Aliases for GRK6 Gene
External Ids for GRK6 Gene
Previous HGNC Symbols for GRK6 Gene
Previous GeneCards Identifiers for GRK6 Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK6 Gene
GRK6 (G Protein-Coupled Receptor Kinase 6) is a Protein Coding gene. Diseases associated with GRK6 include Whim Syndrome. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK5.
UniProtKB/Swiss-Prot Summary for GRK6 Gene
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).