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The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...
Aliases for GRSF1 Gene
Aliases for GRSF1 Gene
External Ids for GRSF1 Gene
- HGNC: 4610
- Entrez Gene: 2926
- Ensembl: ENSG00000132463
- OMIM: 604851
- UniProtKB: Q12849
Previous GeneCards Identifiers for GRSF1 Gene
- GC04M071642
- GC04M071925
- GC04M072085
- GC04M072151
- GC04M072050
- GC04M071681
- GC04M067485
Summaries for GRSF1 Gene
-
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRSF1 Gene
GRSF1 (G-Rich RNA Sequence Binding Factor 1) is a Protein Coding gene. Among its related pathways are Influenza Viral RNA Transcription and Replication and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
UniProtKB/Swiss-Prot Summary for GRSF1 Gene
-
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381).
Additional gene information for GRSF1 Gene
- HGNC(4610)
- Entrez Gene(2926)
- Ensembl(ENSG00000132463)
- OMIM(604851)
- UniProtKB(Q12849)
- Open Targets Platform(ENSG00000132463)
- Search for GRSF1 at DataMed
- Search for GRSF1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRSF1 Gene
Genomics for GRSF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GRSF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRSF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRSF1
- Top Transcription factor binding sites by QIAGEN in the GRSF1 gene promoter:
-
- AML1a
- Arnt
- CP2
- Pax-4a
- XBP-1
Genomic Locations for GRSF1 Gene
Genomic Locations for GRSF1 Gene
- chr4:70,815,783-70,843,274
- (GRCh38/hg38)
- Size:
- 27,492 bases
- Orientation:
- Minus strand
- chr4:71,681,499-71,705,662
- (GRCh37/hg19)
- Size:
- 24,164 bases
- Orientation:
- Minus strand
Genomic View for GRSF1 Gene
Genes around GRSF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by HGNC
- 4q13.3 by Entrez Gene
- 4q13.3 by Ensembl
GRSF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRSF1 Gene
Proteins for GRSF1 Gene
-
Protein details for GRSF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12849-GRSF1_HUMAN
- Recommended name:
- G-rich sequence factor 1
- Protein Accession:
- Q12849
- B3KPW0
- Q4W5S5
- Q6ZST3
- Q8IWD6
- Q8NBD2
Protein attributes for GRSF1 Gene
- Size:
- 480 amino acids
- Molecular mass:
- 53126 Da
- Quaternary structure:
-
- Monomer. Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5 (PubMed:25683715). Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1 (PubMed:23473034). Interacts with the 2 components of the mitochondrial degradosome complex, PNPT1 and SUPV3L1, in an RNA-dependent manner (PubMed:29967381).
- SequenceCaution:
-
- Sequence=AAC95399.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAH40485.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAY40942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAC86863.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=EAX05634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
- Miscellaneous:
-
- Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.
Protein Expression for GRSF1 Gene
Post-translational modifications for GRSF1 Gene
Other Protein References for GRSF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-GRSF1 (aa 87-184) polyclonal antibody
- Novus Biologicals Antibodies for GRSF1
-
Abcam antibodies for GRSF1
- Invitrogen Antibodies for GRSF1 (AFLGC-GRSF1)
-
Biorbyt antibodies for GRSF1
Protein Products
-
OriGene Purified Proteins for GRSF1
- Search Origene for MassSpec and Protein Over-expression Lysates for GRSF1
- Origene Custom Protein Services for GRSF1
- Novus Biologicals proteins for GRSF1
- antibodies-online: Show 3 available GRSF1 Proteins ranked by validation data
- Compare Top GRSF1 Proteins
-
Quality Products:
-
Abcam proteins for GRSF1
Assay Products
- antibodies-online: Show 4 available GRSF1 Elisa Kits ranked by validation data
- Compare Top GRSF1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for GRSF1 Gene
Domains & Families for GRSF1 Gene
Gene Families for GRSF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GRSF1 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for GRSF1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ30937 fis, clone FEBRA2007247, highly similar to G-rich sequence factor 1 (B3KP14_HUMAN)
- cDNA FLJ39736 fis, clone SMINT2016313, highly similar to G-rich sequence factor 1 (B3KPW0_HUMAN)
- G-rich sequence factor 1 (GRSF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q12849- Domain:
-
- The RRM domains mediate RNA-binding.
Function for GRSF1 Gene
Molecular function for GRSF1 Gene
- UniProtKB/Swiss-Prot Function:
- Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381).
- GENATLAS Biochemistry:
- G-rich RNA sequence binding factor 1
Phenotypes From GWAS Catalog for GRSF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IDA | 29967381 |
| GO:0003729 | mRNA binding | TAS | 8036161 |
| GO:0005515 | protein binding | IPI | 24338975 |
Phenotypes for GRSF1 Gene
- MGI mutant phenotypes for GRSF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRSF1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability
- Decreased NF-kappaB reporter expression
- Increased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
Animal Models for GRSF1 Gene
- MGI Knock Outs for GRSF1:
-
- Grsf1 Grsf1<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRSF1 - Select products 50% OFF >
- * GRSF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRSF1
miRNA for GRSF1 Gene
- miRTarBase miRNAs that target GRSF1
-
- hsa-miR-124-3p (MIRT022179)
- hsa-miR-331-3p (MIRT043404)
- hsa-miR-93-5p (MIRT048744)
- hsa-miR-6758-5p (MIRT476038)
- hsa-miR-7151-3p (MIRT476039)
- hsa-miR-5095 (MIRT476040)
- hsa-miR-6780b-5p (MIRT476041)
- hsa-miR-4271 (MIRT476042)
- hsa-miR-4725-3p (MIRT476043)
- hsa-miR-5196-5p (MIRT476044)
- hsa-miR-4747-5p (MIRT476045)
- hsa-miR-4533 (MIRT476046)
- hsa-miR-6837-3p (MIRT476047)
- hsa-miR-6754-3p (MIRT476048)
- hsa-miR-4459 (MIRT476049)
- hsa-miR-412-3p (MIRT476050)
- hsa-miR-6504-3p (MIRT476051)
- hsa-miR-6783-5p (MIRT476052)
- hsa-miR-4779 (MIRT476053)
- hsa-miR-4700-3p (MIRT476054)
- hsa-miR-4428 (MIRT476055)
- hsa-miR-1273e (MIRT657558)
- hsa-miR-6771-5p (MIRT657559)
- hsa-miR-623 (MIRT657560)
- hsa-miR-7977 (MIRT657561)
- hsa-miR-7160-5p (MIRT657562)
- hsa-miR-6884-5p (MIRT657563)
- hsa-miR-4722-5p (MIRT657564)
- hsa-miR-485-5p (MIRT657565)
- hsa-miR-1827 (MIRT657566)
- hsa-miR-4649-3p (MIRT657567)
- hsa-miR-4685-3p (MIRT657568)
- hsa-miR-4287 (MIRT657569)
- hsa-miR-6746-5p (MIRT657570)
- hsa-miR-6780b-3p (MIRT657571)
- hsa-miR-4780 (MIRT657572)
- hsa-miR-665 (MIRT657573)
- hsa-miR-4768-3p (MIRT657574)
- hsa-miR-5690 (MIRT657575)
- hsa-miR-4478 (MIRT657576)
- hsa-miR-4419b (MIRT657577)
- hsa-miR-3929 (MIRT657578)
- hsa-miR-940 (MIRT657579)
- hsa-miR-6808-5p (MIRT657580)
- hsa-miR-6893-5p (MIRT657581)
- hsa-miR-19b-3p (MIRT727524)
- hsa-miR-19a-3p (MIRT727525)
- hsa-miR-101-3p (MIRT734588)
- hsa-miR-106a-3p (MIRT761102)
- hsa-miR-122-5p (MIRT761330)
- hsa-miR-1267 (MIRT761755)
- hsa-miR-1272 (MIRT761781)
- hsa-miR-1304-3p (MIRT762414)
- hsa-miR-130a-3p (MIRT762483)
- hsa-miR-130b-3p (MIRT762501)
- hsa-miR-301a-3p (MIRT764407)
- hsa-miR-301b-3p (MIRT764425)
- hsa-miR-3135b (MIRT764928)
- hsa-miR-3190-5p (MIRT765366)
- hsa-miR-3650 (MIRT766253)
- hsa-miR-3652 (MIRT766286)
- hsa-miR-3664-5p (MIRT766505)
- hsa-miR-3666 (MIRT766545)
- hsa-miR-367-5p (MIRT766710)
- hsa-miR-3926 (MIRT767710)
- hsa-miR-4295 (MIRT768459)
- hsa-miR-4423-5p (MIRT768862)
- hsa-miR-4430 (MIRT768921)
- hsa-miR-454-3p (MIRT770241)
- hsa-miR-4639-3p (MIRT770543)
- hsa-miR-4684-5p (MIRT770996)
- hsa-miR-504-3p (MIRT773050)
- hsa-miR-548c-3p (MIRT774311)
- hsa-miR-548s (MIRT774501)
- hsa-miR-6501-5p (MIRT776527)
- hsa-miR-6771-3p (MIRT778622)
- hsa-miR-6794-3p (MIRT779331)
- hsa-miR-6849-3p (MIRT780288)
- hsa-miR-744-3p (MIRT781717)
- hsa-miR-8057 (MIRT782326)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRSF1
- Browse OriGene Inhibitory RNA Products For GRSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRSF1
Clone Products
- Applied Biological Materials (abm): Clones for GRSF1 - Select products 50% OFF >
- * GRSF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG216357
- MG218866
- MR216357
- MR216357L3
- MR216357L4
- MR218866
- MR218866L3
- MR218866L4
- RC216762
- RC216762L1
- RC216762L2
- RC216762L3
- RC216762L4
- RC216987
- RC216987L3
- RC216987L4
- RG216762
- RG216987
- RR216759
- MR216357L3V
- MR216357L4V
- MR218866L3V
- MR218866L4V
- RC216762L1V
- RC216762L2V
- RC216762L3V
- RC216762L4V
- RC216987L3V
- RC216987L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRSF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRSF1 Gene
Localization for GRSF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRSF1 Gene
- [Isoform 1]: Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:23473033, ECO:0000269 PubMed:23473034, ECO:0000269 PubMed:25683715}.
- [Isoform 2]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 2 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IBA | 21873635 |
| GO:0005737 | cytoplasm | TAS | 8036161 |
| GO:0005739 | mitochondrion | IDA | 29967381 |
| GO:0005759 | mitochondrial matrix | IEA | -- |
| GO:0035770 | ribonucleoprotein granule | IDA | 25683715 |
Pathways & Interactions for GRSF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Influenza Viral RNA Transcription and Replication | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | Viral mRNA Translation | ||
Pathways by source for GRSF1 Gene
6 Reactome pathways for GRSF1 Gene
Interacting Proteins for GRSF1 Gene
Selected Interacting proteins:
Q12849-GRSF1_HUMAN
ENSP00000254799
for GRSF1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GRSF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000962 | positive regulation of mitochondrial RNA catabolic process | IDA | 29967381 |
| GO:0006378 | mRNA polyadenylation | TAS | 8036161 |
| GO:0006396 | RNA processing | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008033 | tRNA processing | IEA | -- |
Transcripts for GRSF1 Gene
mRNA/cDNA for GRSF1 Gene
- 2 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000254799 6610 nts (view in UCSC)
- ENST00000499044 2491 nts (view in UCSC)
- ENST00000502323 1794 nts (view in UCSC)
- ENST00000505068 3561 nts (view in UCSC)
- ENST00000506453 925 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRSF1 - Select products 50% OFF >
- * GRSF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRSF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRSF1
- Browse OriGene Inhibitory RNA Products For GRSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRSF1
Clone Products
- Applied Biological Materials (abm): Clones for GRSF1 - Select products 50% OFF >
- * GRSF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG216357
- MG218866
- MR216357
- MR216357L3
- MR216357L4
- MR218866
- MR218866L3
- MR218866L4
- RC216762
- RC216762L1
- RC216762L2
- RC216762L3
- RC216762L4
- RC216987
- RC216987L3
- RC216987L4
- RG216762
- RG216987
- RR216759
- MR216357L3V
- MR216357L4V
- MR218866L3V
- MR218866L4V
- RC216762L1V
- RC216762L2V
- RC216762L3V
- RC216762L4V
- RC216987L3V
- RC216987L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRSF1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for GRSF1 Gene
- GeneLoc Exon Structure for
- GRSF1
Expression for GRSF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Colon (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Bone marrow stromal cell (7.9) and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRSF1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRSF1
SOURCE GeneReport for Unigene cluster for GRSF1 Gene:
Hs.309763Evidence on tissue expression from TISSUES for GRSF1 Gene
- Nervous system(4.9)
- Intestine(4.5)
- Lung(3.4)
- Kidney(3)
- Eye(2.8)
- Pancreas(2.5)
- Skin(2.4)
- Muscle(2.3)
- Heart(2.3)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for GRSF1
-
OriGene qPCR primer pairs and template standards for GRSF1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRSF1 Gene
Orthologs for GRSF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GRSF1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Grsf1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Grsf1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GRSF1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GRSF1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GRSF1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GRSF1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grsf1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | grsf1 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6946 32 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GRSF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GRSF1 Gene
- ENSEMBL:
- Gene Tree for GRSF1 (if available)
- TreeFam:
- Gene Tree for GRSF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRSF1: view image
Paralogs for GRSF1 Gene
(6) SIMAP similar genes for GRSF1 Gene using alignment to 5 proteins:
- GRSF1_HUMAN
- F5H5I6_HUMAN
- H0Y8R1_HUMAN
- H0YAK1_HUMAN
- H0YAM1_HUMAN
Variants for GRSF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRSF1 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 720187 | Benign: not provided | 70,825,438(-) | GACAA/G | INTRON_VARIANT | |
| 723364 | Benign: not provided | 70,826,183(-) | G/A | SYNONYMOUS_VARIANT | |
| rs17854012 | - | p.Asp277Tyr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3600940 | CNV | loss | 21293372 |
| nsv1012495 | CNV | gain | 25217958 |
| nsv4381 | CNV | insertion | 18451855 |
| nsv594651 | CNV | loss | 21841781 |
| nsv829966 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRSF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRSF1 Gene
Disorders for GRSF1 Gene
Additional Disease Information for GRSF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for GRSF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRSF1 Gene
Publications for GRSF1 Gene
- GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. (PMID: 8036161) Qian Z … Wilusz J (Nucleic acids research 1994) 2 3 4 23
- Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria. (PMID: 29967381) Pietras Z … Szczesny RJ (Nature communications 2018) 3 4
- Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. (PMID: 25683715) Antonicka H … Shoubridge EA (Cell reports 2015) 3 4
- The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. (PMID: 23473033) Antonicka H … Shoubridge EA (Cell metabolism 2013) 3 4
- GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain AA … Martinou JC (Cell metabolism 2013) 3 4
ExternalLinks
Products for GRSF1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- OriGene CRISPR knockouts for GRSF1
- MG216357
- MG218866
- MR216357
- MR216357L3
- MR216357L4
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- MR218866L3
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- RC216762
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- RC216762L4
- RC216987
- RC216987L3
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- RG216762
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- RR216759
- MR216357L3V
- MR216357L4V
- MR218866L3V
- MR218866L4V
- RC216762L1V
- RC216762L2V
- RC216762L3V
- RC216762L4V
- RC216987L3V
- RC216987L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for GRSF1
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins for GRSF1
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- Invitrogen Antibodies for GRSF1 (AFLGC-GRSF1)
- VectorBuilder Custom and pre-made DNA vectors for GRSF1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GRSF1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GRSF1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GRSF1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GRSF1
- antibodies-online: Show 12 available GRSF1 Antibodies ranked by validation data
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- antibodies-online: Show 3 available GRSF1 Proteins ranked by validation data
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- Quality Products:
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for GRSF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GRSF1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRSF1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GRSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRSF1
- Biorbyt antibodies for GRSF1
Sources for GRSF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB