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Aliases for GRHPR Gene

Aliases for GRHPR Gene

  • Glyoxylate And Hydroxypyruvate Reductase 2 3 5
  • Glyoxylate Reductase And Hydroxypyruvate Reductase 2 3
  • Glyoxylate Reductase/Hydroxypyruvate Reductase 2 3
  • GLXR 3 4
  • Primary Hyperoxaluria Type 2 2
  • Glycerate-2-Dehydrogenase 3
  • EC 1.1.1.79 4
  • EC 1.1.1.81 4
  • GLYD 3
  • PH2 3

External Ids for GRHPR Gene

Previous HGNC Symbols for GRHPR Gene

  • GLXR

Previous GeneCards Identifiers for GRHPR Gene

  • GC09P037734
  • GC09P037592

Summaries for GRHPR Gene

Entrez Gene Summary for GRHPR Gene

  • This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRHPR Gene

GRHPR (Glyoxylate And Hydroxypyruvate Reductase) is a Protein Coding gene. Diseases associated with GRHPR include Hyperoxaluria, Primary, Type Ii and Primary Hyperoxaluria. Among its related pathways are Glyoxylate metabolism and glycine degradation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.

UniProtKB/Swiss-Prot for GRHPR Gene

  • Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Gene Wiki entry for GRHPR Gene

Additional gene information for GRHPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRHPR Gene

Genomics for GRHPR Gene

GeneHancer (GH) Regulatory Elements for GRHPR Gene

Promoters and enhancers for GRHPR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I037421 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 622.5 +0.7 665 3.3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 POLR2B ZNF207 ZNF143 SP3 GRHPR SHB CHCHD4P3
GH09I037463 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +43.6 43599 5.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 ZBTB5 DCAF10 EXOSC3 ZCCHC7 RPL21P83 RNF38 TRMT10B GRHPR TMX2P1 POLR1E
GH09I037485 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.9 +64.1 64135 3.5 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B POLR1E RPL21P83 ZCCHC7 EXOSC3 ZBTB5 FBXO10 ENSG00000234160 DCAF10 ENSG00000256966 TOMM5
GH09I037299 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.4 -120.4 -120414 5.9 PKNOX1 SMAD1 NFRKB BMI1 BATF ZBTB40 CHAMP1 TCF12 ATF7 ETV6 PAX5 LOC105376032 GRHPR GC09P037322 ENSG00000228292 ZCCHC7
GH09I037411 Enhancer 0.8 Ensembl ENCODE dbSUPER 15.1 -9.8 -9763 2 E2F1 ZNF687 ZFP36 GRHPR ZBTB5 LINC01627 LOC105376035
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRHPR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRHPR gene promoter:

Genomic Locations for GRHPR Gene

Genomic Locations for GRHPR Gene
chr9:37,422,666-37,436,993
(GRCh38/hg38)
Size:
14,328 bases
Orientation:
Plus strand
chr9:37,422,663-37,436,987
(GRCh37/hg19)

Genomic View for GRHPR Gene

Genes around GRHPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRHPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRHPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRHPR Gene

Proteins for GRHPR Gene

  • Protein details for GRHPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBQ7-GRHPR_HUMAN
    Recommended name:
    Glyoxylate reductase/hydroxypyruvate reductase
    Protein Accession:
    Q9UBQ7
    Secondary Accessions:
    • Q5T945
    • Q9H3E9
    • Q9H636
    • Q9UKX1

    Protein attributes for GRHPR Gene

    Size:
    328 amino acids
    Molecular mass:
    35668 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAD54066.1; Type=Frameshift; Positions=109, 137; Evidence={ECO:0000305}; Sequence=AAG39286.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRHPR Gene

    Alternative splice isoforms for GRHPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRHPR Gene

Post-translational modifications for GRHPR Gene

No Post-translational modifications

No data available for DME Specific Peptides for GRHPR Gene

Domains & Families for GRHPR Gene

Gene Families for GRHPR Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9UBQ7

UniProtKB/Swiss-Prot:

GRHPR_HUMAN :
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Family:
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with GRHPR: view

Function for GRHPR Gene

Molecular function for GRHPR Gene

GENATLAS Biochemistry:
glyoxylate reductase/hydroxypyruvate NADPH dependent,expressed in liver,kidney and blood
UniProtKB/Swiss-Prot CatalyticActivity:
Glycolate + NADP(+) = glyoxylate + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Enzyme Numbers (IUBMB) for GRHPR Gene

Gene Ontology (GO) - Molecular Function for GRHPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008465 glycerate dehydrogenase activity IDA 10484776
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA --
GO:0016618 hydroxypyruvate reductase activity IDA,IEA 10484776
GO:0030267 glyoxylate reductase (NADP) activity TAS --
genes like me logo Genes that share ontologies with GRHPR: view
genes like me logo Genes that share phenotypes with GRHPR: view

Human Phenotype Ontology for GRHPR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for GRHPR Gene

miRTarBase miRNAs that target GRHPR

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for GRHPR Gene

Localization for GRHPR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRHPR gene
Compartment Confidence
extracellular 5
peroxisome 5
cytosol 4
mitochondrion 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRHPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol IBA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with GRHPR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRHPR Gene

Pathways & Interactions for GRHPR Gene

genes like me logo Genes that share pathways with GRHPR: view

Gene Ontology (GO) - Biological Process for GRHPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007588 excretion IMP 10484776
GO:0008152 metabolic process NAS 10524214
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0043648 dicarboxylic acid metabolic process IEA --
GO:0051259 protein oligomerization IDA 16756993
genes like me logo Genes that share ontologies with GRHPR: view

No data available for SIGNOR curated interactions for GRHPR Gene

Drugs & Compounds for GRHPR Gene

(7) Drugs for GRHPR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycolic acid Approved, Investigational Pharma 19
calcium Approved Nutra 0
NADH Approved Nutra 0
Glyoxylic acid Experimental Pharma 0
Hydroxypyruvic acid Experimental Pharma 0

(9) Additional Compounds for GRHPR Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Lactaldehyde
  • (2R)-2-hydroxypropanal
  • (R)-Lactaldehyde
  • D-2-Hydroxypropionaldehyde
  • D-Lactaldehyde
3946-09-6
Glyceric acid
  • (R)-glycerate
  • a,b-Hydroxypropionate
  • a,b-Hydroxypropionic acid
  • D-Glycerate
  • D-Glyceric acid
473-81-4
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with GRHPR: view

Transcripts for GRHPR Gene

Unigene Clusters for GRHPR Gene

Glyoxylate reductase/hydroxypyruvate reductase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRHPR Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d ^ 7a · 7b ·
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10:
SP11: - - - - - - - - - -
SP12:
SP13: -
SP14: - -
SP15:
SP16: - - - - - - - -
SP17:

ExUns: 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: - - -
SP13:
SP14:
SP15: -
SP16:
SP17:

Relevant External Links for GRHPR Gene

GeneLoc Exon Structure for
GRHPR
ECgene alternative splicing isoforms for
GRHPR

Expression for GRHPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRHPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRHPR Gene

This gene is overexpressed in Liver (x5.4).

Protein differential expression in normal tissues from HIPED for GRHPR Gene

This gene is overexpressed in Liver, secretome (9.2) and Liver (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRHPR Gene



Protein tissue co-expression partners for GRHPR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRHPR Gene:

GRHPR

SOURCE GeneReport for Unigene cluster for GRHPR Gene:

Hs.155742

mRNA Expression by UniProt/SwissProt for GRHPR Gene:

Q9UBQ7-GRHPR_HUMAN
Tissue specificity: Ubiquitous. Most abundantly expressed in the liver.

Evidence on tissue expression from TISSUES for GRHPR Gene

  • Liver(4.7)
  • Kidney(4.6)
  • Intestine(4.3)
  • Nervous system(4.3)
  • Lung(3)
  • Skin(2.5)
  • Muscle(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GRHPR Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • urinary
Regions:
Abdomen:
  • kidney
Pelvis:
  • ureter
General:
  • blood
  • red blood cell
genes like me logo Genes that share expression patterns with GRHPR: view

Primer Products

Orthologs for GRHPR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRHPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRHPR 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia GRHPR 33 34
  • 89.54 (n)
cow
(Bos Taurus)
Mammalia GRHPR 33 34
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Grhpr 33 16 34
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Grhpr 33
  • 85.26 (n)
oppossum
(Monodelphis domestica)
Mammalia GRHPR 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRHPR 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRHPR 33 34
  • 72.33 (n)
lizard
(Anolis carolinensis)
Reptilia GRHPR 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grhpr.1 33
  • 68.52 (n)
Str.15297 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398508 33
zebrafish
(Danio rerio)
Actinopterygii grhpra 33 34
  • 66.26 (n)
wufb80f04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6036 33
fruit fly
(Drosophila melanogaster)
Insecta CG1236 35 33 34
  • 57.29 (n)
CG9331 35
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013478 33
  • 57.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOR1 34 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79870 33
  • 46.83 (n)
rice
(Oryza sativa)
Liliopsida Os01g0228600 33
  • 50.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for GRHPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRHPR Gene

ENSEMBL:
Gene Tree for GRHPR (if available)
TreeFam:
Gene Tree for GRHPR (if available)

Paralogs for GRHPR Gene

(1) SIMAP similar genes for GRHPR Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRHPR: view

No data available for Paralogs for GRHPR Gene

Variants for GRHPR Gene

Sequence variations from dbSNP and Humsavar for GRHPR Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1057507 likely-benign, Primary hyperoxaluria 37,436,928(+) A/G 3_prime_UTR_variant, intron_variant
rs1057516292 likely-pathogenic, Primary hyperoxaluria, type II 37,429,833(+) TTT/TT coding_sequence_variant, frameshift
rs1057516299 likely-pathogenic, Primary hyperoxaluria, type II 37,426,653(+) AA/A 5_prime_UTR_variant, coding_sequence_variant, frameshift, intron_variant
rs1057516823 likely-pathogenic, Primary hyperoxaluria, type II 37,432,028(+) A/AA coding_sequence_variant, frameshift
rs1057516831 likely-pathogenic, Primary hyperoxaluria, type II 37,436,749(+) A/ coding_sequence_variant, frameshift, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRHPR Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for GRHPR Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRHPR Gene

Human Gene Mutation Database (HGMD)
GRHPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRHPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRHPR Gene

Disorders for GRHPR Gene

MalaCards: The human disease database

(6) MalaCards diseases for GRHPR Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperoxaluria, primary, type ii
  • hp2
primary hyperoxaluria
  • glycolic aciduria
nephrocalcinosis
  • hypercalcemic nephropathy
nephrolithiasis
  • nephrolithiasis, calcium oxalate
nephrolithiasis, calcium oxalate
  • caon
- elite association - COSMIC cancer census association via MalaCards
Search GRHPR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GRHPR_HUMAN
  • Hyperoxaluria primary 2 (HP2) [MIM:260000]: A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease. {ECO:0000269 PubMed:10484776}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for GRHPR Gene

hyperoxaluria primary type II,autosomal recessive,characterized by nephrolithiasis,nephorcalcinosis leading to oxalosis and renal failure

Additional Disease Information for GRHPR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GRHPR: view

Publications for GRHPR Gene

  1. Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. (PMID: 10524214) Rumsby G … Cregeen DP (Biochimica et biophysica acta 1999) 2 3 4 22 58
  2. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. (PMID: 10484776) Cramer SD … Holmes RP (Human molecular genetics 1999) 2 3 4 22 58
  3. Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. (PMID: 19296982) Levin-Iaina N … Holtzman EJ (The Journal of urology 2009) 3 22 44 58
  4. Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. (PMID: 16756993) Booth MP … Brady RL (Journal of molecular biology 2006) 3 4 22 58
  5. Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias. (PMID: 15327387) Rumsby G … Coulter-Mackie M (Kidney international 2004) 3 22 44 58

Products for GRHPR Gene

Sources for GRHPR Gene

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