Aliases for GRIK3 Gene
External Ids for GRIK3 Gene
Previous GeneCards Identifiers for GRIK3 Gene
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRIK3 Gene
GRIK3 (Glutamate Ionotropic Receptor Kainate Type Subunit 3) is a Protein Coding gene. Diseases associated with GRIK3 include Schizophrenia and Depersonalization Disorder. Among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and glutamate receptor activity. An important paralog of this gene is GRIK2.
UniProtKB/Swiss-Prot Summary for GRIK3 Gene
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.