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Aliases for GRID2IP Gene

Aliases for GRID2IP Gene

  • Grid2 Interacting Protein 2 3 5
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 1 2 3
  • Glutamate Receptor, Ionotropic, Delta 2-Interacting Protein 1 3 4
  • Glutamate Receptor, Ionotropic, Delta 2 (Grid2) Interacting Protein 2

External Ids for GRID2IP Gene

Previous GeneCards Identifiers for GRID2IP Gene

  • GC07M006311
  • GC07U901586
  • GC07M006507

Summaries for GRID2IP Gene

Entrez Gene Summary for GRID2IP Gene

  • Glutamate receptor delta-2 (GRID2; MIM 602368) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells (Matsuda et al., 2006 [PubMed 16835239]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GRID2IP Gene

GRID2IP (Grid2 Interacting Protein) is a Protein Coding gene. An important paralog of this gene is FMN2.

UniProtKB/Swiss-Prot for GRID2IP Gene

  • Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Additional gene information for GRID2IP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRID2IP Gene

Genomics for GRID2IP Gene

GeneHancer (GH) Regulatory Elements for GRID2IP Gene

Promoters and enhancers for GRID2IP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I006481 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.8 +67.8 67780 4.4 SMAD1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 ZHX2 REST SMARCB1 KDELR2 DAGLB ZNF316 C7orf26 USP42 ANKRD61 ZNF12 RNF216 CCZ1B GRID2IP
GH07I006530 Enhancer 0.9 Ensembl ENCODE 13.4 +20.0 20022 1.8 KLF1 MAZ SP3 KLF17 ZEB2 ZBTB8A ZIC2 ZNF335 GLIS2 POLR2A GRID2IP ZDHHC4 ZNF12 LOC101927325
GH07I006525 Enhancer 0.6 Ensembl 13.4 +24.7 24716 1.8 CTCF RNF2 RB1 L3MBTL2 NRF1 BACH1 REST RAD21 ZNF48 ZFHX2 ZDHHC4 GRID2IP C7orf26 ENSG00000232581 LOC101927325
GH07I006502 Enhancer 1 Ensembl ENCODE 7.2 +47.4 47423 2.6 PKNOX1 SIN3A DEAF1 ZBTB7B TCF12 GLIS2 E2F8 ZNF143 ATF7 SP3 LOC101927325 KDELR2 GRID2IP RPL31P34
GH07I007166 Enhancer 0.5 dbSUPER 4.5 -616.2 -616191 2.9 TCF12 RFX1 ZKSCAN8 HLF C1GALT1 GRID2IP ENSG00000244167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRID2IP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRID2IP gene promoter:

Genomic Locations for GRID2IP Gene

Genomic Locations for GRID2IP Gene
54,659 bases
Minus strand

Genomic View for GRID2IP Gene

Genes around GRID2IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRID2IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRID2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID2IP Gene

Proteins for GRID2IP Gene

  • Protein details for GRID2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for GRID2IP Gene

    1211 amino acids
    Molecular mass:
    132276 Da
    Quaternary structure:
    • Interacts with C-terminus of the glutamate receptor GRID2 via PDZ domain.
    • Sequence=EAL23724.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRID2IP Gene

Post-translational modifications for GRID2IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRID2IP Gene

No data available for DME Specific Peptides for GRID2IP Gene

Domains & Families for GRID2IP Gene

Gene Families for GRID2IP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRID2IP Gene


Suggested Antigen Peptide Sequences for GRID2IP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRID2IP: view

No data available for UniProtKB/Swiss-Prot for GRID2IP Gene

Function for GRID2IP Gene

Molecular function for GRID2IP Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.

Phenotypes From GWAS Catalog for GRID2IP Gene

Phenotypes for GRID2IP Gene

genes like me logo Genes that share phenotypes with GRID2IP: view

Animal Models for GRID2IP Gene

MGI Knock Outs for GRID2IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID2IP Gene

Localization for GRID2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID2IP Gene

Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRID2IP gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0043197 dendritic spine IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRID2IP Gene

Pathways & Interactions for GRID2IP Gene

SuperPathways for GRID2IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRID2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060292 long term synaptic depression IEA --
genes like me logo Genes that share ontologies with GRID2IP: view

No data available for Pathways by source and SIGNOR curated interactions for GRID2IP Gene

Drugs & Compounds for GRID2IP Gene

No Compound Related Data Available

Transcripts for GRID2IP Gene

mRNA/cDNA for GRID2IP Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRID2IP Gene

Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRID2IP Gene

No ASD Table

Relevant External Links for GRID2IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRID2IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRID2IP Gene

mRNA differential expression in normal tissues according to GTEx for GRID2IP Gene

This gene is overexpressed in Brain - Cerebellum (x7.4).

Protein differential expression in normal tissues from HIPED for GRID2IP Gene

This gene is overexpressed in Bone marrow stromal cell (37.3) and Serum (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRID2IP Gene

Protein tissue co-expression partners for GRID2IP Gene

NURSA nuclear receptor signaling pathways regulating expression of GRID2IP Gene:


SOURCE GeneReport for Unigene cluster for GRID2IP Gene:


Evidence on tissue expression from TISSUES for GRID2IP Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GRID2IP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID2IP Gene

Orthologs for GRID2IP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID2IP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRID2IP 33 34
  • 99.37 (n)
(Canis familiaris)
Mammalia GRID2IP 33 34
  • 89.49 (n)
(Bos Taurus)
Mammalia GRID2IP 33 34
  • 89.29 (n)
(Rattus norvegicus)
Mammalia Grid2ip 33
  • 87.16 (n)
(Mus musculus)
Mammalia Grid2ip 33 16 34
  • 85.98 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
-- 34
  • 78 (a)
-- 34
  • 71 (a)
(Monodelphis domestica)
Mammalia GRID2IP 34
  • 66 (a)
(Gallus gallus)
Aves GRID2IP 33 34
  • 71.82 (n)
(Anolis carolinensis)
Reptilia GRID2IP 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grid2ip 33
  • 63.55 (n)
(Danio rerio)
Actinopterygii LOC561017 33
  • 61.47 (n)
grid2ipb 34
  • 50 (a)
grid2ipa 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea exc-6 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9833 34
  • 31 (a)
Species where no ortholog for GRID2IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID2IP Gene

Gene Tree for GRID2IP (if available)
Gene Tree for GRID2IP (if available)

Paralogs for GRID2IP Gene

Paralogs for GRID2IP Gene

(1) SIMAP similar genes for GRID2IP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRID2IP: view

Variants for GRID2IP Gene

Sequence variations from dbSNP and Humsavar for GRID2IP Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000025927 -- 6,547,644(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000074170 -- 6,528,981(-) A/G intron_variant
rs1000104534 -- 6,508,180(-) C/A/G/T coding_sequence_variant, synonymous_variant
rs1000180692 -- 6,550,504(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000229441 -- 6,510,524(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRID2IP Gene

Variant ID Type Subtype PubMed ID
dgv11172n54 CNV loss 21841781
esv1914954 OTHER inversion 16254605
esv3440661 CNV insertion 20981092
esv3612034 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1026878 CNV loss 25217958
nsv1074067 CNV deletion 25765185
nsv1119107 CNV deletion 24896259
nsv436904 CNV insertion 17901297
nsv508444 CNV deletion 20534489
nsv515978 CNV loss 19592680
nsv7392 OTHER inversion 18451855
nsv830895 CNV loss 17160897

Variation tolerance for GRID2IP Gene

Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRID2IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID2IP Gene

Disorders for GRID2IP Gene

Additional Disease Information for GRID2IP

No disorders were found for GRID2IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRID2IP Gene

Publications for GRID2IP Gene

  1. Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico. (PMID: 14612983) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 4 58
  2. Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain. (PMID: 16835239) Matsuda K … Yuzaki M (The Journal of biological chemistry 2006) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. (PMID: 25248455) Ek WE … D'Amato M (Gut 2015) 3 58
  5. Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA. (PMID: 17027646) Sonoda T … Kawamoto S (Biochemical and biophysical research communications 2006) 3 58

Products for GRID2IP Gene

Sources for GRID2IP Gene

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