTP1 Gene

Pathways & Interactions for GRTP1 Gene

PathCards logo

SuperPathways for GRTP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0090630 activation of GTPase activity IBA 21873635
genes like me logo Genes that share ontologies with GRTP1: view

No data available for Pathways by source and SIGNOR curated interactions for GRTP1 Gene

Drugs & Compounds for GRTP1 Gene

No Compound Related Data Available

Transcripts for GRTP1 Gene

mRNA/cDNA for GRTP1 Gene

14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRTP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -

Relevant External Links for GRTP1 Gene

GeneLoc Exon Structure for

Expression for GRTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRTP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRTP1 Gene

This gene is overexpressed in Liver (x7.6).

Protein differential expression in normal tissues from HIPED for GRTP1 Gene

This gene is overexpressed in Kidney (47.8) and Fetal Liver (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRTP1 Gene

Protein tissue co-expression partners for GRTP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRTP1

SOURCE GeneReport for Unigene cluster for GRTP1 Gene:


Evidence on tissue expression from TISSUES for GRTP1 Gene

  • Kidney(4.4)
  • Pancreas(4.4)
  • Nervous system(4.3)
  • Lung(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with GRTP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRTP1 Gene

Orthologs for GRTP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRTP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRTP1 31 30
  • 98.51 (n)
(Rattus norvegicus)
Mammalia Grtp1 30
  • 80.85 (n)
(Mus musculus)
Mammalia Grtp1 17 31 30
  • 80.65 (n)
(Canis familiaris)
Mammalia GRTP1 31 30
  • 80.56 (n)
(Bos Taurus)
Mammalia GRTP1 31 30
  • 79.68 (n)
(Monodelphis domestica)
Mammalia GRTP1 31
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia GRTP1 31
  • 65 (a)
(Gallus gallus)
Aves GRTP1 31 30
  • 74.85 (n)
(Anolis carolinensis)
Reptilia GRTP1 31
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grtp1 30
  • 66.26 (n)
Str.11042 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15222 30
(Danio rerio)
Actinopterygii grtp1b 31 30
  • 62.05 (n)
grtp1a 31
  • 57 (a)
wufd05h02 30
fruit fly
(Drosophila melanogaster)
Insecta CG5916 31 30
  • 52.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003798 30
  • 52.17 (n)
(Caenorhabditis elegans)
Secernentea tbc-6 31 30
  • 43.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL201W 30
  • 52.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSB3 31 30
  • 48.33 (n)
MSB4 33 31
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07491g 30
  • 44.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
Species where no ortholog for GRTP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRTP1 Gene

Gene Tree for GRTP1 (if available)
Gene Tree for GRTP1 (if available)
Evolutionary constrained regions (ECRs) for GRTP1: view image

Paralogs for GRTP1 Gene

Variants for GRTP1 Gene

Additional dbSNP identifiers (rs#s) for GRTP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRTP1 Gene

Variant ID Type Subtype PubMed ID
dgv1131e59 CNV duplication 20981092
dgv252e201 CNV deletion 23290073
dgv253e201 CNV deletion 23290073
esv1046944 CNV deletion 17803354
esv1182261 CNV insertion 17803354
esv1364343 CNV deletion 17803354
esv1434678 CNV insertion 17803354
esv1571231 CNV insertion 17803354
esv1739341 CNV deletion 17803354
esv2005167 CNV deletion 18987734
esv26486 CNV loss 19812545
esv2669348 CNV deletion 23128226
esv2743415 CNV deletion 23290073
esv2748274 CNV deletion 23290073
esv2748276 CNV deletion 23290073
esv2748277 CNV deletion 23290073
esv2748278 CNV deletion 23290073
esv2748279 CNV deletion 23290073
esv2748280 CNV deletion 23290073
esv2748287 CNV deletion 23290073
esv28919 CNV gain 19812545
esv29598 CNV gain+loss 19812545
esv3551146 CNV deletion 23714750
esv3633598 CNV loss 21293372
esv3892447 CNV gain 25118596
esv4257 CNV loss 18987735
esv988844 CNV insertion 20482838
nsv1048814 CNV gain 25217958
nsv1070203 CNV deletion 25765185
nsv1110699 CNV insertion 24896259
nsv1115717 CNV deletion 24896259
nsv1121501 CNV deletion 24896259
nsv1138277 CNV deletion 24896259
nsv1143603 CNV deletion 24896259
nsv1143740 CNV deletion 24896259
nsv1145699 CNV deletion 24896259
nsv509521 CNV insertion 20534489
nsv512342 CNV loss 21212237
nsv563316 CNV loss 21841781
nsv563317 CNV loss 21841781
nsv563318 CNV loss 21841781
nsv563319 CNV loss 21841781
nsv563320 CNV loss 21841781
nsv64974 CNV insertion 16902084
nsv951927 CNV deletion 24416366

Variation tolerance for GRTP1 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRTP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRTP1 Gene

Disorders for GRTP1 Gene

Additional Disease Information for GRTP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GRTP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRTP1 Gene

Publications for GRTP1 Gene

  1. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 41 54
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 54
  3. Grtp1, a novel gene regulated by growth hormone. (PMID: 11564724) Lu C … Menon RK (Endocrinology 2001) 2 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for GRTP1 Gene

Sources for GRTP1 Gene