Aliases for GRK3 Gene
External Ids for GRK3 Gene
Previous HGNC Symbols for GRK3 Gene
Previous GeneCards Identifiers for GRK3 Gene
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK3 Gene
GRK3 (G Protein-Coupled Receptor Kinase 3) is a Protein Coding gene. Diseases associated with GRK3 include Whim Syndrome and Bipolar Disorder. Among its related pathways are Neuroscience and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is GRK2.
UniProtKB/Swiss-Prot Summary for GRK3 Gene
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.