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This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
GRID1 (Glutamate Ionotropic Receptor Delta Type Subunit 1) is a Protein Coding gene. Diseases associated with GRID1 include Rett Syndrome and Pitt-Hopkins-Like Syndrome 1. Among its related pathways are Peptide ligand-binding receptors and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and extracellularly glutamate-gated ion channel activity. An important paralog of this gene is GRID2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004970 | ionotropic glutamate receptor activity | IEA | -- |
GO:0005216 | ion channel activity | IEA | -- |
GO:0008066 | glutamate receptor activity | IBA | 21873635 |
GO:0015276 | ligand-gated ion channel activity | IEA,IBA | 21873635 |
GO:0038023 | signaling receptor activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
GO:0045202 | synapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | MECP2 and Associated Rett Syndrome |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0034220 | ion transmembrane transport | IEA | -- |
GO:0035176 | social behavior | IEA,ISS | -- |
GO:0035235 | ionotropic glutamate receptor signaling pathway | IEA | -- |
GO:0035249 | synaptic transmission, glutamatergic | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Latrepirdine | Investigational | Pharma | Brain cell death inhibitor | 0 | ||
ADX-47273 | Pharma | 0 | ||||
IEM 1754 dihydrobroMide | Pharma | 0 | ||||
Ifenprodil Tartrate | Pharma | NMDA receptor antagonist | 0 | |||
NMDA (N-Methyl-D-aspartic acid) | Pharma | NMDA receptor agonist | 0 |
Compound | Action | Cas Number |
---|---|---|
ADX-47273 | 851881-60-2 | |
IEM 1754 dihydrobroMide | 162831-31-4 | |
Ifenprodil Tartrate | NMDA receptor antagonist | 23210-58-4 |
Latrepirdine | Brain cell death inhibitor | 97657-92-6 |
NMDA (N-Methyl-D-aspartic acid) | NMDA receptor agonist | 6384-92-5 |
VU 0361737 | MGlu4 receptor allosteric modulator | 1161205-04-4 |
VU 0364439 | Positive allosteric mGluR-4 modulator | 1246086-78-1 |
VU 0364770 | 61350-00-3 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRID1 31 |
|
OneToOne | |
LOC100612556 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | GRID1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRID1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GRID1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grid1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GRID1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GRID1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRID1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grid1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | grid1a 31 |
|
OneToMany | |
grid1b 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Glu-RI 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | glr-2 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs143353694 | Uncertain Significance: Malignant tumor of prostate | 85,869,077(-) |
G/A NM_017551.3(GRID1):c.884C>T (p.Thr295Met) |
MISSENSE | |
rs201182031 | Benign: Abnormality of neuronal migration | 86,206,442(-) |
G/A NM_017551.3(GRID1):c.442C>T (p.Arg148Cys) |
MISSENSE | |
rs863223382 | Benign: Abnormality of neuronal migration | 86,206,447(-) |
G/A NM_017551.3(GRID1):c.437C>T (p.Pro146Leu) |
MISSENSE | |
rs2306265 | - |
p.Val529Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
rett syndrome |
|
|
pitt-hopkins-like syndrome 1 |
|
|
schizophrenia |
|
|
disease of mental health |
|
|