GRIN1 Gene (Protein Coding)

Glutamate Ionotropic Receptor NMDA Type Subunit 1

GC09P137138
GIFtS:
51
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific f... See more...

Aliases for GRIN1 Gene

Aliases for GRIN1 Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit 1 2 3 5
  • N-Methyl-D-Aspartate Receptor Subunit NR1 2 3 4
  • GluN1 2 3 4
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 2 3
  • Glutamate [NMDA] Receptor Subunit Zeta-1 3 4
  • Glutamate Receptor Ionotropic, NMDA 1 3 4
  • NMD-R1 3 4
  • NMDAR1 3 4
  • N-Methyl-D-Aspartate Receptor Channel, Subunit Zeta-1 3
  • NDHMSD 3
  • NDHMSR 3
  • NMDA1 3
  • GRIN1 5
  • MRD8 3
  • NR1 3

External Ids for GRIN1 Gene

Previous HGNC Symbols for GRIN1 Gene

  • NMDAR1

Previous GeneCards Identifiers for GRIN1 Gene

  • GC09U990032
  • GC09P131724
  • GC09P133473
  • GC09P135390
  • GC09P137308
  • GC09P139152
  • GC09P140032
  • GC09P109493

Summaries for GRIN1 Gene

Entrez Gene Summary for GRIN1 Gene

  • The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIN1 Gene

GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1) is a Protein Coding gene. Diseases associated with GRIN1 include Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Dominant and Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive. Among its related pathways are Protein-protein interactions at synapses and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and signaling receptor binding. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot Summary for GRIN1 Gene

  • Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).

Tocris Summary for GRIN1 Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN1 Gene

Additional gene information for GRIN1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIN1 Gene

Genomics for GRIN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GRIN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J137139 Promoter 1.2 EPDnew Ensembl 250.7 +0.0 24 0.2 MXD4 BHLHE40 NONO SIN3A REST SIN3B SAP130 SAFB MBD1 SMARCE1 GRIN1 L13712-028 LRRC26
GH09J136884 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.7 -252.4 -252436 3.9 CHD2 TBP ZBTB10 MXD4 SP1 CEBPA NR2C1 SMAD5 ETS1 IRF2 LOC105376326 MIR4479 lnc-EDF1-2 TRAF2 GRIN1 EHMT1 PHPT1 SNHG7 CACNA1B RNF208
GH09J137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 +100.1 100118 11.7 ZSCAN16 CHD2 ZBTB10 MXD4 SP1 NR2C1 MNT IKZF1 SMAD5 ETS1 TUBB4B EHMT1 ANAPC2 INPP5E ENTR1 NDOR1 DPH7 LOC651337 MAN1B1 SNHG7
GH09J137221 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16 +87.9 87860 11.5 TBP ZBTB10 MXD4 SP1 FEZF1 NR2C1 MNT IKZF1 SMAD5 ETS1 RNF224 lnc-RNF208-1 RNF208 ENTR1 EHMT1 SNHG7 GRIN1 SEC16A CACNA1B DPH7
GH09J136846 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 -284.8 -284796 17 CHD2 TBP ZBTB10 MXD4 SP1 CEBPA MNT DEK IKZF1 SMAD5 PHPT1 HSALNG0075310 HSALNG0075311 MAMDC4 EHMT1 ENTR1 SNHG7 SEC16A GRIN1 RNF208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIN1

Top Transcription factor binding sites by QIAGEN in the GRIN1 gene promoter:
  • AhR
  • E47
  • GATA-2
  • Hand1
  • Lmo2
  • PPAR-alpha
  • Spz1
  • Tal-1beta
  • Zic1

Genomic Locations for GRIN1 Gene

Latest Assembly
chr9:137,139,092-137,168,759
(GRCh38/hg38)
Size:
29,668 bases
Orientation:
Plus strand

Previous Assembly
chr9:140,033,606-140,063,208
(GRCh37/hg19 by Entrez Gene)
Size:
29,603 bases
Orientation:
Plus strand

chr9:140,032,842-140,063,207
(GRCh37/hg19 by Ensembl)
Size:
30,366 bases
Orientation:
Plus strand

Genomic View for GRIN1 Gene

Genes around GRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRIN1 Gene

Proteins for GRIN1 Gene

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  • Protein details for GRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05586-NMDZ1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 1
    Protein Accession:
    Q05586
    Secondary Accessions:
    • A6NLK7
    • A6NLR1
    • C9K0X1
    • P35437
    • Q12867
    • Q12868
    • Q5VSF3
    • Q5VSF4
    • Q5VSF5
    • Q5VSF6
    • Q5VSF7
    • Q5VSF8
    • Q9UPF8
    • Q9UPF9

    Protein attributes for GRIN1 Gene

    Size:
    938 amino acids
    Molecular mass:
    105373 Da
    Quaternary structure:
    • Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), an epsilon subunit, plus GRIN3A or GRIN3B (in vitro). In vivo, the subunit composition may vary in function of the expression levels of the different subunits. Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (By similarity). Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP (PubMed:18849881). Found in a complex with DLG4 and PRR7 (By similarity). Found in a complex with GRIN2B and PRR7 (PubMed:27458189). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (PubMed:27458189).

    Three dimensional structures from OCA and Proteopedia for GRIN1 Gene

    Alternative splice isoforms for GRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIN1 Gene

Protein Expression for GRIN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRIN1 Gene

  • NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
  • Glycosylation at Asn61, Asn203, Asn239, Asn276, Asn300, Asn350, Asn368, Asn440, Asn471, Asn491, and Asn771
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for GRIN1 Gene

Domains & Families for GRIN1 Gene

Gene Families for GRIN1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for GRIN1 Gene

InterPro:
Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GRIN1 Gene

GenScript: Design optimal peptide antigens:
  • N-methyl-D-aspartate receptor subunit NR1 (NMDZ1_HUMAN)
  • Glutamate receptor, ionotropic, N-methyl D-aspartate 1 (Q5VSF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05586

UniProtKB/Swiss-Prot:

NMDZ1_HUMAN :
  • A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Domain:
  • A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
genes like me logo Genes that share domains with GRIN1: view

Function for GRIN1 Gene

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  6. Cell Lines for research

Molecular function for GRIN1 Gene

UniProtKB/Swiss-Prot Function:
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).
GENATLAS Biochemistry:
N-methyl D-aspartate receptor 1,zeta 1subunit glutamate receptor,ubiquitously expressed in all CNS neurons,hippocampal pyramidal cells and neocortex,basal ganglia,mesencephalic dopaminergic neurons,throughout development and in adult brain,playing a central role in verbal memory and cognitive function

Phenotypes From GWAS Catalog for GRIN1 Gene

Gene Ontology (GO) - Molecular Function for GRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding ISS --
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0004972 NMDA glutamate receptor activity IBA,TAS 17526495
GO:0005216 ion channel activity IEA --
GO:0005262 contributes_to calcium channel activity IDA 7685113
genes like me logo Genes that share ontologies with GRIN1: view
genes like me logo Genes that share phenotypes with GRIN1: view

Human Phenotype Ontology for GRIN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GRIN1 Gene

MGI Knock Outs for GRIN1:

Animal Models for research

miRNA for GRIN1 Gene

miRTarBase miRNAs that target GRIN1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIN1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRIN1 Gene

Localization for GRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN1 Gene

Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIN1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 17526495
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7685113
GO:0008021 synaptic vesicle ISS --
GO:0009986 cell surface ISS 17526495
genes like me logo Genes that share ontologies with GRIN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIN1 Gene

Pathways & Interactions for GRIN1 Gene

PathCards logo

SuperPathways for GRIN1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Post NMDA receptor activation events
Activation of NMDA receptor upon glutamate binding and postsynaptic events
.90
Post NMDA receptor activation events
.90
CREB phosphorylation through the activation of Ras
.78
CREB phosphorylation through the activation of CaMKII
.01
Ras activation uopn Ca2+ infux through NMDA receptor
.01
Unblocking of NMDA receptor, glutamate binding and activation
.01
3 Pathways of neurodegeneration - multiple diseases
Alzheimer disease
.65
Pathways of neurodegeneration - multiple diseases
.65
Amyotrophic lateral sclerosis
.54
Huntington disease
.50
4 Circadian entrainment
Circadian entrainment
.38
Glutamatergic synapse
.38
Synaptic Neurotransmission Pathways: Glutamatergic Excitation
.01
5 Transmission across Chemical Synapses
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
.67
Transmission across Chemical Synapses
.67
Neuronal System
.62
genes like me logo Genes that share pathways with GRIN1: view

Pathways by source for GRIN1 Gene

3 GeneGo (Thomson Reuters) pathways for GRIN1 Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Neurophysiological process PGE2-induced pain processing
  • Signal transduction_Erk Interactions- Inhibition of Erk
8 Qiagen pathways for GRIN1 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • Huntington's Disease Pathway
  • Intracellular Calcium Signaling
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • nNOS Signaling at Neuronal Synapses
1 Cell Signaling Technology pathway for GRIN1 Gene

SIGNOR curated interactions for GRIN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IDA 7685113
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007420 brain development NAS 17526495
genes like me logo Genes that share ontologies with GRIN1: view

Drugs & Compounds for GRIN1 Gene

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(152) Drugs for GRIN1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orphenadrine Approved Pharma Target, antagonist 11
D-serine Approved, Experimental Pharma Agonist, Target, modulator 0
Meperidine Approved Pharma Target, antagonist 88
Glutamic acid Approved Nutra Target 320
Glycine Approved, Vet_approved Nutra Agonist, antagonist 202

(12) Additional Compounds for GRIN1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]MK-801
Ifenprodil hemitartrate
23210-56-2

(5) Tocris Compounds for GRIN1 Gene

Compound Action Cas Number
cis-ACPD Potent NMDA agonist. Also group II mGluR agonist 477331-06-9
HU 211 NMDA receptor antagonist; also NF-kappaB inhibitor 112924-45-5
Ibotenic acid Non-selective NMDA agonist 2552-55-8
Ifenprodil hemitartrate Non-competitive NMDA antagonist. Also sigma ligand 23210-56-2
L-Cysteinesulfinic acid NMDA and mGlu agonist 1115-65-7

(75) ApexBio Compounds for GRIN1 Gene

Compound Action Cas Number
(-)-Huperzine A NMDA receptor antagonist/AChE inhibitor 102518-79-6
(-)-MK 801 NMDA antagonist,potent and selective 121917-57-5
(+)-MK 801 Potent NMDA antagonist 70449-94-4
(+)-MK 801 Maleate Potent NMDA antagonist 77086-22-7
(2R,3S)-Chlorpheg 140924-23-8
(R)-(+)-HA-966 123931-04-4
(R)-4-Carboxyphenylglycine 134052-68-9
(R)-CPP 126453-07-4
(RS)-(Tetrazol-5-yl)glycine 138199-51-6
(RS)-CPP 100828-16-8
(S)-(-)-HA-966 111821-58-0
5,7-Dichlorokynurenic acid 131123-76-7
5,7-Dichlorokynurenic acid sodium salt 1184986-70-6
ACBC 22264-50-2
Arcaine sulfate 14923-17-2
CCMQ 132623-44-0
CGP 37849 127910-31-0
CGP 39551 127910-32-1
CGP 78608 hydrochloride 1135278-54-4
CGS 19755 110347-85-8
CIQ 486427-17-2
cis-ACPD 477331-06-9
Co 101244 hydrochloride 193356-17-1
Conantokin G 93438-65-4
Conantokin-T 127476-26-0
D-AP5 79055-68-8
D-CPP-ene 117414-74-1
DL-AP5 76326-31-3
DL-AP5 Sodium salt 1303993-72-7
DL-AP7 78966-69-5
DQP 1105 380560-89-4
Eliprodil 119431-25-3
Felbamate 25451-15-4
Felbamate hydrate 1177501-39-1
Flupirtine maleate 75507-68-5
Gavestinel 153436-38-5
GLYX 13 117928-94-6
Homoquinolinic acid 490-75-5
HU 211 NMDA antagonist, novel and non-competitive 112924-45-5
Ibotenic acid 2552-55-8
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
L-689,560 potent NMDA antagonist 139051-78-8
L-701,252 151057-13-5
L-701,324 142326-59-8
L-AP5 79055-67-7
L-Cysteinesulfinic acid 1115-65-7
LY 233053 125546-04-5
LY 235959 137433-06-8
MDL-29951 130798-51-5
Memantine hydrochloride NMDA receptor antagonist 41100-52-1
MNI-caged-D-aspartate 845555-94-4
MNI-caged-NMDA 1227675-52-6
N-(4-Hydroxyphenylacetyl)spermine 130210-32-1
N20C hydrochloride 1177583-87-7
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
PMPA (NMDA antagonist) 113919-36-1
PPDA 684283-16-7
PPPA 113190-92-4
QNZ 46 1237744-13-6
Quinolinic acid 89-00-9
Remacemide hydrochloride 111686-79-4
Ro 04-5595 hydrochloride 64047-73-0
Ro 8-4304 hydrochloride 1312991-77-7
SDZ 220-040 174575-40-7
SDZ 220-581 NMDA glutamate receptor subtype antagonist 174575-17-8
SDZ 220-581 hydrochloride NMDA receptor antagonist 179411-93-9
Spermidine trihydrochloride 334-50-9
Spermine tetrahydrochloride 306-67-2
Synthalin sulfate 182285-12-7
TCN 201 852918-02-6
TCN 213 556803-08-8
TCN 237 dihydrochloride 700878-19-9
TCS 46b 302799-86-6
threo Ifenprodil hemitartrate 1312991-83-5
ZD 9379
genes like me logo Genes that share compounds with GRIN1: view

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Transcripts for GRIN1 Gene

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mRNA/cDNA for GRIN1 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIN1

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Alternative Splicing Database (ASD) splice patterns (SP) for GRIN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a ·
SP1:
SP2: -
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:

ExUns: 21b ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

Relevant External Links for GRIN1 Gene

GeneLoc Exon Structure for
GRIN1

Expression for GRIN1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIN1 Gene

mRNA expression in normal human tissues for GRIN1 Gene
mRNA expression by BioGPS for GRIN1 GenemRNA expression by GTEx for GRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIN1 Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.7), Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Nucleus accumbens (basal ganglia) (x4.6), Brain - Putamen (basal ganglia) (x4.2), and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for GRIN1 Gene

This gene is overexpressed in Neutrophil (22.4), Blymphocyte (16.5), Monocytes (12.5), and Frontal cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIN1 Gene



Protein tissue co-expression partners for GRIN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIN1

SOURCE GeneReport for Unigene cluster for GRIN1 Gene:

Hs.558334

Evidence on tissue expression from TISSUES for GRIN1 Gene

  • Nervous system(4.8)
  • Skin(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIN1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • pharynx
  • skull
  • tooth
Thorax:
  • chest wall
  • heart
Abdomen:
  • abdominal wall
  • intestine
  • large intestine
Pelvis:
  • rectum
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with GRIN1: view

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No data available for mRNA Expression by UniProt/SwissProt for GRIN1 Gene

Orthologs for GRIN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GRIN1 31
  • 94 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GRIN1 30 31
  • 93.37 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GRIN1 30 31
  • 92.23 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Grin1 30 17 31
  • 90.33 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Grin1 30
  • 90.28 (n)
Oppossum
(Monodelphis domestica)
 Mammalia GRIN1 31
  • 89 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves GRIN1 30 31
  • 83.56 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GRIN1 31
  • 91 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia grin1 30
  • 79.92 (n)
African clawed frog
(Xenopus laevis)
 Amphibia NR1 30
Zebrafish
(Danio rerio)
 Actinopterygii grin1b 31
  • 88 (a)
 OneToMany
grin1a 30 31
  • 78.33 (n)
 OneToMany
Dr.28352 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12065 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001478 30
  • 60.62 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Nmdar1 30 31 32
  • 60.38 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea nmr-1 30 31 32
  • 44.42 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons GLR5 30
  • 40.53 (n)
Species where no ortholog for GRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum offici