Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008] See more...

Aliases for GRID2IP Gene

Aliases for GRID2IP Gene

  • Grid2 Interacting Protein 2 3 5
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 1 2 3
  • Glutamate Receptor, Ionotropic, Delta 2-Interacting Protein 1 3 4
  • Delphilin 3 4
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 2
  • DELPHILIN 3

External Ids for GRID2IP Gene

Previous GeneCards Identifiers for GRID2IP Gene

  • GC07M006311
  • GC07U901586
  • GC07M006507
  • GC07M006536

Summaries for GRID2IP Gene

Entrez Gene Summary for GRID2IP Gene

  • Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GRID2IP Gene

GRID2IP (Grid2 Interacting Protein) is a Protein Coding gene. Diseases associated with GRID2IP include Cerebral Amyloid Angiopathy, Itm2b-Related, 2 and Donnai-Barrow Syndrome. An important paralog of this gene is FMN2.

UniProtKB/Swiss-Prot Summary for GRID2IP Gene

  • Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Additional gene information for GRID2IP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRID2IP Gene

Genomics for GRID2IP Gene

GeneHancer (GH) Regulatory Elements for GRID2IP Gene

Promoters and enhancers for GRID2IP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J006481 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.8 +67.8 67780 4.4 FOXK2 SIN3A NRF1 POLR2G SP1 NCOR1 GTF2E2 PHF8 ZFX ZIC2 KDELR2 DAGLB lnc-KDELR2-1 USP42 C7orf26 ZNF316 ZNF12 ANKRD61 GRID2IP DQ866756
GH07J006530 Promoter/Enhancer 1 Ensembl ENCODE 13.4 +20.4 20435 0.8 ZBTB26 EZH2 PHF8 GABPB1 KLF8 ZNF335 KLF17 POLR2A KLF1 MAZ GRID2IP ZDHHC4 ZNF12 piR-57460-595 LOC101927325 RF00017-6031 RF00017-6035
GH07J006525 Promoter 0.8 CraniofacialAtlas 13.5 +24.9 24866 0.4 CTCF REST RAD21 SMC3 TFDP1 GABPB1 E2F6 NRF1 EGR1 ZNF48 GRID2IP ZDHHC4 C7orf26 ENSG00000232581 piR-57460-595 LOC101927325 RF00017-6031
GH07J006502 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 7.3 +47.4 47423 2.6 NRF1 SP1 GABPA CTBP1 HDAC2 POLR2A OSR2 DEAF1 PCBP1 SIN3A LOC101927325 KDELR2 GRID2IP piR-50444-418 RF00017-6031
GH07J007166 Enhancer 0.5 dbSUPER 4.5 -616.2 -616191 2.9 TAL1 TCF12 HLF GATA1 ZKSCAN8 RFX1 FOXJ2 C1GALT1 GRID2IP ENSG00000244167 lnc-RSPH10B2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRID2IP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRID2IP

Top Transcription factor binding sites by QIAGEN in the GRID2IP gene promoter:
  • HNF-4alpha1
  • HNF-4alpha2
  • NF-1
  • NF-1/L
  • p53
  • Pax-5
  • POU3F1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for GRID2IP Gene

Genomic Locations for GRID2IP Gene
chr7:6,496,778-6,551,436
(GRCh38/hg38)
Size:
54,659 bases
Orientation:
Minus strand
chr7:6,536,409-6,591,067
(GRCh37/hg19)
Size:
54,659 bases
Orientation:
Minus strand

Genomic View for GRID2IP Gene

Genes around GRID2IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRID2IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRID2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID2IP Gene

Proteins for GRID2IP Gene

  • Protein details for GRID2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D2P6-GRD2I_HUMAN
    Recommended name:
    Delphilin
    Protein Accession:
    A4D2P6

    Protein attributes for GRID2IP Gene

    Size:
    1211 amino acids
    Molecular mass:
    132276 Da
    Quaternary structure:
    • Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain.
    SequenceCaution:
    • Sequence=EAL23724.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRID2IP Gene

Post-translational modifications for GRID2IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRID2IP Gene

No data available for DME Specific Peptides for GRID2IP Gene

Domains & Families for GRID2IP Gene

Gene Families for GRID2IP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRID2IP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRID2IP Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor, ionotropic, delta 2-interacting protein 1 (GRD2I_HUMAN)
genes like me logo Genes that share domains with GRID2IP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GRID2IP Gene

Function for GRID2IP Gene

Molecular function for GRID2IP Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Phenotypes From GWAS Catalog for GRID2IP Gene

Phenotypes for GRID2IP Gene

genes like me logo Genes that share phenotypes with GRID2IP: view

Animal Models for GRID2IP Gene

MGI Knock Outs for GRID2IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRID2IP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID2IP Gene

Localization for GRID2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID2IP Gene

Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRID2IP gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

Pathways & Interactions for GRID2IP Gene

PathCards logo

SuperPathways for GRID2IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060292 long-term synaptic depression IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

No data available for Pathways by source and SIGNOR curated interactions for GRID2IP Gene

Drugs & Compounds for GRID2IP Gene

No Compound Related Data Available

Transcripts for GRID2IP Gene

mRNA/cDNA for GRID2IP Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRID2IP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRID2IP Gene

No ASD Table

Relevant External Links for GRID2IP Gene

GeneLoc Exon Structure for
GRID2IP

Expression for GRID2IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRID2IP Gene

mRNA differential expression in normal tissues according to GTEx for GRID2IP Gene

This gene is overexpressed in Brain - Cerebellum (x7.4).

Protein differential expression in normal tissues from HIPED for GRID2IP Gene

This gene is overexpressed in Bone marrow stromal cell (37.3) and Serum (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRID2IP Gene



Protein tissue co-expression partners for GRID2IP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRID2IP

SOURCE GeneReport for Unigene cluster for GRID2IP Gene:

Hs.512174

Evidence on tissue expression from TISSUES for GRID2IP Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GRID2IP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID2IP Gene

Orthologs for GRID2IP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID2IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRID2IP 31 30
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GRID2IP 31 30
  • 89.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRID2IP 31 30
  • 89.29 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grid2ip 30
  • 87.16 (n)
mouse
(Mus musculus)
Mammalia Grid2ip 17 31 30
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GRID2IP 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRID2IP 31 30
  • 71.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRID2IP 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grid2ip 30
  • 63.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561017 30
  • 61.47 (n)
grid2ipb 31
  • 50 (a)
OneToMany
grid2ipa 31
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea exc-6 31
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9833 31
  • 31 (a)
OneToOne
Species where no ortholog for GRID2IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID2IP Gene

ENSEMBL:
Gene Tree for GRID2IP (if available)
TreeFam:
Gene Tree for GRID2IP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRID2IP: view image

Paralogs for GRID2IP Gene

(1) SIMAP similar genes for GRID2IP Gene using alignment to 3 proteins:

  • GRD2I_HUMAN
  • C9J5F6_HUMAN
  • C9JNS8_HUMAN
genes like me logo Genes that share paralogs with GRID2IP: view

Variants for GRID2IP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRID2IP Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs11761490 - p.Arg20Gln

Additional dbSNP identifiers (rs#s) for GRID2IP Gene

Structural Variations from Database of Genomic Variants (DGV) for GRID2IP Gene

Variant ID Type Subtype PubMed ID
dgv11172n54 CNV loss 21841781
esv1914954 OTHER inversion 16254605
esv3440661 CNV insertion 20981092
esv3612034 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1026878 CNV loss 25217958
nsv1074067 CNV deletion 25765185
nsv1119107 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv508444 CNV deletion 20534489
nsv515978 CNV loss 19592680
nsv7392 OTHER inversion 18451855
nsv830895 CNV loss 17160897

Variation tolerance for GRID2IP Gene

Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRID2IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRID2IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID2IP Gene

Disorders for GRID2IP Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRID2IP Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral amyloid angiopathy, itm2b-related, 2
  • dementia, familial danish; fdd
donnai-barrow syndrome
  • faciooculoacousticorenal syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GRID2IP

genes like me logo Genes that share disorders with GRID2IP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRID2IP Gene

Publications for GRID2IP Gene

  1. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. (PMID: 14612983) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 54
  2. Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain. (PMID: 16835239) Matsuda K … Yuzaki M (The Journal of biological chemistry 2006) 3 4 54
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  4. Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation. (PMID: 30726710) Gógl G … Nyitray L (Journal of molecular biology 2019) 3 54
  5. The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation. (PMID: 29282276) Silkworth WT … Vizcarra CL (Molecular biology of the cell 2018) 3 54

Products for GRID2IP Gene

  • Biorbyt antibodies for GRID2IP

Sources for GRID2IP Gene