The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015] See more...

Aliases for GRIN3B Gene

Aliases for GRIN3B Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit 3B 2 3 5
  • GluN3B 2 3 4
  • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B 2 3
  • N-Methyl-D-Aspartate Receptor Subtype 3B 3 4
  • Glutamate Receptor Ionotropic, NMDA 3B 3 4
  • NMDAR3B 3 4
  • NR3B 3 4
  • NMDA Type Glutamate Receptor Subunit NR3B 3
  • Glutamate [NMDA] Receptor Subunit 3B 3
  • NMDA Receptor Subunit 3B 3
  • GRIN3B 5

External Ids for GRIN3B Gene

Previous GeneCards Identifiers for GRIN3B Gene

  • GC19P001076
  • GC19M001069
  • GC19P000940
  • GC19P000947
  • GC19P000951

Summaries for GRIN3B Gene

Entrez Gene Summary for GRIN3B Gene

  • The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

GeneCards Summary for GRIN3B Gene

GRIN3B (Glutamate Ionotropic Receptor NMDA Type Subunit 3B) is a Protein Coding gene. Diseases associated with GRIN3B include Depersonalization Disorder and Schizophrenia. Among its related pathways are Nicotine addiction and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include calcium channel activity and ionotropic glutamate receptor activity. An important paralog of this gene is GRIN3A.

UniProtKB/Swiss-Prot Summary for GRIN3B Gene

  • NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Tocris Summary for GRIN3B Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN3B Gene

Additional gene information for GRIN3B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIN3B Gene

Genomics for GRIN3B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRIN3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIN3B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIN3B

Top Transcription factor binding sites by QIAGEN in the GRIN3B gene promoter:
  • AP-4
  • COMP1
  • E47
  • MyoD
  • NF-E2
  • NF-E2 p45
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • XBP-1

Genomic Locations for GRIN3B Gene

Genomic Locations for GRIN3B Gene
chr19:1,000,419-1,009,748
(GRCh38/hg38)
Size:
9,330 bases
Orientation:
Plus strand
chr19:1,000,418-1,009,731
(GRCh37/hg19)
Size:
9,314 bases
Orientation:
Plus strand

Genomic View for GRIN3B Gene

Genes around GRIN3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIN3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIN3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN3B Gene

Proteins for GRIN3B Gene

  • Protein details for GRIN3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60391-NMD3B_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3B
    Protein Accession:
    O60391
    Secondary Accessions:
    • Q5EAK7
    • Q7RTW9

    Protein attributes for GRIN3B Gene

    Size:
    1043 amino acids
    Molecular mass:
    112992 Da
    Quaternary structure:
    • Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).
    SequenceCaution:
    • Sequence=AAC12680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIN3B Gene

Post-translational modifications for GRIN3B Gene

  • Glycosylation at Asn69, Asn344, Asn451, Asn465, and Asn786
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN3B Gene

Domains & Families for GRIN3B Gene

Gene Families for GRIN3B Gene

Protein Domains for GRIN3B Gene

InterPro:
Blocks:
  • Ionotropic glutamate receptor
  • NMDA receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GRIN3B Gene

GenScript: Design optimal peptide antigens:
  • N-methyl-D-aspartate receptor subtype 3B (NMD3B_HUMAN)
  • NMDA receptor subunit 3B (Q5F0I4_HUMAN)
  • NMDA receptor subunit 3B (Q5F0I5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60391

UniProtKB/Swiss-Prot:

NMD3B_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
genes like me logo Genes that share domains with GRIN3B: view

Function for GRIN3B Gene

Molecular function for GRIN3B Gene

UniProtKB/Swiss-Prot Function:
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Phenotypes From GWAS Catalog for GRIN3B Gene

Gene Ontology (GO) - Molecular Function for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0004972 contributes_to NMDA glutamate receptor activity IBA 21873635
GO:0005216 ion channel activity IEA --
GO:0005261 cation channel activity ISS --
GO:0005262 contributes_to calcium channel activity IEA,ISS 11735224
genes like me logo Genes that share ontologies with GRIN3B: view
genes like me logo Genes that share phenotypes with GRIN3B: view

Animal Models for GRIN3B Gene

MGI Knock Outs for GRIN3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIN3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GRIN3B Gene

Localization for GRIN3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN3B Gene

Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIN3B gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0017146 NMDA selective glutamate receptor complex IEA,NAS 11735224
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIN3B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIN3B Gene

Pathways & Interactions for GRIN3B Gene

genes like me logo Genes that share pathways with GRIN3B: view

Pathways by source for GRIN3B Gene

2 Qiagen pathways for GRIN3B Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • Pathogenesis of ALS

Gene Ontology (GO) - Biological Process for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway IBA,ISS --
GO:0035249 synaptic transmission, glutamatergic IBA --
GO:0050804 modulation of chemical synaptic transmission IBA --
genes like me logo Genes that share ontologies with GRIN3B: view

No data available for SIGNOR curated interactions for GRIN3B Gene

Drugs & Compounds for GRIN3B Gene

(40) Drugs for GRIN3B Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orphenadrine Approved Pharma Target, antagonist 10
Glycine Approved, Vet_approved Nutra Agonist, Full agonist, Target, substrate 196
Acamprosate Approved, Investigational Pharma Target, antagonist 43
Aripiprazole Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Target, ligand Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 397
Atomoxetine Approved Pharma Target, blocker 0

(2) Additional Compounds for GRIN3B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Perfluoroacetic acid
  • Trifluoressigsaeure
  • Trifluoroacetate
76-05-1
Ifenprodil hemitartrate
23210-56-2

(5) Tocris Compounds for GRIN3B Gene

Compound Action Cas Number
cis-ACPD Potent NMDA agonist. Also group II mGluR agonist 477331-06-9
HU 211 NMDA receptor antagonist; also NF-kappaB inhibitor 112924-45-5
Ibotenic acid Non-selective NMDA agonist 2552-55-8
Ifenprodil hemitartrate Non-competitive NMDA antagonist. Also sigma ligand 23210-56-2
L-Cysteinesulfinic acid NMDA and mGlu agonist 1115-65-7

(1) ApexBio Compounds for GRIN3B Gene

Compound Action Cas Number
(+)-MK 801 Potent NMDA antagonist 70449-94-4
genes like me logo Genes that share compounds with GRIN3B: view

Drug Products

Transcripts for GRIN3B Gene

mRNA/cDNA for GRIN3B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIN3B

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN3B Gene

No ASD Table

Relevant External Links for GRIN3B Gene

GeneLoc Exon Structure for
GRIN3B

Expression for GRIN3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIN3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIN3B Gene

This gene is overexpressed in Fallopian Tube (x5.3) and Cervix - Endocervix (x4.9).

Protein differential expression in normal tissues from HIPED for GRIN3B Gene

This gene is overexpressed in Pancreatic juice (52.4) and Lung (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIN3B Gene



Protein tissue co-expression partners for GRIN3B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIN3B

SOURCE GeneReport for Unigene cluster for GRIN3B Gene:

Hs.660378

Evidence on tissue expression from TISSUES for GRIN3B Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GRIN3B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIN3B Gene

Orthologs for GRIN3B Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN3B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GRIN3B 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GRIN3B 30
  • 83.81 (n)
Cow
(Bos Taurus)
Mammalia GRIN3B 30 31
  • 80.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Grin3b 30
  • 78.83 (n)
Mouse
(Mus musculus)
Mammalia Grin3b 30 17 31
  • 78.58 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GRIN3B 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GRIN3B 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GRIN3B 30 31
  • 70.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GRIN3B 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia grin3b 30
  • 58.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571394 30
  • 62.3 (n)
GRIN3B (2 of 2) 31
  • 52 (a)
OneToMany
grin3b 31
  • 48 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Ir8a 31
  • 21 (a)
ManyToMany
Ir25a 31
  • 19 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea glr-7 31
  • 21 (a)
ManyToMany
glr-8 31
  • 20 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for GRIN3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRIN3B Gene

ENSEMBL:
Gene Tree for GRIN3B (if available)
TreeFam:
Gene Tree for GRIN3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIN3B: view image

Paralogs for GRIN3B Gene

(1) SIMAP similar genes for GRIN3B Gene using alignment to 3 proteins:

  • NMD3B_HUMAN
  • Q5F0I4_HUMAN
  • Q5F0I5_HUMAN
genes like me logo Genes that share paralogs with GRIN3B: view

Variants for GRIN3B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIN3B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
780495 Benign: not provided 1,008,705(+) G/A MISSENSE_VARIANT
785597 Benign: not provided 1,004,710(+) A/G SYNONYMOUS_VARIANT
785598 Benign: not provided 1,005,187(+) G/A SYNONYMOUS_VARIANT
rs1043645806 - p.Arg336Cys
rs1253903191 - p.Arg470His

Additional dbSNP identifiers (rs#s) for GRIN3B Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIN3B Gene

Variant ID Type Subtype PubMed ID
esv2758743 CNV gain+loss 17122850
nsv1143893 CNV deletion 24896259
nsv1160555 CNV deletion 26073780
nsv469845 CNV loss 16826518
nsv470101 CNV loss 18288195
nsv578188 CNV loss 21841781
nsv578189 CNV loss 21841781
nsv833704 CNV gain 17160897
nsv953938 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for GRIN3B Gene

Gene Damage Index Score: 26.29; 99.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIN3B Gene

Human Gene Mutation Database (HGMD)
GRIN3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIN3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN3B Gene

Disorders for GRIN3B Gene

MalaCards: The human disease database

(4) MalaCards diseases for GRIN3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
depersonalization disorder
  • neurotic derealization
schizophrenia
  • sczd
opioid addiction
  • opiate dependence
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GRIN3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GRIN3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIN3B Gene

Publications for GRIN3B Gene

  1. Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PMID: 20016182) Liu HP … Tsai FJ (Dementia and geriatric cognitive disorders 2009) 3 23 41
  2. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. (PMID: 15722182) Bendel O … von Euler G (Neuroscience letters 2005) 3 4 23
  3. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PMID: 11735224) Andersson O … von Euler G (Genomics 2001) 3 4 23
  4. Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. (PMID: 22833210) Tarabeux J … Krebs MO (Translational psychiatry 2011) 3 4
  5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 41

Products for GRIN3B Gene

Sources for GRIN3B Gene