This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009] See more...

Aliases for GRID1 Gene

Aliases for GRID1 Gene

  • Glutamate Ionotropic Receptor Delta Type Subunit 1 2 3 5
  • Glutamate Receptor Ionotropic, Delta-1 3 4
  • GluR Delta-1 Subunit 3 4
  • GluD1 3 4
  • Glutamate Receptor, Ionotropic, Delta 1 2
  • Glutamate Receptor Delta-1 Subunit 3
  • KIAA1220 4

External Ids for GRID1 Gene

Previous GeneCards Identifiers for GRID1 Gene

  • GC10M086316
  • GC10M086581
  • GC10M087490
  • GC10M087023
  • GC10M087349
  • GC10M081205

Summaries for GRID1 Gene

Entrez Gene Summary for GRID1 Gene

  • This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

GeneCards Summary for GRID1 Gene

GRID1 (Glutamate Ionotropic Receptor Delta Type Subunit 1) is a Protein Coding gene. Diseases associated with GRID1 include Chromosome 17Q21.31 Duplication Syndrome and Rett Syndrome. Among its related pathways are Peptide ligand-binding receptors and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and extracellularly glutamate-gated ion channel activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot Summary for GRID1 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Gene Wiki entry for GRID1 Gene

Additional gene information for GRID1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRID1 Gene

Genomics for GRID1 Gene

GeneHancer (GH) Regulatory Elements for GRID1 Gene

Promoters and enhancers for GRID1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J086366 Promoter/Enhancer 1.8 EPDnew Ensembl CraniofacialAtlas dbSUPER 517.3 0.0 -6 1.6 HNRNPK EP300 USF1 ZFX ZIC2 ZBTB10 ZNF423 ZBTB26 EZH2 ZNF341 GRID1 NUTM2A HSALNG0079392
GH10J086392 Promoter 0.9 EPDnew 500.3 -26.0 -26028 0.1 TRIM22 ARNT MEF2B NBN WRNIP1 ELF1 IKZF1 NR2F1 NFATC3 ATF2 lnc-GRID1-5 GRID1 lnc-GRID1-4
GH10J086399 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 17.2 -34.6 -34608 3.9 ZBTB40 CTCF SIN3A TCF12 POLR2G USF1 PHF8 TEAD4 ZFX ZNF639 ENSG00000287475 ENSG00000286359 ENSG00000227896 ENSG00000272631 WAPL GRID1 NUTM2A-AS1 SHLD2 ADIRF LDB3
GH10J086752 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -389.6 -389608 8 MYC POLR2G RBAK GTF2E2 PHF8 TEAD4 ZFX ZNF639 CTCF ZNF10 ENSG00000272631 BMPR1A lnc-MMRN2-4 ENSG00000227896 NUTM2A-AS1 WAPL GRID1 SHLD2 GLUD1
GH10J086345 Enhancer 1 Ensembl ENCODE dbSUPER 27.1 +20.1 20090 2.3 REST EP300 BRCA1 NR3C1 CEBPB CHD2 RCOR1 SMARCB1 MAX MAZ GRID1 RF01045-022
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRID1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRID1

Top Transcription factor binding sites by QIAGEN in the GRID1 gene promoter:
  • Bach2
  • C/EBPbeta
  • E2F
  • E2F-1
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Pax-5

Genomic Locations for GRID1 Gene

Genomic Locations for GRID1 Gene
chr10:85,599,552-86,366,795
(GRCh38/hg38)
Size:
767,244 bases
Orientation:
Minus strand
chr10:87,359,312-88,126,250
(GRCh37/hg19)
Size:
766,939 bases
Orientation:
Minus strand

Genomic View for GRID1 Gene

Genes around GRID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRID1 Gene

Proteins for GRID1 Gene

  • Protein details for GRID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULK0-GRID1_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, delta-1
    Protein Accession:
    Q9ULK0
    Secondary Accessions:
    • B3KXD5
    • B7Z7L0
    • Q8IXT3

    Protein attributes for GRID1 Gene

    Size:
    1009 amino acids
    Molecular mass:
    112131 Da
    Quaternary structure:
    • Dimer. Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2.

    Alternative splice isoforms for GRID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRID1 Gene

Post-translational modifications for GRID1 Gene

  • Glycosylation at Asn498, Asn200, and Asn422
  • Modification sites at PhosphoSitePlus

Other Protein References for GRID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRID1 Gene

Domains & Families for GRID1 Gene

Protein Domains for GRID1 Gene

Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature
  • Bacterial extracellular solute-binding protein, family 3
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRID1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50913, highly similar to Glutamate receptor delta-1 subunit (B7Z7L0_HUMAN)
  • Glutamate receptor delta-1 subunit (GRID1_HUMAN)
  • Glutamate receptor, ionotropic, delta 1 (Q5JQ58_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULK0

UniProtKB/Swiss-Prot:

GRID1_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily.
genes like me logo Genes that share domains with GRID1: view

Function for GRID1 Gene

Molecular function for GRID1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Phenotypes From GWAS Catalog for GRID1 Gene

Gene Ontology (GO) - Molecular Function for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0008066 glutamate receptor activity IBA 21873635
GO:0015276 ligand-gated ion channel activity IEA --
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with GRID1: view
genes like me logo Genes that share phenotypes with GRID1: view

Animal Models for GRID1 Gene

MGI Knock Outs for GRID1:

Animal Model Products

CRISPR Products

miRNA for GRID1 Gene

miRTarBase miRNAs that target GRID1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRID1 Gene

Localization for GRID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRID1 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRID1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with GRID1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRID1 Gene

Pathways & Interactions for GRID1 Gene

genes like me logo Genes that share pathways with GRID1: view

Pathways by source for GRID1 Gene

1 BioSystems pathway for GRID1 Gene
1 KEGG pathway for GRID1 Gene

Gene Ontology (GO) - Biological Process for GRID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0035176 social behavior ISS,IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway IEA --
GO:0035249 synaptic transmission, glutamatergic IBA 21873635
genes like me logo Genes that share ontologies with GRID1: view

No data available for SIGNOR curated interactions for GRID1 Gene

Drugs & Compounds for GRID1 Gene

(9) Drugs for GRID1 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Full agonist, Agonist, Target 289
Latrepirdine Investigational Pharma Brain cell death inhibitor 0
ADX-47273 Pharma 0
IEM 1754 dihydrobroMide Pharma 0
Ifenprodil Tartrate Pharma NMDA receptor antagonist 0

(8) ApexBio Compounds for GRID1 Gene

Compound Action Cas Number
ADX-47273 851881-60-2
IEM 1754 dihydrobroMide 162831-31-4
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
Latrepirdine Brain cell death inhibitor 97657-92-6
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
genes like me logo Genes that share compounds with GRID1: view

Drug Products

Transcripts for GRID1 Gene

mRNA/cDNA for GRID1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRID1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3:

Relevant External Links for GRID1 Gene

GeneLoc Exon Structure for
GRID1

Expression for GRID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRID1 Gene

Protein differential expression in normal tissues from HIPED for GRID1 Gene

This gene is overexpressed in CD4 Tcells (24.8), Frontal cortex (24.5), Fetal Brain (8.3), and Adipocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRID1 Gene



Protein tissue co-expression partners for GRID1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRID1

SOURCE GeneReport for Unigene cluster for GRID1 Gene:

Hs.530653

Evidence on tissue expression from TISSUES for GRID1 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Lung(3.1)
genes like me logo Genes that share expression patterns with GRID1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRID1 Gene

Orthologs for GRID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRID1 31
  • 100 (a)
OneToOne
LOC100612556 30
  • 99.35 (n)
oppossum
(Monodelphis domestica)
Mammalia GRID1 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRID1 31 30
  • 92.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GRID1 31 30
  • 92.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Grid1 17 31 30
  • 91.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRID1 31
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRID1 31 30
  • 79.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRID1 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grid1 30
  • 73.45 (n)
zebrafish
(Danio rerio)
Actinopterygii grid1a 31
  • 74 (a)
OneToMany
grid1b 31 30
  • 73.83 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Glu-RI 31
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-2 31
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for GRID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRID1 Gene

ENSEMBL:
Gene Tree for GRID1 (if available)
TreeFam:
Gene Tree for GRID1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRID1: view image

Paralogs for GRID1 Gene

(7) SIMAP similar genes for GRID1 Gene using alignment to 3 proteins:

  • GRID1_HUMAN
  • B7Z7L0_HUMAN
  • G3V186_HUMAN
genes like me logo Genes that share paralogs with GRID1: view

Variants for GRID1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRID1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs143353694 Uncertain Significance: Malignant tumor of prostate 85,869,077(-) G/A MISSENSE_VARIANT
rs201182031 Benign: Abnormality of neuronal migration 86,206,442(-) G/A MISSENSE_VARIANT
rs863223382 Benign: Abnormality of neuronal migration 86,206,447(-) G/A MISSENSE_VARIANT
rs2306265 - p.Val529Ile

Additional dbSNP identifiers (rs#s) for GRID1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GRID1 Gene

Variant ID Type Subtype PubMed ID
dgv1316n54 CNV loss 21841781
dgv1317n54 CNV loss 21841781
dgv1318n54 CNV gain 21841781
dgv1319n54 CNV loss 21841781
dgv265e212 CNV loss 25503493
esv1111287 CNV insertion 17803354
esv24557 CNV loss 19812545
esv2592801 CNV insertion 19546169
esv2657402 CNV deletion 23128226
esv2666181 CNV deletion 23128226
esv2666548 CNV deletion 23128226
esv2670315 CNV deletion 23128226
esv2671815 CNV deletion 23128226
esv2676888 CNV deletion 23128226
esv28516 CNV loss 19812545
esv29595 CNV loss 19812545
esv3306559 CNV mobile element insertion 20981092
esv3308597 CNV mobile element insertion 20981092
esv3310272 CNV mobile element insertion 20981092
esv3442515 CNV insertion 20981092
esv3546608 CNV deletion 23714750
esv3546610 CNV deletion 23714750
esv3546613 CNV deletion 23714750
esv3546614 CNV deletion 23714750
esv3579025 CNV loss 25503493
esv3579030 CNV loss 25503493
esv3579031 CNV loss 25503493
esv3624077 CNV loss 21293372
esv3624078 CNV loss 21293372
esv3624079 CNV loss 21293372
esv3624080 CNV loss 21293372
esv3624082 CNV loss 21293372
esv3624083 CNV loss 21293372
esv3624084 CNV loss 21293372
esv3624085 CNV loss 21293372
esv3891878 CNV loss 25118596
esv6406 CNV gain 19470904
esv999303 CNV loss 20482838
nsv1051761 CNV loss 25217958
nsv1052427 CNV gain 25217958
nsv1121818 CNV deletion 24896259
nsv1127129 CNV deletion 24896259
nsv1141879 OTHER inversion 24896259
nsv1159755 CNV duplication 26073780
nsv442200 CNV loss 18776908
nsv471918 CNV novel sequence insertion 20440878
nsv473108 CNV novel sequence insertion 20440878
nsv473771 CNV novel sequence insertion 20440878
nsv515541 CNV loss 19592680
nsv519532 CNV loss 19592680
nsv520914 CNV loss 19592680
nsv522357 CNV loss 19592680
nsv525816 CNV loss 19592680
nsv525817 CNV loss 19592680
nsv551761 CNV loss 21841781
nsv551762 CNV loss 21841781
nsv551763 CNV loss 21841781
nsv551764 CNV loss 21841781
nsv551773 CNV loss 21841781
nsv551774 CNV loss 21841781
nsv7477 CNV insertion 18451855
nsv831935 CNV gain 17160897
nsv831936 CNV loss 17160897
nsv831938 CNV gain 17160897

Variation tolerance for GRID1 Gene

Residual Variation Intolerance Score: 2.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRID1 Gene

Human Gene Mutation Database (HGMD)
GRID1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRID1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRID1 Gene

Disorders for GRID1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GRID1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 17q21.31 duplication syndrome
  • 17q21.31 microduplication syndrome
rett syndrome
  • rtt
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GRID1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRID1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRID1 Gene

Publications for GRID1 Gene

  1. Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. (PMID: 19346103) Treutlein J … Rietschel M (Schizophrenia research 2009) 3 23 41 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 41 54
  4. A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. (PMID: 17490860) Guo SZ … He L (Schizophrenia research 2007) 3 41 54
  5. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PMID: 16380905) Fallin MD … Pulver AE (American journal of human genetics 2005) 3 41 54

Products for GRID1 Gene

Sources for GRID1 Gene