Aliases for GRIP2 Gene

Aliases for GRIP2 Gene

  • Glutamate Receptor Interacting Protein 2 2 3 5
  • Glutamate Receptor-Interacting Protein 2 3 4
  • KIAA1719 2 4
  • GRIP-2 4
  • GRIP2 5

External Ids for GRIP2 Gene

Previous GeneCards Identifiers for GRIP2 Gene

  • GC03M014505
  • GC03M014757
  • GC03M014886
  • GC03M014906
  • GC03M015418
  • GC03M014508
  • GC03M014628

Summaries for GRIP2 Gene

GeneCards Summary for GRIP2 Gene

GRIP2 (Glutamate Receptor Interacting Protein 2) is a Protein Coding gene. Diseases associated with GRIP2 include Brain Stem Astrocytic Neoplasm and Fraser Syndrome 1. Among its related pathways are Transmission across Chemical Synapses and Trafficking of AMPA receptors. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and receptor signaling complex scaffold activity. An important paralog of this gene is GRIP1.

UniProtKB/Swiss-Prot Summary for GRIP2 Gene

  • May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Gene Wiki entry for GRIP2 Gene

Additional gene information for GRIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIP2 Gene

Genomics for GRIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J014601 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 +0.2 229 1.7 CTCF ZNF692 ZIC2 ZNF24 EZH2 SCRT2 ZBTB20 ZNF10 ZXDB REST ENSG00000283392 GRIP2 lnc-GRIP2-5 METTL6 LOC105376960 SLC6A6
GH03J014540 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 613.2 +63.0 62995 1.6 ZIC2 ZFHX2 KLF17 EGR2 GATA2 GRIP2 lnc-XPC-10 RNU6-905P RF00026-691 SLC6A6
GH03J014604 Enhancer 0.2 Ensembl 600.7 -1.9 -1905 0.2 GRIP2 lnc-GRIP2-5 piR-38351-294 ENSG00000283392 LOC105376960 CCDC174
GH03J014520 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 25 +79.0 79037 6.3 KDM1A JUND PRDM1 ZNF600 SCRT2 CEBPB EGR1 ESR1 FOSL1 ZNF623 GRIP2 RNU6-905P RF00026-691 lnc-XPC-9-002 lnc-XPC-10 SLC6A6
GH03J014531 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.6 +68.8 68795 5.2 RFX5 KDM1A ZIC2 POLR2A GABPA KLF9 SP2 CBX3 HMBOX1 HDAC2 GRIP2 RF00026-691 RNU6-905P lnc-XPC-10 SLC6A6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIP2

Top Transcription factor binding sites by QIAGEN in the GRIP2 gene promoter:
  • AML1a
  • Brachyury
  • c-Jun
  • FOXO1
  • FOXO1a
  • HOXA3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for GRIP2 Gene

Genomic Locations for GRIP2 Gene
chr3:14,485,105-14,602,996
(GRCh38/hg38)
Size:
117,892 bases
Orientation:
Minus strand
chr3:14,530,619-14,583,588
(GRCh37/hg19)
Size:
52,970 bases
Orientation:
Minus strand

Genomic View for GRIP2 Gene

Genes around GRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIP2 Gene

Proteins for GRIP2 Gene

  • Protein details for GRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E4-GRIP2_HUMAN
    Recommended name:
    Glutamate receptor-interacting protein 2
    Protein Accession:
    Q9C0E4
    Secondary Accessions:
    • A0A087WU38
    • Q8TEH9
    • Q9H7H3

    Protein attributes for GRIP2 Gene

    Size:
    1043 amino acids
    Molecular mass:
    112573 Da
    Quaternary structure:
    • Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR.
    SequenceCaution:
    • Sequence=BAB21810.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Due to intron retention.
    • [Isoform 3]: Incomplete sequence. Due to intron retention.

    Three dimensional structures from OCA and Proteopedia for GRIP2 Gene

    Alternative splice isoforms for GRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIP2 Gene

Post-translational modifications for GRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRIP2 Gene

Domains & Families for GRIP2 Gene

Gene Families for GRIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRIP2 Gene

InterPro:
Blocks:
  • PDZ/DHR/GLGF domain
ProtoNet:

Suggested Antigen Peptide Sequences for GRIP2 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor-interacting protein 2 (GRIP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9C0E4

UniProtKB/Swiss-Prot:

GRIP2_HUMAN :
  • PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity).
  • Belongs to the GRIP2 family.
Domain:
  • PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity).
Family:
  • Belongs to the GRIP2 family.
genes like me logo Genes that share domains with GRIP2: view

Function for GRIP2 Gene

Molecular function for GRIP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Phenotypes From GWAS Catalog for GRIP2 Gene

Gene Ontology (GO) - Molecular Function for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0030159 receptor signaling complex scaffold activity IEA --
GO:0035254 glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with GRIP2: view
genes like me logo Genes that share phenotypes with GRIP2: view

Animal Models for GRIP2 Gene

MGI Knock Outs for GRIP2:

Animal Model Products

CRISPR Products

miRNA for GRIP2 Gene

miRTarBase miRNAs that target GRIP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIP2 Gene

Localization for GRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIP2 Gene

Cytoplasm. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIP2 gene
Compartment Confidence
plasma membrane 4
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GRIP2: view

Pathways & Interactions for GRIP2 Gene

genes like me logo Genes that share pathways with GRIP2: view

Gene Ontology (GO) - Biological Process for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0014824 artery smooth muscle contraction IEA --
GO:0015031 protein transport IEA --
GO:0045777 positive regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with GRIP2: view

No data available for SIGNOR curated interactions for GRIP2 Gene

Drugs & Compounds for GRIP2 Gene

No Compound Related Data Available

Transcripts for GRIP2 Gene

mRNA/cDNA for GRIP2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIP2

Alternative Splicing Database (ASD) splice patterns (SP) for GRIP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for GRIP2 Gene

GeneLoc Exon Structure for
GRIP2

Expression for GRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIP2 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.7) and Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for GRIP2 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIP2 Gene



Protein tissue co-expression partners for GRIP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIP2

SOURCE GeneReport for Unigene cluster for GRIP2 Gene:

Hs.517819

Evidence on tissue expression from TISSUES for GRIP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GRIP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIP2 Gene

Orthologs for GRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GRIP2 30
  • 98.8 (n)
Dog
(Canis familiaris)
Mammalia GRIP2 30
  • 89.49 (n)
Cow
(Bos Taurus)
Mammalia GRIP2 30
  • 88.1 (n)
Rat
(Rattus norvegicus)
Mammalia Grip2 30
  • 83.61 (n)
Mouse
(Mus musculus)
Mammalia Grip2 30 17
  • 83.46 (n)
Chicken
(Gallus gallus)
Aves GRIP2 30
  • 72.4 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia grip2 30
  • 69.35 (n)
Zebrafish
(Danio rerio)
Actinopterygii grip2b 30
  • 66.53 (n)
wufi03h07 30
Species where no ortholog for GRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GRIP2 Gene

ENSEMBL:
Gene Tree for GRIP2 (if available)
TreeFam:
Gene Tree for GRIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIP2: view image

Paralogs for GRIP2 Gene

Paralogs for GRIP2 Gene

(1) SIMAP similar genes for GRIP2 Gene using alignment to 1 proteins:

  • GRIP2_HUMAN
genes like me logo Genes that share paralogs with GRIP2: view

Variants for GRIP2 Gene

Additional dbSNP identifiers (rs#s) for GRIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIP2 Gene

Variant ID Type Subtype PubMed ID
esv2724945 CNV deletion 23290073
nsv1072671 CNV deletion 25765185
nsv1123628 CNV deletion 24896259
nsv3712 CNV insertion 18451855
nsv460447 CNV loss 19166990
nsv470427 CNV loss 18288195
nsv518216 CNV loss 19592680
nsv521453 CNV loss 19592680
nsv525798 CNV gain 19592680
nsv589772 CNV loss 21841781
nsv822002 CNV gain 20364138

Additional Variant Information for GRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for GRIP2 Gene

Disorders for GRIP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain stem astrocytic neoplasm
  • brainstem astrocytoma
fraser syndrome 1
  • frasrs1
- elite association - COSMIC cancer census association via MalaCards
Search GRIP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GRIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIP2 Gene

Publications for GRIP2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4
  5. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin SH … Civelli O (Molecular pharmacology 2001) 3 4

Products for GRIP2 Gene

Sources for GRIP2 Gene