GRIA2 Gene (Protein Coding)

Glutamate Ionotropic Receptor AMPA Type Subunit 2

GC04P157204
GIFtS:
51
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels ... See more...

Aliases for GRIA2 Gene

Aliases for GRIA2 Gene

  • Glutamate Ionotropic Receptor AMPA Type Subunit 2 2 3 5
  • GluA2 2 3 4
  • Glutamate Receptor, Ionotropic, AMPA 2 2 3
  • AMPA-Selective Glutamate Receptor 2 3 4
  • Glutamate Receptor 2 3 4
  • GluR-K2 3 4
  • GluR-2 3 4
  • GluR-B 3 4
  • GLUR2 3 4
  • GLURB 2 3
  • Glutamate Receptor Ionotropic, AMPA 2 4
  • NEDLIB 3
  • HBGR2 3
  • GRIA2 5

External Ids for GRIA2 Gene

Previous HGNC Symbols for GRIA2 Gene

  • GLUR2

Previous GeneCards Identifiers for GRIA2 Gene

  • GC04P159021
  • GC04P158572
  • GC04P158719
  • GC04P158499
  • GC04P158361
  • GC04P158141
  • GC04P153892

Summaries for GRIA2 Gene

Entrez Gene Summary for GRIA2 Gene

  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIA2 Gene

GRIA2 (Glutamate Ionotropic Receptor AMPA Type Subunit 2) is a Protein Coding gene. Diseases associated with GRIA2 include Neurodevelopmental Disorder With Language Impairment And Behavioral Abnormalities and Status Epilepticus. Among its related pathways are Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include ionotropic glutamate receptor activity and AMPA glutamate receptor activity. An important paralog of this gene is GRIA4.

UniProtKB/Swiss-Prot Summary for GRIA2 Gene

  • Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Tocris Summary for GRIA2 Gene

  • AMPA receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and kainate receptors. AMPA receptors mediate fast excitatory synaptic transmission and play a role in hippocampal synaptic long-term potentiation and depression.

Gene Wiki entry for GRIA2 Gene

Additional gene information for GRIA2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRIA2 Gene

Genomics for GRIA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GRIA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J157222 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +18.1 18118 4.2 MXD4 REST KLF11 ZEB1 SIN3A KMT2B THAP11 CTBP1 SMAD4 SAP130 GRIA2 RNU6-582P HSALNG0038114 HSALNG0038115 GASK1B
GH04J156597 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 10.3 -606.7 -606737 3.3 RXRA BHLHE40 FOS SCRT2 NR2F2 ENSG00000249479 LINC02272 RNU6-582P ENSG00000249819 GRIA2 HSALNG0038085 piR-32559-330 PDGFC CTSO
GH04J157265 Enhancer 0.5 FANTOM5 Ensembl 11 +61.3 61318 0.6 USF1 HSALNG0038115 GRIA2 RNU6-582P ENSG00000249819 GLRB PDGFC HSALNG0038114 GASK1B
GH04J156790 Enhancer 0.5 Ensembl 9.2 -412.3 -412281 3 FOXA2 TEAD3 SOX5 ARID3A MIXL1 KAT8 SOX13 CREB1 TEAD1 ENSG00000248629 RNU6-582P ENSG00000249819 GRIA2 lnc-GLRB-9 HSALNG0038097 lnc-CTSO-2 PDGFC CTSO
GH04J157244 Enhancer 0.4 FANTOM5 Ensembl 13.8 +40.2 40219 0.8 GRIA2 ENSG00000249819 RNU6-582P HSALNG0038114 HSALNG0038115 GASK1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRIA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRIA2

Top Transcription factor binding sites by QIAGEN in the GRIA2 gene promoter:
  • Chx10
  • p53
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU6F1 (c2)

Genomic Locations for GRIA2 Gene

Latest Assembly
chr4:157,204,182-157,370,583
(GRCh38/hg38)
Size:
166,402 bases
Orientation:
Plus strand

Previous Assembly
chr4:158,141,272-158,287,227
(GRCh37/hg19 by Entrez Gene)
Size:
145,956 bases
Orientation:
Plus strand

chr4:158,125,334-158,287,227
(GRCh37/hg19 by Ensembl)
Size:
161,894 bases
Orientation:
Plus strand

Genomic View for GRIA2 Gene

Genes around GRIA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIA2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRIA2 Gene

Proteins for GRIA2 Gene

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  • Protein details for GRIA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42262-GRIA2_HUMAN
    Recommended name:
    Glutamate receptor 2
    Protein Accession:
    P42262
    Secondary Accessions:
    • A8MT92
    • I6L997
    • Q96FP6

    Protein attributes for GRIA2 Gene

    Size:
    883 amino acids
    Molecular mass:
    98821 Da
    Quaternary structure:
    • Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with GRIP2. Isoform 1, but not isoform 3, interacts with PICK1/PRKCABP. Interacts with GRIA1 and SYNDIG1. Interacts with LRFN1 (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts with OLFM2 (By similarity). Interacts with AP4B1, AP4E1 and AP4M1; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity). Forms a complex with NSG1, GRIP1 and STX12; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Interacts with IQSEC1; the interaction is required for ARF6 activation (By similarity).
    Miscellaneous:
    • The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

    Three dimensional structures from OCA and Proteopedia for GRIA2 Gene

    Alternative splice isoforms for GRIA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIA2 Gene

Protein Expression for GRIA2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRIA2 Gene

  • Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
  • Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation.
  • Glycosylation at Asn256, Asn370, Asn406, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for GRIA2

No data available for DME Specific Peptides for GRIA2 Gene

Domains & Families for GRIA2 Gene

Gene Families for GRIA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for GRIA2 Gene

InterPro:
Blocks:
  • Extracellular ligand-binding receptor
  • Ionotropic glutamate receptor
  • NMDA receptor signature

Suggested Antigen Peptide Sequences for GRIA2 Gene

GenScript: Design optimal peptide antigens:
  • Glutamate receptor ionotropic, AMPA 2 (GRIA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42262

UniProtKB/Swiss-Prot:

GRIA2_HUMAN :
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
Domain:
  • The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
genes like me logo Genes that share domains with GRIA2: view

Function for GRIA2 Gene

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Molecular function for GRIA2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
GENATLAS Biochemistry:
glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class,with flip and flop isoforms,mediating the fast component of excitatory post synaptic currents in the central nervous system,interacting with and signaling through the protein-kinase LYN

Phenotypes From GWAS Catalog for GRIA2 Gene

Gene Ontology (GO) - Molecular Function for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding NAS 20032460
GO:0004970 ionotropic glutamate receptor activity IEA,IDA 20614889
GO:0004971 contributes_to AMPA glutamate receptor activity TAS,NAS 20032460
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding IPI 12130635
genes like me logo Genes that share ontologies with GRIA2: view
genes like me logo Genes that share phenotypes with GRIA2: view

Human Phenotype Ontology for GRIA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GRIA2 Gene

MGI Knock Outs for GRIA2:

Animal Models for research

  • Taconic Biosciences Mouse Models for GRIA2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRIA2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRIA2 Gene

Localization for GRIA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIA2 Gene

Cell membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane. Multi-pass membrane protein. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). {ECO:0000250, ECO:0000250 UniProtKB:P23819}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIA2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0009897 external side of plasma membrane TAS 21221849
genes like me logo Genes that share ontologies with GRIA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRIA2 Gene

Pathways & Interactions for GRIA2 Gene

genes like me logo Genes that share pathways with GRIA2: view

Pathways by source for GRIA2 Gene

1 GeneGo (Thomson Reuters) pathway for GRIA2 Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
5 Qiagen pathways for GRIA2 Gene
  • CREB Pathway
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • Intracellular Calcium Signaling
  • Neuropathic Pain-Signaling in Dorsal Horn Neurons
  • Pathogenesis of ALS
2 Cell Signaling Technology pathways for GRIA2 Gene

SIGNOR curated interactions for GRIA2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for GRIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction TAS 8003671
GO:0007268 chemical synaptic transmission TAS 8003671
GO:0034220 ion transmembrane transport IEA --
GO:0035235 ionotropic glutamate receptor signaling pathway IEA,IDA 20614889
genes like me logo Genes that share ontologies with GRIA2: view

Drugs & Compounds for GRIA2 Gene

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(127) Drugs for GRIA2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclothiazide Approved Pharma Allosteric regulator, Positive, inhibitor 0
Butabarbital Approved, Illicit Pharma Target, antagonist 0
Butalbital Approved, Illicit Pharma Target, antagonist 0
Butethal Approved, Illicit Pharma Target, antagonist 0
Methylphenobarbital Approved Pharma Target, antagonist 0

(4) Additional Compounds for GRIA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3'-Hydroxyhexobarbital
  • 3'-Hydroxyhexobarbital, (R-(r*,s*))-isomer
  • 3'-Hydroxyhexobarbital, (r*,s*)-(+-)-isomer
  • 3'-Hydroxyhexobarbital, (S-(r*,r*))-isomer
  • 3'-Hydroxyhexobarbital, (S-(r*,s*))-isomer
  • 3'-Hydroxyhexobarbitone
 427-29-2

(4) Tocris Compounds for GRIA2 Gene

Compound Action Cas Number
(R)-AMPA Inactive isomer of (RS)-AMPA (Cat. No. 0169) 83654-13-1
(RS)-AMPA Selective AMPA agonist 74341-63-2
L-Quisqualic acid AMPA/group I mGlu agonist 52809-07-1
Piracetam Nootropic; modulates Na+-flux at AMPA receptors 7491-74-9

(51) ApexBio Compounds for GRIA2 Gene

Compound Action Cas Number
(R)-AMPA 83654-13-1
(RS)-AMPA 74341-63-2
(RS)-AMPA hydrobromide 171259-81-7
(S)-(-)-5-Fluorowillardiine 140187-23-1
(S)-AMPA 83643-88-3
(S)-CPW 399 AMPA agonist,subtype-selective,weakly desensitizing 389888-02-2
1-BCP 34023-62-6
ADX-47273 851881-60-2
Ampalex Ampakine and nootropic 154235-83-3
Aniracetam Nootropic drug for senile dementia 72432-10-1
CFM-2 178616-26-7
Cl-HIBO 909400-43-7
CMPDA 380607-77-2
CNQX 115066-14-3
CNQX disodium salt 479347-85-8
CP 465022 hydrochloride AMPA receptor antagonist, non-competitive and selective 199655-36-2
CX 546 215923-54-9
Cyclothiazide 2259-96-3
Diazoxide 364-98-7
DNQX disodium salt 1312992-24-7
Evans Blue tetrasodium salt potent inhibitor of AMPA and kainate receptor-mediated currents (GluRl and GIuR6) 314-13-6
GYKI 47261 dihydrochloride AMPA receptor antagonist, non-competitive and selective 1217049-32-5
GYKI 52466 dihydrochloride 102771-26-6
GYKI 53655 hydrochloride 143692-48-2
IDRA 21 22503-72-6
IEM 1460 121034-89-7
IEM 1754 dihydrobroMide 162831-31-4
IEM 1925 dihydrobromide 258282-23-4
Ifenprodil Tartrate NMDA receptor antagonist 23210-58-4
Latrepirdine Brain cell death inhibitor 97657-92-6
L-Quisqualic acid 52809-07-1
LY451395 Allosteric modulator 375345-95-2
Naspm trihydrochloride 1049731-36-3
NBQX 118876-58-7
NBQX disodium salt 479347-86-9
NMDA (N-Methyl-D-aspartic acid) NMDA receptor agonist 6384-92-5
Noopept Nootropic and neuroprotective agent 157115-85-0
NPEC-caged-(S)-AMPA 1257323-84-4
Pep1-AGL
Pep1-TGL
Pep2m, myristoylated
PEPA 141286-78-4
Philanthotoxin 74 1227301-51-0
S 18986 175340-20-2
SYM 2206 173952-44-8
UBP 282 544697-47-4
VU 0361737 MGlu4 receptor allosteric modulator 1161205-04-4
VU 0364439 Positive allosteric mGluR-4 modulator 1246086-78-1
VU 0364770 61350-00-3
YM 90K hydrochloride 154164-30-4
ZK 200775 161605-73-8
genes like me logo Genes that share compounds with GRIA2: view

Drug products for research

Transcripts for GRIA2 Gene

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mRNA/cDNA for GRIA2 Gene

5 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

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Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for GRIA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for GRIA2 Gene

GeneLoc Exon Structure for
GRIA2

Expression for GRIA2 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRIA2 Gene

mRNA expression in normal human tissues for GRIA2 Gene
mRNA expression by BioGPS for GRIA2 GenemRNA expression by GTEx for GRIA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIA2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Cortex (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for GRIA2 Gene

This gene is overexpressed in Brain (22.1), Fetal Brain (17.3), and Frontal cortex (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIA2 Gene



Protein tissue co-expression partners for GRIA2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRIA2

SOURCE GeneReport for Unigene cluster for GRIA2 Gene:

Hs.32763

Evidence on tissue expression from TISSUES for GRIA2 Gene

  • Nervous system(5)
  • Eye(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GRIA2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIA2 Gene

Orthologs for GRIA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GRIA2 29 30
  • 99.66 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GRIA2 30
  • 99 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GRIA2 30
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GRIA2 29 30
  • 94.41 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gria2 29
  • 93.92 (n)
Mouse
(Mus musculus)
 Mammalia Gria2 29 16 30
  • 93.85 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GRIA2 29 30
  • 93.8 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves GRIA2 29 30
  • 88.41 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GRIA2 30
  • 93 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gria2 29
  • 84.05 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.8583 29
Zebrafish
(Danio rerio)
 Actinopterygii gria2a 30
  • 84 (a)
 OneToMany
gria2b 30
  • 82 (a)
 OneToMany
gria2.2 29
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11155 31
  • 51 (a)
Glu-RI 31
  • 41 (a)
CG9935 31
  • 39 (a)
Glu-RIB 31
  • 35 (a)
Kai-RIA 31
  • 35 (a)
CG15627 31
  • 33 (a)
Glu-RIIA 31
  • 30 (a)
CG4226 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
 Secernentea glr-1 31
  • 38 (a)
glr-4 31
  • 31 (a)
Species where no ortholog for GRIA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRIA2 Gene

ENSEMBL:
Gene Tree for GRIA2 (if available)
TreeFam:
Gene Tree for GRIA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRIA2: view image
Alliance of Genome Resources:
Additional Orthologs for GRIA2

Paralogs for GRIA2 Gene

Paralogs for GRIA2 Gene

(11) SIMAP similar genes for GRIA2 Gene using alignment to 11 proteins:

  • GRIA2_HUMAN
  • A8MT92_HUMAN
  • D6R9Z0_HUMAN
  • D6RBV7_HUMAN
  • D6RDX5_HUMAN
  • D6REK8_HUMAN
  • D6RFM6_HUMAN
  • F8W7L6_HUMAN
  • G8HBB1_HUMAN
  • H0Y972_HUMAN
  • I6L997_HUMAN
genes like me logo Genes that share paralogs with GRIA2: view

Variants for GRIA2 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRIA2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
1012507 Likely Pathogenic: not provided 157,332,903(+) C/T
NM_001083619.3(GRIA2):c.967C>T (p.Arg323Ter) 		NONSENSE
769220 Benign: not provided 157,336,723(+) A/.
NM_000826.4(GRIA2):c.1820= (p.Gln607=) 		MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION
929838 Pathogenic: Neurodevelopmental disorder with language impairment and behavioral abnormalities 157,336,728(+) G/A
NM_001083619.3(GRIA2):c.1825G>A (p.Gly609Arg) 		MISSENSE
929839 Pathogenic: Neurodevelopmental disorder with language impairment and behavioral abnormalities 157,332,841(+) A/G
NM_001083619.3(GRIA2):c.905A>G (p.Asp302Gly) 		MISSENSE
929840 Pathogenic: Neurodevelopmental disorder with language impairment and behavioral abnormalities 157,336,485(+) C/A
NM_001083619.3(GRIA2):c.1582C>A (p.Pro528Thr) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GRIA2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GRIA2 Gene

Variant ID Type Subtype PubMed ID
dgv1038e214 CNV gain 21293372
esv1631445 CNV insertion 17803354
esv2759291 CNV gain 17122850
esv3602808 CNV loss 21293372
esv3602809 CNV gain 21293372
esv3602810 CNV gain 21293372
nsv1017691 CNV gain 25217958
nsv1018387 CNV gain 25217958
nsv1031579 CNV gain 25217958
nsv1073809 CNV deletion 25765185
nsv1116403 CNV insertion 24896259
nsv293530 CNV insertion 16902084
nsv830123 CNV gain 17160897

Variation tolerance for GRIA2 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIA2 Gene

Human Gene Mutation Database (HGMD)
GRIA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIA2
Leiden Open Variation Database (LOVD)
GRIA2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIA2 Gene

Disorders for GRIA2 Gene

MalaCards: The human disease database

(28) MalaCards diseases for GRIA2 Gene - From: OMI, CVR, COP, and GCD

Disorder Aliases PubMed IDs
neurodevelopmental disorder with language impairment and behavioral abnormalities
  • nedlib
status epilepticus
  • grand mal status
depression
  • clinical depression
lateral sclerosis
  • adult-onset primary lateral sclerosis
tarp syndrome
  • tarps
- elite association - COSMIC cancer census association via MalaCards
Search GRIA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRIA2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GRIA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIA2 Gene

Publications for GRIA2 Gene

  1. Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors. (PMID: 19651138) Clayton A … Aricescu AR (Journal of molecular biology 2009) 3 4 22
  2. Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain. (PMID: 8003671) Sun W … Montal M (Neuroreport 1994) 3 4 22
  3. AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. (PMID: 31300657) Salpietro V … Houlden H (Nature communications 2019) 3 72
  4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 40
  5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40

ExternalLinks

View latest publications for GRIA2 gene in Mastermind

Products for GRIA2 Gene

Sources for GRIA2 Gene