This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for GREB1 Gene

Aliases for GREB1 Gene

  • Growth Regulating Estrogen Receptor Binding 1 2 3 5
  • Growth Regulation By Estrogen In Breast Cancer 1 2 3
  • Gene Regulated By Estrogen In Breast Cancer 2 3
  • Gene Regulated In Breast Cancer 1 Protein 3 4
  • Protein GREB1 3 4
  • KIAA0575 4

External Ids for GREB1 Gene

Previous GeneCards Identifiers for GREB1 Gene

  • GC02P011537
  • GC02P011725
  • GC02P011695
  • GC02P011624
  • GC02P011591
  • GC02P011674
  • GC02P011524
  • GC02P011536

Summaries for GREB1 Gene

Entrez Gene Summary for GREB1 Gene

  • This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GREB1 Gene

GREB1 (Growth Regulating Estrogen Receptor Binding 1) is a Protein Coding gene. Diseases associated with GREB1 include Breast Cancer and Amelogenesis Imperfecta, Type Ig. Among its related pathways are Ectoderm Differentiation. An important paralog of this gene is GREB1L.

UniProtKB/Swiss-Prot Summary for GREB1 Gene

  • May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

Additional gene information for GREB1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GREB1 Gene

Genomics for GREB1 Gene

GeneHancer (GH) Regulatory Elements for GREB1 Gene

Promoters and enhancers for GREB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J011480 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 511.3 +0.7 711 4.3 FOXK2 ZNF217 EP300 TCF12 MYC POLR2G ZFX ZIC2 FOXA1 ZBTB10 GREB1 lnc-E2F6-8 lnc-E2F6-9 LPIN1 LOC100506405 ROCK2
GH02J011464 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 -16.6 -16640 3 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 NRF1 MYC TCF12 POLR2G USF1 E2F6 lnc-ROCK2-7 GREB1 NOL10 lnc-E2F6-6 piR-40921
GH02J011539 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.2 +60.1 60133 6.9 FOXK2 ZNF217 POLR2G USF1 NCOR1 ZFX ZIC2 KDM6A CLOCK TCF7 MIR4429 GREB1 NOL10 PDIA6 ENSG00000272275 LPIN1 LOC100506405 TRG-CCC7-1
GH02J011611 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 500.1 +129.9 129860 1.2 CEBPG CEBPB NFE2 FOSL1 BCOR NRF1 MAFG ZNF384 USF2 AGO2 GREB1 piR-43105-339 lnc-NTSR2-6
GH02J011562 Promoter/Enhancer 0.6 EPDnew dbSUPER 500.2 +78.8 78837 0.1 RBM22 ENSG00000285626 RF00001-162 RF00004-061 RNA5SP85 RNU2-13P GREB1 LPIN1 LOC100506405 TRG-CCC7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GREB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GREB1

Top Transcription factor binding sites by QIAGEN in the GREB1 gene promoter:
  • oct-B2
  • oct-B3
  • POU2F1
  • Sox5

Genomic Locations for GREB1 Gene

Genomic Locations for GREB1 Gene
chr2:11,482,341-11,642,788
(GRCh38/hg38)
Size:
160,448 bases
Orientation:
Plus strand
chr2:11,674,242-11,782,914
(GRCh37/hg19)
Size:
108,673 bases
Orientation:
Plus strand

Genomic View for GREB1 Gene

Genes around GREB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GREB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GREB1 Gene

Proteins for GREB1 Gene

  • Protein details for GREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ZG55-GREB1_HUMAN
    Recommended name:
    Protein GREB1
    Protein Accession:
    Q4ZG55
    Secondary Accessions:
    • A6NHD0
    • A6NKN0
    • B5MDA9
    • O60321
    • Q7Z5S2
    • Q9H2Q6
    • Q9H2Q7
    • Q9H2Q8

    Protein attributes for GREB1 Gene

    Size:
    1949 amino acids
    Molecular mass:
    216467 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25501.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GREB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GREB1 Gene

Post-translational modifications for GREB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GREB1 Gene

Domains & Families for GREB1 Gene

Gene Families for GREB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GREB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GREB1 Gene

GenScript: Design optimal peptide antigens:
  • Gene regulated in breast cancer 1 protein (GREB1_HUMAN)
  • GREB1 protein (Q6IPM5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4ZG55

UniProtKB/Swiss-Prot:

GREB1_HUMAN :
  • Belongs to the GREB1 family.
Family:
  • Belongs to the GREB1 family.
genes like me logo Genes that share domains with GREB1: view

Function for GREB1 Gene

Molecular function for GREB1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
UniProtKB/Swiss-Prot Induction:
Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.

Phenotypes From GWAS Catalog for GREB1 Gene

genes like me logo Genes that share phenotypes with GREB1: view

Animal Models for GREB1 Gene

MGI Knock Outs for GREB1:
  • Greb1 Greb1<tm1b(KOMP)Wtsi>

Clone Products

  • Addgene plasmids for GREB1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GREB1 Gene

Localization for GREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GREB1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GREB1 gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 18570454
genes like me logo Genes that share ontologies with GREB1: view

Pathways & Interactions for GREB1 Gene

PathCards logo

SuperPathways for GREB1 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with GREB1: view

Pathways by source for GREB1 Gene

1 BioSystems pathway for GREB1 Gene

SIGNOR curated interactions for GREB1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for GREB1 Gene

None

Drugs & Compounds for GREB1 Gene

No Compound Related Data Available

Transcripts for GREB1 Gene

mRNA/cDNA for GREB1 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GREB1

Alternative Splicing Database (ASD) splice patterns (SP) for GREB1 Gene

No ASD Table

Relevant External Links for GREB1 Gene

GeneLoc Exon Structure for
GREB1

Expression for GREB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GREB1 Gene

This gene is overexpressed in Ovary (x17.0) and Prostate (x5.0).

Protein differential expression in normal tissues from HIPED for GREB1 Gene

This gene is overexpressed in Esophagus (30.5), Retina (29.4), and Ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GREB1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GREB1

SOURCE GeneReport for Unigene cluster for GREB1 Gene:

Hs.467733

mRNA Expression by UniProt/SwissProt for GREB1 Gene:

Q4ZG55-GREB1_HUMAN
Tissue specificity: Expressed in proliferating prostatic tissue and prostate cancer.

Evidence on tissue expression from TISSUES for GREB1 Gene

  • Nervous system(4.1)
  • Skin(4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with GREB1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GREB1 Gene

Orthologs for GREB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GREB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GREB1 31 30
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GREB1 31 30
  • 88.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GREB1 31 30
  • 87.59 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Greb1 17 31 30
  • 84.86 (n)
rat
(Rattus norvegicus)
Mammalia Greb1 30
  • 84.42 (n)
oppossum
(Monodelphis domestica)
Mammalia GREB1 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves GREB1 31 30
  • 72.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GREB1 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia greb1 30
  • 68.18 (n)
Str.16465 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.13835 30
zebrafish
(Danio rerio)
Actinopterygii greb1 31 30
  • 65.64 (n)
OneToOne
Dr.17964 30
Species where no ortholog for GREB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GREB1 Gene

ENSEMBL:
Gene Tree for GREB1 (if available)
TreeFam:
Gene Tree for GREB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GREB1: view image

Paralogs for GREB1 Gene

Paralogs for GREB1 Gene

(1) SIMAP similar genes for GREB1 Gene using alignment to 4 proteins:

  • GREB1_HUMAN
  • C9JIG0_HUMAN
  • F8W6E5_HUMAN
  • Q6IPM5_HUMAN

Pseudogenes.org Pseudogenes for GREB1 Gene

genes like me logo Genes that share paralogs with GREB1: view

Variants for GREB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GREB1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
717821 Benign: not provided 11,618,577(+) G/A SYNONYMOUS_VARIANT
725180 Likely Benign: not provided 11,593,134(+) C/G INTRON_VARIANT
728253 Benign: not provided 11,598,720(+) G/A SYNONYMOUS_VARIANT
733620 Benign: not provided 11,580,760(+) G/A MISSENSE_VARIANT
734582 Likely Benign: not provided 11,640,439(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GREB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GREB1 Gene

Variant ID Type Subtype PubMed ID
esv1008112 CNV insertion 20482838
esv1097706 CNV insertion 17803354
esv1172824 CNV insertion 17803354
esv1626684 CNV insertion 17803354
esv1662162 CNV insertion 17803354
esv2719672 CNV deletion 23290073
esv2719674 CNV deletion 23290073
esv2719675 CNV deletion 23290073
esv2719676 CNV deletion 23290073
nsv1134830 CNV deletion 24896259
nsv1138749 CNV deletion 24896259
nsv472919 CNV novel sequence insertion 20440878
nsv953449 CNV deletion 24416366

Variation tolerance for GREB1 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.48; 99.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GREB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GREB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GREB1 Gene

Disorders for GREB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GREB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
amelogenesis imperfecta, type ig
  • ai1g
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GREB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GREB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GREB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GREB1 Gene

Publications for GREB1 Gene

  1. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. (PMID: 11103799) Ghosh MG … Weigel RJ (Cancer research 2000) 2 3 4 23 54
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  3. Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. (PMID: 17666587) Sun J … Slingerland JM (Molecular endocrinology (Baltimore, Md.) 2007) 3 4 54
  4. Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences. (PMID: 17463000) Deschênes J … Mader S (The Journal of biological chemistry 2007) 3 4 54
  5. GREB1 is a novel androgen-regulated gene required for prostate cancer growth. (PMID: 16496412) Rae JM … Lippman ME (The Prostate 2006) 3 4 54

Products for GREB1 Gene

  • Biorbyt antibodies for GREB1

Sources for GREB1 Gene