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Aliases for GRSF1 Gene

Aliases for GRSF1 Gene

  • G-Rich RNA Sequence Binding Factor 1 2 3 5
  • GRSF-1 3 4
  • G-Rich Sequence Factor 1 3

External Ids for GRSF1 Gene

Previous GeneCards Identifiers for GRSF1 Gene

  • GC04M071642
  • GC04M071925
  • GC04M072085
  • GC04M072151
  • GC04M072050
  • GC04M071681
  • GC04M067485

Summaries for GRSF1 Gene

Entrez Gene Summary for GRSF1 Gene

  • The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRSF1 Gene

GRSF1 (G-Rich RNA Sequence Binding Factor 1) is a Protein Coding gene. Among its related pathways are Influenza Viral RNA Transcription and Replication and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.

UniProtKB/Swiss-Prot for GRSF1 Gene

  • Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.

Additional gene information for GRSF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRSF1 Gene

Genomics for GRSF1 Gene

GeneHancer (GH) Regulatory Elements for GRSF1 Gene

Promoters and enhancers for GRSF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I070836 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +4.5 4540 3.8 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 GC04P070840 GRSF1 UTP3 JCHAIN RUFY3 DCK PIR34937
GH04I070837 Promoter 0.7 EPDnew 550.4 +7.0 6962 0.1 ATF7 PRDM10 SPI1 GRSF1 UTP3 JCHAIN GC04P070840 PIR34937
GH04I070844 Enhancer 0.5 ENCODE 550.8 -1.1 -1095 0.1 SMARCA5 NR2F1 IKZF1 RUNX3 GRSF1 ENSG00000283313
GH04I070901 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.9 -59.8 -59759 3 HNRNPUL1 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 MOB1B DCK GRSF1 UTP3 JCHAIN
GH04I070969 Enhancer 0.8 ENCODE dbSUPER 11.5 -127.6 -127646 2.2 SOX5 SOX13 GATAD2A TFE3 FOXA2 FOXA3 HMG20A THRB SMAD4 HNF4A DCK RUFY3 GRSF1 JCHAIN UTP3 MOB1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRSF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRSF1 gene promoter:

Genomic Locations for GRSF1 Gene

Genomic Locations for GRSF1 Gene
chr4:70,815,782-70,843,274
(GRCh38/hg38)
Size:
27,493 bases
Orientation:
Minus strand
chr4:71,681,499-71,705,662
(GRCh37/hg19)

Genomic View for GRSF1 Gene

Genes around GRSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRSF1 Gene

Proteins for GRSF1 Gene

  • Protein details for GRSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12849-GRSF1_HUMAN
    Recommended name:
    G-rich sequence factor 1
    Protein Accession:
    Q12849
    Secondary Accessions:
    • B3KPW0
    • Q4W5S5
    • Q6ZST3
    • Q8IWD6
    • Q8NBD2

    Protein attributes for GRSF1 Gene

    Size:
    480 amino acids
    Molecular mass:
    53126 Da
    Quaternary structure:
    • Monomer. Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5 (PubMed:25683715). Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1.
    Miscellaneous:
    • Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.
    SequenceCaution:
    • Sequence=AAC95399.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAH40485.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAY40942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAC86863.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=EAX05634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRSF1 Gene

    Alternative splice isoforms for GRSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRSF1 Gene

Post-translational modifications for GRSF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRSF1 Gene

Domains & Families for GRSF1 Gene

Gene Families for GRSF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRSF1: view

No data available for UniProtKB/Swiss-Prot for GRSF1 Gene

Function for GRSF1 Gene

Molecular function for GRSF1 Gene

GENATLAS Biochemistry:
G-rich RNA sequence binding factor 1
UniProtKB/Swiss-Prot Function:
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.

Gene Ontology (GO) - Molecular Function for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003729 mRNA binding TAS 8036161
genes like me logo Genes that share ontologies with GRSF1: view
genes like me logo Genes that share phenotypes with GRSF1: view

miRNA for GRSF1 Gene

miRTarBase miRNAs that target GRSF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRSF1 Gene

Localization for GRSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRSF1 Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRSF1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8036161
GO:0005739 mitochondrion IDA --
GO:0035770 ribonucleoprotein granule IDA 25683715
GO:0042645 mitochondrial nucleoid IEA,IDA 25683715
genes like me logo Genes that share ontologies with GRSF1: view

Pathways & Interactions for GRSF1 Gene

genes like me logo Genes that share pathways with GRSF1: view

Gene Ontology (GO) - Biological Process for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation TAS 8036161
GO:0006396 RNA processing IEA --
GO:0006397 mRNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with GRSF1: view

No data available for SIGNOR curated interactions for GRSF1 Gene

Drugs & Compounds for GRSF1 Gene

No Compound Related Data Available

Transcripts for GRSF1 Gene

Unigene Clusters for GRSF1 Gene

G-rich RNA sequence binding factor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRSF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for GRSF1 Gene

GeneLoc Exon Structure for
GRSF1
ECgene alternative splicing isoforms for
GRSF1

Expression for GRSF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRSF1 Gene

This gene is overexpressed in Bone marrow stromal cell (7.9) and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRSF1 Gene



Protein tissue co-expression partners for GRSF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRSF1 Gene:

GRSF1

SOURCE GeneReport for Unigene cluster for GRSF1 Gene:

Hs.309763

Evidence on tissue expression from TISSUES for GRSF1 Gene

  • Nervous system(4.5)
  • Lung(3.1)
  • Eye(2.8)
  • Pancreas(2.5)
  • Kidney(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with GRSF1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRSF1 Gene

Orthologs for GRSF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRSF1 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia GRSF1 33 34
  • 92.24 (n)
cow
(Bos Taurus)
Mammalia GRSF1 33 34
  • 90.76 (n)
mouse
(Mus musculus)
Mammalia Grsf1 33 16 34
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Grsf1 33
  • 86.08 (n)
oppossum
(Monodelphis domestica)
Mammalia GRSF1 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRSF1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRSF1 33 34
  • 62.12 (n)
lizard
(Anolis carolinensis)
Reptilia GRSF1 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grsf1 33
  • 62.4 (n)
zebrafish
(Danio rerio)
Actinopterygii grsf1 33 34
  • 56.67 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG6946 35
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for GRSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRSF1 Gene

ENSEMBL:
Gene Tree for GRSF1 (if available)
TreeFam:
Gene Tree for GRSF1 (if available)

Paralogs for GRSF1 Gene

Paralogs for GRSF1 Gene

(6) SIMAP similar genes for GRSF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRSF1: view

Variants for GRSF1 Gene

Sequence variations from dbSNP and Humsavar for GRSF1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000102523 -- 70,831,292(-) T/C intron_variant
rs1000193248 -- 70,826,618(-) T/G intron_variant
rs1000200954 -- 70,818,804(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000225733 -- 70,826,878(-) T/C intron_variant
rs10002655 -- 70,824,762(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRSF1 Gene

Variant ID Type Subtype PubMed ID
esv3600940 CNV loss 21293372
nsv1012495 CNV gain 25217958
nsv4381 CNV insertion 18451855
nsv594651 CNV loss 21841781
nsv829966 CNV loss 17160897

Variation tolerance for GRSF1 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRSF1 Gene

Human Gene Mutation Database (HGMD)
GRSF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRSF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRSF1 Gene

Disorders for GRSF1 Gene

Additional Disease Information for GRSF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GRSF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRSF1 Gene

Publications for GRSF1 Gene

  1. GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. (PMID: 8036161) Qian Z … Wilusz J (Nucleic acids research 1994) 2 3 4 22 58
  2. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. (PMID: 25683715) Antonicka H … Shoubridge EA (Cell reports 2015) 3 4 58
  3. The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. (PMID: 23473033) Antonicka H … Shoubridge EA (Cell metabolism 2013) 3 4 58
  4. GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain AA … Martinou JC (Cell metabolism 2013) 3 4 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for GRSF1 Gene

Sources for GRSF1 Gene

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