Aliases for GRIN3A Gene
External Ids for GRIN3A Gene
Previous GeneCards Identifiers for GRIN3A Gene
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRIN3A Gene
GRIN3A (Glutamate Ionotropic Receptor NMDA Type Subunit 3A) is a Protein Coding gene. Diseases associated with GRIN3A include Macrodactyly and Schizophrenia. Among its related pathways are Circadian entrainment and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein phosphatase 2A binding. An important paralog of this gene is GRIN3B.
UniProtKB/Swiss-Prot Summary for GRIN3A Gene
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.