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Aliases for GRPR Gene

Aliases for GRPR Gene

  • Gastrin Releasing Peptide Receptor 2 3 5
  • GRP-Preferring Bombesin Receptor 3 4
  • Bombesin Receptor 2 2 3
  • GRP-R 3 4
  • Gastrin-Releasing Peptide Receptor 3
  • BB2R 3
  • BB2 3

External Ids for GRPR Gene

Previous GeneCards Identifiers for GRPR Gene

  • GC0XP015862
  • GC0XP014967
  • GC0XP015343
  • GC0XP015503
  • GC0XP015901
  • GC0XP016051
  • GC0XP013896

Summaries for GRPR Gene

Entrez Gene Summary for GRPR Gene

  • Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRPR Gene

GRPR (Gastrin Releasing Peptide Receptor) is a Protein Coding gene. Diseases associated with GRPR include Agoraphobia and Autism. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is NMBR.

UniProtKB/Swiss-Prot for GRPR Gene

  • Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).

Tocris Summary for GRPR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for GRPR Gene

Additional gene information for GRPR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPR Gene

Genomics for GRPR Gene

GeneHancer (GH) Regulatory Elements for GRPR Gene

Promoters and enhancers for GRPR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ015853 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.1 -268.1 -268085 4 HDGF PKNOX1 SIN3A FEZF1 YY1 POLR2B E2F8 ZNF143 ZNF207 SP3 AP1S2 GRPR ZRSR2 CA5B RNU5F-7P GC0XM015916 GC0XP015773
GH0XJ016122 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 +0.2 165 1 CTCF ATF1 TRIM22 SIN3A REST RAD21 RFX5 NFYB ZNF143 SMC3 GRPR MAGEB17
GH0XJ016123 Promoter 0.5 EPDnew 650.7 -1.0 -1029 0.1 GRPR PIR40959
GH0XJ016124 Enhancer 0.2 ENCODE 650.7 +1.3 1265 0.7 GRPR MAGEB17
GH0XJ016185 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.9 +63.2 63213 2.8 MEIS2 ATF1 PKNOX1 USF1 TEAD4 JUN BATF FOSL1 ZNF316 POLR2A GRPR ZRSR2 RPL6P30 LOC102724124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRPR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRPR gene promoter:
  • Nkx2-5
  • Lmo2
  • c-Myb
  • E47
  • CUTL1
  • AML1a
  • Sox5
  • HNF-3beta
  • STAT5A

Genomic Locations for GRPR Gene

Genomic Locations for GRPR Gene
chrX:16,123,301-16,153,518
(GRCh38/hg38)
Size:
30,218 bases
Orientation:
Plus strand
chrX:16,141,424-16,171,641
(GRCh37/hg19)
Size:
30,218 bases
Orientation:
Plus strand

Genomic View for GRPR Gene

Genes around GRPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPR Gene

Proteins for GRPR Gene

  • Protein details for GRPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30550-GRPR_HUMAN
    Recommended name:
    Gastrin-releasing peptide receptor
    Protein Accession:
    P30550
    Secondary Accessions:
    • B2R910

    Protein attributes for GRPR Gene

    Size:
    384 amino acids
    Molecular mass:
    43199 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRPR Gene

Post-translational modifications for GRPR Gene

  • Glycosylation at Asn20
  • Modification sites at PhosphoSitePlus

Other Protein References for GRPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPR Gene

Domains & Families for GRPR Gene

Gene Families for GRPR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GRPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30550

UniProtKB/Swiss-Prot:

GRPR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GRPR: view

Function for GRPR Gene

Molecular function for GRPR Gene

UniProtKB/Swiss-Prot Function:
Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).
GENATLAS Biochemistry:
gastrin releasing peptide receptor

Gene Ontology (GO) - Molecular Function for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008188 neuropeptide receptor activity IEA,ISS --
GO:0008528 G-protein coupled peptide receptor activity IDA,TAS 1655761
GO:0042923 neuropeptide binding IEA --
genes like me logo Genes that share ontologies with GRPR: view
genes like me logo Genes that share phenotypes with GRPR: view

Animal Models for GRPR Gene

MGI Knock Outs for GRPR:

miRNA for GRPR Gene

miRTarBase miRNAs that target GRPR

Clone Products

  • Addgene plasmids for GRPR
  • R&D Systems cDNA Clones for GRPR (Gastrin-releasing Peptide R/GRPR)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRPR Gene

Localization for GRPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRPR gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRPR: view

Pathways & Interactions for GRPR Gene

genes like me logo Genes that share pathways with GRPR: view

SIGNOR curated interactions for GRPR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS,IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with GRPR: view

Drugs & Compounds for GRPR Gene

(41) Drugs for GRPR Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Bombesin Investigational Pharma Full agonist, Agonist Involved in gastrointestinal tract function 9
ranatensin Pharma Full agonist, Agonist 0
BIM 187 Pharma Bombesin/GRP receptor agonist 0
(D-Ala<sup>11</sup>]bombesin Pharma Full agonist, Agonist 0

(19) Additional Compounds for GRPR Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[(3-Ph-Pr<sup>6</sup>), His<sup>7</sup>,D-Ala<sup>11</sup>,D-Pro<sup>13</sup>,psi13-14),Phe<sup>14</sup>]bombesin-(6-14)
Antagonist
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
[D-Phe<sup>6</sup>,Cpa<sup>14</sup>,psi13-14]bombesin-(6-14)
Antagonist
[Leu<sup>14</sup>, psi 13-14)]bombesin
Antagonist
10-OBn-7alpha-F-gingkolide B
Full agonist, Agonist

(5) Tocris Compounds for GRPR Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
genes like me logo Genes that share compounds with GRPR: view

Transcripts for GRPR Gene

mRNA/cDNA for GRPR Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRPR Gene

Gastrin-releasing peptide receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRPR
  • R&D Systems cDNA Clones for GRPR (Gastrin-releasing Peptide R/GRPR)

Alternative Splicing Database (ASD) splice patterns (SP) for GRPR Gene

No ASD Table

Relevant External Links for GRPR Gene

GeneLoc Exon Structure for
GRPR
ECgene alternative splicing isoforms for
GRPR

Expression for GRPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRPR Gene

This gene is overexpressed in Pancreas (x18.2), Esophagus - Gastroesophageal Junction (x7.9), and Esophagus - Muscularis (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of GRPR Gene:

GRPR

SOURCE GeneReport for Unigene cluster for GRPR Gene:

Hs.567282

mRNA Expression by UniProt/SwissProt for GRPR Gene:

P30550-GRPR_HUMAN
Tissue specificity: Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.

Evidence on tissue expression from TISSUES for GRPR Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with GRPR: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRPR Gene

Orthologs for GRPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GRPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRPR 34 33
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRPR 34 33
  • 90.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRPR 34 33
  • 90.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Grpr 16 34 33
  • 87.73 (n)
rat
(Rattus norvegicus)
Mammalia Grpr 33
  • 87.64 (n)
oppossum
(Monodelphis domestica)
Mammalia GRPR 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRPR 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRPR 34 33
  • 77.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRPR 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grpr 33
  • 72.11 (n)
zebrafish
(Danio rerio)
Actinopterygii grpr 34 33
  • 71.47 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30106 35
  • 37 (a)
CCHa2r 34
  • 27 (a)
ManyToMany
CCHa1r 34
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK455.3 35
  • 29 (a)
Species where no ortholog for GRPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPR Gene

ENSEMBL:
Gene Tree for GRPR (if available)
TreeFam:
Gene Tree for GRPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRPR: view image

Paralogs for GRPR Gene

Paralogs for GRPR Gene

(7) SIMAP similar genes for GRPR Gene using alignment to 1 proteins:

  • GRPR_HUMAN
genes like me logo Genes that share paralogs with GRPR: view

Variants for GRPR Gene

Sequence variations from dbSNP and Humsavar for GRPR Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000029339 -- 16,137,552(+) A/C intron_variant
rs1000229914 -- 16,143,594(+) G/T intron_variant
rs1000341758 -- 16,122,794(+) A/G upstream_transcript_variant
rs1000447252 -- 16,131,596(+) A/T intron_variant
rs1000458644 -- 16,131,927(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRPR Gene

Variant ID Type Subtype PubMed ID
nsv436917 CNV insertion 17901297

Variation tolerance for GRPR Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRPR Gene

Human Gene Mutation Database (HGMD)
GRPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRPR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPR Gene

Disorders for GRPR Gene

MalaCards: The human disease database

(7) MalaCards diseases for GRPR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agoraphobia
  • fear of open spaces
autism
  • autistic disorder
prostate cancer
  • prostate cancer, susceptibility to
lung cancer
  • lung cancer, susceptibility to
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search GRPR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRPR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRPR Gene

Publications for GRPR Gene

  1. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges LM … Hamilton SP (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
  2. Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism. (PMID: 14729406) Marui T … Sasaki T (Brain & development 2004) 3 22 44 58
  3. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. (PMID: 11245983) Xiao D … Weber HC (Gene 2001) 3 4 22 58
  4. BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells. (PMID: 19642024) Schmidt AL … Roesler R (Journal of molecular neuroscience : MN 2010) 3 22 58
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58

Products for GRPR Gene

Sources for GRPR Gene

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