Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene i... See more...

Aliases for GRIK3 Gene

Aliases for GRIK3 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 3 2 3 5
  • Glutamate Receptor Ionotropic, Kainate 3 3 4
  • Excitatory Amino Acid Receptor 5 3 4
  • Glutamate Receptor 7 3 4
  • GluR-7 3 4
  • GLUR7 3 4
  • GluK3 3 4
  • EAA5 3 4
  • DJ1090M5.1 (Glutamate Receptor, Ionotropic, Kainate 3 (GLUR7)) 3
  • Glutamate Receptor, Ionotropic, Kainate 3 2
  • GluR7a 3
  • GluR7 4
  • GLR7 3

External Ids for GRIK3 Gene

Previous GeneCards Identifiers for GRIK3 Gene

  • GC01M037087
  • GC01M036321
  • GC01M036693
  • GC01M036694
  • GC01M036935
  • GC01M037261
  • GC01M035378

Summaries for GRIK3 Gene

Entrez Gene Summary for GRIK3 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIK3 Gene

GRIK3 (Glutamate Ionotropic Receptor Kainate Type Subunit 3) is a Protein Coding gene. Diseases associated with GRIK3 include Schizophrenia and Obsessive-Compulsive Disorder. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and glutamate receptor activity. An important paralog of this gene is GRIK2.

UniProtKB/Swiss-Prot Summary for GRIK3 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Tocris Summary for GRIK3 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Gene Wiki entry for GRIK3 Gene

Additional gene information for GRIK3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIK3 Gene

Genomics for GRIK3 Gene

GeneHancer (GH) Regulatory Elements for GRIK3 Gene

Promoters and enhancers for GRIK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037034 Promoter 1.2 EPDnew Ensembl 500.7 +0.0 47 1 ZBTB26 EZH2 ZNF76 ZFHX2 E2F6 GATA3 ZNF335 KLF17 ZNF18 ZNF398 GRIK3 RF00017-160
GH01J037036 Enhancer 0.8 Ensembl ENCODE 505 -1.8 -1818 0.9 CTCF ZBTB11 GABPA SMC3 SPI1 ETS1 TAL1 ZBTB7A FOXP2 VEZF1 GRIK3 RF00017-161 lnc-GRIK3-1
GH01J037037 Enhancer 0.9 Ensembl ENCODE 7.9 -3.7 -3681 1.7 CTCF ZIC2 RFX1 CEBPB SMC3 ZBTB17 CEBPG RAD21 ESR1 GATA3 GRIK3 RF00017-161 lnc-GRIK3-1
GH01J037071 Enhancer 0.6 Ensembl ENCODE 11.4 -37.7 -37655 1.1 TAL1 BHLHE40 CBFA2T2 CBFA2T3 GRIK3 piR-50308-025 RF00017-161 lnc-GRIK3-1
GH01J036947 Enhancer 0.5 Ensembl 10.9 +86.8 86847 1 USF1 ZKSCAN1 GLIS1 ZNF398 MAZ PRDM10 DPF2 SCRT2 GRIK3 RF00017-159 lnc-CSF3R-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIK3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIK3

Top Transcription factor binding sites by QIAGEN in the GRIK3 gene promoter:
  • AhR
  • Arnt
  • FOXL1
  • GATA-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for GRIK3 Gene

Genomic Locations for GRIK3 Gene
chr1:36,795,527-37,034,548
(GRCh38/hg38)
Size:
239,022 bases
Orientation:
Minus strand
chr1:37,261,128-37,499,844
(GRCh37/hg19)
Size:
238,717 bases
Orientation:
Minus strand

Genomic View for GRIK3 Gene

Genes around GRIK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK3 Gene

Proteins for GRIK3 Gene

  • Protein details for GRIK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13003-GRIK3_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 3
    Protein Accession:
    Q13003
    Secondary Accessions:
    • A9Z1Z8
    • B1AMS6
    • Q13004
    • Q16136

    Protein attributes for GRIK3 Gene

    Size:
    919 amino acids
    Molecular mass:
    104037 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).

    Alternative splice isoforms for GRIK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK3 Gene

Post-translational modifications for GRIK3 Gene

  • Glycosylation at Asn70, Asn76, Asn278, Asn381, Asn415, Asn426, Asn433, and Asn548
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIK3 Gene

Domains & Families for GRIK3 Gene

Gene Families for GRIK3 Gene

Protein Domains for GRIK3 Gene

Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIK3 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor 7 (GRIK3_HUMAN)
  • Glutamate receptor 7 (Q96QG5_HUMAN)
  • Glutamate receptor 7 (Q96SC0_HUMAN)
  • Glutamate receptor 7 (Q96SC1_HUMAN)
  • Glutamate receptor 7 (Q96SC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13003

UniProtKB/Swiss-Prot:

GRIK3_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.
genes like me logo Genes that share domains with GRIK3: view

Function for GRIK3 Gene

Molecular function for GRIK3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
GENATLAS Biochemistry:
glutamate receptor 7,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

Phenotypes From GWAS Catalog for GRIK3 Gene

Gene Ontology (GO) - Molecular Function for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA 9144652
GO:0004970 ionotropic glutamate receptor activity ISS,IDA --
GO:0005216 ion channel activity IEA --
GO:0008066 glutamate receptor activity TAS 8128318
GO:0015276 ligand-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIK3: view
genes like me logo Genes that share phenotypes with GRIK3: view

Animal Models for GRIK3 Gene

MGI Knock Outs for GRIK3:

Animal Model Products

CRISPR Products

miRNA for GRIK3 Gene

miRTarBase miRNAs that target GRIK3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIK3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK3 Gene

Localization for GRIK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK3 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0005887 integral component of plasma membrane IDA 7719709
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIK3 Gene

Pathways & Interactions for GRIK3 Gene

genes like me logo Genes that share pathways with GRIK3: view

Gene Ontology (GO) - Biological Process for GRIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA --
GO:0007215 glutamate receptor signaling pathway IDA 7719709
GO:0007216 G protein-coupled glutamate receptor signaling pathway IDA 9144652
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK3: view

No data available for SIGNOR curated interactions for GRIK3 Gene

Drugs & Compounds for GRIK3 Gene

(25) Drugs for GRIK3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Full agonist, Agonist, Target 289
Topiramate Approved Pharma Target, antagonist GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 273
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
Tezampanel Investigational Pharma AMPA and receptor antagonist 0
kainate Pharma Full agonist, Agonist 0

(1) Additional Compounds for GRIK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for GRIK3 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(12) ApexBio Compounds for GRIK3 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK3: view

Drug Products

Transcripts for GRIK3 Gene

mRNA/cDNA for GRIK3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIK3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK3 Gene

No ASD Table

Relevant External Links for GRIK3 Gene

GeneLoc Exon Structure for
GRIK3

Expression for GRIK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK3 Gene

This gene is overexpressed in Nerve - Tibial (x6.0) and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for GRIK3 Gene

This gene is overexpressed in Plasma (34.7), Heart (15.8), and Fetal Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIK3 Gene



Protein tissue co-expression partners for GRIK3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIK3

SOURCE GeneReport for Unigene cluster for GRIK3 Gene:

Hs.128848

Evidence on tissue expression from TISSUES for GRIK3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with GRIK3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK3 Gene

Orthologs for GRIK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK3 31 30
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK3 31
  • 99 (a)
OneToOne
LOC608269 30
  • 93.54 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIK3 31
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK3 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK3 31 30
  • 93.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik3 30
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Grik3 17 31 30
  • 90.17 (n)
chicken
(Gallus gallus)
Aves GRIK3 31 30
  • 83.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK3 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498426 30
  • 75.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334689 30
  • 75.37 (n)
GRIK3 31
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11155 32
  • 53 (a)
CG3822 31 32
  • 47 (a)
ManyToMany
CG9935 32
  • 42 (a)
Kai-RIA 32
  • 37 (a)
CG5621 31 32
  • 34 (a)
ManyToMany
KaiRIA 31
  • 33 (a)
ManyToMany
clumsy 31 32
  • 33 (a)
ManyToMany
CG15627 32
  • 32 (a)
GluRIIE 31
  • 31 (a)
ManyToMany
Glu-RIIA 32
  • 31 (a)
CG4226 32
  • 30 (a)
GluRIIA 31
  • 29 (a)
ManyToMany
Glu-RIIB 32
  • 29 (a)
GluRIIC 31
  • 28 (a)
ManyToMany
GluRIIB 31
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-4 32
  • 35 (a)
Species where no ortholog for GRIK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK3 Gene

ENSEMBL:
Gene Tree for GRIK3 (if available)
TreeFam:
Gene Tree for GRIK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIK3: view image

Paralogs for GRIK3 Gene

(14) SIMAP similar genes for GRIK3 Gene using alignment to 6 proteins:

  • GRIK3_HUMAN
  • A9Z1Z8_HUMAN
  • Q96QG5_HUMAN
  • Q96SC0_HUMAN
  • Q96SC1_HUMAN
  • Q96SC2_HUMAN
genes like me logo Genes that share paralogs with GRIK3: view

Variants for GRIK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIK3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711826 Benign: not provided 36,853,726(-) C/T INTRON_VARIANT
717890 Benign: not provided 36,841,856(-) T/C SYNONYMOUS_VARIANT
722099 Likely Benign: not provided 36,891,083(-) C/T SYNONYMOUS_VARIANT
727964 Likely Benign: not provided 36,806,096(-) T/A INTRON_VARIANT
731061 Benign: not provided 36,859,976(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GRIK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIK3 Gene

Variant ID Type Subtype PubMed ID
dgv19e201 CNV deletion 23290073
dgv231n54 CNV loss 21841781
dgv232n54 CNV gain 21841781
esv1102722 CNV insertion 17803354
esv23328 CNV loss 19812545
esv2459868 CNV deletion 19546169
esv2538711 CNV insertion 19546169
esv2553528 CNV loss 19546169
esv2747007 CNV deletion 23290073
esv2747030 CNV deletion 23290073
esv2747052 CNV deletion 23290073
esv2747074 CNV deletion 23290073
esv2747096 CNV deletion 23290073
esv2747107 CNV deletion 23290073
esv2747118 CNV deletion 23290073
esv2747129 CNV deletion 23290073
esv2747142 CNV deletion 23290073
esv2906 CNV loss 18987735
esv3151 CNV loss 18987735
esv3560793 CNV deletion 23714750
esv7566 CNV loss 19470904
nsv1003721 CNV gain 25217958
nsv1124223 CNV deletion 24896259
nsv1137749 CNV deletion 24896259
nsv1150669 CNV deletion 26484159
nsv466 CNV deletion 18451855
nsv473098 CNV novel sequence insertion 20440878
nsv522473 CNV loss 19592680
nsv546001 CNV loss 21841781
nsv546002 CNV loss 21841781
nsv546011 CNV loss 21841781
nsv546012 CNV loss 21841781
nsv546013 CNV loss 21841781
nsv821045 CNV duplication 20802225
nsv834713 CNV gain 17160897
nsv950621 CNV deletion 24416366

Variation tolerance for GRIK3 Gene

Residual Variation Intolerance Score: 2.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK3 Gene

Human Gene Mutation Database (HGMD)
GRIK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK3 Gene

Disorders for GRIK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GRIK3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
obsessive-compulsive disorder
  • ocd
neuronitis
alcohol dependence
  • alcoholism
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search GRIK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRIK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK3 Gene

Publications for GRIK3 Gene

  1. Chromosomal localization of gene for human glutamate receptor subunit-7. (PMID: 8128318) Puranam RS … McNamara JO (Somatic cell and molecular genetics 1993) 2 3 4 23 54
  2. Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population. (PMID: 19921975) Ahmad Y … Sinha S (The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2009) 3 23 41 54
  3. An association of GRIK3 Ser310Ala functional polymorphism with personality traits. (PMID: 19221446) Minelli A … Gennarelli M (Neuropsychobiology 2009) 3 23 41 54
  4. Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. (PMID: 16958029) Schiffer HH … Heinemann SF (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 23 41 54
  5. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H … Fukumaki Y (Psychiatry research 2006) 3 23 41 54

Products for GRIK3 Gene

Sources for GRIK3 Gene