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This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009] See more...
Aliases for GRID1 Gene
Aliases for GRID1 Gene
External Ids for GRID1 Gene
- HGNC: 4575
- Entrez Gene: 2894
- Ensembl: ENSG00000182771
- OMIM: 610659
- UniProtKB: Q9ULK0
Previous GeneCards Identifiers for GRID1 Gene
- GC10M086316
- GC10M086581
- GC10M087490
- GC10M087023
- GC10M087349
- GC10M081205
Summaries for GRID1 Gene
-
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
GeneCards Summary for GRID1 Gene
GRID1 (Glutamate Ionotropic Receptor Delta Type Subunit 1) is a Protein Coding gene. Diseases associated with GRID1 include Chromosome 17Q21.31 Duplication Syndrome and Rett Syndrome. Among its related pathways are Peptide ligand-binding receptors and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and extracellularly glutamate-gated ion channel activity. An important paralog of this gene is GRID2.
UniProtKB/Swiss-Prot Summary for GRID1 Gene
-
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Additional gene information for GRID1 Gene
- Monarch Initiative
- Search for GRID1 at DataMed
- Search for GRID1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRID1 Gene
Genomics for GRID1 Gene
GeneHancer (GH) Regulatory Elements for GRID1 Gene
Promoters and enhancers for GRID1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRID1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRID1
- Top Transcription factor binding sites by QIAGEN in the GRID1 gene promoter:
-
- Bach2
- C/EBPbeta
- E2F
- E2F-1
- GR
- GR-alpha
- GR-beta
- HEN1
- Pax-5
Genomic Locations for GRID1 Gene
Genomic Locations for GRID1 Gene
- chr10:85,599,552-86,366,795
- (GRCh38/hg38)
- Size:
- 767,244 bases
- Orientation:
- Minus strand
- chr10:87,359,312-88,126,250
- (GRCh37/hg19)
- Size:
- 766,939 bases
- Orientation:
- Minus strand
Genomic View for GRID1 Gene
Genes around GRID1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.1-q23.2 by HGNC
- 10q23.1-q23.2 by Entrez Gene
- 10q23.2 by Ensembl
GRID1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRID1 Gene
Proteins for GRID1 Gene
-
Protein details for GRID1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULK0-GRID1_HUMAN
- Recommended name:
- Glutamate receptor ionotropic, delta-1
- Protein Accession:
- Q9ULK0
- B3KXD5
- B7Z7L0
- Q8IXT3
Protein attributes for GRID1 Gene
- Size:
- 1009 amino acids
- Molecular mass:
- 112131 Da
- Quaternary structure:
-
- Dimer. Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2.
Protein Expression for GRID1 Gene
Post-translational modifications for GRID1 Gene
Other Protein References for GRID1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GRID1 Antibody
- Creative Diagnostics Anti-GRID1 (aa 349-441) polyclonal antibody
- Novus Biologicals Antibodies for GRID1
-
Abcam antibodies for GRID1
- Invitrogen Antibodies for GRID1 (AFLGC-GRID1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRID1
Protein Products
- Creative Biomart Recombinant Human GRID1
-
OriGene Purified Proteins for GRID1
- Search Origene for MassSpec and Protein Over-expression Lysates for GRID1
- Origene Custom Protein Services for GRID1
- Novus Biologicals proteins for GRID1
- antibodies-online: Show 9 available GRID1 Proteins ranked by validation data
- Compare Top GRID1 Proteins
-
Quality Products:
-
Abcam proteins for GRID1
Assay Products
No data available for DME Specific Peptides for GRID1 Gene
Domains & Families for GRID1 Gene
Gene Families for GRID1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GRID1 Gene
- Blocks:
-
- Extracellular ligand-binding receptor
- Ionotropic glutamate receptor
- NMDA receptor signature
- Bacterial extracellular solute-binding protein, family 3
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRID1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50913, highly similar to Glutamate receptor delta-1 subunit (B7Z7L0_HUMAN)
- Glutamate receptor delta-1 subunit (GRID1_HUMAN)
- Glutamate receptor, ionotropic, delta 1 (Q5JQ58_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULK0UniProtKB/Swiss-Prot:
GRID1_HUMAN :- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
- Family:
-
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
Function for GRID1 Gene
Molecular function for GRID1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Phenotypes From GWAS Catalog for GRID1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004970 | ionotropic glutamate receptor activity | IEA | -- |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0008066 | glutamate receptor activity | IBA | 21873635 |
| GO:0015276 | ligand-gated ion channel activity | IEA | -- |
| GO:0038023 | signaling receptor activity | IEA | -- |
Phenotypes for GRID1 Gene
- MGI mutant phenotypes for GRID1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRID1:
Animal Models for GRID1 Gene
- MGI Knock Outs for GRID1:
-
- Grid1 Grid1<tm1Jnz>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRID1 - Select products 50% OFF >
- * GRID1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRID1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRID1
- genomics-online: gRNA clones - Search for available GRID1 gRNA products
- Overview of 107 available GRID1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
miRNA for GRID1 Gene
- miRTarBase miRNAs that target GRID1
-
- hsa-mir-5011-5p (MIRT517498)
- hsa-mir-190a-3p (MIRT517499)
- hsa-mir-410-3p (MIRT517500)
- hsa-mir-1277-5p (MIRT517501)
- hsa-mir-6848-3p (MIRT623747)
- hsa-mir-6843-3p (MIRT623748)
- hsa-mir-6873-3p (MIRT623749)
- hsa-mir-377-3p (MIRT623750)
- hsa-mir-6895-3p (MIRT623751)
- hsa-mir-138-5p (MIRT623752)
- hsa-mir-6131 (MIRT623753)
- hsa-mir-133a-5p (MIRT623754)
- hsa-mir-3663-5p (MIRT623755)
- hsa-mir-6817-3p (MIRT623756)
- hsa-mir-7110-3p (MIRT623757)
- hsa-mir-342-3p (MIRT623758)
- hsa-mir-6722-5p (MIRT623759)
- hsa-mir-6768-5p (MIRT623760)
- hsa-mir-8485 (MIRT623761)
- hsa-mir-4709-3p (MIRT628176)
- hsa-mir-4699-5p (MIRT628177)
- hsa-mir-1238-3p (MIRT657595)
- hsa-mir-670-3p (MIRT657596)
- hsa-mir-6867-3p (MIRT657597)
- hsa-mir-6749-3p (MIRT657598)
- hsa-mir-6792-3p (MIRT657599)
- hsa-mir-4691-5p (MIRT657600)
- hsa-mir-642a-5p (MIRT657601)
- hsa-mir-6826-3p (MIRT657602)
- hsa-mir-3124-3p (MIRT657603)
- hsa-mir-4287 (MIRT657604)
- hsa-mir-4685-3p (MIRT657605)
- hsa-mir-7113-3p (MIRT657606)
- hsa-mir-4469 (MIRT657607)
- hsa-mir-6769b-3p (MIRT657608)
- hsa-mir-4723-3p (MIRT657609)
- hsa-mir-3183 (MIRT657610)
- hsa-mir-660-3p (MIRT657611)
- hsa-mir-5193 (MIRT657612)
- hsa-mir-2276-5p (MIRT657613)
- hsa-mir-6892-3p (MIRT657614)
- hsa-mir-5196-3p (MIRT657615)
- hsa-mir-4283 (MIRT710754)
- hsa-mir-4448 (MIRT710755)
- hsa-mir-423-5p (MIRT710756)
- hsa-mir-3184-5p (MIRT710757)
- hsa-mir-4530 (MIRT710758)
- hsa-mir-922 (MIRT710759)
- hsa-mir-1298-3p (MIRT710760)
- hsa-mir-3126-3p (MIRT710761)
- hsa-mir-6813-5p (MIRT710762)
- hsa-mir-6856-5p (MIRT710763)
- hsa-mir-6085 (MIRT710764)
- hsa-mir-6758-5p (MIRT710765)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRID1
- Browse OriGene Inhibitory RNA Products For GRID1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRID1
- genomics-online: shRNA clones - Search for available GRID1 shRNA products
- Overview of 107 available GRID1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GRID1 - Select products 50% OFF >
- * GRID1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRID1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRID1
- genomics-online: cdna clones - Search for available GRID1 CDNA products
- Overview of 107 available GRID1 gene related products
- orf clones - Search for available GRID1 ORF products
- Overview of 107 available GRID1 gene related products
Cell Line Products
-
Horizon Cell Lines for GRID1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID1 Gene
Localization for GRID1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRID1 Gene
- Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA,IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRID1 Gene
Pathways & Interactions for GRID1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | MECP2 and Associated Rett Syndrome | ||
Pathways by source for GRID1 Gene
1 BioSystems pathway for GRID1 Gene
1 KEGG pathway for GRID1 Gene
Interacting Proteins for GRID1 Gene
GPS-Prot Interaction Network for GRID1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0034220 | ion transmembrane transport | IEA | -- |
| GO:0035176 | social behavior | ISS,IEA | -- |
| GO:0035235 | ionotropic glutamate receptor signaling pathway | IEA | -- |
| GO:0035249 | synaptic transmission, glutamatergic | IBA | 21873635 |
No data available for SIGNOR curated interactions for GRID1 Gene
Drugs & Compounds for GRID1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic acid | Approved | Nutra | Full agonist, Agonist, Target | 289 | ||
| Latrepirdine | Investigational | Pharma | Brain cell death inhibitor | 0 | ||
| ADX-47273 | Pharma | 0 | ||||
| IEM 1754 dihydrobroMide | Pharma | 0 | ||||
| Ifenprodil Tartrate | Pharma | NMDA receptor antagonist | 0 |
(8) ApexBio Compounds for GRID1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ADX-47273 | 851881-60-2 | |
| IEM 1754 dihydrobroMide | 162831-31-4 | |
| Ifenprodil Tartrate | NMDA receptor antagonist | 23210-58-4 |
| Latrepirdine | Brain cell death inhibitor | 97657-92-6 |
| NMDA (N-Methyl-D-aspartic acid) | NMDA receptor agonist | 6384-92-5 |
| VU 0361737 | MGlu4 receptor allosteric modulator | 1161205-04-4 |
| VU 0364439 | Positive allosteric mGluR-4 modulator | 1246086-78-1 |
| VU 0364770 | 61350-00-3 |
Transcripts for GRID1 Gene
mRNA/cDNA for GRID1 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000327946 6154 bps (ENST00000327946.12)
- ENST00000464741 3243 bps (ENST00000464741.2)
- ENST00000552278 787 bps (ENST00000552278.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRID1 - Select products 50% OFF >
- * GRID1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRID1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRID1
- genomics-online: gRNA clones - Search for available GRID1 gRNA products
- Overview of 107 available GRID1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRID1
- Browse OriGene Inhibitory RNA Products For GRID1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRID1
- genomics-online: shRNA clones - Search for available GRID1 shRNA products
- Overview of 107 available GRID1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GRID1 - Select products 50% OFF >
- * GRID1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRID1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRID1
- genomics-online: cdna clones - Search for available GRID1 CDNA products
- Overview of 107 available GRID1 gene related products
- orf clones - Search for available GRID1 ORF products
- Overview of 107 available GRID1 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for GRID1 Gene
- GeneLoc Exon Structure for
- GRID1
Expression for GRID1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
This gene is overexpressed in CD4 Tcells (24.8), Frontal cortex (24.5), Fetal Brain (8.3), and Adipocyte (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRID1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRID1
SOURCE GeneReport for Unigene cluster for GRID1 Gene:
Hs.530653Evidence on tissue expression from TISSUES for GRID1 Gene
- Nervous system(4.4)
- Liver(4.2)
- Lung(3.1)
Primer Products
-
OriGene qPCR primer pairs for GRID1
- genomics-online: primer clones - Search for available GRID1 Primer products
- Overview of 107 available GRID1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID1 Gene
Orthologs for GRID1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRID1 31 |
|
OneToOne | |
| LOC100612556 30 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | GRID1 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GRID1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GRID1 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Grid1 17 31 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRID1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRID1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRID1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grid1 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grid1a 31 |
|
OneToMany | |
| grid1b 31 30 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Glu-RI 31 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | glr-2 31 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GRID1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GRID1 Gene
- ENSEMBL:
- Gene Tree for GRID1 (if available)
- TreeFam:
- Gene Tree for GRID1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRID1: view image
Paralogs for GRID1 Gene
Paralogs for GRID1 Gene
(7) SIMAP similar genes for GRID1 Gene using alignment to 3 proteins:
- GRID1_HUMAN
- B7Z7L0_HUMAN
- G3V186_HUMAN
Variants for GRID1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRID1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs143353694 | Uncertain Significance: Malignant tumor of prostate | 85,869,077(-) | G/A | MISSENSE_VARIANT | |
| rs201182031 | Benign: Abnormality of neuronal migration | 86,206,442(-) | G/A | MISSENSE_VARIANT | |
| rs863223382 | Benign: Abnormality of neuronal migration | 86,206,447(-) | G/A | MISSENSE_VARIANT | |
| rs2306265 | - | p.Val529Ile |
Residual Variation Intolerance Score:
2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.27;
70.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRID1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID1 Gene
Disorders for GRID1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17q21.31 duplication syndrome |
|
|
| rett syndrome |
|
|
| schizophrenia |
|
|
Search GRID1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRID1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GRID1 Gene
Publications for GRID1 Gene
- Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (PMID: 19346103) Treutlein J … Rietschel M (Schizophrenia research 2009) 3 23 41 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 41 54
- A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. (PMID: 17490860) Guo SZ … He L (Schizophrenia research 2007) 3 41 54
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PMID: 16380905) Fallin MD … Pulver AE (American journal of human genetics 2005) 3 41 54
ExternalLinks
Products for GRID1 Gene
- Custom Antibody Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for GRID1
- Origene Custom Protein Services for GRID1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRID1
- Browse OriGene Inhibitory RNA Products For GRID1
- OriGene qPCR primer pairs for GRID1
- OriGene CRISPR knockouts for GRID1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GRID1
- Sino Biological Human cDNA Clone for GRID1
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
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- Novus Biologicals proteins for GRID1
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- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for GRID1
- Abcam proteins for GRID1
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- Browse Primary Antibodies
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- Invitrogen Antibodies for GRID1 (AFLGC-GRID1)
- ApexBio compounds for GRID1
- VectorBuilder Custom and pre-made DNA vectors for GRID1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GRID1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GRID1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GRID1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GRID1
- antibodies-online: Show 18 available GRID1 Antibodies ranked by validation data
- Compare Top GRID1 Antibodies
- antibodies-online: Show 13 available GRID1 Elisa Kits ranked by validation data
- Compare Top GRID1 Elisa Kits
- antibodies-online: Show 9 available GRID1 Proteins ranked by validation data
- Compare Top GRID1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for GRID1
- Search Santa Cruz Biotechnology (SCBT) for GRID1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GRID1
- Horizon Cell Lines for GRID1
- genomics-online: cdna clones - Search for available GRID1 CDNA products
- Overview of 107 available GRID1 gene related products
- orf clones - Search for available GRID1 ORF products
- Overview of 107 available GRID1 gene related products
- genomics-online: gRNA clones - Search for available GRID1 gRNA products
- Overview of 107 available GRID1 gene related products
- genomics-online: primer clones - Search for available GRID1 Primer products
- Overview of 107 available GRID1 gene related products
- genomics-online: shRNA clones - Search for available GRID1 shRNA products
- Overview of 107 available GRID1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRID1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRID1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GRID1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRID1
Sources for GRID1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody