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The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1) is a Protein Coding gene. Diseases associated with GRIN1 include Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Dominant and Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive. Among its related pathways are Protein-protein interactions at synapses and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is GRIN2A.
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001540 | amyloid-beta binding | ISS | -- |
GO:0004970 | ionotropic glutamate receptor activity | IEA | -- |
GO:0004972 | NMDA glutamate receptor activity | IBA,TAS | 17526495 |
GO:0005216 | ion channel activity | IEA | -- |
GO:0005262 | contributes_to calcium channel activity | IDA | 7685113 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | ISS | 17526495 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IDA | 7685113 |
GO:0008021 | synaptic vesicle | ISS | -- |
GO:0009986 | cell surface | ISS | 17526495 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Post NMDA receptor activation events | ||
3 | Pathways of neurodegeneration - multiple diseases | ||
4 | Circadian entrainment | ||
5 | Transmission across Chemical Synapses |
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0006812 | cation transport | IDA | 7685113 |
GO:0007268 | chemical synaptic transmission | IBA | 21873635 |
GO:0007420 | brain development | NAS | 17526495 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Orphenadrine | Approved | Pharma | Target, antagonist | 11 | ||
D-serine | Approved, Experimental | Pharma | Agonist, Target, modulator | 0 | ||
Meperidine | Approved | Pharma | Target, antagonist | 88 | ||
Glutamic acid | Approved | Nutra | Target | 320 | ||
Glycine | Approved, Vet_approved | Nutra | Agonist, antagonist | 202 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>3</sup>H]MK-801 |
|
|
|
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Ifenprodil hemitartrate |
|
23210-56-2 |
|
|
Compound | Action | Cas Number |
---|---|---|
cis-ACPD | Potent NMDA agonist. Also group II mGluR agonist | 477331-06-9 |
HU 211 | NMDA receptor antagonist; also NF-kappaB inhibitor | 112924-45-5 |
Ibotenic acid | Non-selective NMDA agonist | 2552-55-8 |
Ifenprodil hemitartrate | Non-competitive NMDA antagonist. Also sigma ligand | 23210-56-2 |
L-Cysteinesulfinic acid | NMDA and mGlu agonist | 1115-65-7 |
Compound | Action | Cas Number |
---|---|---|
(-)-Huperzine A | NMDA receptor antagonist/AChE inhibitor | 102518-79-6 |
(-)-MK 801 | NMDA antagonist,potent and selective | 121917-57-5 |
(+)-MK 801 | Potent NMDA antagonist | 70449-94-4 |
(+)-MK 801 Maleate | Potent NMDA antagonist | 77086-22-7 |
(2R,3S)-Chlorpheg | 140924-23-8 | |
(R)-(+)-HA-966 | 123931-04-4 | |
(R)-4-Carboxyphenylglycine | 134052-68-9 | |
(R)-CPP | 126453-07-4 | |
(RS)-(Tetrazol-5-yl)glycine | 138199-51-6 | |
(RS)-CPP | 100828-16-8 | |
(S)-(-)-HA-966 | 111821-58-0 | |
5,7-Dichlorokynurenic acid | 131123-76-7 | |
5,7-Dichlorokynurenic acid sodium salt | 1184986-70-6 | |
ACBC | 22264-50-2 | |
Arcaine sulfate | 14923-17-2 | |
CCMQ | 132623-44-0 | |
CGP 37849 | 127910-31-0 | |
CGP 39551 | 127910-32-1 | |
CGP 78608 hydrochloride | 1135278-54-4 | |
CGS 19755 | 110347-85-8 | |
CIQ | 486427-17-2 | |
cis-ACPD | 477331-06-9 | |
Co 101244 hydrochloride | 193356-17-1 | |
Conantokin G | 93438-65-4 | |
Conantokin-T | 127476-26-0 | |
D-AP5 | 79055-68-8 | |
D-CPP-ene | 117414-74-1 | |
DL-AP5 | 76326-31-3 | |
DL-AP5 Sodium salt | 1303993-72-7 | |
DL-AP7 | 78966-69-5 | |
DQP 1105 | 380560-89-4 | |
Eliprodil | 119431-25-3 | |
Felbamate | 25451-15-4 | |
Felbamate hydrate | 1177501-39-1 | |
Flupirtine maleate | 75507-68-5 | |
Gavestinel | 153436-38-5 | |
GLYX 13 | 117928-94-6 | |
Homoquinolinic acid | 490-75-5 | |
HU 211 | NMDA antagonist, novel and non-competitive | 112924-45-5 |
Ibotenic acid | 2552-55-8 | |
Ifenprodil Tartrate | NMDA receptor antagonist | 23210-58-4 |
L-689,560 | potent NMDA antagonist | 139051-78-8 |
L-701,252 | 151057-13-5 | |
L-701,324 | 142326-59-8 | |
L-AP5 | 79055-67-7 | |
L-Cysteinesulfinic acid | 1115-65-7 | |
LY 233053 | 125546-04-5 | |
LY 235959 | 137433-06-8 | |
MDL-29951 | 130798-51-5 | |
Memantine hydrochloride | NMDA receptor antagonist | 41100-52-1 |
MNI-caged-D-aspartate | 845555-94-4 | |
MNI-caged-NMDA | 1227675-52-6 | |
N-(4-Hydroxyphenylacetyl)spermine | 130210-32-1 | |
N20C hydrochloride | 1177583-87-7 | |
NMDA (N-Methyl-D-aspartic acid) | NMDA receptor agonist | 6384-92-5 |
PMPA (NMDA antagonist) | 113919-36-1 | |
PPDA | 684283-16-7 | |
PPPA | 113190-92-4 | |
QNZ 46 | 1237744-13-6 | |
Quinolinic acid | 89-00-9 | |
Remacemide hydrochloride | 111686-79-4 | |
Ro 04-5595 hydrochloride | 64047-73-0 | |
Ro 8-4304 hydrochloride | 1312991-77-7 | |
SDZ 220-040 | 174575-40-7 | |
SDZ 220-581 | NMDA glutamate receptor subtype antagonist | 174575-17-8 |
SDZ 220-581 hydrochloride | NMDA receptor antagonist | 179411-93-9 |
Spermidine trihydrochloride | 334-50-9 | |
Spermine tetrahydrochloride | 306-67-2 | |
Synthalin sulfate | 182285-12-7 | |
TCN 201 | 852918-02-6 | |
TCN 213 | 556803-08-8 | |
TCN 237 dihydrochloride | 700878-19-9 | |
TCS 46b | 302799-86-6 | |
threo Ifenprodil hemitartrate | 1312991-83-5 | |
ZD 9379 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 21b | ^ | 22a | · | 22b | ^ | 23 |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | - | - | |||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRIN1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GRIN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRIN1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grin1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Grin1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GRIN1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GRIN1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRIN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grin1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | NR1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | grin1b 31 |
|
OneToMany | |
grin1a 30 31 |
|
OneToMany | |||
Dr.28352 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12065 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001478 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nmdar1 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | nmr-1 30 31 32 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | GLR5 30 |
|