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Aliases for GRM3 Gene

Aliases for GRM3 Gene

  • Glutamate Metabotropic Receptor 3 2 3 5
  • Glutamate Receptor, Metabotropic 3 2 3
  • GPRC1C 3 4
  • MGLUR3 3 4
  • Metabotropic Glutamate Receptor 3 3
  • MGluR3 4
  • GLUR3 3
  • MGlu3 3

External Ids for GRM3 Gene

Previous GeneCards Identifiers for GRM3 Gene

  • GC07P084809
  • GC07P085871
  • GC07P085886
  • GC07P085885
  • GC07P085917
  • GC07P086111
  • GC07P086274
  • GC07P080884

Summaries for GRM3 Gene

Entrez Gene Summary for GRM3 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM3 Gene

GRM3 (Glutamate Metabotropic Receptor 3) is a Protein Coding gene. Diseases associated with GRM3 include Schizophrenia and Bipolar Disorder. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM2.

UniProtKB/Swiss-Prot for GRM3 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM3 Gene

  • Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Gene Wiki entry for GRM3 Gene

Additional gene information for GRM3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM3 Gene

Genomics for GRM3 Gene

GeneHancer (GH) Regulatory Elements for GRM3 Gene

Promoters and enhancers for GRM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J086644 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.7 +0.8 826 0.3 ZSCAN4 REST ZBTB8A ZNF560 HIC1 ZBTB48 ZNF341 ZNF600 EGR2 GRM3 GC07P086675
GH07J086643 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 650.7 -0.1 -84 0.2 PKNOX1 RFX1 L3MBTL2 ZBTB21 MAX SIN3A ZNF335 POLR2A ZBTB48 GLIS1 GRM3 GC07P086479
GH07J086645 Enhancer 0.8 ENCODE dbSUPER 650.7 +0.1 126 0.2 RFX1 L3MBTL2 MAX SIN3A ZNF335 ZBTB48 POLR2A GLIS1 ZNF600 ZBTB17 GRM3 GC07P086675
GH07J086665 Promoter/Enhancer 0.7 EPDnew dbSUPER 661.8 +21.7 21688 0.1 GRM3 GC07P086675
GH07J086647 Enhancer 0.7 ENCODE dbSUPER 650.7 +0.5 506 0.2 HIC1 ZNF335 ZNF341 SIN3A ZNF600 GRM3 GC07P086675
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRM3 gene promoter:
  • CREB
  • deltaCREB
  • LCR-F1
  • SRY
  • Evi-1
  • HSF1 (long)
  • Sox5
  • IRF-1

Genomic Locations for GRM3 Gene

Genomic Locations for GRM3 Gene
chr7:86,643,914-86,864,884
(GRCh38/hg38)
Size:
220,971 bases
Orientation:
Plus strand
chr7:86,273,230-86,494,200
(GRCh37/hg19)
Size:
220,971 bases
Orientation:
Plus strand

Genomic View for GRM3 Gene

Genes around GRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM3 Gene

Proteins for GRM3 Gene

  • Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14832-GRM3_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 3
    Protein Accession:
    Q14832
    Secondary Accessions:
    • Q2PNZ6
    • Q75MV4
    • Q75N17
    • Q86YG6
    • Q8TBH9

    Protein attributes for GRM3 Gene

    Size:
    879 amino acids
    Molecular mass:
    98879 Da
    Quaternary structure:
    • Interacts with GRASP.
    SequenceCaution:
    • Sequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRM3 Gene

    Alternative splice isoforms for GRM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM3 Gene

Post-translational modifications for GRM3 Gene

  • Glycosylation at Asn439, Asn414, isoforms=2292, and Asn209
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM3 Gene

No data available for DME Specific Peptides for GRM3 Gene

Domains & Families for GRM3 Gene

Gene Families for GRM3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q14832

UniProtKB/Swiss-Prot:

GRM3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM3: view

Function for GRM3 Gene

Molecular function for GRM3 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
GENATLAS Biochemistry:
metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade

Phenotypes From GWAS Catalog for GRM3 Gene

Gene Ontology (GO) - Molecular Function for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001641 group II metabotropic glutamate receptor activity IEA --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA 8840013
GO:0005246 calcium channel regulator activity IEA --
GO:0008066 glutamate receptor activity TAS 8840013
genes like me logo Genes that share ontologies with GRM3: view
genes like me logo Genes that share phenotypes with GRM3: view

Animal Models for GRM3 Gene

MGI Knock Outs for GRM3:
  • Grm3 Grm3<tm1b(KOMP)Wtsi>
  • Grm3 Grm3<tm1Vbn>
  • Grm3 Grm3<tm1Ddsc>
  • Grm3 Grm3<tm1Dgen>

Animal Model Products

  • Taconic Biosciences Mouse Models for GRM3

Clone Products

  • Addgene plasmids for GRM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM3 Gene

Localization for GRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8840013
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRM3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM3 Gene

Pathways & Interactions for GRM3 Gene

genes like me logo Genes that share pathways with GRM3: view

Gene Ontology (GO) - Biological Process for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007194 negative regulation of adenylate cyclase activity TAS 8840013
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA --
GO:0007216 G-protein coupled glutamate receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GRM3: view

No data available for SIGNOR curated interactions for GRM3 Gene

Drugs & Compounds for GRM3 Gene

(132) Drugs for GRM3 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Spaglumic acid Approved Pharma Selective mGlu3 agonist 0
Glutamic Acid Approved Nutra Full agonist, Agonist, antagonist 251
Heroin Approved, Illicit, Investigational Pharma 116
Risperidone Approved, Investigational Pharma Antagonist, Inverse agonist SR-2A inhibitor 498
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0

(8) Additional Compounds for GRM3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRM3 Gene

Compound Action Cas Number
DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist 147782-19-2
L-CCG-l Potent group II mGlu agonist 117857-93-9
MAP4 Potent group II mGlu agonist. Also specific group III mGlu antagonist 157381-42-5
Spaglumic acid Selective mGlu3 agonist 3106-85-2
Xanthurenic acid Selectively activates group II mGlu receptors 59-00-7
genes like me logo Genes that share compounds with GRM3: view

Transcripts for GRM3 Gene

mRNA/cDNA for GRM3 Gene

Unigene Clusters for GRM3 Gene

Glutamate receptor, metabotropic 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRM3

Alternative Splicing Database (ASD) splice patterns (SP) for GRM3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for GRM3 Gene

GeneLoc Exon Structure for
GRM3
ECgene alternative splicing isoforms for
GRM3

Expression for GRM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.7), Brain - Caudate (basal ganglia) (x6.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM3 Gene

This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRM3 Gene



Protein tissue co-expression partners for GRM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRM3 Gene:

GRM3

SOURCE GeneReport for Unigene cluster for GRM3 Gene:

Hs.590575

mRNA Expression by UniProt/SwissProt for GRM3 Gene:

Q14832-GRM3_HUMAN
Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.

Evidence on tissue expression from TISSUES for GRM3 Gene

  • Nervous system(5)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with GRM3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM3 Gene

Orthologs for GRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRM3 34 33
  • 99.73 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRM3 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRM3 34 33
  • 92.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRM3 34 33
  • 92.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grm3 33
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Grm3 16 34 33
  • 89.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRM3 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRM3 34 33
  • 79.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRM3 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grm3 33
  • 74.07 (n)
zebrafish
(Danio rerio)
Actinopterygii grm3 34 33
  • 71.31 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mGluRA 34 33
  • 54.48 (n)
OneToMany
Glu-RA 35
  • 49 (a)
CG30361 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea mgl-1 34 35 33
  • 50.54 (n)
OneToMany
Species where no ortholog for GRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM3 Gene

ENSEMBL:
Gene Tree for GRM3 (if available)
TreeFam:
Gene Tree for GRM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRM3: view image

Paralogs for GRM3 Gene

Paralogs for GRM3 Gene

(11) SIMAP similar genes for GRM3 Gene using alignment to 7 proteins:

  • GRM3_HUMAN
  • A4D1D0_HUMAN
  • B7Z204_HUMAN
  • C9J2I2_HUMAN
  • C9JIT1_HUMAN
  • C9JUH9_HUMAN
  • F5GYZ2_HUMAN
genes like me logo Genes that share paralogs with GRM3: view

Variants for GRM3 Gene

Sequence variations from dbSNP and Humsavar for GRM3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000010616 -- 86,729,603(+) A/T intron_variant
rs1000011289 -- 86,831,072(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000020645 -- 86,741,268(+) C/T intron_variant
rs1000041374 -- 86,696,607(+) T/C intron_variant
rs1000048024 -- 86,799,986(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRM3 Gene

Variant ID Type Subtype PubMed ID
dgv1310e214 CNV gain 21293372
esv2504097 CNV deletion 19546169
esv2667611 CNV deletion 23128226
esv3305507 CNV mobile element insertion 20981092
esv3307636 CNV mobile element insertion 20981092
esv3309610 CNV mobile element insertion 20981092
esv3326124 CNV insertion 20981092
esv3360307 CNV insertion 20981092
esv3373913 CNV insertion 20981092
esv3614018 CNV loss 21293372
esv3614020 CNV loss 21293372
esv7104 CNV gain 19470904
nsv478422 CNV novel sequence insertion 20440878
nsv824201 CNV loss 20364138
nsv831053 CNV gain 17160897

Variation tolerance for GRM3 Gene

Residual Variation Intolerance Score: 4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRM3 Gene

Human Gene Mutation Database (HGMD)
GRM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene

Disorders for GRM3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRM3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
bipolar disorder
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search GRM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene

Publications for GRM3 Gene

  1. Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PMID: 19386277) Tsunoka T … Iwata N (Progress in neuro-psychopharmacology & biological psychiatry 2009) 3 22 44 58
  2. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) Jönsson EG … Terenius L (Neuropsychobiology 2009) 3 22 44 58
  3. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. (PMID: 18197082) Schwab SG … Wildenauer DB (Psychiatric genetics 2008) 3 22 44 58
  4. Alternative splicing of human metabotropic glutamate receptor 3. (PMID: 16417579) Sartorius LJ … Harrison PJ (Journal of neurochemistry 2006) 3 4 22 58
  5. Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex. (PMID: 16585454) Marenco S … Weinberger DR (The American journal of psychiatry 2006) 3 22 44 58

Products for GRM3 Gene

  • Addgene plasmids for GRM3

Sources for GRM3 Gene

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