Aliases for GRSF1 Gene
Aliases for GRSF1 Gene
External Ids for GRSF1 Gene
- HGNC: 4610
- Entrez Gene: 2926
- Ensembl: ENSG00000132463
- OMIM: 604851
- UniProtKB: Q12849
Previous GeneCards Identifiers for GRSF1 Gene
- GC04M071642
- GC04M071925
- GC04M072085
- GC04M072151
- GC04M072050
- GC04M071681
- GC04M067485
Summaries for GRSF1 Gene
-
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRSF1 Gene
GRSF1 (G-Rich RNA Sequence Binding Factor 1) is a Protein Coding gene. Among its related pathways are Influenza Viral RNA Transcription and Replication and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is HNRNPH1.
UniProtKB/Swiss-Prot for GRSF1 Gene
-
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRSF1 Gene
Genomics for GRSF1 Gene
GeneHancer (GH) Regulatory Elements for GRSF1 Gene
Promoters and enhancers for GRSF1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04I070836 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 550.8 | +4.5 | 4540 | 3.8 | HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 | GC04P070840 GRSF1 UTP3 JCHAIN RUFY3 DCK PIR34937 | |
| GH04I070837 | Promoter | 0.7 | EPDnew | 550.4 | +7.0 | 6962 | 0.1 | ATF7 PRDM10 SPI1 | GRSF1 UTP3 JCHAIN GC04P070840 PIR34937 | |
| GH04I070844 | Enhancer | 0.5 | ENCODE | 550.8 | -1.1 | -1095 | 0.1 | SMARCA5 NR2F1 IKZF1 RUNX3 | GRSF1 ENSG00000283313 | |
| GH04I070901 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE | 11.9 | -59.8 | -59759 | 3 | HNRNPUL1 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 | MOB1B DCK GRSF1 UTP3 JCHAIN | |
| GH04I070969 | Enhancer | 0.8 | ENCODE dbSUPER | 11.5 | -127.6 | -127646 | 2.2 | SOX5 SOX13 GATAD2A TFE3 FOXA2 FOXA3 HMG20A THRB SMAD4 HNF4A | DCK RUFY3 GRSF1 JCHAIN UTP3 MOB1B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GRSF1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GRSF1 Gene
Genomic Locations for GRSF1 Gene
- chr4:70,815,782-70,843,274
- (GRCh38/hg38)
- Size:
- 27,493 bases
- Orientation:
- Minus strand
- chr4:71,681,499-71,705,662
- (GRCh37/hg19)
Genomic View for GRSF1 Gene
Genes around GRSF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
GRSF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRSF1 Gene
Proteins for GRSF1 Gene
-
Protein details for GRSF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12849-GRSF1_HUMAN
- Recommended name:
- G-rich sequence factor 1
- Protein Accession:
- Q12849
- B3KPW0
- Q4W5S5
- Q6ZST3
- Q8IWD6
- Q8NBD2
Protein attributes for GRSF1 Gene
- Size:
- 480 amino acids
- Molecular mass:
- 53126 Da
- Quaternary structure:
-
- Monomer. Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5 (PubMed:25683715). Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1.
- Miscellaneous:
-
- Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.
- SequenceCaution:
-
- Sequence=AAC95399.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAH40485.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAY40942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAC86863.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=EAX05634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for GRSF1 Gene
Post-translational modifications for GRSF1 Gene
Other Protein References for GRSF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GRSF1
-
Abcam antibodies for GRSF1
- Invitrogen Antibodies for GRSF1
- GeneTex GRSF1 antibody for GRSF1
Protein Products
-
OriGene Purified Proteins for GRSF1
- Search Origene for MassSpec and Protein Over-expression Lysates for GRSF1
- Origene Custom Protein Services for GRSF1
- Novus Biologicals proteins for GRSF1
- antibodies-online: Search results for 3 available GRSF1 Proteins ranked by validation data
- Compare Top GRSF1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for GRSF1
-
Abcam proteins for GRSF1
Assay Products
- antibodies-online: Search results for 2 available GRSF1 Elisa Kits ranked by validation data
- Compare Top GRSF1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for GRSF1 Gene
Domains & Families for GRSF1 Gene
Gene Families for GRSF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GRSF1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRSF1 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GRSF1 Gene
Function for GRSF1 Gene
Molecular function for GRSF1 Gene
- GENATLAS Biochemistry:
- G-rich RNA sequence binding factor 1
- UniProtKB/Swiss-Prot Function:
- Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0003729 | mRNA binding | TAS | 8036161 |
Phenotypes for GRSF1 Gene
- GenomeRNAi human phenotypes for GRSF1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased ionizing radiation sensitivity
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRSF1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GRSF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRSF1 gene
- Search ViGene Biosciences for GRSF1
CRISPR Products
-
OriGene CRISPR knockouts for GRSF1
- genomics-online: gRNA clones - Search results for 95 available GRSF1 gene related products
- Overview of 95 available GRSF1 gene related products
- Applied Biological Materials CRISPR for GRSF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRSF1
- GenScript: Design CRISPR guide RNA sequences for GRSF1
miRNA for GRSF1 Gene
- miRTarBase miRNAs that target GRSF1
-
- hsa-mir-124-3p (MIRT022179)
- hsa-mir-331-3p (MIRT043404)
- hsa-mir-93-5p (MIRT048744)
- hsa-mir-6758-5p (MIRT476038)
- hsa-mir-7151-3p (MIRT476039)
- hsa-mir-5095 (MIRT476040)
- hsa-mir-6780b-5p (MIRT476041)
- hsa-mir-4271 (MIRT476042)
- hsa-mir-4725-3p (MIRT476043)
- hsa-mir-5196-5p (MIRT476044)
- hsa-mir-4747-5p (MIRT476045)
- hsa-mir-4533 (MIRT476046)
- hsa-mir-6837-3p (MIRT476047)
- hsa-mir-6754-3p (MIRT476048)
- hsa-mir-4459 (MIRT476049)
- hsa-mir-412-3p (MIRT476050)
- hsa-mir-6504-3p (MIRT476051)
- hsa-mir-6783-5p (MIRT476052)
- hsa-mir-4779 (MIRT476053)
- hsa-mir-4700-3p (MIRT476054)
- hsa-mir-4428 (MIRT476055)
- hsa-mir-1273e (MIRT657558)
- hsa-mir-6771-5p (MIRT657559)
- hsa-mir-623 (MIRT657560)
- hsa-mir-7977 (MIRT657561)
- hsa-mir-7160-5p (MIRT657562)
- hsa-mir-6884-5p (MIRT657563)
- hsa-mir-4722-5p (MIRT657564)
- hsa-mir-485-5p (MIRT657565)
- hsa-mir-1827 (MIRT657566)
- hsa-mir-4649-3p (MIRT657567)
- hsa-mir-4685-3p (MIRT657568)
- hsa-mir-4287 (MIRT657569)
- hsa-mir-6746-5p (MIRT657570)
- hsa-mir-6780b-3p (MIRT657571)
- hsa-mir-4780 (MIRT657572)
- hsa-mir-665 (MIRT657573)
- hsa-mir-4768-3p (MIRT657574)
- hsa-mir-5690 (MIRT657575)
- hsa-mir-4478 (MIRT657576)
- hsa-mir-4419b (MIRT657577)
- hsa-mir-3929 (MIRT657578)
- hsa-mir-940 (MIRT657579)
- hsa-mir-6808-5p (MIRT657580)
- hsa-mir-6893-5p (MIRT657581)
- hsa-mir-19b-3p (MIRT727524)
- hsa-mir-19a-3p (MIRT727525)
- hsa-mir-101-3p (MIRT734588)
- hsa-mir-106a-3p (MIRT761102)
- hsa-mir-122-5p (MIRT761330)
- hsa-mir-1267 (MIRT761755)
- hsa-mir-1272 (MIRT761781)
- hsa-mir-1304-3p (MIRT762414)
- hsa-mir-130a-3p (MIRT762483)
- hsa-mir-130b-3p (MIRT762501)
- hsa-mir-301a-3p (MIRT764407)
- hsa-mir-301b-3p (MIRT764425)
- hsa-mir-3135b (MIRT764928)
- hsa-mir-3190-5p (MIRT765366)
- hsa-mir-3650 (MIRT766253)
- hsa-mir-3652 (MIRT766286)
- hsa-mir-3664-5p (MIRT766505)
- hsa-mir-3666 (MIRT766545)
- hsa-mir-367-5p (MIRT766710)
- hsa-mir-3926 (MIRT767710)
- hsa-mir-4295 (MIRT768459)
- hsa-mir-4423-5p (MIRT768862)
- hsa-mir-4430 (MIRT768921)
- hsa-mir-454-3p (MIRT770241)
- hsa-mir-4639-3p (MIRT770543)
- hsa-mir-4684-5p (MIRT770996)
- hsa-mir-504-3p (MIRT773050)
- hsa-mir-548c-3p (MIRT774311)
- hsa-mir-548s (MIRT774501)
- hsa-mir-6501-5p (MIRT776527)
- hsa-mir-6771-3p (MIRT778622)
- hsa-mir-6794-3p (MIRT779331)
- hsa-mir-6849-3p (MIRT780288)
- hsa-mir-744-3p (MIRT781717)
- hsa-mir-8057 (MIRT782326)
miRNA Products
- Search ViGene Biosciences for GRSF1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GRSF1
- Browse OriGene Inhibitory RNA Products For GRSF1
- genomics-online: shRNA clones - Search results for 95 available GRSF1 gene related products
- Overview of 95 available GRSF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRSF1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GRSF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRSF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GRSF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GRSF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GRSF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRSF1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRSF1 Gene
Localization for GRSF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRSF1 Gene
- Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 2 |
| nucleus | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 8036161 |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0035770 | ribonucleoprotein granule | IDA | 25683715 |
| GO:0042645 | mitochondrial nucleoid | IEA,IDA | 25683715 |
Pathways & Interactions for GRSF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Influenza Viral RNA Transcription and Replication | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | Viral mRNA Translation | ||
Pathways by source for GRSF1 Gene
6 Reactome pathways for GRSF1 Gene
Interacting Proteins for GRSF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006378 | mRNA polyadenylation | TAS | 8036161 |
| GO:0006396 | RNA processing | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008033 | tRNA processing | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for SIGNOR curated interactions for GRSF1 Gene
Transcripts for GRSF1 Gene
mRNA/cDNA for GRSF1 Gene
- (4) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (420) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRSF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GRSF1
- genomics-online: gRNA clones - Search results for 95 available GRSF1 gene related products
- Overview of 95 available GRSF1 gene related products
- Applied Biological Materials CRISPR for GRSF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRSF1
- GenScript: Design CRISPR guide RNA sequences for GRSF1
miRNA Products
- Search ViGene Biosciences for GRSF1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GRSF1
- Browse OriGene Inhibitory RNA Products For GRSF1
- genomics-online: shRNA clones - Search results for 95 available GRSF1 gene related products
- Overview of 95 available GRSF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRSF1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GRSF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRSF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GRSF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for GRSF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Stomach (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
-
Thyroid (Endocrine System)
-
Colon (Gastrointestinal Tract)
This gene is overexpressed in Bone marrow stromal cell (7.9) and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRSF1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRSF1 Gene:
GRSF1SOURCE GeneReport for Unigene cluster for GRSF1 Gene:
Hs.309763Evidence on tissue expression from TISSUES for GRSF1 Gene
- Nervous system(4.5)
- Lung(3.1)
- Eye(2.8)
- Pancreas(2.5)
- Kidney(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for GRSF1
-
OriGene qPCR primer pairs and template standards for GRSF1
- genomics-online: primer clones - Search results for 95 available GRSF1 gene related products
- Overview of 95 available GRSF1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRSF1 Gene
Orthologs for GRSF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRSF1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GRSF1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GRSF1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Grsf1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grsf1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRSF1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRSF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRSF1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GRSF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grsf1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grsf1 33 34 |
|
||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6946 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GRSF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GRSF1 Gene
(6) SIMAP similar genes for GRSF1 Gene using alignment to 5 proteins:
Variants for GRSF1 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000102523 | -- | 70,831,292(-) | T/C | intron_variant | |
| rs1000193248 | -- | 70,826,618(-) | T/G | intron_variant | |
| rs1000200954 | -- | 70,818,804(-) | C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000225733 | -- | 70,826,878(-) | T/C | intron_variant | |
| rs10002655 | -- | 70,824,762(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3600940 | CNV | loss | 21293372 |
| nsv1012495 | CNV | gain | 25217958 |
| nsv4381 | CNV | insertion | 18451855 |
| nsv594651 | CNV | loss | 21841781 |
| nsv829966 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRSF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRSF1 Gene
Disorders for GRSF1 Gene
Additional Disease Information for GRSF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GRSF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRSF1 Gene
Publications for GRSF1 Gene
- GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. (PMID: 8036161) Qian Z … Wilusz J (Nucleic acids research 1994) 2 3 4 22 58
- Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. (PMID: 25683715) Antonicka H … Shoubridge EA (Cell reports 2015) 3 4 58
- The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. (PMID: 23473033) Antonicka H … Shoubridge EA (Cell metabolism 2013) 3 4 58
- GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain AA … Martinou JC (Cell metabolism 2013) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
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- Mammalian expression: PiggyBac
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Sources for GRSF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (150) Human Protein Atlas
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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- (158) Applied Biosystems