Aliases for GRM3 Gene
Aliases for GRM3 Gene
External Ids for GRM3 Gene
- HGNC: 4595
- Entrez Gene: 2913
- Ensembl: ENSG00000198822
- OMIM: 601115
- UniProtKB: Q14832
Previous GeneCards Identifiers for GRM3 Gene
- GC07P084809
- GC07P085871
- GC07P085886
- GC07P085885
- GC07P085917
- GC07P086111
- GC07P086274
- GC07P080884
Summaries for GRM3 Gene
-
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRM3 Gene
GRM3 (Glutamate Metabotropic Receptor 3) is a Protein Coding gene. Diseases associated with GRM3 include Schizophrenia and Bipolar Disorder. Among its related pathways are Circadian entrainment and GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM2.
UniProtKB/Swiss-Prot for GRM3 Gene
-
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
-
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.
Additional gene information for GRM3 Gene
- Monarch Initiative
- Search for GRM3 at DataMed
- Search for GRM3 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM3 Gene
Genomics for GRM3 Gene
GeneHancer (GH) Regulatory Elements for GRM3 Gene
Promoters and enhancers for GRM3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I086643 | Promoter/Enhancer | 1.3 | EPDnew ENCODE dbSUPER | 550.8 | -0.1 | -84 | 0.2 | PKNOX1 RFX1 L3MBTL2 ZBTB21 MAX SIN3A ZNF335 POLR2A ZBTB48 GLIS1 | GRM3 LOC105375381 | |
| GH07I086644 | Enhancer | 0.8 | ENCODE dbSUPER | 550.8 | +0.8 | 826 | 0.3 | ZSCAN4 REST ZBTB8A ZNF560 HIC1 ZBTB48 ZNF341 ZNF600 EGR2 EZH2 | GRM3 GC07P086675 | |
| GH07I086645 | Enhancer | 0.8 | ENCODE dbSUPER | 550.8 | +0.1 | 126 | 0.2 | RFX1 L3MBTL2 MAX SIN3A ZNF335 ZBTB48 POLR2A GLIS1 ZNF600 ZBTB17 | GRM3 GC07P086675 | |
| GH07I086647 | Enhancer | 0.7 | ENCODE dbSUPER | 550.8 | +0.5 | 506 | 0.2 | HIC1 ZNF335 ZNF341 SIN3A ZNF600 EZH2 | GRM3 GC07P086675 | |
| GH07I086691 | Promoter | 0.5 | EPDnew | 561.1 | +47.2 | 47171 | 0.1 | GRM3 GC07P086688 GC07P086675 ENSG00000231255 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GRM3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GRM3 gene promoter:
Regulatory Element Products
Genomic Locations for GRM3 Gene
Genomic Locations for GRM3 Gene
- chr7:86,643,914-86,864,884
- (GRCh38/hg38)
- Size:
- 220,971 bases
- Orientation:
- Plus strand
- chr7:86,273,230-86,494,200
- (GRCh37/hg19)
Genomic View for GRM3 Gene
Genes around GRM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q21.11 by Ensembl
- 7q21.11-q21.12 by Entrez Gene
- 7q21.11-q21.12 by HGNC
GRM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRM3 Gene
Proteins for GRM3 Gene
-
Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14832-GRM3_HUMAN
- Recommended name:
- Metabotropic glutamate receptor 3
- Protein Accession:
- Q14832
- Q2PNZ6
- Q75MV4
- Q75N17
- Q86YG6
- Q8TBH9
Protein attributes for GRM3 Gene
- Size:
- 879 amino acids
- Molecular mass:
- 98879 Da
- Quaternary structure:
-
- Interacts with GRASP.
- SequenceCaution:
-
- Sequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for GRM3 Gene
Protein Expression for GRM3 Gene
Post-translational modifications for GRM3 Gene
- Glycosylation at isoforms=2209, isoforms=2292, isoforms=2414, and isoforms=2439
Other Protein References for GRM3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GRM3 (mGluR3)
- Novus Biologicals Antibodies for GRM3
-
Abcam antibodies for GRM3
-
Cloud-Clone Corp. Antibodies for GRM3
- Invitrogen Antibodies for GRM3
- GeneTex GRM3 antibody for GRM3
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRM3
Protein Products
- R&D Systems Proteins and Enzymes for GRM3 (mGluR3)
-
OriGene Purified Proteins for GRM3
- Search Origene for MassSpec and Protein Over-expression Lysates for GRM3
- Origene Custom Protein Services for GRM3
- Novus Biologicals lysates for GRM3
-
Cloud-Clone Corp. Proteins for GRM3
- Search GeneTex for Proteins for GRM3
-
Abcam proteins for GRM3
Assay Products
- antibodies-online: Search results for 11 available GRIA3 Elisa Kits ranked by validation data
- Compare Top GRIA3 Elisa Kits
-
Recommended
- 1 Sheep (Ovine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Mouse (Murine) ELISA Kit
- 1 Monkey ELISA Kit
- 1 Human ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Chicken ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Pig (Porcine) ELISA Kit
- 1 Mouse (Murine) ELISA Kit
- 1 Monkey ELISA Kit
- 1 Human ELISA Kit
- 1 Guinea Pig ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Chicken ELISA Kit
No data available for DME Specific Peptides for GRM3 Gene
Domains & Families for GRM3 Gene
Gene Families for GRM3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for GRM3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRM3 Gene
Graphical View of Domain Structure for InterPro Entry
Q14832- Family:
-
- Belongs to the G-protein coupled receptor 3 family.
Function for GRM3 Gene
Molecular function for GRM3 Gene
- GENATLAS Biochemistry:
- metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade
- UniProtKB/Swiss-Prot Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Phenotypes From GWAS Catalog for GRM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001641 | group II metabotropic glutamate receptor activity | IEA | -- |
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | TAS,IEA | 8840013 |
| GO:0005246 | calcium channel regulator activity | IEA | -- |
| GO:0008066 | glutamate receptor activity | TAS | 8840013 |
Phenotypes for GRM3 Gene
- MGI mutant phenotypes for GRM3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GRM3:
Animal Models for GRM3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRM3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GRM3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM3 gene
- Search ViGene Biosciences for GRM3
CRISPR Products
-
OriGene CRISPR knockouts for GRM3
- genomics-online: gRNA clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- Applied Biological Materials CRISPR for GRM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRM3
- GenScript: Design CRISPR guide RNA sequences for GRM3
miRNA for GRM3 Gene
- miRTarBase miRNAs that target GRM3
miRNA Products
- Search ViGene Biosciences for GRM3
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GRM3
- Browse OriGene Inhibitory RNA Products For GRM3
- genomics-online: shRNA clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM3 gene
Clone Products
- Sino Biological Human cDNA Clone for GRM3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GRM3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRM3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRM3
- genomics-online: cdna clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- orf clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- Applied Biological Materials Clones for GRM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRM3 (mGluR3)
Cell Line Products
-
Horizon Cell Lines for GRM3
-
ViGene Biosciences adenoviral particle packaged cDNA for GRM3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GRM3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM3 Gene
Localization for GRM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8840013 |
| GO:0014069 | postsynaptic density | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRM3 Gene
Pathways & Interactions for GRM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Circadian entrainment | ||
| 4 | Amphetamine addiction | ||
| 5 | Phospholipase D signaling pathway | ||
Pathways by source for GRM3 Gene
1 BioSystems pathway for GRM3 Gene
6 Reactome pathways for GRM3 Gene
4 KEGG pathways for GRM3 Gene
2 R&D Systems pathways for GRM3 Gene
3 Qiagen pathways for GRM3 Gene
Interacting Proteins for GRM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | 8840013 |
| GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway | IEA | -- |
| GO:0007216 | G-protein coupled glutamate receptor signaling pathway | IBA | -- |
No data available for SIGNOR curated interactions for GRM3 Gene
Drugs & Compounds for GRM3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist, antagonist | 251 | ||
| Heroin | Approved, Illicit, Investigational | Pharma | 116 | |||
| Risperidone | Approved, Investigational | Pharma | Antagonist | SR-2A inhibitor | 498 | |
| Spaglumic acid | Approved | Pharma | 0 | |||
| L-Glutamine | Approved, Investigational | Nutra | Full agonist, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for GRM3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DCG IV | Very potent, selective group II mGlu agonist. Also NMDA agonist | 147782-19-2 |
| L-CCG-l | Potent group II mGlu agonist | 117857-93-9 |
| MAP4 | Potent group II mGlu agonist. Also specific group III mGlu antagonist | 157381-42-5 |
| Spaglumic acid | Selective mGlu3 agonist | 3106-85-2 |
| Xanthurenic acid | Selectively activates group II mGlu receptors | 59-00-7 |
(103) ApexBio Compounds for GRM3 Gene
Transcripts for GRM3 Gene
mRNA/cDNA for GRM3 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRM3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GRM3
- genomics-online: gRNA clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- Applied Biological Materials CRISPR for GRM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRM3
- GenScript: Design CRISPR guide RNA sequences for GRM3
miRNA Products
- Search ViGene Biosciences for GRM3
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for GRM3
- Browse OriGene Inhibitory RNA Products For GRM3
- genomics-online: shRNA clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for GRM3 gene
Clone Products
- Sino Biological Human cDNA Clone for GRM3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GRM3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRM3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRM3
- genomics-online: cdna clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- orf clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
- Applied Biological Materials Clones for GRM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GRM3 (mGluR3)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: |
Expression for GRM3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Bergmann Glia Purkinje Cell Layer
- Endothelial Cells Blood Brain Barrier
- Hypothalamus
- Midbrain tegmentum
- Cerebral Cortex
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Optic Nerve
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Glial Cells
- Bergmann Glia Purkinje Cell Layer
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for GRM3 Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.7), Brain - Caudate (basal ganglia) (x6.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.0).
This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRM3 Gene:
GRM3SOURCE GeneReport for Unigene cluster for GRM3 Gene:
Hs.590575mRNA Expression by UniProt/SwissProt for GRM3 Gene:
Q14832-GRM3_HUMAN
Tissue specificity:
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Evidence on tissue expression from TISSUES for GRM3 Gene
- Nervous system(5)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for GRM3
-
OriGene qPCR primer pairs and template standards for GRM3
- genomics-online: primer clones - Search results for 94 available Metabotropic Glutamate Receptor 3 gene related products
- Overview of 94 available Metabotropic Glutamate Receptor 3 gene related products
-
Recommended
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GRM3 Gene
Orthologs for GRM3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRM3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRM3 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GRM3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GRM3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grm3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Grm3 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRM3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRM3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GRM3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grm3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grm3 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mGluRA 33 34 |
|
||
| Glu-RA 35 |
|
|
|||
| CG30361 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | mgl-1 35 33 34 |
|
- Species where no ortholog for GRM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GRM3 Gene
Paralogs for GRM3 Gene
(11) SIMAP similar genes for GRM3 Gene using alignment to 7 proteins:
Variants for GRM3 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010616 | -- | 86,729,603(+) | A/T | intron_variant | |
| rs1000011289 | -- | 86,831,072(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000020645 | -- | 86,741,268(+) | C/T | intron_variant | |
| rs1000041374 | -- | 86,696,607(+) | T/C | intron_variant | |
| rs1000048024 | -- | 86,799,986(+) | C/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv831053 | CNV | gain | 17160897 |
| nsv824201 | CNV | loss | 20364138 |
| nsv478422 | CNV | novel sequence insertion | 20440878 |
| esv7104 | CNV | gain | 19470904 |
| esv3614020 | CNV | loss | 21293372 |
| esv3614018 | CNV | loss | 21293372 |
| esv3373913 | CNV | insertion | 20981092 |
| esv3360307 | CNV | insertion | 20981092 |
| esv3326124 | CNV | insertion | 20981092 |
| esv3309610 | CNV | mobile element insertion | 20981092 |
| esv3307636 | CNV | mobile element insertion | 20981092 |
| esv3305507 | CNV | mobile element insertion | 20981092 |
| esv2667611 | CNV | deletion | 23128226 |
| esv2504097 | CNV | deletion | 19546169 |
| dgv1310e214 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.87;
34.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRM3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene
Disorders for GRM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia |
|
|
| bipolar disorder |
|
Search GRM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene
Publications for GRM3 Gene
- Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PMID: 19386277) Tsunoka T … Iwata N (Progress in neuro-psychopharmacology & biological psychiatry 2009) 3 22 44 58
- DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) Jönsson EG … Terenius L (Neuropsychobiology 2009) 3 22 44 58
- DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. (PMID: 18197082) Schwab SG … Wildenauer DB (Psychiatric genetics 2008) 3 22 44 58
- No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population. (PMID: 16904291) Tochigi M … Sasaki T (Schizophrenia research 2006) 3 22 44 58
- Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex. (PMID: 16585454) Marenco S … Weinberger DR (The American journal of psychiatry 2006) 3 22 44 58
Products for GRM3 Gene
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- Custom Antibody ServicesOriGene Antibodies for GRM3
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- antibodies-online: Search results for 5 available GRIA3 Antibodies ranked by validation data
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- GeneTex GRM3 antibody for GRM3
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- genomics-online: cdna clones - Search results for 94 available GRIA3 gene related products
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Sources for GRM3 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
- (69) OCA
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