Aliases for GRM8 Gene
Aliases for GRM8 Gene
External Ids for GRM8 Gene
- HGNC: 4600
- Entrez Gene: 2918
- Ensembl: ENSG00000179603
- OMIM: 601116
- UniProtKB: O00222
Previous GeneCards Identifiers for GRM8 Gene
- GC07M124556
- GC07M125619
- GC07M125633
- GC07M125609
- GC07M125672
- GC07M125865
- GC07M126078
- GC07M120439
Summaries for GRM8 Gene
-
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRM8 Gene
GRM8 (Glutamate Metabotropic Receptor 8) is a Protein Coding gene. Diseases associated with GRM8 include Schizophrenia. Among its related pathways are Circadian entrainment and GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and group III metabotropic glutamate receptor activity. An important paralog of this gene is GRM4.
UniProtKB/Swiss-Prot for GRM8 Gene
-
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
-
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.
Additional gene information for GRM8 Gene
- Monarch Initiative
- Search for GRM8 at DataMed
- Search for GRM8 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM8 Gene
Genomics for GRM8 Gene
GeneHancer (GH) Regulatory Elements for GRM8 Gene
Promoters and enhancers for GRM8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I127252 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE | 550.8 | -0.2 | -168 | 1.8 | SIN3A ZNF2 YY1 GLIS2 ZNF143 SP3 YY2 MIER2 REST SMARCA4 | GRM8 PRELID3BP10 | |
| GH07I127447 | Enhancer | 0.8 | ENCODE | 9.9 | -194.2 | -194248 | 0.2 | CTCF FOXA2 RB1 NFATC3 ZNF2 RAD21 CC2D1A CBX5 FOXK2 ARID2 | ENSG00000224138 ZNF800 SND1 RBM28 GRM8 PAX4 GC07P127451 | |
| GH07I127018 | Enhancer | 0.3 | FANTOM5 | 1.6 | +235.0 | 235001 | 0.3 | GRM8 ENSG00000230820 MIR592 | ||
| GH07I127165 | Enhancer | 0.2 | FANTOM5 | 1.4 | +87.3 | 87290 | 0.1 | LOC101928333 GRM8 GC07M127144 | ||
| GH07I126966 | Enhancer | 0.2 | FANTOM5 | 0.1 | +286.6 | 286629 | 0.2 | LOC101928333 ENSG00000230820 ENSG00000224981 GRM8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GRM8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GRM8 gene promoter:
Regulatory Element Products
Genomic Locations for GRM8 Gene
Genomic Locations for GRM8 Gene
- chr7:126,438,598-127,253,294
- (GRCh38/hg38)
- Size:
- 814,697 bases
- Orientation:
- Minus strand
- chr7:126,078,652-126,893,348
- (GRCh37/hg19)
Genomic View for GRM8 Gene
Genes around GRM8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q31.33 by Ensembl
- 7q31.33 by Entrez Gene
- 7q31.33 by HGNC
GRM8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRM8 Gene
Proteins for GRM8 Gene
-
Protein details for GRM8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00222-GRM8_HUMAN
- Recommended name:
- Metabotropic glutamate receptor 8
- Protein Accession:
- O00222
- A4D0Y3
- B0FZ74
- B0M0L0
- O15493
- O95945
- O95946
- Q3MIV9
- Q52M02
- Q6J165
Protein attributes for GRM8 Gene
- Size:
- 908 amino acids
- Molecular mass:
- 101741 Da
- Quaternary structure:
-
- Interacts with PICK1.
Protein Expression for GRM8 Gene
Post-translational modifications for GRM8 Gene
Other Protein References for GRM8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GRM8 (mGluR8)
-
Custom Antibody ServicesOriGene Antibodies for GRM8
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-
Abcam antibodies for GRM8
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- GeneTex GRM8 antibody for GRM8
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRM8
Protein Products
- R&D Systems Proteins and Enzymes for GRM8 (mGluR8)
-
OriGene Purified Proteins for GRM8
- Search Origene for MassSpec and Protein Over-expression Lysates for GRM8
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- Search GeneTex for Proteins for GRM8
-
Abcam proteins for GRM8
Assay Products
No data available for DME Specific Peptides for GRM8 Gene
Domains & Families for GRM8 Gene
Gene Families for GRM8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GRM8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRM8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00222- Family:
-
- Belongs to the G-protein coupled receptor 3 family.
Function for GRM8 Gene
Molecular function for GRM8 Gene
- GENATLAS Biochemistry:
- metabotropic glutamate receptor 8,groupe III,G protein coupled receptor superfamily, linked to the inhibition of cAMP cascade
- UniProtKB/Swiss-Prot Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Phenotypes From GWAS Catalog for GRM8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA,IMP | 9473604 |
| GO:0008066 | glutamate receptor activity | IMP | 9473604 |
Phenotypes for GRM8 Gene
- MGI mutant phenotypes for GRM8:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GRM8:
Animal Model Products
-
Taconic Biosciences Mouse Models for GRM8
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRM8
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GRM8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM8 gene
- Search ViGene Biosciences for GRM8
CRISPR Products
-
OriGene CRISPR knockouts for GRM8
- genomics-online: gRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- Applied Biological Materials CRISPR for GRM8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRM8
- GenScript: Design CRISPR guide RNA sequences for GRM8
miRNA for GRM8 Gene
- miRTarBase miRNAs that target GRM8
miRNA Products
- Search ViGene Biosciences for GRM8
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GRM8
- Browse OriGene Inhibitory RNA Products For GRM8
- genomics-online: shRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM8 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for GRM8 in any vector
- XM_011516104.1
- XM_011516107.1
- XM_006715938.2
- NM_000845.2
- XM_011516101.1
- XM_011516098.1
- XM_011516095.1
- NM_001127323.1
- XM_011516092.1
- XM_011516108.1
- XM_011516105.1
- XM_011516102.1
- XM_011516099.1
- XM_011516096.1
- XM_011516093.1
- XM_011516109.1
- XM_011516091.1
- XM_011516106.1
- XM_011516103.1
- XM_011516100.1
- XM_011516097.1
- XM_011516094.1
- VectorBuilder custom plasmid, inducible vectors for GRM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRM8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRM8
- Applied Biological Materials Clones for GRM8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRM8 (mGluR8)
Cell Line Products
-
Horizon Cell Lines for GRM8
-
ViGene Biosciences adenoviral particle packaged cDNA for GRM8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GRM8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM8 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM8 Gene
Localization for GRM8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRM8 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9473604 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0042734 | presynaptic membrane | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM8 Gene
Pathways & Interactions for GRM8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Circadian entrainment | ||
| 4 | Phospholipase D signaling pathway | ||
| 5 | CREB Pathway |
.68
|
|
Pathways by source for GRM8 Gene
2 BioSystems pathways for GRM8 Gene
6 Reactome pathways for GRM8 Gene
3 KEGG pathways for GRM8 Gene
1 R&D Systems pathway for GRM8 Gene
3 Qiagen pathways for GRM8 Gene
Interacting Proteins for GRM8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | IDA | 11166323 |
| GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway | IMP | 9473604 |
| GO:0007601 | visual perception | TAS | 9473604 |
No data available for SIGNOR curated interactions for GRM8 Gene
Drugs & Compounds for GRM8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist, Target, antagonist | 251 | ||
| L-AP4 | Pharma | Agonist | Selective group III mGlu agonist | 0 | ||
| (<i>R,S</i>)-4-PPG | Pharma | Full agonist, Agonist | 0 | |||
| (<i>S</i>)-3,4-DCPG | Pharma | Full agonist, Agonist | 0 | |||
| (1<i>S</i>,3<i>R</i>)-ACPD | Pharma | Full agonist, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| L-SOP |
|
Agonist |
|
(5) Tocris Compounds for GRM8 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (RS)-PPG | Potent, selective mGlu8 agonist | 120667-15-4 |
| (S)-3,4-DCPG | Potent, selective mGlu8a agonist | 201730-11-2 |
| ACPT-I | Group III mGlu agonist | 194918-76-8 |
| L-AP4 | Selective group III mGlu agonist | 23052-81-5 |
| O-Phospho-L-serine | Group III mGlu agonist | 407-41-0 |
Transcripts for GRM8 Gene
mRNA/cDNA for GRM8 Gene
- (18) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRM8 Gene
- Glutamate receptor, metabotropic 8:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GRM8
- genomics-online: gRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- Applied Biological Materials CRISPR for GRM8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRM8
- GenScript: Design CRISPR guide RNA sequences for GRM8
miRNA Products
- Search ViGene Biosciences for GRM8
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GRM8
- Browse OriGene Inhibitory RNA Products For GRM8
- genomics-online: shRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM8 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for GRM8 in any vector
- XM_011516104.1
- XM_011516107.1
- XM_006715938.2
- NM_000845.2
- XM_011516101.1
- XM_011516098.1
- XM_011516095.1
- NM_001127323.1
- XM_011516092.1
- XM_011516108.1
- XM_011516105.1
- XM_011516102.1
- XM_011516099.1
- XM_011516096.1
- XM_011516093.1
- XM_011516109.1
- XM_011516091.1
- XM_011516106.1
- XM_011516103.1
- XM_011516100.1
- XM_011516097.1
- XM_011516094.1
- VectorBuilder custom plasmid, inducible vectors for GRM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRM8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRM8
- Applied Biological Materials Clones for GRM8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRM8 (mGluR8)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: |
Expression for GRM8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
- Mature Choroid Plexus Cells Choroid Plexus
- Neurons
-
Hair
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for GRM8 Gene
This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.1), Brain - Putamen (basal ganglia) (x4.5), Brain - Caudate (basal ganglia) (x4.3), and Brain - Cortex (x4.0).
This gene is overexpressed in Heart (59.0) and Adipocyte (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRM8 Gene:
GRM8SOURCE GeneReport for Unigene cluster for GRM8 Gene:
Hs.449625Evidence on tissue expression from TISSUES for GRM8 Gene
- Nervous system(4.5)
- Intestine(4)
Primer Products
-
OriGene qPCR primer pairs for GRM8
-
OriGene qPCR primer pairs and template standards for GRM8
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM8 Gene
Orthologs for GRM8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRM8 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRM8 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRM8 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GRM8 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GRM8 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Grm8 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grm8 33 |
|
||
| chicken (Gallus gallus) |
Aves | GRM8 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GRM8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100497088 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grm8a 34 |
|
OneToMany | |
| GRM8 (1 of 2) 34 |
|
OneToMany | |||
| LOC569768 33 |
|
||||
| Dr.26085 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mtt 33 |
|
||
| Glu-RA 35 |
|
|
|||
| CG30361 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GPRMGL5 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mgl-1 35 |
|
|
|
| mgl-3 34 |
|
OneToOne |
- Species where no ortholog for GRM8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GRM8 Gene
Paralogs for GRM8 Gene
(8) SIMAP similar genes for GRM8 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for GRM8 Gene
Variants for GRM8 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs139289550 | uncertain-significance, Malignant tumor of prostate | 126,446,249(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000006992 | -- | 126,908,573(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000008357 | -- | 126,951,214(-) | A/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000009216 | -- | 126,569,623(-) | T/C | intron_variant | |
| rs1000012563 | -- | 126,992,362(-) | T/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
6.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.42;
81.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRM8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM8 Gene
Disorders for GRM8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia |
|
Search GRM8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRM8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GRM8 Gene
Publications for GRM8 Gene
- Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. (PMID: 18195715) Nielsen DA … Kreek MJ (Molecular psychiatry 2008) 3 22 44 58
- Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. (PMID: 15211621) Takaki H … Fukumaki Y (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004) 3 22 44 58
- No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PMID: 11912074) Preuss UW … Bondy B (Alcohol and alcoholism (Oxford, Oxfordshire) 2002) 3 22 44 58
- Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. (PMID: 10216218) Malherbe P … Mutel V (Brain research. Molecular brain research 1999) 3 4 22 58
- Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PMID: 9473604) Wu S … Belagaje RM (Brain research. Molecular brain research 1998) 3 4 22 58
Products for GRM8 Gene
- R&D Systems Antibodies for GRM8 (mGluR8)
- R&D Systems Proteins and Enzymes for GRM8 (mGluR8)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for GRM8 (mGluR8)
- Browse Human Proteins and Enzymes
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- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for GRM8
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GRM8
- Search Origene for MassSpec and Protein Over-expression Lysates for GRM8
- Origene Custom Protein Services for GRM8
- Origene shrna and RNAi products in human, mouse, rat for GRM8
- Browse OriGene Inhibitory RNA Products For GRM8
- OriGene qPCR primer pairs and template standards for GRM8
- OriGene qPCR primer pairs for GRM8
- OriGene CRISPR knockouts for GRM8
- OriGene ORF clones in human for GRM8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GRM8
- GenScript: Next-day shipping of latest version cDNA ORF clones for GRM8 in any vector
- XM_011516101.1
- XM_011516098.1
- XM_011516095.1
- NM_001127323.1
- XM_011516092.1
- XM_011516108.1
- XM_011516105.1
- XM_011516102.1
- XM_011516099.1
- XM_011516096.1
- XM_011516093.1
- XM_011516109.1
- XM_011516091.1
- XM_011516106.1
- XM_011516103.1
- XM_011516100.1
- XM_011516097.1
- XM_011516094.1
- NM_000845.2
- XM_006715938.2
- XM_011516107.1
- XM_011516104.1
- GenScript Custom Purified and Recombinant Proteins Services for GRM8
- GenScript Custom Assay Services for GRM8
- GenScript Custom overexpressing Cell Line Services for GRM8
- GenScript: Design CRISPR guide RNA sequences for GRM8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GRM8
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GRM8
- Novus Biologicals lysates and proteins for GRM8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GRM8
- Abcam proteins for GRM8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for GRM8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GRM8
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRM8
- VectorBuilder custom plasmid, inducible vectors for GRM8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRM8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRM8
- antibodies-online: Search results for 82 available GRM8 Antibodies ranked by validation data
- Compare Top GRM8 Antibodies
- antibodies-online: Search results for 14 available GRM8 Elisa Kits ranked by validation data
- Compare Top GRM8 Elisa Kits
- antibodies-online: Search results for 6 available GRM8 Proteins ranked by validation data
- Compare Top GRM8 Proteins
- GeneTex GRM8 antibody for GRM8
- Search GeneTex for Proteins for GRM8
- ViGene Biosciences adenoviral particle packaged cDNA for GRM8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GRM8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GRM8 gene
- Search ViGene Biosciences for GRM8
- Santa Cruz Biotechnology (SCBT) Antibodies for GRM8
- Search Santa Cruz Biotechnology (SCBT) for GRM8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GRM8
- Horizon Cell Lines for GRM8
- genomics-online: cdna clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- orf clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- genomics-online: gRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- genomics-online: primer clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
- genomics-online: shRNA clones - Search results for 92 available GRM8 gene related products
- Overview of 92 available GRM8 gene related products
Sources for GRM8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems