Aliases for GRK3 Gene
External Ids for GRK3 Gene
Previous HGNC Symbols for GRK3 Gene
Previous GeneCards Identifiers for GRK3 Gene
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK3 Gene
GRK3 (G Protein-Coupled Receptor Kinase 3) is a Protein Coding gene. Diseases associated with GRK3 include Whim Syndrome and Cocaine Abuse. Among its related pathways are Corticotropin-releasing hormone signaling pathway and Clathrin-mediated endocytosis. An important paralog of this gene is GRK2.
UniProtKB/Swiss-Prot Summary for GRK3 Gene
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.