Aliases for GRIN2D Gene
External Ids for GRIN2D Gene
Previous HGNC Symbols for GRIN2D Gene
Previous GeneCards Identifiers for GRIN2D Gene
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
GeneCards Summary for GRIN2D Gene
GRIN2D (Glutamate Ionotropic Receptor NMDA Type Subunit 2D) is a Protein Coding gene. Diseases associated with GRIN2D include Developmental And Epileptic Encephalopathy 46 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are RET signaling and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and NMDA glutamate receptor activity. An important paralog of this gene is GRIN2C.
UniProtKB/Swiss-Prot Summary for GRIN2D Gene
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.