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Aliases for GRIK4 Gene

Aliases for GRIK4 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 4 2 3 5
  • Glutamate Receptor, Ionotropic, Kainate 4 2 3
  • Excitatory Amino Acid Receptor 1 3 4
  • GluK4 3 4
  • GRIK 3 4
  • EAA1 3 4
  • KA1 3 4
  • Glutamate Receptor Ionotropic, Kainate 4 3
  • Glutamate Receptor KA-1 4
  • Glutamate Receptor KA1 3

External Ids for GRIK4 Gene

Previous HGNC Symbols for GRIK4 Gene

  • GRIK

Previous GeneCards Identifiers for GRIK4 Gene

  • GC11P122530
  • GC11P122042
  • GC11P120068
  • GC11P120036
  • GC11P116471
  • GC11P120386
  • GC11P120388
  • GC11P120391

Summaries for GRIK4 Gene

Entrez Gene Summary for GRIK4 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GRIK4 Gene

GRIK4 (Glutamate Ionotropic Receptor Kainate Type Subunit 4) is a Protein Coding gene. Diseases associated with GRIK4 include Bipolar Disorder and Schizophrenia. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIK5.

UniProtKB/Swiss-Prot for GRIK4 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Tocris Summary for GRIK4 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Additional gene information for GRIK4 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK4 Gene

Genomics for GRIK4 Gene

GeneHancer (GH) Regulatory Elements for GRIK4 Gene

Promoters and enhancers for GRIK4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I120511 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 0.0 -13 1 HDGF RB1 YBX1 ZNF2 ZNF48 RAD21 ZEB1 GLIS2 ZNF213 ARID2 GRIK4 SC5D GC11P120421
GH11I120563 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 574.4 +53.6 53568 3.3 HDGF RB1 BATF EGR1 ZNF143 FOS BCLAF1 IKZF2 RUNX3 CREM GRIK4 GC11P120575 GC11P120523
GH11I120579 Promoter/Enhancer 1.1 EPDnew FANTOM5 550.2 +68.1 68136 0.3 ZNF366 IKZF1 NFATC1 NBN IKZF2 RUNX3 RELA GRIK4 GC11P120575 GC11P120597
GH11I120906 Enhancer 0.6 ENCODE 48.7 +397.3 397336 4.3 ESRRA MAX CEBPG ZNF217 GATA3 CTBP1 POLR2A MYC EGR2 GRIK4 TECTA GC11P120895 HMGB1P42
GH11I120540 Enhancer 0.7 ENCODE 23.5 +29.4 29360 1.6 SOX5 SOX13 GATAD2A TFAP4 MXI1 SAP130 TEAD1 ARID4B CEBPG MNT GRIK4 GC11P120523 GC11P120575
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRIK4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRIK4 gene promoter:

Genomic Locations for GRIK4 Gene

Genomic Locations for GRIK4 Gene
chr11:120,511,700-120,988,904
(GRCh38/hg38)
Size:
477,205 bases
Orientation:
Plus strand
chr11:120,382,468-120,859,613
(GRCh37/hg19)

Genomic View for GRIK4 Gene

Genes around GRIK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK4 Gene

Proteins for GRIK4 Gene

  • Protein details for GRIK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16099-GRIK4_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Protein Accession:
    Q16099
    Secondary Accessions:
    • A8K9L1

    Protein attributes for GRIK4 Gene

    Size:
    956 amino acids
    Molecular mass:
    107246 Da
    Quaternary structure:
    • Forms a heteromeric channel with GRIK1 or GRIK3.

neXtProt entry for GRIK4 Gene

Post-translational modifications for GRIK4 Gene

  • Glycosylation at isoforms=158, isoforms=220, isoforms=272, isoforms=286, posLast=323323, posLast=408408, posLast=415415, and isoforms=479

No data available for DME Specific Peptides for GRIK4 Gene

Domains & Families for GRIK4 Gene

Gene Families for GRIK4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for GRIK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16099

UniProtKB/Swiss-Prot:

GRIK4_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
genes like me logo Genes that share domains with GRIK4: view

Function for GRIK4 Gene

Molecular function for GRIK4 Gene

GENATLAS Biochemistry:
glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Phenotypes From GWAS Catalog for GRIK4 Gene

Gene Ontology (GO) - Molecular Function for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005234 extracellularly glutamate-gated ion channel activity IEA --
GO:0015276 ligand-gated ion channel activity TAS --
GO:0015277 kainate selective glutamate receptor activity TAS 8263508
genes like me logo Genes that share ontologies with GRIK4: view
genes like me logo Genes that share phenotypes with GRIK4: view

Animal Models for GRIK4 Gene

MGI Knock Outs for GRIK4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK4 Gene

Localization for GRIK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8263508
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIK4 Gene

Pathways & Interactions for GRIK4 Gene

genes like me logo Genes that share pathways with GRIK4: view

Gene Ontology (GO) - Biological Process for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8263508
GO:0006811 ion transport IEA --
GO:0007215 glutamate receptor signaling pathway TAS 8263508
GO:0007268 chemical synaptic transmission TAS 8263508
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK4: view

No data available for SIGNOR curated interactions for GRIK4 Gene

Drugs & Compounds for GRIK4 Gene

(23) Drugs for GRIK4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 257
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
kainate Pharma Full agonist, Agonist 0
Kainic acid Pharma kainate receptor agonist, selective, Potent excitant and neurotoxin 0

(1) Additional Compounds for GRIK4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for GRIK4 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(12) ApexBio Compounds for GRIK4 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK4: view

Drug Products

Transcripts for GRIK4 Gene

mRNA/cDNA for GRIK4 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK4 Gene

Glutamate receptor, ionotropic, kainate 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK4 Gene

No ASD Table

Relevant External Links for GRIK4 Gene

GeneLoc Exon Structure for
GRIK4
ECgene alternative splicing isoforms for
GRIK4

Expression for GRIK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hippocampus (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK4 Gene



Protein tissue co-expression partners for GRIK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIK4 Gene:

GRIK4

SOURCE GeneReport for Unigene cluster for GRIK4 Gene:

Hs.568901

Evidence on tissue expression from TISSUES for GRIK4 Gene

  • Nervous system(4.5)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with GRIK4: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK4 Gene

Orthologs for GRIK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK4 33 34
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIK4 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK4 33 34
  • 94.91 (n)
cow
(Bos Taurus)
Mammalia GRIK4 33 34
  • 93.38 (n)
rat
(Rattus norvegicus)
Mammalia Grik4 33
  • 92.12 (n)
mouse
(Mus musculus)
Mammalia Grik4 33 16 34
  • 91.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK4 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIK4 33 34
  • 85.18 (n)
lizard
(Anolis carolinensis)
Reptilia GRIK4 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik4 33
  • 76.37 (n)
zebrafish
(Danio rerio)
Actinopterygii grik4 33 34
  • 74.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11155 35 34
  • 51 (a)
CG9935 35 34
  • 44 (a)
CG5621 35
  • 36 (a)
clumsy 35
  • 35 (a)
Kai-RIA 35
  • 34 (a)
Glu-RIIA 35
  • 29 (a)
CG15627 35
  • 27 (a)
Glu-RIIB 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-4 35
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os07g0103100 33
  • 43.78 (n)
Species where no ortholog for GRIK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK4 Gene

ENSEMBL:
Gene Tree for GRIK4 (if available)
TreeFam:
Gene Tree for GRIK4 (if available)

Paralogs for GRIK4 Gene

(9) SIMAP similar genes for GRIK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK4: view

Variants for GRIK4 Gene

Sequence variations from dbSNP and Humsavar for GRIK4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1954787 drug-response, antidepressants response - Efficacy, citalopram response - Efficacy 120,792,654(+) T/C genic_upstream_transcript_variant, intron_variant
rs534517447 likely-pathogenic, not provided 120,956,935(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs869312699 likely-pathogenic, not provided 120,986,102(+) CTGGCGCAGGAGGCC/GCT coding_sequence_variant, genic_downstream_transcript_variant, inframe_deletion
rs1000000898 -- 120,558,481(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000003003 -- 120,757,761(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK4 Gene

Variant ID Type Subtype PubMed ID
esv3627908 CNV loss 21293372
esv3627907 CNV gain 21293372
esv3627906 CNV loss 21293372
esv3627905 CNV loss 21293372
esv3548428 CNV deletion 23714750
esv3428981 CNV insertion 20981092
esv3417008 CNV duplication 20981092
esv3365919 CNV insertion 20981092
esv3332666 CNV duplication 20981092
esv28495 CNV loss 19812545
esv27851 CNV gain 19812545
esv2745147 CNV deletion 23290073
esv2745146 CNV deletion 23290073
esv2674567 CNV deletion 23128226
esv2671584 CNV deletion 23128226
esv2666173 CNV deletion 23128226
esv2662643 CNV deletion 23128226
esv2600363 CNV insertion 19546169
esv22400 CNV loss 19812545
dgv1290n100 CNV gain 25217958
dgv1289n100 CNV gain 25217958
nsv975985 CNV duplication 23825009
nsv832286 CNV loss 17160897
nsv826106 CNV loss 20364138
nsv826105 CNV gain 20364138
nsv556476 CNV gain 21841781
nsv556475 CNV loss 21841781
nsv556474 CNV loss 21841781
nsv556473 CNV loss 21841781
nsv556472 CNV loss 21841781
nsv524900 CNV loss 19592680
nsv523053 CNV loss 19592680
nsv523 CNV insertion 18451855
nsv522869 CNV loss 19592680
nsv478755 CNV novel sequence insertion 20440878
nsv477241 CNV novel sequence insertion 20440878
nsv474304 CNV novel sequence insertion 20440878
nsv468881 CNV gain 19166990
nsv1150134 CNV deletion 26484159
nsv1118223 CNV deletion 24896259
nsv1053749 CNV gain 25217958
nsv1053607 CNV gain 25217958
nsv1036388 CNV gain 25217958
esv3627911 CNV loss 21293372
esv3627910 CNV loss 21293372
esv3627909 CNV loss 21293372

Variation tolerance for GRIK4 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK4 Gene

Human Gene Mutation Database (HGMD)
GRIK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK4 Gene

Disorders for GRIK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIK4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GRIK4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIK4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRIK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK4 Gene

Publications for GRIK4 Gene

  1. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PMID: 18289755) Li Z … Shi Y (Progress in neuro-psychopharmacology & biological psychiatry 2008) 3 22 44 58
  2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H … Fukumaki Y (Psychiatry research 2006) 3 22 44 58
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 44 58
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for GRIK4 Gene

Sources for GRIK4 Gene

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