Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA edit... See more...

Aliases for GRIK1 Gene

Aliases for GRIK1 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 1 2 3 5
  • Glutamate Receptor Ionotropic, Kainate 1 3 4
  • Excitatory Amino Acid Receptor 3 3 4
  • Glutamate Receptor 5 3 4
  • GluR-5 3 4
  • GLUR5 3 4
  • GluK1 3 4
  • EAA3 3 4
  • Glutamate Receptor, Ionotropic, Kainate 1 2
  • GluR5 4
  • EEA3 3
  • GLR5 3

External Ids for GRIK1 Gene

Previous HGNC Symbols for GRIK1 Gene

  • GLUR5

Previous GeneCards Identifiers for GRIK1 Gene

  • GC21M027486
  • GC21M029829
  • GC21M029831
  • GC21M030909
  • GC21M016317

Summaries for GRIK1 Gene

Entrez Gene Summary for GRIK1 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIK1 Gene

GRIK1 (Glutamate Ionotropic Receptor Kainate Type Subunit 1) is a Protein Coding gene. Diseases associated with GRIK1 include Juvenile Absence Epilepsy and Monosomy 21. Among its related pathways are Circadian entrainment and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIK2.

UniProtKB/Swiss-Prot Summary for GRIK1 Gene

  • Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Tocris Summary for GRIK1 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Gene Wiki entry for GRIK1 Gene

Additional gene information for GRIK1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIK1 Gene

Genomics for GRIK1 Gene

GeneHancer (GH) Regulatory Elements for GRIK1 Gene

Promoters and enhancers for GRIK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J029939 Promoter 1.4 EPDnew Ensembl CraniofacialAtlas 500.7 +0.3 332 1.4 NRF1 EZH2 KDM5B ZBTB17 ZNF263 MXI1 RBBP5 FOXK2 SIN3A VEZF1 GRIK1 piR-40110-439
GH21J029938 Enhancer 0.3 Ensembl 500.7 +1.3 1332 0.2 EZH2 SUZ12 GRIK1 piR-40110-439
GH21J029904 Enhancer 0.6 ENCODE 11.3 +35.0 34994 0.2 NFIC FOSL1 ZNF395 CEBPG ZNF584 RAD21 ID3 ZNF175 L3MBTL2 ELF1 GRIK1 piR-40110-439
GH21J029870 Enhancer 0.6 Ensembl ENCODE 10.8 +69.0 69032 0.4 USF1 TBP ZNF316 RBBP5 GRIK1 piR-40110-439 RF01061-105
GH21J029089 Enhancer 1 ENCODE dbSUPER 4.4 +848.3 848298 3.3 HNRNPK CTCF ZSCAN5C JUND FOS ZNF639 ZNF10 REST EP300 RAD21 RWDD2B CCT8 N6AMT1 GRIK1-AS1 LTN1 GRIK1 MAP3K7CL lnc-CCT8-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIK1

Top Transcription factor binding sites by QIAGEN in the GRIK1 gene promoter:
  • AML1a
  • FOXD3
  • FOXO1
  • FOXO1a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for GRIK1 Gene

Genomic Locations for GRIK1 Gene
chr21:29,536,933-29,940,033
(GRCh38/hg38)
Size:
403,101 bases
Orientation:
Minus strand
chr21:30,909,254-31,312,351
(GRCh37/hg19)
Size:
403,098 bases
Orientation:
Minus strand

Genomic View for GRIK1 Gene

Genes around GRIK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK1 Gene

Proteins for GRIK1 Gene

  • Protein details for GRIK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39086-GRIK1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 1
    Protein Accession:
    P39086
    Secondary Accessions:
    • Q13001
    • Q86SU9

    Protein attributes for GRIK1 Gene

    Size:
    918 amino acids
    Molecular mass:
    103981 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA.

    Three dimensional structures from OCA and Proteopedia for GRIK1 Gene

    Alternative splice isoforms for GRIK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK1 Gene

Post-translational modifications for GRIK1 Gene

  • Glycosylation at Asn68, Asn74, Asn276, Asn379, Asn428, Asn439, Asn446, and Asn561
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIK1 Gene

Domains & Families for GRIK1 Gene

Gene Families for GRIK1 Gene

Protein Domains for GRIK1 Gene

Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIK1 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor, ionotropic, kainate 1, isoform CRA_b (D3DSE2_HUMAN)
  • Glutamate receptor 5 (GRIK1_HUMAN)
  • Glutamate receptor (Q71UA3_HUMAN)
  • Glutamate receptor (Q9UNN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P39086

UniProtKB/Swiss-Prot:

GRIK1_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
genes like me logo Genes that share domains with GRIK1: view

Function for GRIK1 Gene

Molecular function for GRIK1 Gene

UniProtKB/Swiss-Prot Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
GENATLAS Biochemistry:
glutamate receptor K1,ionotropic,kainate (2-carboxy-4-(1-methylethenyl)-3-pyrrolidinacetic) class

Phenotypes From GWAS Catalog for GRIK1 Gene

Gene Ontology (GO) - Molecular Function for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0008066 glutamate receptor activity IBA 21873635
GO:0015276 ligand-gated ion channel activity IEA --
GO:0015277 kainate selective glutamate receptor activity IDA 9335499
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with GRIK1: view
genes like me logo Genes that share phenotypes with GRIK1: view

Animal Models for GRIK1 Gene

MGI Knock Outs for GRIK1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GRIK1 Gene

Localization for GRIK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 8260617
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIK1 Gene

Pathways & Interactions for GRIK1 Gene

genes like me logo Genes that share pathways with GRIK1: view

Pathways by source for GRIK1 Gene

Gene Ontology (GO) - Biological Process for GRIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007215 glutamate receptor signaling pathway TAS 8260617
GO:0007268 chemical synaptic transmission TAS 10580501
GO:0007399 nervous system development TAS 8260617
GO:0007417 central nervous system development TAS 10580501
genes like me logo Genes that share ontologies with GRIK1: view

No data available for SIGNOR curated interactions for GRIK1 Gene

Drugs & Compounds for GRIK1 Gene

(41) Drugs for GRIK1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Topiramate Approved Pharma antagonist, Target GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 273
Glutamic acid Approved Nutra Full agonist, Agonist, Target 289
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
Tezampanel Investigational Pharma Target AMPA and receptor antagonist 0
ATPA Pharma Full agonist, Agonist 0

(2) Additional Compounds for GRIK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for GRIK1 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(14) ApexBio Compounds for GRIK1 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Evans Blue tetrasodium salt potent inhibitor of AMPA and kainate receptor-mediated currents (GluRl and GIuR6) 314-13-6
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK1: view

Drug Products

Transcripts for GRIK1 Gene

mRNA/cDNA for GRIK1 Gene

8 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - - -
SP3:
SP4: -

Relevant External Links for GRIK1 Gene

GeneLoc Exon Structure for
GRIK1

Expression for GRIK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK1 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.9), Brain - Hippocampus (x5.4), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Amygdala (x4.8), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for GRIK1 Gene

This gene is overexpressed in CD4 Tcells (47.6) and Monocytes (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIK1 Gene



Protein tissue co-expression partners for GRIK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIK1

SOURCE GeneReport for Unigene cluster for GRIK1 Gene:

Hs.664641

mRNA Expression by UniProt/SwissProt for GRIK1 Gene:

P39086-GRIK1_HUMAN
Tissue specificity: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.

Evidence on tissue expression from TISSUES for GRIK1 Gene

  • Nervous system(4.8)
  • Eye(4.4)
genes like me logo Genes that share expression patterns with GRIK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK1 Gene

Orthologs for GRIK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK1 31 30
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK1 31 30
  • 92.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK1 31 30
  • 92.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Grik1 17 31 30
  • 90.71 (n)
rat
(Rattus norvegicus)
Mammalia Grik1 30
  • 90.56 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIK1 31
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK1 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIK1 31 30
  • 82.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK1 31
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik1 30
  • 79.68 (n)
zebrafish
(Danio rerio)
Actinopterygii GRIK1 (1 of 2) 31
  • 83 (a)
OneToMany
grik1a 31
  • 80 (a)
OneToMany
LOC561540 30
  • 76.56 (n)
wufv36b03 30
fruit fly
(Drosophila melanogaster)
Insecta CG11155 32 30
  • 54.52 (n)
CG3822 31 32
  • 49 (a)
ManyToMany
CG9935 32
  • 43 (a)
Kai-RIA 32
  • 38 (a)
KaiRIA 31
  • 35 (a)
ManyToMany
GluRIIE 31
  • 34 (a)
ManyToMany
clumsy 31 32
  • 32 (a)
ManyToMany
CG5621 31 32
  • 32 (a)
ManyToMany
Glu-RIIA 32
  • 32 (a)
CG15627 32
  • 32 (a)
GluRIIA 31
  • 31 (a)
ManyToMany
Glu-RIIB 32
  • 28 (a)
CG4226 32
  • 28 (a)
GluRIIB 31
  • 27 (a)
ManyToMany
GluRIIC 31
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-5 30
  • 48.08 (n)
glr-4 32
  • 34 (a)
Species where no ortholog for GRIK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK1 Gene

ENSEMBL:
Gene Tree for GRIK1 (if available)
TreeFam:
Gene Tree for GRIK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIK1: view image

Paralogs for GRIK1 Gene

(12) SIMAP similar genes for GRIK1 Gene using alignment to 9 proteins:

  • GRIK1_HUMAN
  • D3DSE2_HUMAN
  • E7ENK3_HUMAN
  • E7EPY9_HUMAN
  • E7EPZ0_HUMAN
  • E9PD61_HUMAN
  • F5H1W5_HUMAN
  • F8W7X3_HUMAN
  • H7BYG7_HUMAN
genes like me logo Genes that share paralogs with GRIK1: view

Variants for GRIK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIK1 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs143252117 - p.Ala332Val
rs363494 - p.Ile757Val
rs363503 - p.Ala870Val
rs363504 - p.Leu902Ser
rs761410270 - p.Arg862Gln

Additional dbSNP identifiers (rs#s) for GRIK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRIK1 Gene

Variant ID Type Subtype PubMed ID
dgv808e214 CNV gain 21293372
esv1004829 CNV insertion 20482838
esv1010713 CNV deletion 20482838
esv2540796 CNV insertion 19546169
esv2660792 CNV deletion 23128226
esv2667733 CNV deletion 23128226
esv2671877 CNV deletion 23128226
esv2676813 CNV deletion 23128226
esv27684 CNV loss 19812545
esv28655 CNV loss 19812545
esv3304857 CNV mobile element insertion 20981092
esv3325613 CNV insertion 20981092
esv3557616 CNV deletion 23714750
esv3646802 CNV loss 21293372
esv3646805 CNV loss 21293372
esv3646806 CNV loss 21293372
esv3646807 CNV loss 21293372
esv3646809 CNV loss 21293372
nsv1114283 CNV deletion 24896259
nsv459235 CNV gain 19166990
nsv470898 CNV gain 18288195
nsv478662 CNV novel sequence insertion 20440878
nsv528222 CNV loss 19592680
nsv587353 CNV gain 21841781
nsv834073 CNV gain 17160897
nsv834074 CNV loss 17160897

Variation tolerance for GRIK1 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIK1 Gene

Human Gene Mutation Database (HGMD)
GRIK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK1 Gene

Disorders for GRIK1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for GRIK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
juvenile absence epilepsy
  • childhood absence epilepsy
monosomy 21
  • 21q deletion syndrome
nondisjunction
  • mosaicism, chromosomal
temporal lobe epilepsy
  • epilepsy, temporal lobe
childhood absence epilepsy
  • absence seizure
- elite association - COSMIC cancer census association via MalaCards
Search GRIK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRIK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK1 Gene

Publications for GRIK1 Gene

  1. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. (PMID: 11702055) Shibata H … Fukumaki Y (Psychiatric genetics 2001) 3 4 23 41 54
  2. A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers. (PMID: 19331489) Ray LA … Monti PM (Experimental and clinical psychopharmacology 2009) 3 23 41 54
  3. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. (PMID: 9259378) Sander T … Janz D (American journal of medical genetics 1997) 3 23 41 54
  4. cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration. (PMID: 8589992) Korczak B … Kamboj RK (Receptors & channels 1995) 3 4 23 54
  5. Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6. (PMID: 8260617) Gregor P … Uhl GR (Neuroreport 1993) 3 4 23 54

Products for GRIK1 Gene

  • Boster Bio Antibodies for GRIK1
  • Boster Bio ELISA Kits for GRIK1

Sources for GRIK1 Gene