GRM8 Gene (Protein Coding)

Glutamate Metabotropic Receptor 8

GC07M126438
GIFtS:
45
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that ... See more...

Aliases for GRM8 Gene

Aliases for GRM8 Gene

  • Glutamate Metabotropic Receptor 8 2 3 5
  • GPRC1H 2 3 4
  • MGLUR8 2 3 4
  • Glutamate Receptor, Metabotropic 8 2 3
  • Metabotropic Glutamate Receptor 8 3 4
  • GLUR8 2 3
  • MGlu8 2 3
  • MGluR8 4
  • GRM8 5

External Ids for GRM8 Gene

Previous GeneCards Identifiers for GRM8 Gene

  • GC07M124556
  • GC07M125619
  • GC07M125633
  • GC07M125609
  • GC07M125672
  • GC07M125865
  • GC07M126078
  • GC07M120439

Summaries for GRM8 Gene

Entrez Gene Summary for GRM8 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM8 Gene

GRM8 (Glutamate Metabotropic Receptor 8) is a Protein Coding gene. Diseases associated with GRM8 include Chromosome 17Q21.31 Duplication Syndrome and Creutzfeldt-Jakob Disease. Among its related pathways are Signaling by GPCR and Taste transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and group III metabotropic glutamate receptor activity. An important paralog of this gene is GRM4.

UniProtKB/Swiss-Prot Summary for GRM8 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM8 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Gene Wiki entry for GRM8 Gene

Additional gene information for GRM8 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRM8 Gene

Genomics for GRM8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GRM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J127252 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 607.6 +0.1 104 2.8 CTCF PRDM10 PRDM1 ZNF143 ZIC2 PATZ1 REST RAD21 ZNF501 TRIM22 GRM8 GRM8-AS1
GH07J127447 Enhancer 0.8 ENCODE 9.9 -194.4 -194449 0.2 CTCF ZNF512 FOXA1 ZNF143 REST RAD21 TRIM22 CBX3 HMBOX1 ZNF10 ENSG00000224138 ZNF800 SND1 RBM28 GRM8 PAX4 piR-48222-336 lnc-ARF5-10 ARF5
GH07J127224 Enhancer 0.3 Ensembl 11.5 +25.8 25793 0.2 CTCF ZNF652 GRM8 GRM8-AS1
GH07J127215 Enhancer 0.2 Ensembl 11.1 +37.7 37692 0.4 GRM8-AS1 GRM8
GH07J127322 Enhancer 0.2 Ensembl 10.6 -68.6 -68608 0.2 GRM8 GRM8-AS1 piR-48965-136 ENSG00000224138 ZNF800
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRM8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRM8

Top Transcription factor binding sites by QIAGEN in the GRM8 gene promoter:
  • Brachyury
  • HTF
  • Nkx2-5
  • POU3F2
  • SRF (504 AA)

Genomic Locations for GRM8 Gene

Genomic Locations for GRM8 Gene
chr7:126,438,598-127,253,093
(GRCh38/hg38)
Size:
814,496 bases
Orientation:
Minus strand
chr7:126,078,652-126,893,348
(GRCh37/hg19)
Size:
814,697 bases
Orientation:
Minus strand

Genomic View for GRM8 Gene

Genes around GRM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRM8 Gene

Proteins for GRM8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GRM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00222-GRM8_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 8
    Protein Accession:
    O00222
    Secondary Accessions:
    • A4D0Y3
    • B0FZ74
    • B0M0L0
    • O15493
    • O95945
    • O95946
    • Q3MIV9
    • Q52M02
    • Q6J165

    Protein attributes for GRM8 Gene

    Size:
    908 amino acids
    Molecular mass:
    101741 Da
    Quaternary structure:
    • Interacts with PICK1.

    Three dimensional structures from OCA and Proteopedia for GRM8 Gene

    Alternative splice isoforms for GRM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM8 Gene

Protein Expression for GRM8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRM8 Gene

  • Glycosylation at Asn95, Asn298, Asn452, Asn480, and Asn565
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRM8 Gene

Domains & Families for GRM8 Gene

Gene Families for GRM8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRM8 Gene

InterPro:
Blocks:
  • Metabotropic glutamate receptor signature
  • G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
  • Extracellular ligand-binding receptor
  • Metabotropic glutamate receptor 8 signature
ProtoNet:

Suggested Antigen Peptide Sequences for GRM8 Gene

GenScript: Design optimal peptide antigens:
  • Metabotropic glutamate receptor 8 (GRM8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00222

UniProtKB/Swiss-Prot:

GRM8_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM8: view

Function for GRM8 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GRM8 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
GENATLAS Biochemistry:
metabotropic glutamate receptor 8,groupe III,G protein coupled receptor superfamily, linked to the inhibition of cAMP cascade

Phenotypes From GWAS Catalog for GRM8 Gene

Gene Ontology (GO) - Molecular Function for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001642 group III metabotropic glutamate receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA,IMP 9473604
GO:0008066 glutamate receptor activity IMP 9473604
genes like me logo Genes that share ontologies with GRM8: view
genes like me logo Genes that share phenotypes with GRM8: view

Animal Models for GRM8 Gene

MGI Knock Outs for GRM8:
  • Grm8 Grm8<tm1Dgen>
  • Grm8 Grm8<tm1Duv>
  • Grm8 Grm8<tm1En>
  • Grm8 Grm8<tm2a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for GRM8

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRM8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM8 Gene

Localization for GRM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRM8 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRM8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM8 Gene

Pathways & Interactions for GRM8 Gene

genes like me logo Genes that share pathways with GRM8: view

Pathways by source for GRM8 Gene

1 R&D Systems pathway for GRM8 Gene
3 Qiagen pathways for GRM8 Gene
  • CREB Pathway
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • Signaling in Gap Junctions

Gene Ontology (GO) - Biological Process for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA 11166323
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IMP 9473604
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GRM8: view

No data available for SIGNOR curated interactions for GRM8 Gene

Drugs & Compounds for GRM8 Gene

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  1. Drug

(21) Drugs for GRM8 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Agonist, Full agonist, Target, antagonist 304
L-AP4 Pharma Agonist, Full agonist Selective group III mGlu agonist 0
(<i>R,S</i>)-4-PPG Pharma Agonist, Full agonist 0
(<i>S</i>)-3,4-DCPG Pharma Agonist, Full agonist 0
(1<i>S</i>,3<i>R</i>)-ACPD Pharma Agonist, Full agonist 0

(2) Additional Compounds for GRM8 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-SOP
Agonist, Full agonist

(5) Tocris Compounds for GRM8 Gene

Compound Action Cas Number
(RS)-PPG Potent, selective mGlu8 agonist 120667-15-4
(S)-3,4-DCPG Potent, selective mGlu8a agonist 201730-11-2
ACPT-I Group III mGlu agonist 194918-76-8
L-AP4 Selective group III mGlu agonist 23052-81-5
O-Phospho-L-serine Group III mGlu agonist 407-41-0
genes like me logo Genes that share compounds with GRM8: view

Transcripts for GRM8 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GRM8 Gene

8 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRM8

Alternative Splicing Database (ASD) splice patterns (SP) for GRM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for GRM8 Gene

GeneLoc Exon Structure for
GRM8

Expression for GRM8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRM8 Gene

mRNA expression in normal human tissues for GRM8 Gene
mRNA expression by GTEx for GRM8 GenemRNA expression by BioGPS for GRM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM8 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.1), Brain - Putamen (basal ganglia) (x4.5), Brain - Caudate (basal ganglia) (x4.3), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM8 Gene

This gene is overexpressed in Heart (59.0) and Adipocyte (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRM8 Gene



Protein tissue co-expression partners for GRM8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRM8

SOURCE GeneReport for Unigene cluster for GRM8 Gene:

Hs.449625

Evidence on tissue expression from TISSUES for GRM8 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
  • Kidney(2.1)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with GRM8: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM8 Gene

Orthologs for GRM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GRM8 30
  • 99.74 (n)
Oppossum
(Monodelphis domestica)
 Mammalia GRM8 31
  • 97 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GRM8 31
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GRM8 30 31
  • 93.61 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GRM8 30
  • 93.06 (n)
Mouse
(Mus musculus)
 Mammalia Grm8 30 17 31
  • 91.7 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Grm8 30
  • 91.7 (n)
Chicken
(Gallus gallus)
 Aves GRM8 30 31
  • 84.05 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GRM8 31
  • 91 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC100497088 30
  • 79.32 (n)
Zebrafish
(Danio rerio)
 Actinopterygii grm8a 31
  • 83 (a)
 OneToMany
GRM8 (1 of 2) 31
  • 81 (a)
 OneToMany
LOC569768 30
  • 73.01 (n)
Dr.26085 30
Fruit Fly
(Drosophila melanogaster)
 Insecta mtt 30
  • 51.67 (n)
Glu-RA 32
  • 46 (a)
CG30361 32
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta GPRMGL5 30
  • 50.76 (n)
Worm
(Caenorhabditis elegans)
 Secernentea mgl-1 32
  • 37 (a)
mgl-3 31
  • 31 (a)
 OneToOne
Species where no ortholog for GRM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRM8 Gene

ENSEMBL:
Gene Tree for GRM8 (if available)
TreeFam:
Gene Tree for GRM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRM8: view image

Paralogs for GRM8 Gene

Paralogs for GRM8 Gene

(8) SIMAP similar genes for GRM8 Gene using alignment to 4 proteins:

  • GRM8_HUMAN
  • C9J7I1_HUMAN
  • E7ETK3_HUMAN
  • H7C4V5_HUMAN

Pseudogenes.org Pseudogenes for GRM8 Gene

genes like me logo Genes that share paralogs with GRM8: view

Variants for GRM8 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRM8 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
712683 Benign: not provided 126,533,896(-) A/G INTRON_VARIANT
712684 Benign: not provided 127,243,109(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
722089 Likely Benign: not provided 126,533,195(-) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
722342 Benign: not provided 126,533,165(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
722343 Benign: not provided 126,533,387(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GRM8 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRM8 Gene

Variant ID Type Subtype PubMed ID
dgv1329e214 CNV loss 21293372
dgv1959e212 CNV loss 25503493
dgv3662n106 CNV deletion 24896259
esv1000131 CNV insertion 20482838
esv1000509 CNV deletion 20482838
esv1009957 CNV deletion 20482838
esv1300352 CNV deletion 17803354
esv1480862 CNV insertion 17803354
esv1733605 CNV deletion 17803354
esv2019229 CNV deletion 18987734
esv2158688 CNV deletion 18987734
esv23929 CNV loss 19812545
esv2606684 CNV deletion 19546169
esv2609252 CNV deletion 19546169
esv2622637 CNV deletion 19546169
esv26377 CNV gain+loss 19812545
esv2668105 CNV deletion 23128226
esv2670600 CNV deletion 23128226
esv2678710 CNV deletion 23128226
esv2735116 CNV deletion 23290073
esv2735118 CNV deletion 23290073
esv2735119 CNV deletion 23290073
esv2735120 CNV deletion 23290073
esv2735121 CNV deletion 23290073
esv2735122 CNV deletion 23290073
esv2735123 CNV deletion 23290073
esv2759562 CNV loss 17122850
esv2761365 CNV loss 21179565
esv2761367 CNV loss 21179565
esv27641 CNV gain 19812545
esv3347869 CNV insertion 20981092
esv3350870 CNV duplication 20981092
esv3365094 CNV insertion 20981092
esv3367822 CNV duplication 20981092
esv33690 CNV loss 17666407
esv33698 CNV loss 17666407
esv3373213 CNV insertion 20981092
esv3379634 CNV duplication 20981092
esv3410812 CNV insertion 20981092
esv3433844 CNV insertion 20981092
esv3435518 CNV insertion 20981092
esv3445328 CNV insertion 20981092
esv3542399 CNV deletion 23714750
esv3542401 CNV deletion 23714750
esv3572126 CNV loss 25503493
esv3572127 CNV loss 25503493
esv3572130 CNV loss 25503493
esv3572132 CNV loss 25503493
esv3572133 CNV loss 25503493
esv3614931 CNV loss 21293372
esv3614936 CNV loss 21293372
esv3614938 CNV loss 21293372
esv3614939 CNV gain 21293372
esv3614940 CNV loss 21293372
esv3614951 CNV loss 21293372
esv3614952 CNV loss 21293372
esv3891200 CNV loss 25118596
esv3891206 CNV loss 25118596
esv5207 CNV loss 18987735
nsv1027369 CNV gain 25217958
nsv1027558 CNV loss 25217958
nsv1032108 CNV loss 25217958
nsv1032612 CNV loss 25217958
nsv1075058 CNV deletion 25765185
nsv1075994 CNV deletion 25765185
nsv1076949 CNV deletion 25765185
nsv1129285 CNV insertion 24896259
nsv1137288 CNV deletion 24896259
nsv1143191 CNV tandem duplication 24896259
nsv1154027 CNV deletion 26484159
nsv436533 CNV deletion 17901297
nsv437572 CNV loss 16327808
nsv473619 CNV novel sequence insertion 20440878
nsv499782 CNV loss 21111241
nsv510114 OTHER sequence alteration 20534489
nsv517633 CNV loss 19592680
nsv518034 CNV loss 19592680
nsv521803 CNV gain 19592680
nsv5938 CNV insertion 18451855
nsv5939 CNV deletion 18451855
nsv5940 CNV deletion 18451855
nsv5941 CNV insertion 18451855
nsv608376 CNV loss 21841781
nsv608377 CNV loss 21841781
nsv608378 CNV loss 21841781
nsv608379 CNV loss 21841781
nsv608380 CNV loss 21841781
nsv819682 CNV gain 19587683
nsv8211 CNV loss 18304495
nsv8212 CNV loss 18304495
nsv831121 CNV gain 17160897
nsv981575 CNV duplication 23825009

Variation tolerance for GRM8 Gene

Residual Variation Intolerance Score: 6.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRM8 Gene

Human Gene Mutation Database (HGMD)
GRM8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRM8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM8 Gene

Disorders for GRM8 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GRM8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 17q21.31 duplication syndrome
  • 17q21.31 microduplication syndrome
creutzfeldt-jakob disease
  • cjd
juvenile absence epilepsy
  • childhood absence epilepsy
alcohol dependence
  • alcoholism
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GRM8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRM8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GRM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM8 Gene

Publications for GRM8 Gene

  1. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. (PMID: 18195715) Nielsen DA … Kreek MJ (Molecular psychiatry 2008) 3 23 41
  2. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. (PMID: 15211621) Takaki H … Fukumaki Y (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004) 3 23 41
  3. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PMID: 11912074) Preuss UW … Bondy B (Alcohol and alcoholism (Oxford, Oxfordshire) 2002) 3 23 41
  4. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. (PMID: 10216218) Malherbe P … Mutel V (Brain research. Molecular brain research 1999) 3 4 23
  5. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PMID: 9473604) Wu S … Belagaje RM (Brain research. Molecular brain research 1998) 3 4 23

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