Aliases for GRHPR Gene
External Ids for GRHPR Gene
Previous HGNC Symbols for GRHPR Gene
Previous GeneCards Identifiers for GRHPR Gene
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRHPR Gene
GRHPR (Glyoxylate And Hydroxypyruvate Reductase) is a Protein Coding gene. Diseases associated with GRHPR include Hyperoxaluria, Primary, Type Ii and Primary Hyperoxaluria. Among its related pathways are Glyoxylate and dicarboxylate metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is PHGDH.
UniProtKB/Swiss-Prot Summary for GRHPR Gene
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.