This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provide... See more...

Aliases for GRK5 Gene

Aliases for GRK5 Gene

  • G Protein-Coupled Receptor Kinase 5 2 3 4 5
  • G Protein-Coupled Receptor Kinase GRK5 3 4
  • EC 2.7.11.16 4 52
  • GPRK5 3 4
  • EC 2.7.11 52
  • FP2025 3

External Ids for GRK5 Gene

Previous HGNC Symbols for GRK5 Gene

  • GPRK5

Previous GeneCards Identifiers for GRK5 Gene

  • GC10P120631
  • GC10P120957
  • GC10P114596

Summaries for GRK5 Gene

Entrez Gene Summary for GRK5 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

GeneCards Summary for GRK5 Gene

GRK5 (G Protein-Coupled Receptor Kinase 5) is a Protein Coding gene. Diseases associated with GRK5 include Systolic Heart Failure and Asthma. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK6.

UniProtKB/Swiss-Prot Summary for GRK5 Gene

  • Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

Gene Wiki entry for GRK5 Gene

Additional gene information for GRK5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRK5 Gene

Genomics for GRK5 Gene

GeneHancer (GH) Regulatory Elements for GRK5 Gene

Promoters and enhancers for GRK5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRK5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRK5

Top Transcription factor binding sites by QIAGEN in the GRK5 gene promoter:
  • AML1a
  • AP-2gamma
  • CREB
  • deltaCREB
  • Gfi-1
  • IRF-7A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • YY1

Genomic Locations for GRK5 Gene

Genomic Locations for GRK5 Gene
chr10:119,207,571-119,459,745
(GRCh38/hg38)
Size:
252,175 bases
Orientation:
Plus strand
chr10:120,967,101-121,215,131
(GRCh37/hg19)
Size:
248,031 bases
Orientation:
Plus strand

Genomic View for GRK5 Gene

Genes around GRK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK5 Gene

Proteins for GRK5 Gene

  • Protein details for GRK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34947-GRK5_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 5
    Protein Accession:
    P34947
    Secondary Accessions:
    • D3DRD0
    • Q5T059

    Protein attributes for GRK5 Gene

    Size:
    590 amino acids
    Molecular mass:
    67787 Da
    Quaternary structure:
    • Interacts with ST13 (via the C-terminus 303-319 AA). Interacts with TP53/p53. Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin). Interacts with HDAC5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRK5 Gene

neXtProt entry for GRK5 Gene

Selected DME Specific Peptides for GRK5 Gene

P34947:
  • SLCDKQP
  • RKEKVKREEV
  • ENIVANTV
  • KGKSKKW
  • QPIGRLLFR
  • GRVGTVGYMAPE
  • MNGGDLK
  • GHIRISDLGL
  • IPWQNEM
  • KDVLDIEQFSTVKGV
  • GRLLFRQFCETRPGLE
  • FLQWKWLERQPVTKNTFR
  • YRVLGKGGFGEVCACQVRA
  • TIMNGGD
  • GNPGFEE
  • RDLKPEN
  • LNEKQIL
  • LQWKWLE
  • PPFVPDP
  • YMAPEVL
  • LKAREGG
  • YETKDALCLVLT
  • KKRIKKRKGE
  • PPKKGLLQRLF
  • RISDLGLA
  • KPENILLD

Post-translational modifications for GRK5 Gene

  • Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GRK5 Gene

Protein Domains for GRK5 Gene

Blocks:
  • Protein kinase C-terminal domain
  • Regulator of G-protein signalling (RGS) protein signature
  • GPCR kinase signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRK5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57156, highly similar to G protein-coupled receptor kinase 5 (EC 2.7.11.16) (B4DPB3_HUMAN)
  • G protein-coupled receptor kinase GRK5 (GRK5_HUMAN)
  • GRK5 protein (Q24JT8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P34947

UniProtKB/Swiss-Prot:

GRK5_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with GRK5: view

Function for GRK5 Gene

Molecular function for GRK5 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:12008, Rhea:RHEA-COMP:11260, Rhea:RHEA-COMP:11261, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.16;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by calmodulin with an IC(50) of 50 nM. Calmodulin inhibits GRK5 association with receptor and phospholipid.
UniProtKB/Swiss-Prot Induction:
Overexpressed during heart failure.

Enzyme Numbers (IUBMB) for GRK5 Gene

Phenotypes From GWAS Catalog for GRK5 Gene

Gene Ontology (GO) - Molecular Function for GRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 20124405
GO:0004703 G protein-coupled receptor kinase activity IEA --
GO:0005080 protein kinase C binding TAS 9813065
GO:0005515 protein binding IPI 17986524
genes like me logo Genes that share ontologies with GRK5: view
genes like me logo Genes that share phenotypes with GRK5: view

Animal Models for GRK5 Gene

MGI Knock Outs for GRK5:
  • Grk5 Grk5<tm1Rjl>
  • Grk5 Grk5<tm1b(KOMP)Mbp>
  • Grk5 Grk5<tm1Dgen>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRK5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRK5 Gene

Localization for GRK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK5 Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRK5 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nuclear speckles (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 7685906
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GRK5: view

Pathways & Interactions for GRK5 Gene

genes like me logo Genes that share pathways with GRK5: view

Pathways by source for GRK5 Gene

1 GeneGo (Thomson Reuters) pathway for GRK5 Gene
  • Development Angiotensin signaling via beta-Arrestin
2 Qiagen pathways for GRK5 Gene
  • Chemokine Signaling
  • Colorectal Cancer Metastasis

SIGNOR curated interactions for GRK5 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for GRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS 8626574
genes like me logo Genes that share ontologies with GRK5: view

Drugs & Compounds for GRK5 Gene

(14) Drugs for GRK5 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 582
Escitalopram Approved Pharma 0
Antihypertensives Pharma 0
Beta Blocking Agents Pharma 0

(5) Additional Compounds for GRK5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRK5: view

Transcripts for GRK5 Gene

mRNA/cDNA for GRK5 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRK5

Alternative Splicing Database (ASD) splice patterns (SP) for GRK5 Gene

No ASD Table

Relevant External Links for GRK5 Gene

GeneLoc Exon Structure for
GRK5

Expression for GRK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRK5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRK5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRK5

SOURCE GeneReport for Unigene cluster for GRK5 Gene:

Hs.524625

mRNA Expression by UniProt/SwissProt for GRK5 Gene:

P34947-GRK5_HUMAN
Tissue specificity: Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney.

Evidence on tissue expression from TISSUES for GRK5 Gene

  • Nervous system(4.4)
  • Heart(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with GRK5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRK5 Gene

Orthologs for GRK5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRK5 31 30
  • 97.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRK5 31 30
  • 92.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRK5 31 30
  • 92.43 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRK5 31
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grk5 30
  • 88.76 (n)
mouse
(Mus musculus)
Mammalia Grk5 17 31 30
  • 88.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRK5 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRK5 31 30
  • 80.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRK5 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497344 30
  • 77.85 (n)
zebrafish
(Danio rerio)
Actinopterygii grk5l 31
  • 73 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004117 30
  • 64.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gprk2 31 30
  • 63.9 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-1 31 30
  • 57.49 (n)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.47505 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9515 31
  • 65 (a)
OneToMany
Species where no ortholog for GRK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK5 Gene

ENSEMBL:
Gene Tree for GRK5 (if available)
TreeFam:
Gene Tree for GRK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRK5: view image

Paralogs for GRK5 Gene

Paralogs for GRK5 Gene

genes like me logo Genes that share paralogs with GRK5: view

Variants for GRK5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GRK5 Gene

GRK5_HUMAN-P34947
Variant Leu-41 variant is rare in European-Americans individuals but common in African-Americans individuals (40% of the African-American individuals studied carry at least one allele). Variant leu-41 is associated with decreased mortality in African-Americans with heart failure or cardiac ischemia.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRK5 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
709987 Benign: not provided 119,423,275(+) C/T INTRON_VARIANT
727786 Likely Benign: not provided 119,452,805(+) C/T SYNONYMOUS_VARIANT
730648 Likely Benign: not provided 119,423,276(+) G/A INTRON_VARIANT
762502 Benign: not provided 119,443,725(+) C/T SYNONYMOUS_VARIANT
773238 Benign: not provided 119,423,182(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GRK5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRK5 Gene

Variant ID Type Subtype PubMed ID
dgv108e201 CNV deletion 23290073
dgv109e201 CNV deletion 23290073
dgv110e201 CNV deletion 23290073
dgv111e201 CNV deletion 23290073
dgv510e59 CNV duplication 20981092
dgv524n106 CNV deletion 24896259
dgv525n106 CNV duplication 24896259
esv1002455 CNV deletion 20482838
esv1752195 CNV insertion 17803354
esv2639258 CNV deletion 19546169
esv2658883 CNV deletion 23128226
esv2668115 CNV deletion 23128226
esv2670333 CNV deletion 23128226
esv2671031 CNV deletion 23128226
esv2741650 CNV deletion 23290073
esv2741661 CNV deletion 23290073
esv2741672 CNV deletion 23290073
esv2741683 CNV deletion 23290073
esv2741718 CNV deletion 23290073
esv2741729 CNV deletion 23290073
esv2741740 CNV deletion 23290073
esv2741751 CNV deletion 23290073
esv2741807 CNV deletion 23290073
esv2741840 CNV deletion 23290073
esv2741851 CNV deletion 23290073
esv3624702 CNV loss 21293372
esv3624704 CNV loss 21293372
esv4668 CNV loss 18987735
esv9149 CNV loss 19470904
nsv1038739 CNV gain 25217958
nsv1069967 CNV deletion 25765185
nsv1070895 CNV deletion 25765185
nsv1111464 CNV deletion 24896259
nsv1115225 CNV deletion 24896259
nsv1125179 CNV insertion 24896259
nsv1130649 CNV deletion 24896259
nsv1143523 CNV deletion 24896259
nsv1144519 CNV deletion 24896259
nsv1149379 CNV duplication 26484159
nsv481023 CNV novel sequence insertion 20440878
nsv522432 CNV loss 19592680
nsv552214 CNV loss 21841781
nsv825584 CNV gain 20364138
nsv832007 CNV gain 17160897
nsv951863 CNV deletion 24416366

Variation tolerance for GRK5 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.67; 89.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRK5 Gene

Human Gene Mutation Database (HGMD)
GRK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRK5

SNP Genotyping and Copy Number Assay Products

Disorders for GRK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRK5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systolic heart failure
  • heart failure, systolic
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search GRK5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRK5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRK5 Gene

Publications for GRK5 Gene

  1. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. (PMID: 18425130) Liggett SB … Dorn GW (Nature medicine 2008) 3 4 23 41 54
  2. Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. (PMID: 7685906) Kunapuli P … Benovic JL (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 23 54
  3. L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome. (PMID: 20023040) Spinelli L … Trimarco B (European journal of heart failure 2010) 3 23 41 54
  4. Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. (PMID: 20038610) Baameur F … Clark RB (Molecular pharmacology 2010) 3 4 23 54
  5. Clinical and genetic modifiers of long-term survival in heart failure. (PMID: 19628119) Cresci S … Dorn GW (Journal of the American College of Cardiology 2009) 3 23 41 54

Products for GRK5 Gene

  • Boster Bio Antibodies for GRK5
  • Boster Bio ELISA Kits for GRK5

Sources for GRK5 Gene