Aliases for GRN Gene
Aliases for GRN Gene
External Ids for GRN Gene
- HGNC: 4601
- Entrez Gene: 2896
- Ensembl: ENSG00000030582
- OMIM: 138945
- UniProtKB: P28799
Previous GeneCards Identifiers for GRN Gene
- GC17P042164
- GC17P044599
- GC17P042433
- GC17P042897
- GC17P039778
- GC17P038189
- GC17P042422
Summaries for GRN Gene
-
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRN Gene
GRN (Granulin Precursor) is a Protein Coding gene. Diseases associated with GRN include Ceroid Lipofuscinosis, Neuronal, 11 and Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related. Among its related pathways are Integrated Breast Cancer Pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include growth factor activity.
UniProtKB/Swiss-Prot for GRN Gene
-
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
-
Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
Additional gene information for GRN Gene
- Monarch Initiative
- Search for GRN at DataMed
- Search for GRN at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRN Gene
Genomics for GRN Gene
GeneHancer (GH) Regulatory Elements for GRN Gene
Promoters and enhancers for GRN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRN on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GRN gene promoter:
-
- C/EBPbeta
- GR
- GR-alpha
- GR-beta
Regulatory Element Products
Genomic Locations for GRN Gene
Genomic Locations for GRN Gene
- chr17:44,345,086-44,353,106
- (GRCh38/hg38)
- Size:
- 8,021 bases
- Orientation:
- Plus strand
- chr17:42,422,491-42,430,470
- (GRCh37/hg19)
- Size:
- 7,980 bases
- Orientation:
- Plus strand
Genomic View for GRN Gene
Genes around GRN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
- 17q21.31 by Ensembl
GRN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRN Gene
Proteins for GRN Gene
-
Protein details for GRN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28799-GRN_HUMAN
- Recommended name:
- Granulins
- Protein Accession:
- P28799
- D3DX55
- P23781
- P23782
- P23783
- P23784
- Q53HQ8
- Q53Y88
- Q540U8
- Q9BWE7
- Q9H8S1
- Q9UCH0
Protein attributes for GRN Gene
- Size:
- 593 amino acids
- Molecular mass:
- 63544 Da
- Quaternary structure:
-
- Acrogranin/Progranulin is secreted as a homodimer.
Three dimensional structures from OCA and Proteopedia for GRN Gene
Protein Expression for GRN Gene
Post-translational modifications for GRN Gene
- Granulins are disulfide bridged.
- Glycosylation at isoforms=3530, isoforms=2, 3368, Asn265, Asn236, isoforms=2182, and Asn118
- Modification sites at PhosphoSitePlus
Other Protein References for GRN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GRN (Progranulin/PGRN)
- Novus Biologicals Antibodies for GRN
-
Abcam antibodies for GRN
- Invitrogen Antibodies for GRN (AFLGC-GRN)
- antibodies-online: Search results for 159 available Granulin Antibodies ranked by validation data
- Compare Top Granulin Antibodies
-
Quality Products:
- ABIN2785816
- ABIN728668
- ABIN4315995
- ABIN2000867
- ABIN1169394
- ABIN439720
- ABIN1881391
- ABIN4315998
- ABIN4315997
- ABIN2854868
- ABIN2785816
- ABIN728668
- ABIN4315995
- ABIN2000867
- ABIN1169394
- ABIN439720
- ABIN1881391
- ABIN4315998
- ABIN4315997
- ABIN2854868
- ABIN2785816
- ABIN728668
- ABIN4315995
- ABIN2000867
- ABIN1169394
- ABIN439720
- ABIN1881391
- ABIN4315998
- ABIN4315997
- ABIN2854868
- GeneTex GRN Antibody for GRN
-
Boster Bio Antibodies for GRN
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRN
- Sino Biological Antibodies for GRN
Protein Products
- R&D Systems Proteins and Enzymes for GRN (Progranulin/PGRN)
-
OriGene Purified Proteins for GRN
- Search Origene for MassSpec and Protein Over-expression Lysates for GRN
- Origene Custom Protein Services for GRN
- Sino Biological Recombinant Proteins for GRN
- Sino Biological Cell Lysates for GRN
- ProSpec Recombinant Proteins for GRN
- antibodies-online: Search results for 45 available Granulin Proteins ranked by validation data
- Compare Top Granulin Proteins
-
Quality Products:
- ABIN1027659
- ABIN3133601
- ABIN3080977
- ABIN1525749
- ABIN1355792
- ABIN1027657
- ABIN1608949
- ABIN1608450
- ABIN1608782
- ABIN1525867
- ABIN1027659
- ABIN3133601
- ABIN3080977
- ABIN1525749
- ABIN1355792
- ABIN1027657
- ABIN1608949
- ABIN1608450
- ABIN1608782
- ABIN1525867
- ABIN1027659
- ABIN3133601
- ABIN3080977
- ABIN1525749
- ABIN1355792
- ABIN1027657
- ABIN1608949
- ABIN1608450
- ABIN1608782
- ABIN1525867
- GeneTex Proteins for GRN
-
ProSci Proteins for GRN
-
Abcam proteins for GRN
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for GRN (Progranulin/PGRN)
- antibodies-online: Search results for 108 available Granulin Elisa Kits ranked by validation data
- Compare Top Granulin Elisa Kits
-
Quality Products:
- ABIN1889363
- ABIN1672874
- ABIN432881
- ABIN775480
- ABIN777444
- ABIN994949
- ABIN779608
- ABIN1562870
- ABIN1057565
- ABIN994950
- ABIN1889363
- ABIN1672874
- ABIN432881
- ABIN775480
- ABIN777444
- ABIN994949
- ABIN779608
- ABIN1562870
- ABIN1057565
- ABIN994950
- ABIN1889363
- ABIN1672874
- ABIN432881
- ABIN775480
- ABIN777444
- ABIN994949
- ABIN779608
- ABIN1562870
- ABIN1057565
- ABIN994950
-
Abcam assays for GRN
- Sino Biological Assays for GRN
No data available for DME Specific Peptides for GRN Gene
Domains & Families for GRN Gene
Gene Families for GRN Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for GRN Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRN Gene
Graphical View of Domain Structure for InterPro Entry
P28799- Family:
-
- Belongs to the granulin family.
Function for GRN Gene
Molecular function for GRN Gene
- UniProtKB/Swiss-Prot Function:
- Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
- UniProtKB/Swiss-Prot Function:
- Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
- GENATLAS Biochemistry:
- granulin,cysteine rich protein with growth modulatory activity,expressed by many epithelial cells,overexpressed in adrenal carcinoma
Phenotypes From GWAS Catalog for GRN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12900424 |
| GO:0008083 | growth factor activity | TAS | 1542665 |
Phenotypes for GRN Gene
- MGI mutant phenotypes for GRN:
-
inferred from 8 alleles
- pigmentation phenotype
- vision/eye phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- immune system phenotype
- GenomeRNAi human phenotypes for GRN:
Animal Models for GRN Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GRN
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRN
-
CRISPR Products
-
OriGene CRISPR knockouts for GRN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRN
- genomics-online: gRNA clones - Search results for 142 available Granulin gene related products
- Overview of 142 available Granulin gene related products
- Applied Biological Materials CRISPR for GRN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRN
- GenScript: Design CRISPR guide RNA sequences for GRN
miRNA for GRN Gene
- miRTarBase miRNAs that target GRN
-
- hsa-mir-659-3p (MIRT000034)
- hsa-mir-107 (MIRT004761)
- hsa-mir-29b-3p (MIRT005486)
- hsa-mir-9-5p (MIRT021404)
- hsa-mir-8056 (MIRT627121)
- hsa-mir-4752 (MIRT627122)
- hsa-mir-3691-5p (MIRT627123)
- hsa-mir-376c-5p (MIRT627124)
- hsa-mir-376b-5p (MIRT627125)
- hsa-mir-5191 (MIRT627126)
- hsa-mir-3939 (MIRT627127)
- hsa-mir-7114-5p (MIRT627128)
- hsa-mir-8485 (MIRT627129)
- hsa-mir-588 (MIRT735490)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRN
- Browse OriGene Inhibitory RNA Products For GRN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRN
- genomics-online: shRNA clones - Search results for 142 available Granulin gene related products
- Overview of 142 available Granulin gene related products
Clone Products
- Sino Biological Human cDNA Clone for GRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRN
- Applied Biological Materials Clones for GRN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GRN
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRN Gene
Localization for GRN Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRN Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
- Endoplasmic reticulum (4)
- Endosomes (4)
- Lysosomes (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005764 | lysosome | IDA | -- |
| GO:0005768 | endosome | IDA | -- |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
Pathways & Interactions for GRN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Integrated Breast Cancer Pathway | ||
Pathways by source for GRN Gene
1 BioSystems pathway for GRN Gene
3 Reactome pathways for GRN Gene
Interacting Proteins for GRN Gene
Selected Interacting proteins:
P28799-GRN_HUMAN
ENSP00000053867
for GRN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | NAS | 1542665 |
| GO:0010469 | regulation of signaling receptor activity | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
Transcripts for GRN Gene
mRNA/cDNA for GRN Gene
- (4) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (1630) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000639447 1314 bps
- ENST00000586242 665 bps (uc060gad.1)
- ENST00000585348 600 bps (uc060gac.1)
- ENST00000589923 437 bps (uc060gab.1)
- ENST00000586443 1557 bps (uc060gaa.1)
CRISPR Products
-
OriGene CRISPR knockouts for GRN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRN
- genomics-online: gRNA clones - Search results for 142 available Granulin gene related products
- Overview of 142 available Granulin gene related products
- Applied Biological Materials CRISPR for GRN
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRN
- GenScript: Design CRISPR guide RNA sequences for GRN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRN
- Browse OriGene Inhibitory RNA Products For GRN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRN
- genomics-online: shRNA clones - Search results for 142 available Granulin gene related products
- Overview of 142 available Granulin gene related products
Clone Products
- Sino Biological Human cDNA Clone for GRN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRN
- Applied Biological Materials Clones for GRN
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | - | - | |||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: |
Expression for GRN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Trophoblast (Extraembryonic Tissues)
- Trophoblast Cells Trophoblast
- Trophoblast
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for GRN Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Amniocyte (26.4), Urine (17.5), and Monocytes (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRN Gene
NURSA nuclear receptor signaling pathways regulating expression of GRN Gene:
GRNSOURCE GeneReport for Unigene cluster for GRN Gene:
Hs.514220mRNA Expression by UniProt/SwissProt for GRN Gene:
P28799-GRN_HUMAN
Tissue specificity:
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Evidence on tissue expression from TISSUES for GRN Gene
- Blood(5)
- Kidney(5)
- Lung(5)
- Nervous system(5)
- Intestine(4.8)
- Liver(4.8)
- Spleen(4.8)
- Skin(4.7)
- Bone marrow(4.5)
- Heart(4)
- Pancreas(3.9)
- Stomach(3.8)
- Thyroid gland(3.4)
- Muscle(2.8)
- Eye(2.4)
- Lymph node(2.4)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GRN Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- nervous
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- face
- head
- jaw
- mandible
- maxilla
- mouth
- nose
- pharynx
- skull
- tongue
Thorax:
- esophagus
Abdomen:
- stomach
Pelvis:
- prostate
- urinary bladder
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for GRN
-
OriGene qPCR primer pairs and template standards for GRN
- genomics-online: primer clones - Search results for 142 available Granulin gene related products
- Overview of 142 available Granulin gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for GRN Gene
Orthologs for GRN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRN 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GRN 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Grn 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Grn 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | GRN 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GRN 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRN 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRN 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grn 33 |
|
||
| Str.4560 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | grn-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grna 34 33 |
|
OneToMany | |
| grnb 34 |
|
OneToMany | |||
| wufj14b08 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | T22H2.6b 35 |
|
|
|
| T22H2.6a 35 |
|
|
|||
| pgrn-1 34 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7332 34 |
|
OneToOne |
- Species where no ortholog for GRN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GRN Gene
- ENSEMBL:
- Gene Tree for GRN (if available)
- TreeFam:
- Gene Tree for GRN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRN: view image
Paralogs for GRN Gene
No data available for Paralogs for GRN Gene
Variants for GRN Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001043987 | uncertain-significance, Frontotemporal dementia | 44,345,163(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs111435385 | benign, Frontotemporal dementia, ubiquitin-positive | 44,349,206(+) | G/A | coding_sequence_variant, synonymous_variant | |
| rs116547342 | likely-benign, Frontotemporal dementia | 44,353,078(+) | G/A | 3_prime_UTR_variant | |
| rs138473783 | likely-benign, benign, not specified, Frontotemporal dementia, Frontotemporal dementia, ubiquitin-positive | 44,350,525(+) | G/A | coding_sequence_variant, synonymous_variant | |
| rs140298583 | likely-benign, benign, not specified, Frontotemporal dementia, ubiquitin-positive | 44,352,062(+) | G/A/T | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5606n54 | CNV | loss | 21841781 |
| dgv5607n54 | CNV | loss | 21841781 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv475965 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.37;
42.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRN Gene
Disorders for GRN Gene
(47) MalaCards diseases for GRN Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ceroid lipofuscinosis, neuronal, 11 |
|
|
| frontotemporal lobar degeneration with tdp43 inclusions, grn-related |
|
|
| frontotemporal dementia |
|
|
| progressive non-fluent aphasia |
|
|
| aphasia |
|
Search GRN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GRN_HUMAN- Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. {ECO:0000269 PubMed:16862116, ECO:0000269 PubMed:16983685, ECO:0000269 PubMed:18183624}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Ceroid lipofuscinosis, neuronal, 11 (CLN11) [MIM:614706]: A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. {ECO:0000269 PubMed:22608501}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GRN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for GRN Gene
Publications for GRN Gene
- Structure and chromosomal location of the human granulin gene. (PMID: 1417868) Bhandari V … Bateman A (Biochemical and biophysical research communications 1992) 2 3 4 22 58
- Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. (PMID: 19649643) Chen-Plotkin AS … Lee VM (Acta neuropathologica 2010) 3 22 44 58
- GRN variability contributes to sporadic frontotemporal lobar degeneration. (PMID: 20061636) Galimberti D … Scarpini E (Journal of Alzheimer's disease : JAD 2010) 3 22 44 58
- Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly. (PMID: 20197700) Dickson DW … Rademakers R (Neuro-degenerative diseases 2010) 3 22 44 58
- An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. (PMID: 19016491) Viswanathan J … Hiltunen M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
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Sources for GRN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (14) ProtoNet
- (15) Blocks
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (104) GeneTex
- (105) Taconic Biosciences
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- (107)