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Aliases for GRIFIN Gene

Aliases for GRIFIN Gene

  • Galectin-Related Inter-Fiber Protein 2 3 4 5
  • Putative Grifin 3
  • Grifin 3

External Ids for GRIFIN Gene

Previous GeneCards Identifiers for GRIFIN Gene

  • GC00U990794
  • GC07M002482

Summaries for GRIFIN Gene

GeneCards Summary for GRIFIN Gene

GRIFIN (Galectin-Related Inter-Fiber Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9.

Additional gene information for GRIFIN Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIFIN Gene

Genomics for GRIFIN Gene

GeneHancer (GH) Regulatory Elements for GRIFIN Gene

Promoters and enhancers for GRIFIN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I002476 Enhancer 1 Ensembl ENCODE 550.8 -0.9 -901 3.5 RB1 ARID4B ZNF48 RAD21 ZNF335 GLIS2 ZNF143 RCOR1 CREM EGR2 GRIFIN LFNG
GH07I002507 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 -33.8 -33823 6 FOXA2 ARID4B ZNF766 GLIS2 RUNX3 SP5 PPARG NFIL3 RCOR2 ETV4 LFNG BRAT1 GRIFIN
GH07I002451 Enhancer 1.1 Ensembl ENCODE 0.3 +24.8 24831 1.8 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 ARID2 ZNF143 CHST12 BRAT1 IQCE LOC645357 EIF3B SNX8 TTYH3 AMZ1 LFNG GRIFIN
GH07I002471 Enhancer 0.8 Ensembl ENCODE 0.4 +5.4 5371 0.8 BCOR SMARCA5 TFAP4 HDAC2 SAP130 KDM1A ZBTB7B ETS1 GRIFIN GC07P002406
GH07I002468 Enhancer 0.7 ENCODE 0.4 +7.8 7833 0.2 CTCF RB1 KLF17 SIN3A ZIC2 ZBTB7B ZNF48 RAD21 CC2D1A GLIS2 GRIFIN GC07P002406
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRIFIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for GRIFIN Gene

Genomic Locations for GRIFIN Gene
2,259 bases
Minus strand

Genomic View for GRIFIN Gene

Genes around GRIFIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIFIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIFIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIFIN Gene

Proteins for GRIFIN Gene

  • Protein details for GRIFIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0A087WXP5

    Protein attributes for GRIFIN Gene

    144 amino acids
    Molecular mass:
    15999 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=EAL23956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIFIN Gene

Post-translational modifications for GRIFIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRIFIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIFIN Gene

Domains & Families for GRIFIN Gene

Gene Families for GRIFIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRIFIN Gene

Suggested Antigen Peptide Sequences for GRIFIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The galectin domain is atypical and does not bind beta-galactoside sugars.
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
genes like me logo Genes that share domains with GRIFIN: view

Function for GRIFIN Gene

Phenotypes From GWAS Catalog for GRIFIN Gene

Gene Ontology (GO) - Molecular Function for GRIFIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GRIFIN: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRIFIN Gene

Localization for GRIFIN Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GRIFIN Gene

Pathways & Interactions for GRIFIN Gene

SuperPathways for GRIFIN Gene

No Data Available

Interacting Proteins for GRIFIN Gene

Gene Ontology (GO) - Biological Process for GRIFIN Gene


No data available for Pathways by source and SIGNOR curated interactions for GRIFIN Gene

Drugs & Compounds for GRIFIN Gene

No Compound Related Data Available

Transcripts for GRIFIN Gene


(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIFIN Gene

No ASD Table

Relevant External Links for GRIFIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIFIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIFIN Gene

mRNA differential expression in normal tissues according to GTEx for GRIFIN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6) and Skin - Not Sun Exposed (Suprapubic) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of GRIFIN Gene:


mRNA Expression by UniProt/SwissProt for GRIFIN Gene:

Tissue specificity: Not detected in lens.
genes like me logo Genes that share expression patterns with GRIFIN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIFIN Gene

Orthologs for GRIFIN Gene

Evolution for GRIFIN Gene

Gene Tree for GRIFIN (if available)
Gene Tree for GRIFIN (if available)

No data available for Orthologs for GRIFIN Gene

Paralogs for GRIFIN Gene

genes like me logo Genes that share paralogs with GRIFIN: view

Variants for GRIFIN Gene

Sequence variations from dbSNP and Humsavar for GRIFIN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000350866 -- 2,476,695(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001101597 -- 2,473,418(-) A/C/G downstream_transcript_variant
rs1001310919 -- 2,477,691(-) G/A upstream_transcript_variant
rs1001635760 -- 2,475,397(-) C/T intron_variant
rs1001909414 -- 2,476,079(-) C/A/T coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for GRIFIN Gene

Variant ID Type Subtype PubMed ID
nsv1032737 CNV gain 25217958
nsv471216 CNV loss 18288195
nsv950792 CNV deletion 24416366

Additional Variant Information for GRIFIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRIFIN Gene

Disorders for GRIFIN Gene

Additional Disease Information for GRIFIN

No disorders were found for GRIFIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIFIN Gene

Publications for GRIFIN Gene

  1. A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. (PMID: 18087242) Zhou X … Qu J (Molecular vision 2007) 2 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. GRIFIN, a novel lens-specific protein related to the galectin family. (PMID: 9786891) Ogden AT … Lang RA (The Journal of biological chemistry 1998) 2 3 58
  5. Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens. (PMID: 19296714) Barton KA … Petrash JM (Biochemistry 2009) 3 58

Products for GRIFIN Gene

Sources for GRIFIN Gene

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