The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family ... See more...

Aliases for GRK3 Gene

Aliases for GRK3 Gene

  • G Protein-Coupled Receptor Kinase 3 2 3 5
  • BARK2 2 3 4
  • Adrenergic, Beta, Receptor Kinase 2 2 3
  • Beta-Adrenergic Receptor Kinase 2 3 4
  • EC 2.7.11.15 4 50
  • Beta-ARK-2 3 4
  • ADRBK2 3 4
  • G-Protein-Coupled Receptor Kinase 3 4
  • EC 2.7.11 50
  • GRK3 5

External Ids for GRK3 Gene

Previous HGNC Symbols for GRK3 Gene

  • ADRBK2

Previous GeneCards Identifiers for GRK3 Gene

  • GC22P025517
  • GC22P025565
  • GC22P025806

Summaries for GRK3 Gene

Entrez Gene Summary for GRK3 Gene

  • The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRK3 Gene

GRK3 (G Protein-Coupled Receptor Kinase 3) is a Protein Coding gene. Diseases associated with GRK3 include Whim Syndrome and Cocaine Abuse. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Clathrin-mediated endocytosis. An important paralog of this gene is GRK2.

UniProtKB/Swiss-Prot Summary for GRK3 Gene

  • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Gene Wiki entry for GRK3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRK3 Gene

Genomics for GRK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRK3

Genomic Locations for GRK3 Gene

Latest Assembly
chr22:25,564,675-25,729,294
(GRCh38/hg38)
Size:
164,620 bases
Orientation:
Plus strand

Previous Assembly
chr22:25,960,642-26,125,261
(GRCh37/hg19 by Entrez Gene)
Size:
164,620 bases
Orientation:
Plus strand

chr22:25,960,816-26,125,261
(GRCh37/hg19 by Ensembl)
Size:
164,446 bases
Orientation:
Plus strand

Genomic View for GRK3 Gene

Genes around GRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK3 Gene

Proteins for GRK3 Gene

  • Protein details for GRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35626-ARBK2_HUMAN
    Recommended name:
    Beta-adrenergic receptor kinase 2
    Protein Accession:
    P35626
    Secondary Accessions:
    • Q9UGW9

    Protein attributes for GRK3 Gene

    Size:
    688 amino acids
    Molecular mass:
    79710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRK3 Gene

Selected DME Specific Peptides for GRK3 Gene

P35626:
  • CSHPFSK
  • SVEETQIK
  • LRGDIFQ
  • KFTRFCQWKNVELNIHL
  • YAFHTPDKL
  • YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR
  • VVYRDLK
  • GKDCIMHGYM
  • GGKQFVLQC
  • PPRGEVNAADAFDIGSFDEEDTKGIKL
  • SADWFSLG
  • LPEPSIRSVMQ
  • RISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG
  • EAQRLLRRAPKFLNK
  • GNPFLTQWQRRYFYLFPNRLEWRGE
  • EIILGLEHMHNRFVVYRDLKPANILLDEHGH
  • GHSPFRQHK
  • DCPFIVCM
  • YMAPEVL
  • LFQPYIEEIC
  • RISDLGLA
  • ILGLEHMH
  • FILDLMNGGD

Post-translational modifications for GRK3 Gene

Other Protein References for GRK3 Gene

Domains & Families for GRK3 Gene

Gene Families for GRK3 Gene

Protein Domains for GRK3 Gene

InterPro:
Blocks:
  • GPCR kinase signature
  • Regulator of G-protein signalling (RGS) protein signature
  • Protein kinase C-terminal domain
  • Pleckstrin-like

Suggested Antigen Peptide Sequences for GRK3 Gene

GenScript: Design optimal peptide antigens:
  • G-protein-coupled receptor kinase 3 (ARBK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35626

UniProtKB/Swiss-Prot:

ARBK2_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with GRK3: view

Function for GRK3 Gene

Molecular function for GRK3 Gene

UniProtKB/Swiss-Prot Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+); Xref=Rhea:RHEA:19429, Rhea:RHEA-COMP:11222, Rhea:RHEA-COMP:11223, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=2.7.11.15;.

Enzyme Numbers (IUBMB) for GRK3 Gene

Phenotypes From GWAS Catalog for GRK3 Gene

Gene Ontology (GO) - Molecular Function for GRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 8427589
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004703 G protein-coupled receptor kinase activity IEA --
GO:0005515 protein binding IPI 23455922
genes like me logo Genes that share ontologies with GRK3: view
genes like me logo Genes that share phenotypes with GRK3: view

Animal Models for GRK3 Gene

MGI Knock Outs for GRK3:

miRNA for GRK3 Gene

miRTarBase miRNAs that target GRK3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRK3 Gene

Localization for GRK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRK3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with GRK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRK3 Gene

Pathways & Interactions for GRK3 Gene

genes like me logo Genes that share pathways with GRK3: view

Pathways by source for GRK3 Gene

1 GeneGo (Thomson Reuters) pathway for GRK3 Gene
  • Development Angiotensin signaling via beta-Arrestin
2 Qiagen pathways for GRK3 Gene
  • Chemokine Signaling
  • Colorectal Cancer Metastasis
2 Cell Signaling Technology pathways for GRK3 Gene

SIGNOR curated interactions for GRK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for GRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA,TAS 8427589
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0016310 phosphorylation IEA --
GO:0031623 receptor internalization IDA 20074556
genes like me logo Genes that share ontologies with GRK3: view

Drugs & Compounds for GRK3 Gene

(12) Drugs for GRK3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1706
ATP Investigational Nutra Target 0

(4) Additional Compounds for GRK3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with GRK3: view

Transcripts for GRK3 Gene

mRNA/cDNA for GRK3 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRK3

Alternative Splicing Database (ASD) splice patterns (SP) for GRK3 Gene

No ASD Table

Relevant External Links for GRK3 Gene

GeneLoc Exon Structure for
GRK3

Expression for GRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRK3

Evidence on tissue expression from TISSUES for GRK3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with GRK3: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRK3 Gene

Orthologs for GRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADRBK2 29 30
  • 99.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 93 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia ADRBK2 30
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ADRBK2 29 30
  • 89.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADRBK2 29 30
  • 89.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adrbk2 29
  • 83.77 (n)
Mouse
(Mus musculus)
Mammalia Adrbk2 29 30
  • 83.14 (n)
OneToOne
Grk3 16
Chicken
(Gallus gallus)
Aves ADRBK2 29 30
  • 82.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 83 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adrbk2 29
  • 82.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii adrbk2 29 30
  • 76.26 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012026 29
  • 63.41 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Gprk1 29 30
  • 63.19 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea grk-2 29 30
  • 63.67 (n)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3907 29
Species where no ortholog for GRK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRK3 Gene

ENSEMBL:
Gene Tree for GRK3 (if available)
TreeFam:
Gene Tree for GRK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRK3: view image
Alliance of Genome Resources:
Additional Orthologs for GRK3

Paralogs for GRK3 Gene

Paralogs for GRK3 Gene

Pseudogenes.org Pseudogenes for GRK3 Gene

genes like me logo Genes that share paralogs with GRK3: view

Variants for GRK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRK3 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs145971750 Benign: not provided 25,687,641(+) C/A
NM_005160.4(GRK3):c.931C>A (p.Arg311=)
SYNONYMOUS
VAR_040382 A lung bronchoalveolar carcinoma sample p.Arg104Lys
rs2272859 -- p.Val409Met
rs55700971 -- p.Arg50Ser
rs55740593 -- p.Asn60Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GRK3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GRK3 Gene

Variant ID Type Subtype PubMed ID
dgv100e203 CNV gain+loss 21179565
dgv175e55 CNV gain 17911159
dgv4550n100 CNV gain 25217958
dgv4554n100 CNV loss 25217958
dgv577n27 CNV gain 19166990
dgv731e201 CNV deletion 23290073
dgv8074n54 CNV gain 21841781
dgv828e199 CNV deletion 23128226
esv26366 CNV gain 19812545
esv2724087 CNV deletion 23290073
esv2724088 CNV deletion 23290073
esv2751952 CNV gain 17911159
esv2758829 CNV gain+loss 17122850
esv3647477 CNV gain 21293372
esv3647478 CNV gain 21293372
esv3893465 CNV gain+loss 25118596
nsv1058343 CNV loss 25217958
nsv1066595 CNV gain 25217958
nsv1077418 CNV duplication 25765185
nsv1126013 CNV deletion 24896259
nsv436347 CNV deletion 17901297
nsv469691 CNV gain+loss 16826518
nsv471189 CNV gain 18288195
nsv471598 CNV gain+loss 15918152
nsv517205 CNV gain+loss 19592680
nsv7350 OTHER inversion 18451855
nsv962784 CNV duplication 23825009
nsv964615 CNV duplication 23825009
nsv9892 CNV gain 18304495
nsv9893 CNV gain 18304495

Variation tolerance for GRK3 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRK3 Gene

Human Gene Mutation Database (HGMD)
GRK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRK3
Leiden Open Variation Database (LOVD)
GRK3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRK3 Gene

Disorders for GRK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GRK3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
whim syndrome
  • whims
cocaine abuse
  • cocaine-related disorders
bipolar disorder
  • bipolar depression
immune deficiency disease
  • primary immunodeficiency disease
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search GRK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRK3

genes like me logo Genes that share disorders with GRK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRK3 Gene

Publications for GRK3 Gene

  1. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PMID: 7695743) Calabrese G … De Blasi A (Genomics 1994) 2 3 22
  2. Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2. (PMID: 8427589) Parruti G … De Blasi A (Biochemical and biophysical research communications 1993) 3 4 22
  3. beta-Adrenoceptor and GRK3 expression in human lymphocytes is related to blood pressure and urinary albumin excretion. (PMID: 20216086) Oliver E … D'Ocon P (Journal of hypertension 2010) 3 22
  4. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. (PMID: 19766236) McCarthy MJ … Turner EE (Journal of psychiatric research 2010) 3 22
  5. Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. (PMID: 18274673) Balabanian K … Bachelerie F (The Journal of clinical investigation 2008) 3 22

Products for GRK3 Gene

Sources for GRK3 Gene