Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GRSF1 (G-Rich RNA Sequence Binding Factor 1) is a Protein Coding gene. Among its related pathways are Influenza Viral RNA Transcription and Replication and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,IDA | 29967381 |
GO:0003729 | mRNA binding | TAS | 8036161 |
GO:0005515 | protein binding | IPI | 24338975 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IBA | 21873635 |
GO:0005737 | cytoplasm | TAS | 8036161 |
GO:0005739 | mitochondrion | IDA | 29967381 |
GO:0005759 | mitochondrial matrix | IEA | -- |
GO:0035770 | ribonucleoprotein granule | IDA | 25683715 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Influenza Viral RNA Transcription and Replication | ||
2 | HIV Life Cycle |
.45
|
|
3 | Viral mRNA Translation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000962 | positive regulation of mitochondrial RNA catabolic process | IDA | 29967381 |
GO:0006378 | mRNA polyadenylation | TAS | 8036161 |
GO:0006396 | RNA processing | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0008033 | tRNA processing | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grsf1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Grsf1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GRSF1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GRSF1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GRSF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRSF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grsf1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | grsf1 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6946 32 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
720187 | Benign: not provided | 70,825,438(-) | GACAA/G | INTRON_VARIANT | |
723364 | Benign: not provided | 70,826,183(-) | G/A | SYNONYMOUS_VARIANT | |
rs17854012 | - | p.Asp277Tyr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3600940 | CNV | loss | 21293372 |
nsv1012495 | CNV | gain | 25217958 |
nsv4381 | CNV | insertion | 18451855 |
nsv594651 | CNV | loss | 21841781 |
nsv829966 | CNV | loss | 17160897 |
No disorders were found for GRSF1 Gene.