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GRPEL1 (GrpE Like 1, Mitochondrial) is a Protein Coding gene. Diseases associated with GRPEL1 include Deafness, Autosomal Dominant 69 and Human Monocytic Ehrlichiosis. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chaperone binding. An important paralog of this gene is GRPEL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000774 | adenyl-nucleotide exchange factor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 28514442 |
GO:0042803 | protein homodimerization activity | IEA | -- |
GO:0051082 | unfolded protein binding | IDA | 11311562 |
GO:0051087 | chaperone binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001405 | PAM complex, Tim23 associated import motor | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | IEA,IDA | -- |
GO:0005759 | mitochondrial matrix | IEA,IDA | 11311562 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of proteins | ||
2 | Mitochondrial protein import |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006457 | protein folding | IEA | -- |
GO:0030150 | protein import into mitochondrial matrix | IBA | 21873635 |
GO:0050790 | regulation of catalytic activity | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||
SP2: | - | - | |||||||||||||||||
SP3: | - | ||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRPEL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRPEL1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | GRPEL1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GRPEL1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Grpel1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Grpel1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GRPEL1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRPEL1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grpel1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23742 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | grpel1 30 31 |
|
OneToOne | |
Dr.5829 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12646 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011150 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Roe1 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | C34C12.8 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MGE1 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D07326g 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os08g0338700 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01516 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mge1 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6300 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
deafness, autosomal dominant 69 |
|
|
human monocytic ehrlichiosis |
|
|