This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits... See more...

Aliases for GRIK5 Gene

Aliases for GRIK5 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 5 2 3 5
  • GluK5 2 3 4
  • KA2 2 3 4
  • Glutamate Receptor Ionotropic, Kainate 5 3 4
  • Excitatory Amino Acid Receptor 2 3 4
  • GRIK2 3 4
  • EAA2 3 4
  • Glutamate Receptor, Ionotropic, Kainate 5 2
  • Glutamate Receptor KA-2 4
  • Glutamate Receptor KA2 3
  • GRIK5 5

External Ids for GRIK5 Gene

Previous HGNC Symbols for GRIK5 Gene

  • GRIK2

Previous GeneCards Identifiers for GRIK5 Gene

  • GC19M043142
  • GC19M042894
  • GC19M047178
  • GC19M047194
  • GC19M042502
  • GC19M038934

Summaries for GRIK5 Gene

Entrez Gene Summary for GRIK5 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for GRIK5 Gene

GRIK5 (Glutamate Ionotropic Receptor Kainate Type Subunit 5) is a Protein Coding gene. Diseases associated with GRIK5 include Brugada Syndrome 3 and Schizophrenia. Among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is GRIK4.

UniProtKB/Swiss-Prot Summary for GRIK5 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

Tocris Summary for GRIK5 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Gene Wiki entry for GRIK5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIK5 Gene

Genomics for GRIK5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRIK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042065 Promoter 0.4 EPDnew 600.4 +6.0 6000 0.1 NRF1 piR-35532 GRIK5 ZNF574 ATP1A3
GH19J042042 Promoter 0.4 EPDnew 600.3 +28.9 28933 0.1 ZNF148 piR-52294-065 GRIK5 piR-47675-064 ZNF574 ATP1A3
GH19J042073 Enhancer 0.4 Ensembl 600.7 -1.4 -1397 0.4 ZNF316 ZNF121 MAFK GRIK5 ZNF574 lnc-POU2F2-1 POU2F2
GH19J041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.2 +768.5 768503 17 ZNF221 ARHGAP35 SP1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 ITPKC TMEM91
GH19J042216 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13 -146.8 -146797 6.8 ZNF221 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 IKZF1 POU2F2 ZNF526 DEDD2 hsa-miR-5095-280 lnc-DEDD2-1 ZNF574 GRIK5 GSK3A CIC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIK5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIK5

Top Transcription factor binding sites by QIAGEN in the GRIK5 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a

Genomic Locations for GRIK5 Gene

Genomic Locations for GRIK5 Gene
chr19:41,998,316-42,071,804
(GRCh38/hg38)
Size:
73,489 bases
Orientation:
Minus strand
chr19:42,502,473-42,573,650
(GRCh37/hg19)
Size:
71,178 bases
Orientation:
Minus strand

Genomic View for GRIK5 Gene

Genes around GRIK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK5 Gene

Proteins for GRIK5 Gene

  • Protein details for GRIK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16478-GRIK5_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 5
    Protein Accession:
    Q16478
    Secondary Accessions:
    • Q8WWG8

    Protein attributes for GRIK5 Gene

    Size:
    980 amino acids
    Molecular mass:
    109265 Da
    Quaternary structure:
    • Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

    Alternative splice isoforms for GRIK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK5 Gene

Post-translational modifications for GRIK5 Gene

  • Glycosylation at Asn219, Asn271, Asn285, Asn322, Asn372, Asn394, Asn400, Asn407, Asn414, and Asn478
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIK5 Gene

Domains & Families for GRIK5 Gene

Protein Domains for GRIK5 Gene

InterPro:
Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GRIK5 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor KA-2 (GRIK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16478

UniProtKB/Swiss-Prot:

GRIK5_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
genes like me logo Genes that share domains with GRIK5: view

Function for GRIK5 Gene

Molecular function for GRIK5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.
GENATLAS Biochemistry:
glutamate receptor KA2,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

Phenotypes From GWAS Catalog for GRIK5 Gene

Gene Ontology (GO) - Molecular Function for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0008066 glutamate receptor activity IEA,IBA 21873635
GO:0015276 ligand-gated ion channel activity IBA 21873635
GO:0015277 kainate selective glutamate receptor activity IEA,IDA 1321949
genes like me logo Genes that share ontologies with GRIK5: view
genes like me logo Genes that share phenotypes with GRIK5: view

Animal Models for GRIK5 Gene

MGI Knock Outs for GRIK5:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIK5

CRISPR Products

miRNA for GRIK5 Gene

miRTarBase miRNAs that target GRIK5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIK5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK5 Gene

Localization for GRIK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK5 Gene

Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK5 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 3
extracellular 2
cytoskeleton 2
mitochondrion 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0008328 ionotropic glutamate receptor complex IEA --
genes like me logo Genes that share ontologies with GRIK5: view

Pathways & Interactions for GRIK5 Gene

genes like me logo Genes that share pathways with GRIK5: view

Gene Ontology (GO) - Biological Process for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IEA --
GO:0006811 ion transport IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK5: view

No data available for SIGNOR curated interactions for GRIK5 Gene

Drugs & Compounds for GRIK5 Gene

(22) Drugs for GRIK5 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Topiramate Approved Pharma Target, antagonist GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 277
Butabarbital Approved, Illicit Pharma Target, antagonist 0
Glutamic acid Approved Nutra Agonist, Full agonist, Target 304
Domoic acid Experimental Pharma Agonist, Full agonist Potent, selective kainate agonist 0
Tezampanel Investigational Pharma 0

(2) Additional Compounds for GRIK5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for GRIK5 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(13) ApexBio Compounds for GRIK5 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK5: view

Drug Products

Transcripts for GRIK5 Gene

mRNA/cDNA for GRIK5 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIK5

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK5 Gene

No ASD Table

Relevant External Links for GRIK5 Gene

GeneLoc Exon Structure for
GRIK5

Expression for GRIK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK5 Gene

This gene is overexpressed in Testis (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIK5 Gene



Protein tissue co-expression partners for GRIK5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIK5

SOURCE GeneReport for Unigene cluster for GRIK5 Gene:

Hs.367799

Evidence on tissue expression from TISSUES for GRIK5 Gene

  • Nervous system(4.7)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GRIK5: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK5 Gene

Orthologs for GRIK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GRIK5 30 31
  • 99.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GRIK5 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GRIK5 30 31
  • 93.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GRIK5 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Grik5 30 17 31
  • 91.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Grik5 30
  • 91.66 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GRIK5 31
  • 91 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GRIK5 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia grik5 30
  • 74.35 (n)
Zebrafish
(Danio rerio)
Actinopterygii GRIK5 (2 of 2) 31
  • 79 (a)
OneToMany
grik5 30 31
  • 74.77 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG11155 31 32
  • 39 (a)
ManyToMany
CG9935 31 32
  • 36 (a)
ManyToMany
Kai-RIA 32
  • 35 (a)
CG5621 32
  • 35 (a)
clumsy 32
  • 35 (a)
CG15627 32
  • 33 (a)
Glu-RIIA 32
  • 30 (a)
CG4226 32
  • 28 (a)
Glu-RIIB 32
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea glr-4 32
  • 34 (a)
Species where no ortholog for GRIK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRIK5 Gene

ENSEMBL:
Gene Tree for GRIK5 (if available)
TreeFam:
Gene Tree for GRIK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIK5: view image

Paralogs for GRIK5 Gene

(8) SIMAP similar genes for GRIK5 Gene using alignment to 2 proteins:

  • GRIK5_HUMAN
  • M0QXF6_HUMAN
genes like me logo Genes that share paralogs with GRIK5: view

Variants for GRIK5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIK5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
710767 Likely Benign: not provided 42,053,704(-) C/T SYNONYMOUS_VARIANT
775414 Benign: not provided 42,005,910(-) G/A SYNONYMOUS_VARIANT
779044 Benign: not provided 42,003,351(-) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GRIK5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIK5 Gene

Variant ID Type Subtype PubMed ID
dgv3550n100 CNV gain 25217958
dgv6459n54 CNV loss 21841781
esv24829 CNV loss 19812545
esv2677186 CNV deletion 23128226
esv3644397 CNV loss 21293372
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv579629 CNV loss 21841781

Variation tolerance for GRIK5 Gene

Residual Variation Intolerance Score: 9.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK5 Gene

Disorders for GRIK5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GRIK5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome 3
  • brgda3
schizophrenia
  • sczd
autosomal dominant non-syndromic intellectual disability 5
  • mrd5
bipolar disorder
  • major affective disorder 1
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search GRIK5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIK5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GRIK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK5 Gene

Publications for GRIK5 Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 23 41
  2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H … Fukumaki Y (Psychiatry research 2006) 3 23 41
  3. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. (PMID: 7527545) Szpirer C … Copeland NG (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 23
  4. Genome-wide association study on bipolar disorder in the Bulgarian population. (PMID: 21771265) Yosifova A … Nakamura Y (Genes, brain, and behavior 2011) 3 41
  5. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PMID: 19125103) Arai S … Fukumaki Y (Psychiatric genetics 2009) 3 41

Products for GRIK5 Gene

Sources for GRIK5 Gene