GRPEL1 Gene (Protein Coding)

GrpE Like 1, Mitochondrial

GC04M007060
GIFtS:
39

Aliases for GRPEL1 Gene

Aliases for GRPEL1 Gene

  • GrpE Like 1, Mitochondrial 2 3 5
  • GrpE Protein Homolog 1, Mitochondrial 3 4
  • Mt-GrpE#1 3 4
  • HMGE 3 4
  • GrpE-Like 1, Mitochondrial (E. Coli) 2
  • GrpE-Like Protein Cochaperone 3
  • GREPEL1 4
  • GrpE 3

External Ids for GRPEL1 Gene

Previous GeneCards Identifiers for GRPEL1 Gene

  • GC04M007054
  • GC04M007126
  • GC04M007179
  • GC04M007061

Summaries for GRPEL1 Gene

GeneCards Summary for GRPEL1 Gene

GRPEL1 (GrpE Like 1, Mitochondrial) is a Protein Coding gene. Diseases associated with GRPEL1 include Lymphangitis and Human Monocytic Ehrlichiosis. Among its related pathways are Mitochondrial protein import and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chaperone binding. An important paralog of this gene is GRPEL2.

UniProtKB/Swiss-Prot Summary for GRPEL1 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562).

Additional gene information for GRPEL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRPEL1 Gene

Genomics for GRPEL1 Gene

GeneHancer (GH) Regulatory Elements for GRPEL1 Gene

Promoters and enhancers for GRPEL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRPEL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRPEL1 gene promoter:
  • AREB6
  • FOXL1
  • HNF-4alpha1
  • NF-1
  • NF-1/L
  • Nkx5-1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • Zic1

Genomic Locations for GRPEL1 Gene

Genomic Locations for GRPEL1 Gene
chr4:7,058,895-7,068,073
(GRCh38/hg38)
Size:
9,179 bases
Orientation:
Minus strand
chr4:7,060,633-7,069,924
(GRCh37/hg19)
Size:
9,292 bases
Orientation:
Minus strand

Genomic View for GRPEL1 Gene

Genes around GRPEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPEL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRPEL1 Gene

Proteins for GRPEL1 Gene

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  • Protein details for GRPEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAV7-GRPE1_HUMAN
    Recommended name:
    GrpE protein homolog 1, mitochondrial
    Protein Accession:
    Q9HAV7
    Secondary Accessions:
    • B2R783
    • Q549M6

    Protein attributes for GRPEL1 Gene

    Size:
    217 amino acids
    Molecular mass:
    24279 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B (PubMed:11311562).

neXtProt entry for GRPEL1 Gene

Protein Expression for GRPEL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRPEL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRPEL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPEL1 Gene

Domains & Families for GRPEL1 Gene

Gene Families for GRPEL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRPEL1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRPEL1 Gene

GenScript: Design optimal peptide antigens:
  • GrpE protein homolog (B4DWV5_HUMAN)
  • Mt-GrpE#1 (GRPE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HAV7

UniProtKB/Swiss-Prot:

GRPE1_HUMAN :
  • Belongs to the GrpE family.
Family:
  • Belongs to the GrpE family.
genes like me logo Genes that share domains with GRPEL1: view

Function for GRPEL1 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  6. Cell Line

Molecular function for GRPEL1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562).

Phenotypes From GWAS Catalog for GRPEL1 Gene

Gene Ontology (GO) - Molecular Function for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IBA 21873635
GO:0042803 protein homodimerization activity IEA --
GO:0051082 unfolded protein binding IDA 11311562
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with GRPEL1: view
genes like me logo Genes that share phenotypes with GRPEL1: view

Animal Model Products

CRISPR Products

miRNA for GRPEL1 Gene

miRTarBase miRNAs that target GRPEL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRPEL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRPEL1 Gene

Localization for GRPEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPEL1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRPEL1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001405 PAM complex, Tim23 associated import motor IBA 21873635
GO:0005634 nucleus IDA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005759 mitochondrial matrix IDA,IEA 11311562
genes like me logo Genes that share ontologies with GRPEL1: view

Pathways & Interactions for GRPEL1 Gene

PathCards logo

SuperPathways for GRPEL1 Gene

genes like me logo Genes that share pathways with GRPEL1: view

Pathways by source for GRPEL1 Gene

2 Reactome pathways for GRPEL1 Gene

Gene Ontology (GO) - Biological Process for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0030150 protein import into mitochondrial matrix IBA 21873635
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GRPEL1: view

No data available for SIGNOR curated interactions for GRPEL1 Gene

Drugs & Compounds for GRPEL1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GRPEL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GRPEL1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(248) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRPEL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for GRPEL1 Gene

GeneLoc Exon Structure for
GRPEL1
ECgene alternative splicing isoforms for
GRPEL1

Expression for GRPEL1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRPEL1 Gene

mRNA expression in normal human tissues for GRPEL1 Gene
mRNA expression by GTEx for GRPEL1 GenemRNA expression by BioGPS for GRPEL1 Gene

Protein differential expression in normal tissues from HIPED for GRPEL1 Gene

This gene is overexpressed in Liver, secretome (12.9), Peripheral blood mononuclear cells (8.3), and Adrenal (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRPEL1 Gene



Protein tissue co-expression partners for GRPEL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRPEL1 Gene:

GRPEL1

SOURCE GeneReport for Unigene cluster for GRPEL1 Gene:

Hs.443723

Evidence on tissue expression from TISSUES for GRPEL1 Gene

  • Nervous system(4.7)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with GRPEL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRPEL1 Gene

Orthologs for GRPEL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRPEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GRPEL1 33 32
  • 99.54 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia GRPEL1 33 32
  • 86.27 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 86 (a)
 OneToMany
-- 33
  • 86 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia GRPEL1 33 32
  • 85.1 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GRPEL1 33
  • 85 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Grpel1 32
  • 84.02 (n)
mouse
(Mus musculus)
 Mammalia Grpel1 17 33 32
  • 83.72 (n)
chicken
(Gallus gallus)
 Aves GRPEL1 33 32
  • 74.11 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GRPEL1 33
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia grpel1 32
  • 71.77 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23742 32
zebrafish
(Danio rerio)
 Actinopterygii grpel1 33 32
  • 66.35 (n)
 OneToOne
Dr.5829 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12646 32
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011150 32
  • 59.83 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Roe1 33 32
  • 54.8 (n)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C34C12.8 33 32
  • 51.65 (n)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MGE1 35 33 32
  • 48.77 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D07326g 32
  • 48.19 (n)
rice
(Oryza sativa)
 Liliopsida Os08g0338700 32
  • 53.06 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU01516 32
  • 48.84 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes mge1 32
  • 47.27 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.6300 33
  • 39 (a)
 OneToMany
Species where no ortholog for GRPEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPEL1 Gene

ENSEMBL:
Gene Tree for GRPEL1 (if available)
TreeFam:
Gene Tree for GRPEL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRPEL1: view image

Paralogs for GRPEL1 Gene

Paralogs for GRPEL1 Gene

(2) SIMAP similar genes for GRPEL1 Gene using alignment to 1 proteins:

  • GRPE1_HUMAN

Pseudogenes.org Pseudogenes for GRPEL1 Gene

genes like me logo Genes that share paralogs with GRPEL1: view

Variants for GRPEL1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for GRPEL1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000228503 -- 7,061,757(-) C/T intron_variant
rs1000535252 -- 7,063,266(-) T/C intron_variant
rs1000656791 -- 7,067,355(-) G/A intron_variant
rs1000686735 -- 7,062,287(-) C/T intron_variant
rs1000966325 -- 7,062,998(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRPEL1 Gene

Variant ID Type Subtype PubMed ID
esv2759221 CNV gain 17122850
esv34033 CNV loss 18971310
esv34196 OTHER inversion 12058347
nsv4217 CNV deletion 18451855
nsv428436 CNV gain 18775914
nsv469847 CNV gain 16826518

Variation tolerance for GRPEL1 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRPEL1 Gene

Human Gene Mutation Database (HGMD)
GRPEL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRPEL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPEL1 Gene

Disorders for GRPEL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GRPEL1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lymphangitis
human monocytic ehrlichiosis
  • ehrlichiosis chafeensis
whipple disease
  • intestinal lipodystrophy
immunodysregulation, polyendocrinopathy, and enteropathy, x-linked
  • ipex
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GRPEL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRPEL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRPEL1 Gene

Publications for GRPEL1 Gene

  1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. (PMID: 11311562) Choglay AA … Cheetham ME (Gene 2001) 2 3 4 56
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Free human mitochondrial GrpE is a symmetric dimer in solution. (PMID: 12840016) Borges JC … Ramos CH (The Journal of biological chemistry 2003) 2 3 56
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56

ExternalLinks

View latest publications for GRPEL1 gene in Mastermind

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