Aliases for GRIA4 Gene
External Ids for GRIA4 Gene
Previous HGNC Symbols for GRIA4 Gene
Previous GeneCards Identifiers for GRIA4 Gene
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRIA4 Gene
GRIA4 (Glutamate Ionotropic Receptor AMPA Type Subunit 4) is a Protein Coding gene. Diseases associated with GRIA4 include Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities and Schizophrenia. Among its related pathways are Circadian entrainment and Long-term potentiation. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and AMPA glutamate receptor activity. An important paralog of this gene is GRIA2.
UniProtKB/Swiss-Prot Summary for GRIA4 Gene
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.