Aliases for GRK1 Gene
External Ids for GRK1 Gene
Previous HGNC Symbols for GRK1 Gene
Previous GeneCards Identifiers for GRK1 Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK1 Gene
GRK1 (G Protein-Coupled Receptor Kinase 1) is a Protein Coding gene. Diseases associated with GRK1 include Oguchi Disease 2 and Oguchi Disease. Among its related pathways are Phototransduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK6.
UniProtKB/Swiss-Prot Summary for GRK1 Gene
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).