Aliases for GRIK1-AS2 Gene

Subcategory (RNA class) for GRIK1-AS2 Gene

lncRNA

Number of RNA Genes sources:

1 / 17

Aliases for GRIK1-AS2 Gene

  • GRIK1 Antisense RNA 2 2 3
  • GRIK1 Antisense RNA 2 (Non-Protein Coding) 2 3
  • Transcription Regulator Protein BACH1 4
  • Chromosome 21 Open Reading Frame 41 2
  • BTB Domain And CNC Homolog 1 5
  • Non-Protein Coding RNA 258 2
  • BTB And CNC Homolog 1 4
  • HSALNG0132562 164
  • NCRNA00258 3
  • GRIK1-AS2 2
  • C21orf41 3
  • HA2303 4
  • BACH1 5

External Ids for GRIK1-AS2 Gene

Previous HGNC Symbols for GRIK1-AS2 Gene

  • C21orf41
  • NCRNA00258

Previous GeneCards Identifiers for GRIK1-AS2 Gene

  • GC21P030970

Summaries for GRIK1-AS2 Gene

GeneCards Summary for GRIK1-AS2 Gene

GRIK1-AS2 (GRIK1 Antisense RNA 2) is an RNA Gene, and is affiliated with the lncRNA class. Among its related pathways are Integrated Cancer Pathway and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and heme binding. An important paralog of this gene is BACH2.

UniProtKB/Swiss-Prot Summary for GRIK1-AS2 Gene

  • Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).

Additional gene information for GRIK1-AS2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIK1-AS2 Gene

Genomics for GRIK1-AS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRIK1-AS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIK1-AS2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for GRIK1-AS2 Gene

Genomic Locations for GRIK1-AS2 Gene
chr21:29,194,071-29,630,751
(GRCh38/hg38)
Size:
436,681 bases
Orientation:
Plus strand
chr21:30,968,360-31,003,067
(GRCh37/hg19)
Size:
34,708 bases
Orientation:
Plus strand

Genomic View for GRIK1-AS2 Gene

Genes around GRIK1-AS2 on UCSC Golden Path with GeneCards custom track
GRIK1-AS2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
GRIK1-AS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK1-AS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK1-AS2 Gene

Proteins for GRIK1-AS2 Gene

  • Protein details for GRIK1-AS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14867-BACH1_HUMAN
    Recommended name:
    Transcription regulator protein BACH1
    Protein Accession:
    O14867
    Secondary Accessions:
    • O43285
    • Q6ICU0

    Protein attributes for GRIK1-AS2 Gene

    Size:
    736 amino acids
    Molecular mass:
    81958 Da
    Quaternary structure:
    • Heterodimer of BACH1 and MAFK.

    Three dimensional structures from OCA and Proteopedia for GRIK1-AS2 Gene

neXtProt entry for GRIK1-AS2 Gene

Post-translational modifications for GRIK1-AS2 Gene

  • Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRIK1-AS2 Gene

Domains & Families for GRIK1-AS2 Gene

Gene Families for GRIK1-AS2 Gene

Protein Domains for GRIK1-AS2 Gene

InterPro:
Blocks:
  • BTB/POZ domain
  • bZIP transcription factor, bZIP_1
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O14867

UniProtKB/Swiss-Prot:

BACH1_HUMAN :
  • Belongs to the bZIP family. CNC subfamily.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with GRIK1-AS2: view

No data available for Suggested Antigen Peptide Sequences for GRIK1-AS2 Gene

Function for GRIK1-AS2 Gene

Molecular function for GRIK1-AS2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).

Phenotypes From GWAS Catalog for GRIK1-AS2 Gene

Gene Ontology (GO) - Molecular Function for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IMP --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

Phenotypes for GRIK1-AS2 Gene

GenomeRNAi human phenotypes for GRIK1-AS2:
genes like me logo Genes that share phenotypes with GRIK1-AS2: view

Animal Model Products

CRISPR Products

miRNA for GRIK1-AS2 Gene

miRTarBase miRNAs that target GRIK1-AS2

Transcription Factor Targets for GRIK1-AS2 Gene

Selected GeneGlobe predicted Target genes for GRIK1-AS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for GRIK1-AS2 Gene

Localization for GRIK1-AS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Gene Ontology (GO) - Cellular Components for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm HDA --
GO:0005829 cytosol HDA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GRIK1-AS2 Gene

Pathways & Interactions for GRIK1-AS2 Gene

PathCards logo

SuperPathways for GRIK1-AS2 Gene

genes like me logo Genes that share pathways with GRIK1-AS2: view

Pathways by source for GRIK1-AS2 Gene

2 BioSystems pathways for GRIK1-AS2 Gene

Gene Ontology (GO) - Biological Process for GRIK1-AS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP --
GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle IMP --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006281 DNA repair IMP --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with GRIK1-AS2: view

No data available for SIGNOR curated interactions for GRIK1-AS2 Gene

Drugs & Compounds for GRIK1-AS2 Gene

No Compound Related Data Available

Transcripts for GRIK1-AS2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for GRIK1-AS2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D82C_9606 lncRNA 1073 3

HGNC: 1282,

RefSeq: NR_033368,

LncBook: HSALNT0272550,

GRIK1-AS2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for GRIK1-AS2 Gene

1 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1-AS2 Gene

No ASD Table

Relevant External Links for GRIK1-AS2 Gene

GeneLoc Exon Structure for
GRIK1-AS2

Expression for GRIK1-AS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIK1-AS2 Gene

Protein differential expression in normal tissues from HIPED for GRIK1-AS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIK1-AS2 Gene



Protein tissue co-expression partners for GRIK1-AS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIK1-AS2

SOURCE GeneReport for Unigene cluster for GRIK1-AS2 Gene:

Hs.659368
genes like me logo Genes that share expression patterns with GRIK1-AS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK1-AS2 Gene

Orthologs for GRIK1-AS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK1-AS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BACH1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia BACH1 31
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia BACH1 31
  • 81 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Bach1 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BACH1 31
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BACH1 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BACH1 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BACH1 31
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii bach1 31
  • 46 (a)
OneToMany
BACH1 (2 of 2) 31
  • 30 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta cnc 31
  • 8 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for GRIK1-AS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GRIK1-AS2 Gene

ENSEMBL:
Gene Tree for GRIK1-AS2 (if available)
TreeFam:
Gene Tree for GRIK1-AS2 (if available)

Paralogs for GRIK1-AS2 Gene

Variants for GRIK1-AS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIK1-AS2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
733036 Likely Benign: not provided 29,598,875(+) A/G SYNONYMOUS_VARIANT
785671 Benign: not provided 29,596,523(+) A/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GRIK1-AS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIK1-AS2 Gene

Variant ID Type Subtype PubMed ID
esv2676813 CNV deletion 23128226
esv28655 CNV loss 19812545
esv3646802 CNV loss 21293372

Variation tolerance for GRIK1-AS2 Gene

Gene Damage Index Score: 0.40; 8.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK1-AS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK1-AS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK1-AS2 Gene

Disorders for GRIK1-AS2 Gene

Additional Disease Information for GRIK1-AS2

No disorders were found for GRIK1-AS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIK1-AS2 Gene

Publications for GRIK1-AS2 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  3. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan MK … Harper JW (Molecular cell 2013) 4
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 4

Products for GRIK1-AS2 Gene

Sources for GRIK1-AS2 Gene