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Aliases for GRIFIN Gene

Aliases for GRIFIN Gene

  • Galectin-Related Inter-Fiber Protein 2 3 4 5
  • Grifin 3 4
  • Putative Grifin 3

External Ids for GRIFIN Gene

Previous GeneCards Identifiers for GRIFIN Gene

  • GC00U990794
  • GC07M002482

Summaries for GRIFIN Gene

GeneCards Summary for GRIFIN Gene

GRIFIN (Galectin-Related Inter-Fiber Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS7B.

Additional gene information for GRIFIN Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIFIN Gene

Genomics for GRIFIN Gene

GeneHancer (GH) Regulatory Elements for GRIFIN Gene

Promoters and enhancers for GRIFIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J002476 Promoter/Enhancer 1.3 Ensembl ENCODE 600.7 -1.3 -1288 1.6 CTCF PPARG RAD21 CREB1 GLIS2 ZIC2 REST RFX1 IRF2 ZNF512B GRIFIN LFNG
GH07J002507 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -33.8 -33823 6 ELF3 RERE ZNF687 SP1 PPARG SP5 GLIS2 HMG20B ZNF600 RELA LFNG BRAT1 GRIFIN
GH07J002468 Enhancer 0.7 ENCODE 0.4 +7.8 7833 0.2 CC2D1A CTCF RAD21 GLIS2 ARID2 ZIC2 ZNF143 REST TRIM22 PATZ1 GRIFIN GC07P002406
GH07J002451 Enhancer 0.9 ENCODE 0.3 +24.8 24773 1.7 ZFX CTCF ZNF148 CEBPG MYC TFE3 ZNF384 RAD21 KAT8 GLIS2 CHST12 BRAT1 ENSG00000230914 IQCE EIF3B SNX8 TTYH3 AMZ1 LFNG GRIFIN
GH07J002439 Enhancer 0.9 Ensembl ENCODE 0.3 +35.8 35807 2.2 CEBPG NCOA3 CREB1 GATAD2B TARDBP CEBPA CTBP1 ZBTB26 ESRRA PKNOX1 LFNG BRAT1 GC07P002406 GRIFIN CHST12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIFIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for GRIFIN Gene

Genomic Locations for GRIFIN Gene
chr7:2,474,636-2,476,894
(GRCh38/hg38)
Size:
2,259 bases
Orientation:
Minus strand
chr7:2,514,360-2,516,528
(GRCh37/hg19)
Size:
2,169 bases
Orientation:
Minus strand

Genomic View for GRIFIN Gene

Genes around GRIFIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIFIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIFIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIFIN Gene

Proteins for GRIFIN Gene

  • Protein details for GRIFIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1Z8-GRIFN_HUMAN
    Recommended name:
    Grifin
    Protein Accession:
    A4D1Z8
    Secondary Accessions:
    • A0A087WXP5

    Protein attributes for GRIFIN Gene

    Size:
    144 amino acids
    Molecular mass:
    15999 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=EAL23956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIFIN Gene

Post-translational modifications for GRIFIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRIFIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIFIN Gene

Domains & Families for GRIFIN Gene

Gene Families for GRIFIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRIFIN Gene

Suggested Antigen Peptide Sequences for GRIFIN Gene

GenScript: Design optimal peptide antigens:
  • Galectin-related inter-fiber protein (GRIFN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A4D1Z8

UniProtKB/Swiss-Prot:

GRIFN_HUMAN :
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
Domain:
  • The galectin domain is atypical and does not bind beta-galactoside sugars.
genes like me logo Genes that share domains with GRIFIN: view

Function for GRIFIN Gene

Phenotypes From GWAS Catalog for GRIFIN Gene

Gene Ontology (GO) - Molecular Function for GRIFIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with GRIFIN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIFIN

Clone Products

  • Applied Biological Materials (abm): Clones for GRIFIN - Now 50% OFF >
  • * GRIFIN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GRIFIN tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRIFIN Gene

Localization for GRIFIN Gene

Gene Ontology (GO) - Cellular Components for GRIFIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with GRIFIN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GRIFIN Gene

Pathways & Interactions for GRIFIN Gene

PathCards logo

SuperPathways for GRIFIN Gene

No Data Available

Interacting Proteins for GRIFIN Gene

Gene Ontology (GO) - Biological Process for GRIFIN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRIFIN Gene

Drugs & Compounds for GRIFIN Gene

No Compound Related Data Available

Transcripts for GRIFIN Gene

mRNA/cDNA for GRIFIN Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIFIN

Clone Products

  • Applied Biological Materials (abm): Clones for GRIFIN - Now 50% OFF >
  • * GRIFIN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GRIFIN tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GRIFIN Gene

No ASD Table

Relevant External Links for GRIFIN Gene

GeneLoc Exon Structure for
GRIFIN
ECgene alternative splicing isoforms for
GRIFIN

Expression for GRIFIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIFIN Gene

mRNA differential expression in normal tissues according to GTEx for GRIFIN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.6) and Skin - Not Sun Exposed (Suprapubic) (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of GRIFIN Gene:

GRIFIN

mRNA Expression by UniProt/SwissProt for GRIFIN Gene:

A4D1Z8-GRIFN_HUMAN
Tissue specificity: Not detected in lens.
genes like me logo Genes that share expression patterns with GRIFIN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIFIN Gene

Orthologs for GRIFIN Gene

Evolution for GRIFIN Gene

ENSEMBL:
Gene Tree for GRIFIN (if available)
TreeFam:
Gene Tree for GRIFIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIFIN: view image

No data available for Orthologs for GRIFIN Gene

Paralogs for GRIFIN Gene

genes like me logo Genes that share paralogs with GRIFIN: view

Variants for GRIFIN Gene

Sequence variations from dbSNP and Humsavar for GRIFIN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000350866 -- 2,476,695(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001101597 -- 2,473,418(-) A/C/G downstream_transcript_variant
rs1001310919 -- 2,477,691(-) G/A upstream_transcript_variant
rs1001635760 -- 2,475,397(-) C/T intron_variant
rs1001909414 -- 2,476,079(-) C/A/T coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for GRIFIN Gene

Variant ID Type Subtype PubMed ID
nsv1032737 CNV gain 25217958
nsv471216 CNV loss 18288195
nsv950792 CNV deletion 24416366

Additional Variant Information for GRIFIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIFIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRIFIN Gene

Disorders for GRIFIN Gene

Additional Disease Information for GRIFIN

No disorders were found for GRIFIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIFIN Gene

Publications for GRIFIN Gene

  1. A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. (PMID: 18087242) Zhou X … Qu J (Molecular vision 2007) 2 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. GRIFIN, a novel lens-specific protein related to the galectin family. (PMID: 9786891) Ogden AT … Lang RA (The Journal of biological chemistry 1998) 2 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for GRIFIN Gene

Sources for GRIFIN Gene

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