Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRIK1-AS2 Gene

Subcategory (RNA class) for GRIK1-AS2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for GRIK1-AS2 Gene

  • GRIK1 Antisense RNA 2 2 3
  • GRIK1 Antisense RNA 2 (Non-Protein Coding) 2 3
  • BACH1 4 5
  • Chromosome 21 Open Reading Frame 41 2
  • BTB Domain And CNC Homolog 1 5
  • Non-Protein Coding RNA 258 2
  • BTB And CNC Homolog 1 4
  • NCRNA00258 3
  • C21orf41 3
  • HA2303 4

External Ids for GRIK1-AS2 Gene

Previous HGNC Symbols for GRIK1-AS2 Gene

  • C21orf41
  • NCRNA00258

Previous GeneCards Identifiers for GRIK1-AS2 Gene

  • GC21P030970

Summaries for GRIK1-AS2 Gene

GeneCards Summary for GRIK1-AS2 Gene

GRIK1-AS2 (GRIK1 Antisense RNA 2) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are Integrated Breast Cancer Pathway and Integrated Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and heme binding. An important paralog of this gene is BACH2.

UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

  • Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Additional gene information for GRIK1-AS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK1-AS2 Gene

Genomics for GRIK1-AS2 Gene

GeneHancer (GH) Regulatory Elements for GRIK1-AS2 Gene

Promoters and enhancers for GRIK1-AS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I029193 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.7 1705 4.2 PKNOX1 FOXA2 ARNT IRF4 YY1 ZNF766 CBX5 ZNF143 FOS KLF13 BACH1 GRIK1-AS2 RPL23P2 LINC00189 USP16 MAP3K7CL ENSG00000232855 GC21M029206
GH21I029194 Enhancer 0.7 ENCODE dbSUPER 550.8 -0.8 -796 0.2 POLR2A NRF1 RCOR1 CHD2 LINC00189 GRIK1-AS2 BACH1 ENSG00000224649
GH21I029639 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +446.1 446138 1.6 GTF2E2 TEAD4 MAX BACH1 ZNF644 ZBTB40 RELA CHAMP1 FOSL1 CC2D1A BACH1 GRIK1-AS2 ENSG00000273464 LOC105372768 GRIK1
GH21I029647 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.3 +453.5 453451 0.3 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 E2F8 BACH1 GRIK1-AS2 USP16 ENSG00000273464 LOC105372768 GRIK1
GH21I029641 Enhancer 1.2 ENCODE dbSUPER 11.3 +448.2 448177 1.3 HDGF PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 GATA2 LTN1 ENSG00000231125 USP16 RPL12P9 BACH1 GRIK1-AS2 ENSG00000273464 LOC105372768 GRIK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRIK1-AS2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GRIK1-AS2 Gene

Genomic Locations for GRIK1-AS2 Gene
chr21:29,194,071-29,630,751
(GRCh38/hg38)
Size:
436,681 bases
Orientation:
Plus strand
chr21:30,968,360-31,003,067
(GRCh37/hg19)

Genomic View for GRIK1-AS2 Gene

Genes around GRIK1-AS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK1-AS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK1-AS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK1-AS2 Gene

Proteins for GRIK1-AS2 Gene

  • Protein details for GRIK1-AS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14867-BACH1_HUMAN
    Recommended name:
    Transcription regulator protein BACH1
    Protein Accession:
    O14867
    Secondary Accessions:
    • O43285
    • Q6ICU0

    Protein attributes for GRIK1-AS2 Gene

    Size:
    736 amino acids
    Molecular mass:
    81958 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GRIK1-AS2 Gene

neXtProt entry for GRIK1-AS2 Gene

Post-translational modifications for GRIK1-AS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRIK1-AS2 Gene

Domains & Families for GRIK1-AS2 Gene

Graphical View of Domain Structure for InterPro Entry

O14867

UniProtKB/Swiss-Prot:

BACH1_HUMAN :
  • Belongs to the bZIP family. CNC subfamily.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with GRIK1-AS2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for GRIK1-AS2 Gene

Function for GRIK1-AS2 Gene

Molecular function for GRIK1-AS2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

Phenotypes From GWAS Catalog for GRIK1-AS2 Gene

Gene Ontology (GO) - Molecular Function for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP --
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

Phenotypes for GRIK1-AS2 Gene

GenomeRNAi human phenotypes for GRIK1-AS2:
genes like me logo Genes that share phenotypes with GRIK1-AS2: view

Animal Model Products

Transcription Factor Targets for GRIK1-AS2 Gene

Selected GeneGlobe predicted Target genes for GRIK1-AS2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for GRIK1-AS2 Gene

Localization for GRIK1-AS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK1-AS2 gene
Compartment Confidence
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIK1-AS2 Gene

Pathways & Interactions for GRIK1-AS2 Gene

genes like me logo Genes that share pathways with GRIK1-AS2: view

Pathways by source for GRIK1-AS2 Gene

2 BioSystems pathways for GRIK1-AS2 Gene

Gene Ontology (GO) - Biological Process for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle IMP --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006281 DNA repair IMP --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

No data available for SIGNOR curated interactions for GRIK1-AS2 Gene

Drugs & Compounds for GRIK1-AS2 Gene

No Compound Related Data Available

Transcripts for GRIK1-AS2 Gene

mRNA/cDNA for GRIK1-AS2 Gene

(3) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK1-AS2 Gene

GRIK1 antisense RNA 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1-AS2 Gene

No ASD Table

Relevant External Links for GRIK1-AS2 Gene

GeneLoc Exon Structure for
GRIK1-AS2
ECgene alternative splicing isoforms for
GRIK1-AS2

Expression for GRIK1-AS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIK1-AS2 Gene

Protein differential expression in normal tissues from HIPED for GRIK1-AS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK1-AS2 Gene



Protein tissue co-expression partners for GRIK1-AS2 Gene

SOURCE GeneReport for Unigene cluster for GRIK1-AS2 Gene:

Hs.659368
genes like me logo Genes that share expression patterns with GRIK1-AS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK1-AS2 Gene

Orthologs for GRIK1-AS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK1-AS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BACH1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BACH1 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BACH1 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bach1 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BACH1 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BACH1 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves BACH1 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BACH1 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bach1 34
  • 46 (a)
OneToMany
BACH1 (2 of 2) 34
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cnc 34
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for GRIK1-AS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIK1-AS2 Gene

ENSEMBL:
Gene Tree for GRIK1-AS2 (if available)
TreeFam:
Gene Tree for GRIK1-AS2 (if available)

Paralogs for GRIK1-AS2 Gene

genes like me logo Genes that share paralogs with GRIK1-AS2: view

Variants for GRIK1-AS2 Gene

Sequence variations from dbSNP and Humsavar for GRIK1-AS2 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000119200 -- 29,624,435(+) G/A/T intron_variant
rs1000184149 -- 29,615,340(+) C/T intron_variant
rs1000242067 -- 29,609,349(+) A/G intron_variant
rs1000421437 -- 29,603,779(+) G/A intron_variant
rs1000542265 -- 29,610,515(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK1-AS2 Gene

Variant ID Type Subtype PubMed ID
esv2676813 CNV deletion 23128226
esv28655 CNV loss 19812545
esv3646802 CNV loss 21293372

Variation tolerance for GRIK1-AS2 Gene

Gene Damage Index Score: 0.40; 8.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK1-AS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK1-AS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Disorders for GRIK1-AS2 Gene

Additional Disease Information for GRIK1-AS2

No disorders were found for GRIK1-AS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIK1-AS2 Gene

Publications for GRIK1-AS2 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for GRIK1-AS2 Gene

Sources for GRIK1-AS2 Gene

Content
Loading form....