GRM3 Gene (Protein Coding)

Glutamate Metabotropic Receptor 3

GC07P086643
GIFtS:
47
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that ... See more...

Aliases for GRM3 Gene

Aliases for GRM3 Gene

  • Glutamate Metabotropic Receptor 3 2 3 5
  • GPRC1C 2 3 4
  • MGLUR3 2 3 4
  • Glutamate Receptor, Metabotropic 3 2 3
  • Metabotropic Glutamate Receptor 3 3 4
  • MGlu3 2 3
  • MGluR3 4
  • GLUR3 3
  • GRM3 5

External Ids for GRM3 Gene

Previous GeneCards Identifiers for GRM3 Gene

  • GC07P084809
  • GC07P085871
  • GC07P085886
  • GC07P085885
  • GC07P085917
  • GC07P086111
  • GC07P086274
  • GC07P080884

Summaries for GRM3 Gene

Entrez Gene Summary for GRM3 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM3 Gene

GRM3 (Glutamate Metabotropic Receptor 3) is a Protein Coding gene. Diseases associated with GRM3 include Bipolar I Disorder and Bipolar Disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM2.

UniProtKB/Swiss-Prot Summary for GRM3 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM3 Gene

  • Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Gene Wiki entry for GRM3 Gene

Additional gene information for GRM3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRM3 Gene

Genomics for GRM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GRM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J086643 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.1 92 2 SIN3A ZNF341 ZBTB48 REST TAF1 ZBTB21 GLIS1 GATA2 L3MBTL2 ZNF560 GRM3 HSALNG0059351 CROT TP53TG1 ELAPOR2
GH07J086653 Promoter/Enhancer 0.7 Ensembl dbSUPER 250.7 +1.4 1392 0.2 EGR2 EZH2 ZFHX2 GRM3 HSALNG0059351 ENSG00000231255 ELAPOR2
GH07J086665 Promoter/Enhancer 0.5 EPDnew dbSUPER 261.8 +21.7 21693 0.1 GRM3 HSALNG0059351 ENSG00000231255 ELAPOR2
GH07J086651 Promoter/Enhancer 0.7 FANTOM5 Ensembl dbSUPER 21.1 +2.2 2191 1 HSALNG0059351 GRM3 ELAPOR2 ENSG00000231255
GH07J086667 Enhancer 0.7 Ensembl ENCODE dbSUPER 11.6 +24.4 24392 1.8 CTCF RAD21 ZNF654 GRM3 HSALNG0059351 ENSG00000231255 ELAPOR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRM3

Top Transcription factor binding sites by QIAGEN in the GRM3 gene promoter:
  • CREB
  • deltaCREB
  • Evi-1
  • HSF1 (long)
  • IRF-1
  • LCR-F1
  • Sox5
  • SRY

Genomic Locations for GRM3 Gene

Latest Assembly
chr7:86,643,909-86,864,884
(GRCh38/hg38)
Size:
220,976 bases
Orientation:
Plus strand

Previous Assembly
chr7:86,273,225-86,494,195
(GRCh37/hg19 by Entrez Gene)
Size:
220,971 bases
Orientation:
Plus strand

chr7:86,273,230-86,494,200
(GRCh37/hg19 by Ensembl)
Size:
220,971 bases
Orientation:
Plus strand

Genomic View for GRM3 Gene

Genes around GRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRM3 Gene

Proteins for GRM3 Gene

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  • Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14832-GRM3_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 3
    Protein Accession:
    Q14832
    Secondary Accessions:
    • Q2PNZ6
    • Q75MV4
    • Q75N17
    • Q86YG6
    • Q8TBH9

    Protein attributes for GRM3 Gene

    Size:
    879 amino acids
    Molecular mass:
    98879 Da
    Quaternary structure:
    • Interacts with TAMALIN.
    SequenceCaution:
    • Sequence=AAD15616.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain.

    Three dimensional structures from OCA and Proteopedia for GRM3 Gene

    Alternative splice isoforms for GRM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM3 Gene

Protein Expression for GRM3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRM3 Gene

  • Glycosylation at Asn209, Asn292, Asn414, and Asn439
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRM3 Gene

Domains & Families for GRM3 Gene

Gene Families for GRM3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRM3 Gene

InterPro:
Blocks:
  • Metabotropic glutamate receptor signature
  • G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
  • Metabotropic glutamate receptor 3 signature
  • Extracellular ligand-binding receptor
ProtoNet:

Suggested Antigen Peptide Sequences for GRM3 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor, metabotropic 3, isoform CRA_b (A4D1D0_HUMAN)
  • cDNA FLJ57103, highly similar to Metabotropic glutamate receptor 3 (B7Z204_HUMAN)
  • Metabotropic glutamate receptor 3 (GRM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14832

UniProtKB/Swiss-Prot:

GRM3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM3: view

Function for GRM3 Gene

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  6. Cell Lines for research

Molecular function for GRM3 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
GENATLAS Biochemistry:
metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade

Phenotypes From GWAS Catalog for GRM3 Gene

Gene Ontology (GO) - Molecular Function for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA 21873635
GO:0001641 group II metabotropic glutamate receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA,TAS 8840013
GO:0005246 calcium channel regulator activity IEA --
GO:0008066 glutamate receptor activity TAS 8840013
genes like me logo Genes that share ontologies with GRM3: view
genes like me logo Genes that share phenotypes with GRM3: view

Animal Models for GRM3 Gene

MGI Knock Outs for GRM3:
  • Grm3 Grm3<tm1Dgen>
  • Grm3 Grm3<tm1Vbn>
  • Grm3 Grm3<tm1b(KOMP)Wtsi>
  • Grm3 Grm3<tm1Ddsc>

Animal Models for research

  • Taconic Biosciences Mouse Models for GRM3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM3 Gene

Localization for GRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRM3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM3 Gene

Pathways & Interactions for GRM3 Gene

genes like me logo Genes that share pathways with GRM3: view

Pathways by source for GRM3 Gene

1 BioSystems pathway for GRM3 Gene
3 Qiagen pathways for GRM3 Gene
  • CREB Pathway
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • Signaling in Gap Junctions

Gene Ontology (GO) - Biological Process for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007194 negative regulation of adenylate cyclase activity TAS 8840013
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA --
GO:0007216 G protein-coupled glutamate receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GRM3: view

No data available for SIGNOR curated interactions for GRM3 Gene

Drugs & Compounds for GRM3 Gene

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(128) Drugs for GRM3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Agonist, Full agonist, antagonist 320
Risperidone Approved, Investigational Pharma SR-2A inhibitor 545
L-Glutamine Approved, Investigational Nutra 0
Spaglumic acid Experimental Pharma Selective mGlu3 agonist 0
(S)-MCPG Experimental Pharma 0

(10) Additional Compounds for GRM3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRM3 Gene

Compound Action Cas Number
DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist 147782-19-2
L-CCG-l Potent group II mGlu agonist 117857-93-9
MAP4 Potent group II mGlu agonist. Also specific group III mGlu antagonist 157381-42-5
Spaglumic acid Selective mGlu3 agonist 3106-85-2
Xanthurenic acid Selectively activates group II mGlu receptors 59-00-7

(101) ApexBio Compounds for GRM3 Gene

Compound Action Cas Number
(±)-LY 395756 852679-66-4
(±)-trans-ACPD 67684-64-4
(1S,3R)-ACPD 111900-32-4
(R)-3,4-DCPG 201730-10-1
(R)-3-Carboxy-4-hydroxyphenylglycine 13861-03-5
(RS)-3,4-DCPG 176796-64-8
(RS)-3,5-DHPG 19641-83-9
(RS)-3-Hydroxyphenylglycine 31932-87-3
(RS)-4-Carboxy-3-hydroxyphenylglycine 134052-66-7
(RS)-4-Carboxyphenylglycine 7292-81-1
(RS)-APICA 170847-18-4
(RS)-MCPG 146669-29-6
(RS)-MCPG disodium salt 1303994-09-3
(RS)-PPG 120667-15-4
(S)-3,4-DCPG 201730-11-2
(S)-3,5-DHPG 162870-29-3
(S)-3-Carboxy-4-hydroxyphenylglycine 55136-48-6
(S)-3-Hydroxyphenylglycine 71301-82-1
(S)-4-Carboxy-3-hydroxyphenylglycine 85148-82-9
(S)-4-Carboxyphenylglycine 134052-73-6
(S)-HexylHIBO 334887-48-8
(S)-MCPG 150145-89-4
3-MATIDA 518357-51-2
ACDPP hydrochloride 37804-11-8
ACPT-I 194918-76-8
AIDA 168560-79-0
BINA 866823-73-6
CBiPES hydrochloride 856702-40-4
CDPPB 781652-57-1
CHPG Sodium salt 1303993-73-8
Cinnabarinic acid 606-59-7
CPCCOEt 179067-99-3
CPPG 183364-82-1
D-AP4 78739-01-2
DCB 6971-97-7
DCG IV 147782-19-2
Desmethyl-YM 298198 1177767-57-5
DFB 15332-10-2
DL-AP4 20263-07-4
DL-AP4 Sodium salt 1263093-79-3
DMeOB 40252-74-2
E4CPG 170846-89-6
EGLU 170984-72-2
Fenobam 57653-26-6
HexylHIBO 334887-43-3
JNJ 16259685 409345-29-5
Kynurenic acid 492-27-3
Kynurenic acid sodium salt 2439-02-3
L-AP4 23052-81-5
L-AP6 78944-89-5
L-BMAA hydrochloride 16012-55-8
L-CCG-l 117857-93-9
L-Glutamine 56-85-9
LY 2389575 hydrochloride 885104-09-6
LY 354740 176199-48-7
LY 456236 hydrochloride 338736-46-2
LY 487379 hydrochloride 353229-59-1
LY341495 Metabotropic glutamate receptor antagonist 201943-63-7
MAP4 157381-42-5
MFZ 10-7 1224431-15-5
ML 289 1382481-79-9
ML 337 1443118-44-2
MMPIP hydrochloride 479077-02-6
MNI 137 946619-21-2
MNI-caged-L-glutamate 295325-62-1
MSOP 66515-29-5
MSPG 169209-64-7
MTPG 169209-66-9
N-Acetylglycyl-D-glutamic acid 135701-69-8
NPEC-caged-(1S,3R)-ACPD 1315379-60-2
NPEC-caged-(S)-3,4-DCPG 1257323-85-5
NPEC-caged-LY 379268
NPS 2390 226878-01-9
O-Phospho-L-serine 407-41-0
PHCCC 179068-02-1
Ro 01-6128 302841-86-7
Ro 64-5229 246852-46-0
Ro 67-4853 302841-89-0
Ro 67-7476 298690-60-5
RuBi-Glutamate
Salsolinol-1-carboxylic acid 57256-34-5
SIB 1757 31993-01-8
SIB 1893 6266-99-5
Spaglumic acid 3106-85-2
S-Sulfo-L-cysteine sodium salt 7381-67-1
TC-N 22A 1314140-00-5
TCN 238 125404-04-8
UBP1112 339526-74-8
VU 0155041 1093757-42-6
VU 0155041 sodium salt 1259372-69-4
VU 0285683 327056-22-4
VU 0360172 hydrochloride 1309976-62-2
VU 0360223 1274859-33-4
VU 1545 890764-63-3
VU 29 890764-36-0
Xanthurenic acid 59-00-7
YM 202074 299900-84-8
YM 230888 446257-23-4
YM 298198 hydrochloride 1216398-09-2
Z-Cyclopentyl-AP4 103439-17-4
γDGG 6729-55-1
genes like me logo Genes that share compounds with GRM3: view

Drug products for research

Transcripts for GRM3 Gene

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mRNA/cDNA for GRM3 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRM3

Alternative Splicing Database (ASD) splice patterns (SP) for GRM3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for GRM3 Gene

GeneLoc Exon Structure for
GRM3

Expression for GRM3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRM3 Gene

mRNA expression in normal human tissues for GRM3 Gene
mRNA expression by BioGPS for GRM3 GenemRNA expression by GTEx for GRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.7), Brain - Caudate (basal ganglia) (x6.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM3 Gene

This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRM3 Gene



Protein tissue co-expression partners for GRM3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRM3

SOURCE GeneReport for Unigene cluster for GRM3 Gene:

Hs.590575

mRNA Expression by UniProt/SwissProt for GRM3 Gene:

Q14832-GRM3_HUMAN
Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.

Evidence on tissue expression from TISSUES for GRM3 Gene

  • Nervous system(5)
  • Blood(4.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with GRM3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM3 Gene

Orthologs for GRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GRM3 30 31
  • 99.73 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GRM3 31
  • 95 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GRM3 30 31
  • 92.07 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GRM3 30 31
  • 92.03 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Grm3 30
  • 89.95 (n)
Mouse
(Mus musculus)
 Mammalia Grm3 30 17 31
  • 89.65 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GRM3 31
  • 87 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves GRM3 30 31
  • 79.98 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GRM3 31
  • 87 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia grm3 30
  • 74.07 (n)
Zebrafish
(Danio rerio)
 Actinopterygii grm3 30 31
  • 71.31 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta mGluRA 30 31
  • 54.48 (n)
 OneToMany
Glu-RA 32
  • 49 (a)
CG30361 32
  • 39 (a)
Worm
(Caenorhabditis elegans)
 Secernentea mgl-1 30 31 32
  • 50.54 (n)
 OneToMany
Species where no ortholog for GRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRM3 Gene

ENSEMBL:
Gene Tree for GRM3 (if available)
TreeFam:
Gene Tree for GRM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRM3: view image

Paralogs for GRM3 Gene

Paralogs for GRM3 Gene

(11) SIMAP similar genes for GRM3 Gene using alignment to 7 proteins:

  • GRM3_HUMAN
  • A4D1D0_HUMAN
  • B7Z204_HUMAN
  • C9J2I2_HUMAN
  • C9JIT1_HUMAN
  • C9JUH9_HUMAN
  • F5GYZ2_HUMAN
genes like me logo Genes that share paralogs with GRM3: view

Variants for GRM3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRM3 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs112184476 Benign: not provided 86,839,542(+) C/T
NM_000840.2(GRM3):c.2028C>T (p.Gly676=) 		SYNONYMOUS_VARIANT,INTRON
rs112722806 Likely Benign: not provided 86,838,987(+) G/A
NM_000840.2(GRM3):c.1473G>A (p.Ser491=) 		SYNONYMOUS_VARIANT,INTRON
rs138568176 Likely Benign: not provided 86,839,743(+) C/T
NM_000840.2(GRM3):c.2229C>T (p.Tyr743=) 		SYNONYMOUS_VARIANT,INTRON
rs17161027 Likely Benign: not provided 86,839,434(+) C/T
NM_000840.2(GRM3):c.1920C>T (p.Ile640=) 		SYNONYMOUS_VARIANT,INTRON
rs56763064 Benign: not provided 86,765,277(+) G/A
NM_000840.2(GRM3):c.132G>A (p.Leu44=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GRM3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GRM3 Gene

Variant ID Type Subtype PubMed ID
dgv1310e214 CNV gain 21293372
esv2504097 CNV deletion 19546169
esv2667611 CNV deletion 23128226
esv3305507 CNV mobile element insertion 20981092
esv3307636 CNV mobile element insertion 20981092
esv3309610 CNV mobile element insertion 20981092
esv3326124 CNV insertion 20981092
esv3360307 CNV insertion 20981092
esv3373913 CNV insertion 20981092
esv3614018 CNV loss 21293372
esv3614020 CNV loss 21293372
esv7104 CNV gain 19470904
nsv478422 CNV novel sequence insertion 20440878
nsv824201 CNV loss 20364138
nsv831053 CNV gain 17160897

Variation tolerance for GRM3 Gene

Residual Variation Intolerance Score: 4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRM3 Gene

Human Gene Mutation Database (HGMD)
GRM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRM3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene

Disorders for GRM3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GRM3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
bipolar i disorder
bipolar disorder
  • bipolar depression
schizophrenia
  • sczd
status epilepticus
  • grand mal status
major depressive disorder
  • mdd
- elite association - COSMIC cancer census association via MalaCards
Search GRM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene

Publications for GRM3 Gene

  1. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) Jönsson EG … Terenius L (Neuropsychobiology 2009) 3 23 41
  2. Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PMID: 19386277) Tsunoka T … Iwata N (Progress in neuro-psychopharmacology & biological psychiatry 2009) 3 23 41
  3. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. (PMID: 18197082) Schwab SG … Wildenauer DB (Psychiatric genetics 2008) 3 23 41
  4. Alternative splicing of human metabotropic glutamate receptor 3. (PMID: 16417579) Sartorius LJ … Harrison PJ (Journal of neurochemistry 2006) 3 4 23
  5. No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population. (PMID: 16904291) Tochigi M … Sasaki T (Schizophrenia research 2006) 3 23 41

ExternalLinks

View latest publications for GRM3 gene in Mastermind

Products for GRM3 Gene

  • Addgene plasmids for GRM3

Sources for GRM3 Gene