Aliases for GREM2 Gene
External Ids for GREM2 Gene
Previous GeneCards Identifiers for GREM2 Gene
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for GREM2 Gene
GREM2 (Gremlin 2, DAN Family BMP Antagonist) is a Protein Coding gene. Diseases associated with GREM2 include Tooth Agenesis, Selective, 9 and Tooth Agenesis. Among its related pathways are Signaling by GPCR and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and heparin binding. An important paralog of this gene is GREM1.
UniProtKB/Swiss-Prot Summary for GREM2 Gene
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.