L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors th... See more...

Aliases for GRM7 Gene

Aliases for GRM7 Gene

  • Glutamate Metabotropic Receptor 7 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 87 2 3
  • Glutamate Receptor, Metabotropic 7 2 3
  • Metabotropic Glutamate Receptor 7 3 4
  • GPRC1G 3 4
  • MGLUR7 3 4
  • PPP1R87 3
  • MGluR7 4
  • GLUR7 3
  • MGLU7 3

External Ids for GRM7 Gene

Previous GeneCards Identifiers for GRM7 Gene

  • GC03P006816
  • GC03P006877

Summaries for GRM7 Gene

Entrez Gene Summary for GRM7 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for GRM7 Gene

GRM7 (Glutamate Metabotropic Receptor 7) is a Protein Coding gene. Diseases associated with GRM7 include Age-Related Hearing Loss and Deafness, Autosomal Dominant 28. Among its related pathways are Signaling by GPCR and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is GRM8.

UniProtKB/Swiss-Prot Summary for GRM7 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM7 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Gene Wiki entry for GRM7 Gene

Additional gene information for GRM7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRM7 Gene

Genomics for GRM7 Gene

GeneHancer (GH) Regulatory Elements for GRM7 Gene

Promoters and enhancers for GRM7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J006860 Promoter 1.4 EPDnew Ensembl CraniofacialAtlas 500.2 +91.4 91357 1.7 SAP30 SMC3 MXI1 TAF1 CHD1 SUZ12 TBP CHD2 EGR1 EZH2 GRM7 GRM7-AS2 piR-31534-473 LOC105376945
GH03J006769 Promoter 1.3 EPDnew Ensembl 500.7 +0.1 100 1 CTCF REST CTBP1 NCOR1 CREB3L1 NKRF GABPA POLR2H ZBTB8A MNT GRM7 piR-33432-330 piR-46002-378 piR-57176-440 KY945935 GRM7-AS3
GH03J007305 Enhancer 0.7 Ensembl ENCODE 6.2 +538.5 538500 5.8 GATA3 NR2F2 STAT3 FOS RCOR1 RXRA GATA2 JUN POLR2A MAFK GRM7 piR-48209-499 piR-61101-472
GH03J007205 Enhancer 0.6 ENCODE 4.6 +436.0 435955 0.6 EP300 ARNT MEF2B IKZF1 BMI1 NR2F1 TBX21 MXI1 CUX1 ATF7 GRM7 HSALNG0023949 piR-40348-028
GH03J007271 Enhancer 0.5 Ensembl ENCODE 4.5 +502.2 502190 1.2 FOS JUN GRM7 piR-61101-471 ENSG00000288030
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRM7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRM7

Top Transcription factor binding sites by QIAGEN in the GRM7 gene promoter:
  • AP-4
  • AREB6
  • c-Myb
  • Egr-1
  • FOXL1
  • LCR-F1
  • Pax-6
  • POU2F1a
  • S8

Genomic Locations for GRM7 Gene

Genomic Locations for GRM7 Gene
971,533 bases
Plus strand
971,531 bases
Plus strand

Genomic View for GRM7 Gene

Genes around GRM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM7 Gene

Proteins for GRM7 Gene

  • Protein details for GRM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 7
    Protein Accession:
    Secondary Accessions:
    • Q8NFS2
    • Q8NFS3
    • Q8NFS4

    Protein attributes for GRM7 Gene

    915 amino acids
    Molecular mass:
    102251 Da
    Quaternary structure:
    • Interacts with PICK1.
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for GRM7 Gene

    Alternative splice isoforms for GRM7 Gene


neXtProt entry for GRM7 Gene

Post-translational modifications for GRM7 Gene

  • Glycosylation at Asn98, Asn458, Asn486, and Asn572
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRM7 Gene

Domains & Families for GRM7 Gene

Gene Families for GRM7 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRM7 Gene

  • G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
  • Extracellular ligand-binding receptor
  • Metabotropic glutamate receptor signature
  • Metabotropic glutamate receptor 7 signature

Suggested Antigen Peptide Sequences for GRM7 Gene

GenScript: Design optimal peptide antigens:
  • GRM7 protein (B7ZKK0_HUMAN)
  • GRM7 protein (B9EGG9_HUMAN)
  • Metabotropic glutamate receptor 7 (GRM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM7: view

Function for GRM7 Gene

Molecular function for GRM7 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Phenotypes From GWAS Catalog for GRM7 Gene

Gene Ontology (GO) - Molecular Function for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001642 group III metabotropic glutamate receptor activity IDA 9144652
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005246 calcium channel regulator activity IBA 21873635
GO:0008066 glutamate receptor activity IDA 9473604
GO:0010855 adenylate cyclase inhibitor activity IDA 9473604
genes like me logo Genes that share ontologies with GRM7: view
genes like me logo Genes that share phenotypes with GRM7: view

Animal Models for GRM7 Gene

MGI Knock Outs for GRM7:

miRNA for GRM7 Gene

miRTarBase miRNAs that target GRM7

Clone Products

  • Addgene plasmids for GRM7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM7 Gene

Localization for GRM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRM7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane NAS,IBA 9473604
GO:0005938 cell cortex IDA 9630572
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 12746871
genes like me logo Genes that share ontologies with GRM7: view

Pathways & Interactions for GRM7 Gene

genes like me logo Genes that share pathways with GRM7: view

Pathways by source for GRM7 Gene

3 Qiagen pathways for GRM7 Gene
  • CREB Pathway
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • Signaling in Gap Junctions

Gene Ontology (GO) - Biological Process for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 NOT behavioral fear response IMP 17167337
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA 9473604
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GRM7: view

No data available for SIGNOR curated interactions for GRM7 Gene

Drugs & Compounds for GRM7 Gene

(125) Drugs for GRM7 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Full agonist, Agonist, Target, antagonist 289
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist SR-2A inhibitor 528
Spaglumic acid Experimental Pharma Selective mGlu3 agonist 0
Fenobam Investigational Pharma Negative, Allosteric regulator 0
Kynurenic acid Investigational Pharma Agonist 4

(3) Additional Compounds for GRM7 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist

(5) Tocris Compounds for GRM7 Gene

Compound Action Cas Number
(RS)-PPG Potent, selective mGlu8 agonist 120667-15-4
(S)-3,4-DCPG Potent, selective mGlu8a agonist 201730-11-2
ACPT-I Group III mGlu agonist 194918-76-8
L-AP4 Selective group III mGlu agonist 23052-81-5
O-Phospho-L-serine Group III mGlu agonist 407-41-0

(102) ApexBio Compounds for GRM7 Gene

Compound Action Cas Number
(±)-LY 395756 852679-66-4
(±)-trans-ACPD 67684-64-4
(1S,3R)-ACPD 111900-32-4
(R)-3,4-DCPG 201730-10-1
(R)-3-Carboxy-4-hydroxyphenylglycine 13861-03-5
(RS)-3,4-DCPG 176796-64-8
(RS)-3,5-DHPG 19641-83-9
(RS)-3-Hydroxyphenylglycine 31932-87-3
(RS)-4-Carboxy-3-hydroxyphenylglycine 134052-66-7
(RS)-4-Carboxyphenylglycine 7292-81-1
(RS)-APICA 170847-18-4
(RS)-MCPG 146669-29-6
(RS)-MCPG disodium salt 1303994-09-3
(RS)-PPG 120667-15-4
(S)-3,4-DCPG 201730-11-2
(S)-3,5-DHPG 162870-29-3
(S)-3-Carboxy-4-hydroxyphenylglycine 55136-48-6
(S)-3-Hydroxyphenylglycine 71301-82-1
(S)-4-Carboxy-3-hydroxyphenylglycine 85148-82-9
(S)-4-Carboxyphenylglycine 134052-73-6
(S)-HexylHIBO 334887-48-8
(S)-MCPG 150145-89-4
2,4-Dihydroxyphenylacetyl-L-asparagine 111872-98-1
3-MATIDA 518357-51-2
ACDPP hydrochloride 37804-11-8
ACPT-I 194918-76-8
AIDA 168560-79-0
AMN 082 dihydrochloride MGlu7 agonist,first selective and potent 97075-46-2
BINA 866823-73-6
CBiPES hydrochloride 856702-40-4
CDPPB 781652-57-1
CHPG Sodium salt 1303993-73-8
Cinnabarinic acid 606-59-7
CPCCOEt 179067-99-3
CPPG 183364-82-1
D-AP4 78739-01-2
DCB 6971-97-7
DCG IV 147782-19-2
Desmethyl-YM 298198 1177767-57-5
DFB 15332-10-2
DL-AP4 20263-07-4
DL-AP4 Sodium salt 1263093-79-3
DMeOB 40252-74-2
E4CPG 170846-89-6
EGLU 170984-72-2
Fenobam 57653-26-6
HexylHIBO 334887-43-3
JNJ 16259685 409345-29-5
Kynurenic acid 492-27-3
Kynurenic acid sodium salt 2439-02-3
L-AP4 23052-81-5
L-AP6 78944-89-5
L-BMAA hydrochloride 16012-55-8
L-CCG-l 117857-93-9
LY 2389575 hydrochloride 885104-09-6
LY 354740 176199-48-7
LY 379268 disodium salt
LY 456236 hydrochloride 338736-46-2
LY 487379 hydrochloride 353229-59-1
MAP4 157381-42-5
MFZ 10-7 1224431-15-5
ML 289 1382481-79-9
ML 337 1443118-44-2
MMPIP hydrochloride 479077-02-6
MNI 137 946619-21-2
MNI-caged-L-glutamate 295325-62-1
MSOP 66515-29-5
MSPG 169209-64-7
MTPG 169209-66-9
N-Acetylglycyl-D-glutamic acid 135701-69-8
NPEC-caged-(1S,3R)-ACPD 1315379-60-2
NPEC-caged-(S)-3,4-DCPG 1257323-85-5
NPEC-caged-LY 379268
NPS 2390 226878-01-9
O-Phospho-L-serine 407-41-0
PHCCC 179068-02-1
Ro 01-6128 302841-86-7
Ro 64-5229 246852-46-0
Ro 67-4853 302841-89-0
Ro 67-7476 298690-60-5
Salsolinol-1-carboxylic acid 57256-34-5
SIB 1757 31993-01-8
SIB 1893 6266-99-5
Spaglumic acid 3106-85-2
S-Sulfo-L-cysteine sodium salt 7381-67-1
TC-N 22A 1314140-00-5
TCN 238 125404-04-8
UBP1112 339526-74-8
VU 0155041 1093757-42-6
VU 0155041 sodium salt 1259372-69-4
VU 0285683 327056-22-4
VU 0360172 hydrochloride 1309976-62-2
VU 0360223 1274859-33-4
VU 1545 890764-63-3
VU 29 890764-36-0
Xanthurenic acid 59-00-7
YM 202074 299900-84-8
YM 230888 446257-23-4
YM 298198 hydrochloride 1216398-09-2
Z-Cyclopentyl-AP4 103439-17-4
γDGG 6729-55-1
genes like me logo Genes that share compounds with GRM7: view

Drug Products

Transcripts for GRM7 Gene

mRNA/cDNA for GRM7 Gene

9 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GRM7

Alternative Splicing Database (ASD) splice patterns (SP) for GRM7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2: - - - - - -

Relevant External Links for GRM7 Gene

GeneLoc Exon Structure for

Expression for GRM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRM7 Gene

mRNA differential expression in normal tissues according to GTEx for GRM7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Hypothalamus (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Hippocampus (x5.1), Brain - Cortex (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for GRM7 Gene

This gene is overexpressed in Placenta (23.8), Heart (22.5), and Platelet (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRM7 Gene

Protein tissue co-expression partners for GRM7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRM7

SOURCE GeneReport for Unigene cluster for GRM7 Gene:


mRNA Expression by UniProt/SwissProt for GRM7 Gene:

Tissue specificity: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.

Evidence on tissue expression from TISSUES for GRM7 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with GRM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM7 Gene

Orthologs for GRM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GRM7 31
  • 100 (a)
LOC484674 30
  • 94.72 (n)
(Pan troglodytes)
Mammalia GRM7 31 30
  • 99.45 (n)
(Monodelphis domestica)
Mammalia GRM7 31
  • 93 (a)
(Bos Taurus)
Mammalia GRM7 31 30
  • 92.82 (n)
(Mus musculus)
Mammalia Grm7 17 31 30
  • 91.66 (n)
(Rattus norvegicus)
Mammalia Grm7 30
  • 91.51 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 71 (a)
(Gallus gallus)
Aves GRM7 31 30
  • 83.26 (n)
(Anolis carolinensis)
Reptilia GRM7 31
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grm7 30
  • 76.63 (n)
Str.3166 30
(Danio rerio)
Actinopterygii LOC100331190 30
  • 73.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glu-RA 32
  • 47 (a)
CG30361 32
  • 41 (a)
(Caenorhabditis elegans)
Secernentea mgl-3 30
  • 47.48 (n)
mgl-1 32
  • 38 (a)
Species where no ortholog for GRM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM7 Gene

Gene Tree for GRM7 (if available)
Gene Tree for GRM7 (if available)
Evolutionary constrained regions (ECRs) for GRM7: view image

Paralogs for GRM7 Gene

Paralogs for GRM7 Gene

(9) SIMAP similar genes for GRM7 Gene using alignment to 9 proteins:

  • C9JU97_HUMAN
  • H7C3K2_HUMAN
  • L8E797_HUMAN
genes like me logo Genes that share paralogs with GRM7: view

Variants for GRM7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRM7 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
709766 Benign: not provided 7,146,493(+) T/C SYNONYMOUS_VARIANT
710421 Benign: not provided 7,452,611(+) G/A SYNONYMOUS_VARIANT
714944 Likely Benign: not provided 6,861,466(+) C/T SYNONYMOUS_VARIANT
720769 Benign: not provided 7,680,174(+) G/C SYNONYMOUS_VARIANT
722285 Benign: not provided 6,861,469(+) G/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GRM7 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRM7 Gene

Variant ID Type Subtype PubMed ID
dgv4674n100 CNV gain 25217958
dgv4675n100 CNV gain 25217958
dgv8204n54 CNV loss 21841781
dgv8205n54 CNV loss 21841781
dgv8206n54 CNV loss 21841781
esv1005105 CNV insertion 20482838
esv1450820 CNV insertion 17803354
esv22695 CNV loss 19812545
esv2342652 CNV deletion 18987734
esv24058 CNV loss 19812545
esv2455660 CNV deletion 19546169
esv2590123 CNV insertion 19546169
esv2656815 CNV deletion 23128226
esv2660996 CNV deletion 23128226
esv2662447 CNV deletion 23128226
esv2664422 CNV deletion 23128226
esv2670179 CNV deletion 23128226
esv2674760 CNV deletion 23128226
esv2678085 CNV deletion 23128226
esv2724857 CNV deletion 23290073
esv2724858 CNV deletion 23290073
esv2724859 CNV deletion 23290073
esv2724860 CNV deletion 23290073
esv2724862 CNV deletion 23290073
esv2752015 CNV loss 17911159
esv2759128 CNV gain 17122850
esv2763214 CNV gain 21179565
esv28710 CNV gain 19812545
esv3304662 CNV mobile element insertion 20981092
esv3333219 CNV insertion 20981092
esv3561412 CNV deletion 23714750
esv3561418 CNV deletion 23714750
esv3561420 CNV deletion 23714750
esv3568597 CNV loss 25503493
esv3568599 CNV loss 25503493
esv3568600 CNV loss 25503493
esv3568601 CNV loss 25503493
esv3575541 CNV gain 25503493
esv3595176 CNV loss 21293372
esv3595177 CNV loss 21293372
esv3595181 CNV loss 21293372
esv3595182 CNV loss 21293372
esv3595183 CNV loss 21293372
esv3595185 CNV loss 21293372
esv3595187 CNV gain 21293372
esv3595189 CNV loss 21293372
esv3595190 CNV loss 21293372
esv3595191 CNV loss 21293372
esv3595196 CNV gain 21293372
esv3595197 CNV gain 21293372
esv3595198 CNV loss 21293372
esv3595199 CNV gain 21293372
esv3893653 CNV loss 25118596
esv3893654 CNV loss 25118596
esv3893655 CNV loss 25118596
esv3893658 CNV loss 25118596
esv5346 CNV loss 18987735
esv8633 CNV loss 19470904
esv9380 OTHER inversion 19470904
esv998955 CNV deletion 20482838
nsv1002130 CNV loss 25217958
nsv1006252 CNV gain 25217958
nsv1006339 CNV loss 25217958
nsv1006895 CNV gain 25217958
nsv1007359 CNV loss 25217958
nsv1013659 CNV loss 25217958
nsv1072236 CNV deletion 25765185
nsv1072662 CNV deletion 25765185
nsv1072663 CNV deletion 25765185
nsv1072664 CNV deletion 25765185
nsv1072816 CNV deletion 25765185
nsv1074566 CNV deletion 25765185
nsv1123619 CNV deletion 24896259
nsv1123620 CNV deletion 24896259
nsv1123621 CNV deletion 24896259
nsv1131677 CNV deletion 24896259
nsv1131678 CNV deletion 24896259
nsv236588 CNV deletion 16902084
nsv237180 CNV deletion 16902084
nsv237477 CNV deletion 16902084
nsv460377 CNV gain 19166990
nsv507081 OTHER sequence alteration 20534489
nsv518755 CNV loss 19592680
nsv524074 CNV loss 19592680
nsv524307 CNV loss 19592680
nsv526975 CNV loss 19592680
nsv589568 CNV gain 21841781
nsv589569 CNV gain 21841781
nsv589570 CNV loss 21841781
nsv589573 CNV gain 21841781
nsv589574 CNV loss 21841781
nsv589575 CNV loss 21841781
nsv589582 CNV loss 21841781
nsv589583 CNV loss 21841781
nsv589584 CNV gain 21841781
nsv589585 CNV loss 21841781
nsv818125 CNV loss 17921354
nsv818126 CNV loss 17921354
nsv834610 CNV gain 17160897
nsv956823 CNV deletion 24416366
nsv997695 CNV loss 25217958

Variation tolerance for GRM7 Gene

Residual Variation Intolerance Score: 7.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRM7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM7 Gene

Disorders for GRM7 Gene

MalaCards: The human disease database

(9) MalaCards diseases for GRM7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
age-related hearing loss
  • age-related hearing impairment
deafness, autosomal dominant 28
  • dfna28
attention deficit-hyperactivity disorder
  • adhd
panic disorder
  • panic disorder 1
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search GRM7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRM7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM7 Gene

Publications for GRM7 Gene

  1. Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. (PMID: 8840028) Makoff A … Emson P (Brain research. Molecular brain research 1996) 2 3 4 23 54
  2. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. (PMID: 19351574) Shibata H … Fukumaki Y (Psychiatry research 2009) 3 23 41 54
  3. A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population. (PMID: 19638256) Ganda C … Wildenauer DB (The international journal of neuropsychopharmacology 2009) 3 23 41 54
  4. GRM7 variants confer susceptibility to age-related hearing impairment. (PMID: 19047183) Friedman RA … Van Camp G (Human molecular genetics 2009) 3 23 41 54
  5. Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. (PMID: 18821564) Mick E … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41 54

Products for GRM7 Gene

  • Boster Bio Antibodies for GRM7
  • Boster Bio ELISA Kits for GRM7

Sources for GRM7 Gene